Skip to main content
Erschienen in: European Radiology 2/2018

11.09.2017 | Emergency Radiology

How to differentiate acute pelvic inflammatory disease from acute appendicitis ? A decision tree based on CT findings

verfasst von: Kim El Hentour, Ingrid Millet, Emmanuelle Pages-Bouic, Fernanda Curros-Doyon, Nicolas Molinari, Patrice Taourel

Erschienen in: European Radiology | Ausgabe 2/2018

Einloggen, um Zugang zu erhalten

Abstract

Purpose

To construct a decision tree based on CT findings to differentiate acute pelvic inflammatory disease (PID) from acute appendicitis (AA) in women with lower abdominal pain and inflammatory syndrome.

Materials and methods

This retrospective study was approved by our institutional review board and informed consent was waived. Contrast-enhanced CT studies of 109 women with acute PID and 218 age-matched women with AA were retrospectively and independently reviewed by two radiologists to identify CT findings predictive of PID or AA. Surgical and laboratory data were used for the PID and AA reference standard. Appropriate tests were performed to compare PID and AA and a CT decision tree using the classification and regression tree (CART) algorithm was generated.

Results

The median patient age was 28 years (interquartile range, 22–39 years). According to the decision tree, an appendiceal diameter ≥ 7 mm was the most discriminating criterion for differentiating acute PID and AA, followed by a left tubal diameter ≥ 10 mm, with a global accuracy of 98.2 % (95 % CI: 96–99.4).

Conclusion

Appendiceal diameter and left tubal thickening are the most discriminating CT criteria for differentiating acute PID from AA.

