Erschienen in:
08.08.2015 | Hepatobiliary-Pancreas
Prognostic value of CT findings to predict survival outcomes in patients with pancreatic neuroendocrine neoplasms: a single institutional study of 161 patients
verfasst von:
Dong Wook Kim, Hyoung Jung Kim, Kyung Won Kim, Jae Ho Byun, So Yeon Kim, Ki Byung Song, Nikhil H. Ramaiya, Sree Harsha Tirumani, Seung-Mo Hong
Erschienen in:
European Radiology
|
Ausgabe 5/2016
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Abstract
Objectives
To evaluate the prognostic value of CT to predict recurrence-free and overall survival in patients with pancreatic neuroendocrine neoplasms (PanNENs).
Methods
Between January 2004 and December 2012, 161 consecutive patients who underwent preoperative triphasic CT and surgical resection with curative intent for PanNENs were identified. The tumour consistency, margin, presence of calcification, pancreatic duct dilatation, bile duct dilatation, vascular invasion, and hepatic metastases were evaluated. The tumour size, arterial enhancement ratio, and portal enhancement ratio were measured. The Cox proportional hazard model was used to determine the association between CT features and recurrence-free survival and overall survival.
Results
By multivariate analysis, tumour size (>3 cm) (hazard ratio, 3.314; p = 0.006), portal enhancement ratio (≤1.1) (hazard ratio, 2.718; p = 0.006), and hepatic metastases (hazard ratio, 4.374; p = 0.003) were independent significant variables for worse recurrence-free survival. Portal enhancement ratio (≤1.1) (hazard ratio, 5.951; p = 0.001) and hepatic metastases (hazard ratio, 4.122; p = 0.021) were independent significant variables for worse overall survival.
Conclusions
Portal enhancement ratio (≤1.1) and hepatic metastases assessed on CT were common independent prognostic factors for worse recurrence-free survival and overall survival in patients with PanNENs.
Key points
• CT is useful to predict survival outcomes in patients with PanNENs.
• Survival outcomes are associated with portal enhancement ratio and hepatic metastases.
• Portal enhancement ratio is prognostic CT biomarker in patients with PanNENs.