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Erschienen in: European Radiology 3/2016

01.03.2016 | Chest

Assessment of CF lung disease using motion corrected PROPELLER MRI: a comparison with CT

verfasst von: Pierluigi Ciet, Goffredo Serra, Silvia Bertolo, Sandra Spronk, Mirco Ros, Francesco Fraioli, Serena Quattrucci, M. Baroukh Assael, Carlo Catalano, Fabio Pomerri, Harm. A. W. M Tiddens, Giovanni Morana

Erschienen in: European Radiology | Ausgabe 3/2016

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Abstract

Objectives

To date, PROPELLER MRI, a breathing-motion-insensitive technique, has not been assessed for cystic fibrosis (CF) lung disease. We compared this technique to CT for assessing CF lung disease in children and adults.

Methods

Thirty-eight stable CF patients (median 21 years, range 6-51 years, 22 female) underwent MRI and CT on the same day. Study protocol included respiratory-triggered PROPELLER MRI and volumetric CT end-inspiratory and -expiratory acquisitions. Two observers scored the images using the CF-MRI and CF-CT systems. Scores were compared with intra-class correlation coefficient (ICC) and Bland-Altman plots. The sensitivity and specificity of MRI versus CT were calculated.

Results

MRI sensitivity for detecting severe CF bronchiectasis was 0.33 (CI 0.09-0.57), while specificity was 100 % (CI 0.88-1). ICCs for bronchiectasis and trapped air were as follows: MRI-bronchiectasis (0.79); CT-bronchiectasis (0.85); MRI-trapped air (0.51); CT-trapped air (0.87). Bland-Altman plots showed an MRI tendency to overestimate the severity of bronchiectasis in mild CF disease and underestimate bronchiectasis in severe disease.

Conclusions

Motion correction in PROPELLER MRI does not improve assessment of CF lung disease compared to CT. However, the good inter- and intra-observer agreement and the high specificity suggest that MRI might play a role in the short-term follow-up of CF lung disease (i.e. pulmonary exacerbations).

Key Points

PROPELLER MRI does not match CT sensitivity to assess CF lung disease.
PROPELLER MRI has lower sensitivity than CT to detect severe bronchiectasis.
PROPELLER MRI has good to very good intra- and inter-observer variability.
PROPELLER MRI can be used for short-term follow-up studies in CF.
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Metadaten
Titel
Assessment of CF lung disease using motion corrected PROPELLER MRI: a comparison with CT
verfasst von
Pierluigi Ciet
Goffredo Serra
Silvia Bertolo
Sandra Spronk
Mirco Ros
Francesco Fraioli
Serena Quattrucci
M. Baroukh Assael
Carlo Catalano
Fabio Pomerri
Harm. A. W. M Tiddens
Giovanni Morana
Publikationsdatum
01.03.2016
Verlag
Springer Berlin Heidelberg
Erschienen in
European Radiology / Ausgabe 3/2016
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-015-3850-9

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