nach oben

Erschienen in:

11.09.2017 | Interventional

Thermal ablation of thyroid nodules: are radiofrequency ablation, microwave ablation and high intensity focused ultrasound equally safe and effective methods?

verfasst von: Yücel Korkusuz, Daniel Gröner, Natascha Raczynski, Oleg Relin, Yasmina Kingeter, Frank Grünwald, Christian Happel

Erschienen in: European Radiology | Ausgabe 3/2018

Einloggen, um Zugang zu erhalten

Abstract

Objectives

This study compares volume reduction of benign thyroid nodules three months after Radiofrequency Ablation (RFA), Microwave Ablation (MWA) or High Intensity Focused Ultrasound (HIFU) to evaluate which of these methods is the most effective and safe alternative to thyroidectomy or radioiodine therapy.

Material and Methods

Ninety-four patients (39 male, 55 female) with a total of 118 benign, symptomatic thyroid nodules were divided into three subgroups. HIFU was applied to 14 patients with small nodules. The other 80 patients were divided up into two groups of 40 patients each for RFA and MWA in the assumption that both methods are comparable effective. The pre-ablative and post-ablative volume was measured by ultrasound.

Results

RFA showed a significant volume reduction of nodules of 50 % (p<0.05), MWA of 44 % (p<0.05) and HIFU of 48 % (p<0.05) three months after ablation. None of the examined ablation techniques caused serious or permanent complications.

Conclusion

RFA, MWA and HIFU showed comparable results considering volume reduction. All methods are safe and effective treatments of benign thyroid nodules.

Key Points

• Thermal Ablation can be used to treat benign thyroid nodules

• Thermal Ablation can be an alternative to thyroidectomy or radioiodine therapy

• Radiofrequency Ablation, Microwave Ablation, High Intensity Focused Ultrasound are safe and effective

Happel C, Kranert WT, Bockisch B et al (2016) 131I and 99m Tc-Uptake in focal thyroid autonomies Development in Germany since the 1980s. Nukleramedzin 55:236–241CrossRef

Gärtner R (2016) Recent data on iodine intake in Germany and Europe. J Trace Elem Med Biol 37:85–90CrossRefPubMed

Raval CB, Rahman SA (2015) Difficult airway challenges-intubation and extubation matters in a case of large goiter with retrosternal extension. Anesth Essays Res 9:247–250CrossRefPubMedPubMedCentral

Majumder KR, Karmakar R, Karim S et al (2016) Malignancy in Solitary Thyroid Nodule. Mymensingh Med J MMJ 25:39–44PubMed

Baumgarten J, Happel C, Ackermann H et al (2017) Evaluation of intra- and interobserver agreement of Technetium-99m-sestamibi imaging in cold thyroid nodules. Nuklearmedizin 56(4):132–138

Sheehan MT, Doi SAR (2016) Transient Hypothyroidism after Radioiodine for Graves’ Disease: Challenges in Interpreting Thyroid Function Tests. Clin Med Res 14:40–45CrossRefPubMedPubMedCentral

Müller F, Happel C, Reinhardt J et al (2014) Evaluation of fear of radiation and isolation before and after radioiodine therapy. Thyroid 24:1151–1155CrossRef

Kariyama K, Wakuta A, Nishimura M et al (2015) Percutaneous Radiofrequency Ablation for Intermediate-Stage Hepatocellular Carcinoma. Oncology 89:19–26CrossRefPubMed

Miao Y, Ni Y, Yu J et al (2000) A comparative study on validation of a novel cooled-wet electrode for radiofrequency liver ablation. Investig Radiol 35:438–444CrossRef

10.

Fischbach F, Lohfink K, Gaffke G et al (2013) Magnetic resonance-guided freehand radiofrequency ablation of malignant liver lesions: a new simplified and time-efficient approach using an interactive open magnetic resonance scan platform and hepatocyte-specific contrast agent. Investig Radiol 48:422–428CrossRef

11.

Kim Y, Lim HK, Park MJ et al (2016) Screening Magnetic Resonance Imaging-Based Prediction Model for Assessing Immediate Therapeutic Response to Magnetic Resonance Imaging-Guided High-Intensity Focused Ultrasound Ablation of Uterine Fibroids. Investig Radiol 51:15–24CrossRef

12.

