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Erschienen in:
22.09.2015 | Oncology
Efficacy and safety of preoperative chemoembolization for resectable hepatocellular carcinoma with portal vein invasion: a prospective comparative study
Erschienen in: European Radiology | Ausgabe 7/2016
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Objectives
To evaluate the outcomes of preoperative transarterial chemoembolization (TACE) for resectable hepatocellular carcinoma (HCC) with portal vein invasion.
Methods
From February 2006 to July 2011, 320 patients initially diagnosed with resectable HCC and portal vein invasion were prospectively non-randomized into two arms. In the immediate resection arm (Arm 1, n = 205) patients received immediate surgical resection. 115 patients were included in the preoperative TACE arm (Arm 2), and eventually 85 patients underwent TACE followed by surgical resection.
Results
The 1-, 3- and 5-year overall survival rates were 48.3 %, 18.7 % and 13.9 % for Arm 1 and 61.2 %, 31.7 % and 25.3 % for Arm 2 (P = 0.001), respectively. In the subgroup analysis of types I and II portal vein tumour thrombus (PVTT), the preoperative TACE arm demonstrated significantly better survival rates than the immediate resection arm (P
I
= 0.001, P
II
= 0.036). However, no significant difference was found for patients with type III PVTT (P
III
= 0.684). No significant difference was found between the two arms in terms of complications and mortality.
Conclusions
Preoperative TACE seems to confer a survival benefit for resectable HCC with PVTT, especially for types I and II PVTT, and preoperative TACE should therefore be recommended as a routine procedure.
Key Points
• Preoperative TACE improves the clinical outcomes for patients with PVTT
• Preoperative TACE could significantly improve the rate of en bloc thrombectomy
• Preoperative TACE does not increase the related adverse events