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Erschienen in: European Radiology 2/2016

01.02.2016 | Urogenital

Angiomyolipoma (AML) without visible fat: Ultrasound, CT and MR imaging features with pathological correlation

verfasst von: Shaheed W. Hakim, Nicola Schieda, Taryn Hodgdon, Matthew D. F. McInnes, Marc Dilauro, Trevor A. Flood

Erschienen in: European Radiology | Ausgabe 2/2016

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Abstract

Objective

To compare imaging findings with histopathology in AML without visible fat (AMLwvf).

Material and methods

With IRB approval, we identified 18 AMLwvf that underwent CT between 2002-2014. A radiologist measured NECT-attenuation, corticomedullary (CM) and nephrographic (NG) enhancement, echogenicity relative to renal cortex (RC) (N = 5), T2W (T2AML/T2RC) signal-intensity (SI), and chemical-shift SI ([SIIN-PHASE − SIOPPOSED-PHASE]/SIIN-PHASE) indices (N = 6). A pathologist re-evaluated 15/18 AMLwvf for 1) < or > 25 % adipocytes/high-power-field (HPF), 2) “many or few” blood vessels. Comparisons were performed using chi-square and independent t-tests.

Results

73.3 %(11/15) of AMLwvf had <25 % adipocytes/HPF and 86.7 %(13/15) had “many” blood vessels. NECT-attenuation was 41.8(±6.9) HU. 61.1 %(11/18) of AMLwvf were hyper-attenuating and 38.9 %(7/18) iso-attenuating; attenuation was associated with %-adipocytes/HPF, (p = 0.01). CM/NG enhancement were 63.3(±20.8)/51.7(±15.5) HU. 72.2 %(13/18) of AMLwvf had wash-out enhancement, with no association with amount of blood vessels at pathology, (p = 0.68). No difference in echogenicity was noted by histology (p > 0.05). All AMLwvf were T2-hypointense (SI ratio = 0.61 [±0.1]). 2/6 AMLwvf showed SI drop on chemical-shift MRI; both were iso-attenuating and were associated with >25 % adipocytes/HPF (p = 0.04).

Conclusions

AMLwvf are typically T2-hypointense and hyper-attenuating with wash-out enhancement due to abundant smooth muscle and vessels respectively. Iso-attenuating AMLwvf with microscopic fat on MRI contain more adipocytes/HPF.

Key Points

Five percent of AML do not demonstrate detectable fat on imaging
These AML are hyperattenuating and T2-hypointense due to abundant smooth muscle
These AML show washout enhancement without association to vessel count at histopathology
Iso-attenuating AML with microscopic fat on MRI show >25 % adipocytes/HPF
The term “AML without visible fat” is proposed to reduce ambiguity
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Metadaten
Titel
Angiomyolipoma (AML) without visible fat: Ultrasound, CT and MR imaging features with pathological correlation
verfasst von
Shaheed W. Hakim
Nicola Schieda
Taryn Hodgdon
Matthew D. F. McInnes
Marc Dilauro
Trevor A. Flood
Publikationsdatum
01.02.2016
Verlag
Springer Berlin Heidelberg
Erschienen in
European Radiology / Ausgabe 2/2016
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-015-3851-8

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