Barral M, Auperin A, Hakime A et al (2016) Percutaneous Thermal Ablation of Breast Cancer Metastases in Oligometastatic Patients. Cardiovasc Intervent Radiol 39:885–893CrossRefPubMed

13.

Pan T, Xie Q-K, Lv N et al (2016) Percutaneous CT-guided Radiofrequency Ablation for Lymph Node Oligometastases from Hepatocellular Carcinoma: A Propensity Score-matching Analysis. Radiology 282:259–270CrossRefPubMed

14.

Thamtorawat S, Rojwatcharapibarn S, Tongdee T et al (2016) The Outcome of Radiofrequency Ablation of Metastatic Liver Tumors. J Med Assoc Thail Chotmaihet Thangphaet 99:424–432

15.

Chheang S, Abtin F, Guteirrez A et al (2013) Imaging Features following Thermal Ablation of Lung Malignancies. Semin Interv Radiol 30:157–168CrossRef

16.

Dupuy DE, Shulman M (2010) Current status of thermal ablation treatments for lung malignancies. Semin Interv Radiol 27:268–275CrossRef

17.

Marinova M, Strunk HM, Rauch M et al (2016) High-intensity focused ultrasound (HIFU) for tumor pain relief in inoperable pancreatic cancer. Evaluation with the pain sensation scale (SES). Schmerz 31:31–39CrossRef

18.

Dupuy DE, Monchik JM, Decrea C et al (2001) Radiofrequency ablation of regional recurrence from well-differentiated thyroid malignancy. Surgery 130:971–977CrossRefPubMed

19.

Park KW, Shin JH, Han B-K et al (2011) Inoperable Symptomatic Recurrent Thyroid Cancers. Preliminary Result of Radiofrequency Ablation. Ann Surg Oncol 18:2564–2568CrossRefPubMed

20.

Korkusuz Y, Erbelding C, Kohlhase K et al (2015) Bipolar radiofrequency ablation of benign symptomatic thyroid nodules. Initial experience with bipolar radiofrequency. RöFo: Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin 188:671–675PubMed

21.

Kim Y-S, Rhim H, Tae K et al (2006) Radiofrequency ablation of benign cold thyroid nodules: initial clinical experience. Thyroid 16(4):361–367

22.

Kohlhase KD, Korkusuz Y, Gröner D et al (2016) Bipolar radiofrequency ablation of benign thyroid nodules using a multiple overlapping shot technique in a 3-month follow-up. Int J Hyperth 32:511–516 1–6CrossRef

23.

Aysan E, Idiz UO, Akbulut H et al (2016) Single-session radiofrequency ablation on benign thyroid nodules: a prospective single center study. Radiofrequency ablation on thyroid. Langenbeck’s Arch Surg Deut Ges Chir 401:357–363CrossRef

24.

Lee KF, Wong J, Hui JW et al (2017) Long-term outcomes of microwave versus radiofrequency ablation for hepatocellular carcinoma by surgical approach. A retrospective comparative study. Asian J Surg 40(4):301–308

25.

Korkusuz H, Fehre N, Sennert M et al (2015) Volume reduction of benign thyroid nodules 3 months after a single treatment with high-intensity focused ultrasound (HIFU). J Ther Ultrasound 3:4CrossRefPubMedPubMedCentral

26.

Wijlemans JW, Greef M, Schubert G et al (2015) A clinically feasible treatment protocol for magnetic resonance-guided high-intensity focused ultrasound ablation in the liver. Investig Radiol 50:24–31CrossRef

27.

Korkusuz H, Sennert M, Fehre N, Happel C et al (2015) Localized Thyroid Tissue Ablation by High Intensity Focused Ultrasound: Volume Reduction, Effects on Thyroid Function and Immune Response. RöFo Fortschr Geb Röntgenstrahlen 187:1011–1015CrossRef

28.

Happel C, Korkusuz H, Kranert WT et al (2014) Combination of ultrasound guided percutaneous microwave ablation and radioiodine therapy for treatment of hyper- and hypofunctioning thyroid nodules. Nuklearmedizin 53:N48–N49PubMed

29.

