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European Radiology

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01.05.2015 | Contrast Media

Assessing liver function in patients with HBV-related HCC: a comparison of T₁ mapping on Gd-EOB-DTPA-enhanced MR imaging with DWI

verfasst von: Ying Ding, Sheng-Xiang Rao, Caizhong Chen, Renchen Li, Meng-Su Zeng

Erschienen in: European Radiology | Ausgabe 5/2015

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Abstract

Objectives

To compare the potential of T₁ mapping on gadoxetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI) and diffusion-weighted imaging (DWI) for assessing liver function in patients with hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC).

Methods

One hundred consecutive patients with known HBV-related HCCs were included. T₁ relaxation time and apparent diffusion coefficient (ADC) of the liver were measured, and the reduction rate of T₁ relaxation time (∆%) was calculated. T₁ relaxation time measurements were compared with ADC values according to the Model for End-Stage Liver Disease (MELD) score.

Results

Hepatobiliary phase (HBP) and ∆% of T₁ relaxation time measurements showed significant correlations with MELD score (rho = 0.571, p < 0.0001; rho = −0.573, p < 0.0001, respectively). HBP and ∆% of T₁ relaxation time were significantly different between good (MELD ≤8) and poor liver function (MELD ≥9) (p < 0.0001 for both). Areas under the receiver operating characteristic curves (AUCs) of T₁ relaxation time for HBP (AUC 0.84) and ∆% (AUC 0.82) were significantly better than for ADC (AUC 0.53; p < 0.0001).

Conclusions

T₁ mapping on Gd-EOB-DTPA-enhanced MRI showed promise for evaluating liver function in patients with HBV-related HCC, while DWI was not reliable. HBP T₁ relaxation time measurement was equally accurate as ∆% measurement.

Key Points

• T ₁ mapping on Gd-EOB-DTPA MRI was accurate for assessing liver function.

• HBP T ₁ relaxation time measurement was as accurate as ∆% T ₁

• T ₁ mapping on Gd-EOB-DTPA MRI was more accurate than DWI-ADC measurement.

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Titel: Assessing liver function in patients with HBV-related HCC: a comparison of T1 mapping on Gd-EOB-DTPA-enhanced MR imaging with DWI
verfasst von: Ying Ding
Sheng-Xiang Rao
Caizhong Chen
Renchen Li
Meng-Su Zeng
Publikationsdatum: 01.05.2015
Verlag: Springer Berlin Heidelberg
Erschienen in: European Radiology / Ausgabe 5/2015
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-014-3542-x

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Assessing liver function in patients with HBV-related HCC: a comparison of T₁ mapping on Gd-EOB-DTPA-enhanced MR imaging with DWI

Abstract

Objectives

Methods

Results

Conclusions

Key Points

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Springer Medizin

Abstract

Objectives

Methods

Results

Conclusions

Key Points

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