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Erschienen in: European Radiology 5/2016

08.08.2015 | Hepatobiliary-Pancreas

Prognostic value of CT findings to predict survival outcomes in patients with pancreatic neuroendocrine neoplasms: a single institutional study of 161 patients

verfasst von: Dong Wook Kim, Hyoung Jung Kim, Kyung Won Kim, Jae Ho Byun, So Yeon Kim, Ki Byung Song, Nikhil H. Ramaiya, Sree Harsha Tirumani, Seung-Mo Hong

Erschienen in: European Radiology | Ausgabe 5/2016

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Abstract

Objectives

To evaluate the prognostic value of CT to predict recurrence-free and overall survival in patients with pancreatic neuroendocrine neoplasms (PanNENs).

Methods

Between January 2004 and December 2012, 161 consecutive patients who underwent preoperative triphasic CT and surgical resection with curative intent for PanNENs were identified. The tumour consistency, margin, presence of calcification, pancreatic duct dilatation, bile duct dilatation, vascular invasion, and hepatic metastases were evaluated. The tumour size, arterial enhancement ratio, and portal enhancement ratio were measured. The Cox proportional hazard model was used to determine the association between CT features and recurrence-free survival and overall survival.

Results

By multivariate analysis, tumour size (>3 cm) (hazard ratio, 3.314; p = 0.006), portal enhancement ratio (≤1.1) (hazard ratio, 2.718; p = 0.006), and hepatic metastases (hazard ratio, 4.374; p = 0.003) were independent significant variables for worse recurrence-free survival. Portal enhancement ratio (≤1.1) (hazard ratio, 5.951; p = 0.001) and hepatic metastases (hazard ratio, 4.122; p = 0.021) were independent significant variables for worse overall survival.

Conclusions

Portal enhancement ratio (≤1.1) and hepatic metastases assessed on CT were common independent prognostic factors for worse recurrence-free survival and overall survival in patients with PanNENs.

Key points

CT is useful to predict survival outcomes in patients with PanNENs.
Survival outcomes are associated with portal enhancement ratio and hepatic metastases.
Portal enhancement ratio is prognostic CT biomarker in patients with PanNENs.
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Metadaten
Titel
Prognostic value of CT findings to predict survival outcomes in patients with pancreatic neuroendocrine neoplasms: a single institutional study of 161 patients
verfasst von
Dong Wook Kim
Hyoung Jung Kim
Kyung Won Kim
Jae Ho Byun
So Yeon Kim
Ki Byung Song
Nikhil H. Ramaiya
Sree Harsha Tirumani
Seung-Mo Hong
Publikationsdatum
08.08.2015
Verlag
Springer Berlin Heidelberg
Erschienen in
European Radiology / Ausgabe 5/2016
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-015-3943-5

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