Mader A, Mader OM, Gröner D et al (2017) Minimally invasive local ablative therapies in combination with radioiodine therapy in benign thyroid disease: preparation, feasibility and efficiency - preliminary results. Int J Hyperth 5:1–10CrossRef

30.

Happel C, Korkusuz H, Koch DA (2015) Combination of ultrasound guided percutaneous microwave ablation and radioiodine therapy in benign thyroid diseases A suitable method to reduce the 131I activity and hospitalization time? Nuklearmedizin 54:118–124CrossRefPubMed

31.

Korkusuz H, Happel C, Koch DA et al (2016) Combination of Ultrasound-Guided Percutaneous Microwave Ablation and Radioiodine Therapy in Benign Thyroid Disease: A 3-Month Follow-Up Study. RöFo Fortschr Geb Röntgenstrahlen 188:60–68

32.

Huffman SD, Huffman NP, Lewandowski R et al (2011) Radiofrequency Ablation Complicated by Skin Burn. Semin Interv Radiol 28:179–182CrossRef

33.

Ha EJ, Baek JH, Lee JH (2011) The efficacy and complications of radiofrequency ablation of thyroid nodules. Curr Opin Endocrinol Diabetes Obes 18:310–314CrossRefPubMed

34.

Feng B, Liang P, Cheng Z et al (2012) Ultrasound-guided percutaneous microwave ablation of benign thyroid nodules. Experimental and clinical studies. Eur J Endocrinol 166:1031–1037CrossRefPubMed

35.

Heck K, Happel C, Grünwald F et al (2015) Percutaneous microwave ablation of thyroid nodules. Effects on thyroid function and antibodies. Int J Hyperth 31:560–567CrossRef

36.

Cesareo R, Pasqualini V, Simeoni C et al (2015) Prospective Study of Effectiveness of Ultrasound-Guided Radiofrequency Ablation Versus Control Group in Patients Affected by Benign Thyroid Nodules. J Clin Endocrinol Metab 100:460–466CrossRefPubMed

37.

Spiezia S, Garberoglio R, Milone F et al (2009) Thyroid Nodules and Related Symptoms Are Stably Controlled Two Years After Radiofrequency Thermal Ablation. Thyroid 19:219–225CrossRefPubMed

38.

Baek JH, Kim YS, Lee D et al (2010) Benign Predominantly Solid Thyroid Nodules. Prospective Study of Efficacy of Sonographically Guided Radiofrequency Ablation Versus Control Condition. Am J Roentgenol 194:1137–1142CrossRef

39.

van Ginhoven TM, Massolt ET, Bijdevaate DC et al (2016) Radiofrequency ablation of a symptomatic benign thyroid nodule. Ned Tijdschr Geneeskd 160:D202PubMed

40.

Kim C, Lee JH, Choi YJ et al (2017) Complications encountered in ultrasonography-guided radiofrequency ablation of benign thyroid nodules and recurrent thyroid cancers. Eur Radiol 27(8):3128–3137CrossRefPubMed

41.

Yu J, Liang P, Yu X et al (2011) A comparison of microwave ablation and bipolar radiofrequency ablation both with an internally cooled probe. Results in ex vivo and in vivo porcine livers. Eur J Radiol 79:124–130CrossRefPubMed

42.

Lee JM, Han JK, Kim HC et al (2007) Switching monopolar radiofrequency ablation technique using multiple, internally cooled electrodes and a multichannel generator: ex vivo and in vivo pilot study. Investig Radiol 42:163–171CrossRef

43.

Yue W, Wang S, Wang B et al (2013) Ultrasound guided percutaneous microwave ablation of benign thyroid nodules. Safety and imaging follow-up in 222 patients. Eur J Radiol 82:e11–e16CrossRefPubMed

44.

Baek JH, Lee JH, Sung JY et al (2012) Complications Encountered in the Treatment of Benign Thyroid Nodules with US-guided Radiofrequency Ablation. A Multicenter Study. Radiology 262:335–342CrossRefPubMed

45.

Orosco RK, Lin HW, Bhattacharyya N (2015) Ambulatory Thyroidectomy. A Multistate Study of Revisits and Complications. Otolaryngol Head Neck Surg 152:1017–1023CrossRefPubMed

46.

