nach oben

European Radiology

Erschienen in:

25.01.2018 | Nuclear Medicine

Benefit of ¹⁸F-fluorocholine PET imaging in parathyroid surgery

verfasst von: G. F. Huber, M. Hüllner, C. Schmid, A. Brunner, B. Sah, D. Vetter, P. A. Kaufmann, G. K. von Schulthess

Erschienen in: European Radiology | Ausgabe 6/2018

Einloggen, um Zugang zu erhalten

Abstract

Objectives

To assess the additional diagnostic value of ¹⁸F-fluorocholine PET imaging in preoperative localization of pathologic parathyroid glands in clinically manifest hyperparathyroidism in case of negative or conflicting ultrasound and scintigraphy results.

Methods

A retrospective, single-institution study of 26 patients diagnosed with hyperparathyroidism. In cases where ultrasound and scintigraphy failed to detect the location of an adenoma in order to allow a focused surgical approach, an additional ¹⁸F-fluorocholine PET scan was performed and its results were compared with the intraoperative findings.

Results

A total of 26 patients underwent ¹⁸F-fluorocholine PET/CT (n = 11) or PET/MRI (n = 15). Adenomas were detected in 25 patients (96.2%). All patients underwent surgery, and the location predicted by PET hybrid imaging was confirmed intraoperatively by frozen section and adequate parathyroid hormone drop after removal. None of the patients needed revision surgery during follow-up.

Conclusions

These results demonstrate that ¹⁸F-fluorocholine PET imaging is a highly accurate method to detect parathyroid adenomas even in case of previous localization failure by other imaging examinations.

Key Points

• With ¹⁸F-fluorocholine PET imaging, parathyroid adenomas could be detected in 96.2%.

• ¹⁸F-fluorocholine imaging is a highly accurate method to detect parathyroid adenomas.

• We encourage its use, where ultrasound fails to detect an adenoma.

von Schulthess GK, Weder W, Goebel N et al (1988) 1.5 T MRI, CT, ultrasonography and scintigraphy in hyperparathyroidism. Eur J Radiol 8:157–164

Noussios G, Anagnostis P, Natsis K (2012) Ectopic parathyroid glands and their anatomical, clinical and surgical implications. Exp Clin Endocrinol Diabetes 120:604–610CrossRefPubMed

Randolph G (2002) Surgery of the Thyroid and Parathyroid Glands, 1st edn. WB Saunders Company, Philadelphia

Suh YJ, Choi JY, Kim SJ et al (2015) Comparison of 4D CT, ultrasonography, and 99mTc sestamibi SPECT/CT in localizing single-gland primary hyperparathyroidism. Otolaryngol Head Neck Surg 152:438–443CrossRefPubMed

Krakauer M, Wieslander B, Myschetzky PS et al (2016) A Prospective Comparative Study of Parathyroid Dual-Phase Scintigraphy, Dual-Isotope Subtraction Scintigraphy, 4D-CT, and Ultrasonography in Primary Hyperparathyroidism. Clin Nucl Med 41:93–100CrossRefPubMed

Sommerauer M, Graf C, Schäfer N et al (2015) Sensitivity and specificity of Dual-Isotope 99mTc-Tetrofosmin and 123I Sodium Iodide Single Photon Emission Computed Tomography (SPECT) in hyperparathyroidism. PLoS One 10(6):e0129194

Nael K, Hur J, Bauer A et al (2015) Dynamic 4D MRI for Characterization of Parathyroid Adenomas: Multiparametric Analysis. AJNR Am J Neuroradiol 36:2147–2152CrossRefPubMed

Merchavy S, Luckman J, Guindy M et al (2016) 4D MRI for the Localization of Parathyroid Adenoma: A Novel Method in Evolution. Otolaryngol Head Neck Surg 154:446–448CrossRefPubMed

Mapelli P, Busnardo E, Magnani P et al (2012) Incidental finding of parathyroid adenoma with 11C-choline PET/CT. Clin Nucl Med 37:593–595CrossRefPubMed

10.

