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24.03.2016 | Urogenital

⁶⁸Ga-PSMA I&T PET/CT for assessment of prostate cancer: evaluation of image quality after forced diuresis and delayed imaging

verfasst von: Thorsten Derlin, Desiree Weiberg, Christoph von Klot, Hans-Jürgen Wester, Christoph Henkenberens, Tobias L. Ross, Hans Christiansen, Axel S. Merseburger, Frank M. Bengel

Erschienen in: European Radiology | Ausgabe 12/2016

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Abstract

Objective

Urinary radiotracer excretion of ⁶⁸Ga-Labelled prostate-specific membrane antigen (PSMA) ligands may complicate the assessment of the prostate region and differentiation of lymph nodes from ureteral activity. The aim of this study was to assess the value of delayed imaging after forced diuresis.

Materials and methods

Sixty-six patients underwent ⁶⁸Ga-PSMA I&T PET/CT for evaluation of prostate cancer at 60 min post-injection. In subgroups of patients, this was amended by delayed imaging after 180 min post-injection, preceded by furosemide and oral hydration early, at the time of tracer injection, or delayed, at 100 min post-injection. Urinary tracer activity within the bladder and focal ureteral activity was analyzed.

Results

After forced diuresis, linear and focal visualization of ureters was significantly reduced. After delayed furosemide, mean and peak bladder activity decreased (p < 0.001), and image quality of the prostate region improved on delayed images (p < 0.001). Early furosemide co-injection with tracer resulted in increased mean and peak bladder activity (p < 0.001) and in deteriorated image quality of the prostate region on delayed images (p = 0.008).

Conclusion

Ga-PSMA I&T PET/CT delayed imaging after forced diuresis can improve the assessment of prostate region and pelvic lymph nodes by removing excreted tracer from the lower urinary tract.

Key points

• Forced diuresis can improve image quality in ⁶⁸ Ga-PSMA I&T.

• After forced diuresis, linear and focal visualization of ureters was reduced.

• Timing of diuresis relative to ⁶⁸ Ga-PSMA I&T injection is important.

• Early furosemide co-injection with tracer resulted in deteriorated image quality on delayed images.

• After delayed furosemide, image quality improved on delayed images.

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Titel: 68Ga-PSMA I&T PET/CT for assessment of prostate cancer: evaluation of image quality after forced diuresis and delayed imaging
verfasst von: Thorsten Derlin
Desiree Weiberg
Christoph von Klot
Hans-Jürgen Wester
Christoph Henkenberens
Tobias L. Ross
Hans Christiansen
Axel S. Merseburger
Frank M. Bengel
Publikationsdatum: 24.03.2016
Verlag: Springer Berlin Heidelberg
Erschienen in: European Radiology / Ausgabe 12/2016
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-016-4308-4

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⁶⁸Ga-PSMA I&T PET/CT for assessment of prostate cancer: evaluation of image quality after forced diuresis and delayed imaging

Abstract

Objective

Materials and methods

Results

Conclusion

Key points

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Update Radiologie

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Springer Medizin

Abstract

Objective

Materials and methods

Results

Conclusion

Key points

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