Key points

• Appendiceal diameter and marked left tubal thickening allow differentiating PID from AA.
• PID should be considered if appendiceal diameter is < 7 mm.
• Marked left tubal diameter indicates PID rather than AA when enlarged appendix.
• No pathological CT findings were identified in 5 % of PID patients.
Literatur
1.
Zurück zum Zitat Sellors J, Mahony J, Goldsmith C et al (1991) The accuracy of clinical findings and laparoscopy in pelvic inflammatory disease. Am J Obstet Gynecol 164:113–120CrossRefPubMed Sellors J, Mahony J, Goldsmith C et al (1991) The accuracy of clinical findings and laparoscopy in pelvic inflammatory disease. Am J Obstet Gynecol 164:113–120CrossRefPubMed
2.
Zurück zum Zitat Centers for Disease Control and Prevention (2010) Sexually transmitted diseases treatment guidelines, 2010. MMWR Recomm Rep 59:63–67 Centers for Disease Control and Prevention (2010) Sexually transmitted diseases treatment guidelines, 2010. MMWR Recomm Rep 59:63–67
3.
Zurück zum Zitat Morcos R, Frost N, Hnat M, Petrunak A, Caldito G (1993) Laparoscopic versus clinical diagnosis of acute pelvic inflammatory disease. J Reprod Med 38:53–56PubMed Morcos R, Frost N, Hnat M, Petrunak A, Caldito G (1993) Laparoscopic versus clinical diagnosis of acute pelvic inflammatory disease. J Reprod Med 38:53–56PubMed
4.
Zurück zum Zitat Maleckiene L, Kajenas S, Nadisauskiene RJ, Railaite DR (2009) Comparison of clinical and laparoscopic diagnoses of pelvic inflammatory disease. Int J Gynaecol Obstet 104:74–75CrossRefPubMed Maleckiene L, Kajenas S, Nadisauskiene RJ, Railaite DR (2009) Comparison of clinical and laparoscopic diagnoses of pelvic inflammatory disease. Int J Gynaecol Obstet 104:74–75CrossRefPubMed
5.
Zurück zum Zitat Bongard F, Landers DV, Lewis F (1985) Differential diagnosis of appendicitis and pelvic inflammatory disease. A prospective analysis. Am J Surg 150:90–96CrossRefPubMed Bongard F, Landers DV, Lewis F (1985) Differential diagnosis of appendicitis and pelvic inflammatory disease. A prospective analysis. Am J Surg 150:90–96CrossRefPubMed
6.
Zurück zum Zitat Webster DP, Schneider CN, Cheche S, Daar AA, Miller G (1993) Differentiating acute appendicitis from pelvic inflammatory disease in women of childbearing age. Am J Emerg Med 11:569–572CrossRefPubMed Webster DP, Schneider CN, Cheche S, Daar AA, Miller G (1993) Differentiating acute appendicitis from pelvic inflammatory disease in women of childbearing age. Am J Emerg Med 11:569–572CrossRefPubMed
7.
Zurück zum Zitat Morishita K, Gushimiyagi M, Hashiguchi M, Stein GH, Tokuda Y (2007) Clinical prediction rule to distinguish pelvic inflammatory disease from acute appendicitis in women of childbearing age. AmJ Emerg Med 25:152–157CrossRef Morishita K, Gushimiyagi M, Hashiguchi M, Stein GH, Tokuda Y (2007) Clinical prediction rule to distinguish pelvic inflammatory disease from acute appendicitis in women of childbearing age. AmJ Emerg Med 25:152–157CrossRef
8.
Zurück zum Zitat Weström L, Joesoef R, Reynolds G, Hagdu A, Thompson SE (1992) Pelvic inflammatory disease and fertility. A cohort study of 1,844 women with laparoscopically verified disease and 657 control women with normal laparoscopic results. Sex Transm Dis 19:185–192CrossRefPubMed Weström L, Joesoef R, Reynolds G, Hagdu A, Thompson SE (1992) Pelvic inflammatory disease and fertility. A cohort study of 1,844 women with laparoscopically verified disease and 657 control women with normal laparoscopic results. Sex Transm Dis 19:185–192CrossRefPubMed
9.
Zurück zum Zitat Buchan H, Vessey M, Goldacre M, Fairweather J (1993) Morbidity following pelvic inflammatory disease. Br J Obstet Gynaecol 100:558–562CrossRefPubMed Buchan H, Vessey M, Goldacre M, Fairweather J (1993) Morbidity following pelvic inflammatory disease. Br J Obstet Gynaecol 100:558–562CrossRefPubMed
10.
Zurück zum Zitat Van Randen A, Bipat S, Zwinderman AH, Ubbink DT, Stoker J, Boermeester MA (2008) Acute appendicitis: metaanalysis of diagnostic performance of CT and graded compression US related to prevalence of disease. Radiology 249:97–106CrossRefPubMed Van Randen A, Bipat S, Zwinderman AH, Ubbink DT, Stoker J, Boermeester MA (2008) Acute appendicitis: metaanalysis of diagnostic performance of CT and graded compression US related to prevalence of disease. Radiology 249:97–106CrossRefPubMed
11.
Zurück zum Zitat Bhosale PR, Javitt MC, Atri M et al (2016) ACR Appropriateness Criteria® Acute Pelvic Pain in the Reproductive Age Group. Ultrasound Q. 32:108–115CrossRefPubMed Bhosale PR, Javitt MC, Atri M et al (2016) ACR Appropriateness Criteria® Acute Pelvic Pain in the Reproductive Age Group. Ultrasound Q. 32:108–115CrossRefPubMed
12.
Zurück zum Zitat Jung SI, Kim YJ, Park HS, Jeon HJ, Jeong K-A (2011) Acute pelvic inflammatory disease: diagnostic performance of CT. J Obstet Gynaecol Res 37:228–235CrossRefPubMed Jung SI, Kim YJ, Park HS, Jeon HJ, Jeong K-A (2011) Acute pelvic inflammatory disease: diagnostic performance of CT. J Obstet Gynaecol Res 37:228–235CrossRefPubMed
13.
Zurück zum Zitat Lee MH, Moon MH, Sung CK, Woo H, Oh S (2014) CT findings of acute pelvic inflammatory disease. Abdom Imaging 39:1350–1355CrossRefPubMed Lee MH, Moon MH, Sung CK, Woo H, Oh S (2014) CT findings of acute pelvic inflammatory disease. Abdom Imaging 39:1350–1355CrossRefPubMed
14.
Zurück zum Zitat Rao PM, Rhea JT, Novelline RA (1997) Sensitivity and specificity of the individual CT signs of appendicitis: experience with 200 helical appendiceal CT examinations. J Comput Assist Tomogr 21:686–692CrossRefPubMed Rao PM, Rhea JT, Novelline RA (1997) Sensitivity and specificity of the individual CT signs of appendicitis: experience with 200 helical appendiceal CT examinations. J Comput Assist Tomogr 21:686–692CrossRefPubMed