Welle CL, Cullen EL, Peller PJ et al (2016) ¹¹C-Choline PET/CT in Recurrent Prostate Cancer and Nonprostatic Neoplastic Processes. Radiographics 36:279–292CrossRefPubMed

11.

Quak E, LHeureux S, Reznik Y et al (2013) F18-Choline, a novel PET tracer for parathyroid adenoma? J Clin Endocrinol Metab 98:3111–3112CrossRefPubMed

12.

Hodolic M, Huchet V, Balogova S et al (2014) Incidental uptake of 18Ffluorocholine (FCH) in the head or in the neck of patients with prostate cancer. Radiol Oncol 48:228–234PubMedPubMedCentral

13.

Cazaentre T, Clivaz F, Triponez F (2014) False-positive result in 18Ffluorocholine PET/CT due to incidental and ectopic parathyroid hyperplasia. Clin Nucl Med 39:328–330CrossRef

14.

Wilhelm SM, Wang TS, Ruan DT et al (2016) The American association of endocrine surgeons guidelines for definitive management of primary hyperparathyroidism. JAMA Surg 151(10):959–968

15.

Barber B, Moher C, Cote D et al (2016) Comparison of single photon emission CT (SPECT) with SPECT/CT imaging in preoperative localization of parathyroid adenomas: a cost-effectiveness analysis. Head Neck 38 Suppl 1:E2062–5

16.

Frank SJ, Goldman-Yassen AE, Koenigsberg T, Libutti SK, Koenigsberg M (2017) Sensitivity of 3-dimensional sonography in preoperative evaluation of parathyroid glands in patients with primary hyperparathyroidism. J Ultrasound Med 36(9):1897–1904

17.

Lalire P, Ly S, Dequelte S et al (2017) Incremental Value of 18F-Fluorocholine PET/CT in the Localization of Double Parathyroid Adenomas. Clin Nucl Med 42:218–220CrossRefPubMed

18.

Huellner MW, Aberle S, Sah BR et al (2017) Visualization of Parathyroid Hyperplasia Using 18F-Fluorocholine PET/MR in a Patient With Secondary Hyperparathyroidism. Eur J Surg Oncol 43:133–137CrossRef

19.

Vellani C, Hodoic M, Chytiris S et al (2017) Early and Delayed 18F-FCH PET/CT Imaging in Parathyroid Adenomas. Clin Nucl Med 42:143–144CrossRefPubMed

20.

Michaud L, Balogova S, Burgess A et al (2015) A pilot comparison of 18F-fluorocholine PET/CT, ultrasonography and 123I/99mTc-sestaMIBI dual-phase dual-isotope scintigraphy in the preoperative localization of hyperfunctioning parathyroid glands in primary or secondary hyperparathyroidism: influence of thyroid anomalies. Medicine (Baltimore) 94(41):e1701

21.

Michaud L, Burgess A, Huchet V et al (2014) Is 18F-fluorocholine-positron emission tomography/computerized tomography a new imaging tool for detecting hyperfunctioning parathyroid glands in primary or secondary hyperparathyroidism? J Clin Endocrinol Metab 99:4531–4536CrossRefPubMed

22.

Kluijfhout WP, Vorselaars WM, Vriens MR et al (2015) Enabling minimal invasive parathyroidectomy for patients with primary hyperparathyroidism using Tc-99m-sestamibi SPECT-CT, ultrasound and first results of (18)F-fluorocholine PET-CT. Eur J Radiol 84:1745–1751CrossRefPubMed

23.

Orevi M, Freedman N, Mishani E et al (2014) Localization of parathyroid adenoma by ¹¹C-choline PET/CT: preliminary results. Clin Nucl Med 39:1033–1038CrossRefPubMed

24.