Mauri G, Cova L, Monaco CG, et al (2016) Benign thyroid nodules treatment using percutaneous laser ablation (PLA) and radiofrequency ablation (RFA). Int J Hyperthermia 33(3):295–299

47.

Wang J-F, Wu T, Hu K-P et al (2017) Complications Following Radiofrequency Ablation of Benign Thyroid Nodules: A Systematic Review. Chin Med J 130:1361–1370CrossRefPubMedPubMedCentral

48.

Korkusuz Y, Mader A, Gröner D et al (2017) Comparison of mono- and bipolar radiofrequency ablation in benign thyroid disease. World J Surg. http://dx.doi.org/10.1007/s00268-017-4039-y

49.

Morelli F, Sacrini A, Pompili G et al (2016) Microwave ablation for thyroid nodules: a new string to the bow for percutaneous treatments? Gland Surg 5:553–558CrossRefPubMedPubMedCentral

50.

Esnault O, Franc B, Menegaux F et al (2011) High-intensity focused ultrasound ablation of thyroid nodules: first human feasibility study. Thyroid 21:965–973CrossRefPubMed

51.

Lang BH-H, Wu ALH (2017) High intensity focused ultrasound (HIFU) ablation of benign thyroid nodules - a systematic review. J Ther Ultrasound 5:11CrossRefPubMedPubMedCentral

52.

Mader OM, Tanha NF, Mader A et al (2017) Comparative study evaluating the efficiency of cooled and uncooled single-treatment MWA in thyroid nodules after a 3-month follow up. Eur J Radiol 4:4–8CrossRef

53.

Yue W-W, Wang S-R, Lu F et al (2017) Radiofrequency ablation vs. microwave ablation for patients with benign thyroid nodules: a propensity score matching study. Endocrine 55:485–495CrossRefPubMed

Titel: Thermal ablation of thyroid nodules: are radiofrequency ablation, microwave ablation and high intensity focused ultrasound equally safe and effective methods?
verfasst von: Yücel Korkusuz
Daniel Gröner
Natascha Raczynski
Oleg Relin
Yasmina Kingeter
Frank Grünwald
Christian Happel
Publikationsdatum: 11.09.2017
Verlag: Springer Berlin Heidelberg
Erschienen in: European Radiology / Ausgabe 3/2018
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-017-5039-x

Neu im Fachgebiet Radiologie

18.04.2024 | Pädiatrische Notfallmedizin | Nachrichten

Update Radiologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Thermal ablation of thyroid nodules: are radiofrequency ablation, microwave ablation and high intensity focused ultrasound equally safe and effective methods?

Abstract

Objectives

Material and Methods

Results

Conclusion

Key Points

Neu im Fachgebiet Radiologie

Fünf Dinge, die im Kindernotfall besser zu unterlassen sind

Wie toxische Männlichkeit der Gesundheit von Männern schadet

Studie bestätigt Potenzial von KI in der Radiologie

Quantitative Angiografie könnte IVUS-Alternative darstellen

Update Radiologie

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

Objectives

Material and Methods

Results

Conclusion

Key Points

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 3/2018

Discrimination of Malignant versus Benign Mediastinal Lymph Nodes Using Diffusion MRI with an IVIM Model

Comparison of virtual monoenergetic and polyenergetic images reconstructed from dual-layer detector CT angiography of the head and neck

Morphological characteristics of chronic total occlusion: predictors of different strategies for long-segment femoral arterial occlusions

Absence of DNA double-strand breaks in human peripheral blood mononuclear cells after 3 Tesla magnetic resonance imaging assessed by γH2AX flow cytometry

Lateral epicondylitis: Associations of MR imaging and clinical assessments with treatment options in patients receiving conservative and arthroscopic managements

Optimising preoperative risk stratification tools for prostate cancer using mpMRI

Neu im Fachgebiet Radiologie

Fünf Dinge, die im Kindernotfall besser zu unterlassen sind

Wie toxische Männlichkeit der Gesundheit von Männern schadet

Studie bestätigt Potenzial von KI in der Radiologie

Quantitative Angiografie könnte IVUS-Alternative darstellen

Update Radiologie