15.
Zurück zum Zitat Choi D, Park H, Lee YR et al (2003) The most useful findings for diagnosing acute appendicitis on contrast-enhanced helical CT. Acta Radiol 44:574–582CrossRefPubMed Choi D, Park H, Lee YR et al (2003) The most useful findings for diagnosing acute appendicitis on contrast-enhanced helical CT. Acta Radiol 44:574–582CrossRefPubMed
16.
Zurück zum Zitat Ives EP, Sung S, McCue P, Durrani H, Halpern EJ (2008) Independent predictors of acute appendicitis on CT with pathologic correlation. Acad Radiol 15:996–1003CrossRefPubMed Ives EP, Sung S, McCue P, Durrani H, Halpern EJ (2008) Independent predictors of acute appendicitis on CT with pathologic correlation. Acad Radiol 15:996–1003CrossRefPubMed
17.
Zurück zum Zitat Van Randen A, Lameris W, van Es HW et al (2010) Profiles of US and CT imaging features with a high probability of appendicitis. Eur Radiol 20:1657–1666CrossRefPubMedPubMedCentral Van Randen A, Lameris W, van Es HW et al (2010) Profiles of US and CT imaging features with a high probability of appendicitis. Eur Radiol 20:1657–1666CrossRefPubMedPubMedCentral
18.
Zurück zum Zitat Godwin BD, Drake FT, Simianu VV et al (2015) A novel reporting system to improve accuracy in appendicitis imaging. Am J Roentgenol 204:1212–1219CrossRef Godwin BD, Drake FT, Simianu VV et al (2015) A novel reporting system to improve accuracy in appendicitis imaging. Am J Roentgenol 204:1212–1219CrossRef
19.
Zurück zum Zitat Eshed I, Halshtok O, Erlich Z et al (2011) Differentiation between right tubo-ovarian abscess and appendicitis using CT-a diagnostic challenge. Clin Radiol 66:1030–1035CrossRefPubMed Eshed I, Halshtok O, Erlich Z et al (2011) Differentiation between right tubo-ovarian abscess and appendicitis using CT-a diagnostic challenge. Clin Radiol 66:1030–1035CrossRefPubMed
20.
Zurück zum Zitat Hiller N, Fux T, Finkelstein A, Mezeh H, Simanovsky N (2016) CT differentiation between tubo-ovarian and appendiceal origin of right lower quadrant abscess: CT, clinical, and laboratory correlation. Emerg Radiol 23:133–139CrossRefPubMed Hiller N, Fux T, Finkelstein A, Mezeh H, Simanovsky N (2016) CT differentiation between tubo-ovarian and appendiceal origin of right lower quadrant abscess: CT, clinical, and laboratory correlation. Emerg Radiol 23:133–139CrossRefPubMed
21.
Zurück zum Zitat Quentin R, Verdon R (2012) Microbiologic basis of diagnosis and treatment of pelvic inflammatory disease. J Gynecol Obstet Biol Reprod 41:850–863CrossRef Quentin R, Verdon R (2012) Microbiologic basis of diagnosis and treatment of pelvic inflammatory disease. J Gynecol Obstet Biol Reprod 41:850–863CrossRef
22.
Zurück zum Zitat Cabarrus M, Sun YL, Courtier JL, Stengel JW, Coakley FV, Webb EM (2013) The prevalence and patterns of intraluminal air in acute appendicitis at CT. Emerg Radiol 20:51–56CrossRefPubMed Cabarrus M, Sun YL, Courtier JL, Stengel JW, Coakley FV, Webb EM (2013) The prevalence and patterns of intraluminal air in acute appendicitis at CT. Emerg Radiol 20:51–56CrossRefPubMed
23.
Zurück zum Zitat Hong HS, Cho HS, Woo JY et al (2016) Intra-Appendiceal Air at CT: Is It a Useful or a Confusing Sign for the Diagnosis of Acute Appendicitis? Korean J Radiol 17:39–46CrossRefPubMedPubMedCentral Hong HS, Cho HS, Woo JY et al (2016) Intra-Appendiceal Air at CT: Is It a Useful or a Confusing Sign for the Diagnosis of Acute Appendicitis? Korean J Radiol 17:39–46CrossRefPubMedPubMedCentral
24.
Zurück zum Zitat Rothrock SG, Green SM, Dobson M, Colucciello SA, Simmons CM (1995) Misdiagnosis of appendicitis in nonpregnant women of childbearing age. J Emerg Med 13:1–8CrossRefPubMed Rothrock SG, Green SM, Dobson M, Colucciello SA, Simmons CM (1995) Misdiagnosis of appendicitis in nonpregnant women of childbearing age. J Emerg Med 13:1–8CrossRefPubMed
25.
Zurück zum Zitat Kim MY, Lee YM, Suh CH, Kim JM (2007) Computed tomographic features of appendiceal serositis in pelvic inflammatory disease: comparison with pathological findings. J Comput Assist Tomogr 31:104–108CrossRefPubMed Kim MY, Lee YM, Suh CH, Kim JM (2007) Computed tomographic features of appendiceal serositis in pelvic inflammatory disease: comparison with pathological findings. J Comput Assist Tomogr 31:104–108CrossRefPubMed
27.
Zurück zum Zitat Nikolaidis P, Hwang CM, Miller FH, Papanicolaou N (2004) The nonvisualized appendix: incidence of acute appendicitis when secondary inflammatory changes are absent. AJR 183:889–892CrossRefPubMed Nikolaidis P, Hwang CM, Miller FH, Papanicolaou N (2004) The nonvisualized appendix: incidence of acute appendicitis when secondary inflammatory changes are absent. AJR 183:889–892CrossRefPubMed
28.
Zurück zum Zitat Ganguli S, Raptopoulos V, Komlos F, Siewert B, Kruskal JB (2006) Right lower quadrant pain: value of the nonvisualized appendix in patients at multidetector CT. Radiology 241:175–180CrossRefPubMed Ganguli S, Raptopoulos V, Komlos F, Siewert B, Kruskal JB (2006) Right lower quadrant pain: value of the nonvisualized appendix in patients at multidetector CT. Radiology 241:175–180CrossRefPubMed
Metadaten
Titel
How to differentiate acute pelvic inflammatory disease from acute appendicitis ? A decision tree based on CT findings
verfasst von
Kim El Hentour
Ingrid Millet
Emmanuelle Pages-Bouic
Fernanda Curros-Doyon
Nicolas Molinari
Patrice Taourel
Publikationsdatum
11.09.2017
Verlag
Springer Berlin Heidelberg
Erschienen in
European Radiology / Ausgabe 2/2018
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-017-5032-4

Weitere Artikel der Ausgabe 2/2018

European Radiology 2/2018 Zur Ausgabe

Update Radiologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.