Lezaic L, Rep S, Sever MJ et al (2014) ¹⁸F-Fluorocholine PET/CT for localization of hyperfunctioning parathyroid tissue in primary hyperparathyroidism: a pilot study. Eur J Nucl Med Mol Imaging 41:2083–2089CrossRefPubMed

25.

Gayed IW, Kim EE, Broussard WF et al (2005) The value of 99mTc-sestamibi SPECT/CT over conventional SPECT in the evaluation of parathyroid adenomas or hyperplasia. J Nucl Med 46:248–252PubMed

26.

Vaz A, Griffiths M (2011) Parathyroid imaging and localization using SPECT/CT: initial results. J Nucl Med Technol 39:195–200CrossRefPubMed

27.

Lavely WC, Goetze S, Friedman KP et al (2007) Comparison of SPECT/CT, SPECT, and planar imaging with single- and dual-phase (99m)Tc-sestamibi parathyroid scintigraphy. J Nucl Med 48:1084–1089CrossRefPubMed

28.

Greenspan BS, Dillehay G, Intenzo C et al (2012) SNM practice guideline for parathyroid scintigraphy 4.0. J Nucl Med Technol 40:111–118CrossRefPubMed

29.

Giussani A, Janzen T, Uusijärvi-Lizana H et al (2012) A compartmental model for biokinetics and dosimetry of 18F-choline in prostate cancer patients. J Nucl Med 53:985–993CrossRefPubMed

30.

van Raalte DH, Vlot MC, Zwijnenburg A et al (2015) F18-Choline PET/CT: a novel tool to localize parathyroid adenoma? Clin Endocrinol 82:910–912CrossRef

Titel: Benefit of 18F-fluorocholine PET imaging in parathyroid surgery
verfasst von: G. F. Huber
M. Hüllner
C. Schmid
A. Brunner
B. Sah
D. Vetter
P. A. Kaufmann
G. K. von Schulthess
Publikationsdatum: 25.01.2018
Verlag: Springer Berlin Heidelberg
Erschienen in: European Radiology / Ausgabe 6/2018
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-017-5190-4

Neu im Fachgebiet Radiologie

23.04.2024 | Pankreaskarzinom | Nachrichten

Update Radiologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Benefit of ¹⁸F-fluorocholine PET imaging in parathyroid surgery

Abstract

Objectives

Methods

Results

Conclusions

Key Points

Neu im Fachgebiet Radiologie

S3-Leitlinie zu Pankreaskrebs aktualisiert

Fünf Dinge, die im Kindernotfall besser zu unterlassen sind

„Nur wer sich gut aufgehoben fühlt, kann auch für Patientensicherheit sorgen“

Wie toxische Männlichkeit der Gesundheit von Männern schadet

Update Radiologie

Springer Medizin

Abstract

Objectives

Methods

Results

Conclusions

Key Points

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 6/2018

Computed tomography use in a large Italian region: trend analysis 2004-2014 of emergency and outpatient CT examinations in children and adults

Gallbladder wall oedema and ascites are independent predictors of progression to hepatic veno-occlusive disease for children with hematopoietic stem cell transplantation

To evaluate the feasibility of magnetic resonance imaging in predicting unusual site ectopic pregnancy: a retrospective cohort study

Initial results of the FUSION-X-US prototype combining 3D automated breast ultrasound and digital breast tomosynthesis

Third generation dual-source CT enables accurate diagnosis of coronary restenosis in all size stents with low radiation dose and preserved image quality

Preclinical ex vivo evaluation of the diagnostic performance of a new device for in situ label-free fluorescence spectral analysis of breast masses

Neu im Fachgebiet Radiologie

S3-Leitlinie zu Pankreaskrebs aktualisiert

Fünf Dinge, die im Kindernotfall besser zu unterlassen sind

„Nur wer sich gut aufgehoben fühlt, kann auch für Patientensicherheit sorgen“

Wie toxische Männlichkeit der Gesundheit von Männern schadet

Update Radiologie