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European Radiology

Erschienen in:

30.04.2018 | Oncology

Evaluation of T categories for pure ground-glass nodules with semi-automatic volumetry: is mass a better predictor of invasive part size than other volumetric parameters?

verfasst von: Hyungjin Kim, Jin Mo Goo, Chang Min Park

Erschienen in: European Radiology | Ausgabe 10/2018

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Abstract

Objectives

This study aimed to investigate the diagnostic advantage of nodule mass in differentiating invasive pulmonary adenocarcinomas (IPAs) among pure ground-glass nodules (pGGNs) over other volumetric measurements. Another aim of this study was to analyse the correlation between volumetric measurements on computed tomography (CT) scans and the pathological invasive component size.

Methods

This Institutional Review Board-approved retrospective study included 117 patients (men:women = 53:64; mean age, 57.3 years) with 117 pGGNs. Semi-automatic segmentation was performed for all nodules, and volumetric measurements, such as nodule volume, attenuation, mass, two-dimensional (2D) average diameter and three-dimensional (3D) longest diameter, were obtained. Receiver operating characteristic (ROC) curve analyses were performed to evaluate the diagnostic performances of the volumetric parameters in discriminating IPAs. Spearman correlation coefficients were calculated between the volumetric measurements and the invasive component size.

Results

Area under the ROC curve for mass was 0.792 (95% CI, 0.691-0.872) in non-enhanced CT and 0.730 (95% CI, 0.607-0.832) in contrast-enhanced CT. Nodule mass was not superior to 2D average diameter for the differentiation of IPAs in both non-enhanced (0.792 vs 0.780; p = 0.501) CT and contrast-enhanced CT scans (0.730 vs 0.700; p = 0.319). The correlation between the volumetric measurements (mass, 3D longest diameter and 2D average diameter) and the invasive component size was moderate (Spearman’s rho, 0.401-0.422) in non-enhanced CT and weak (Spearman’s rho, 0.276-0.310) in contrast-enhanced CT.

Conclusions

Nodule mass measurement had no strength over other volumetric parameters for the prediction of pathological invasiveness in the diagnosis of pGGNs.

Key Points

• Mass is not superior to other volumetric measurements for the diagnosis of pure ground-glass nodules.

• Mass and two-dimensional average diameter exhibited comparable performance for the discrimination of invasive adenocarcinomas among pure ground-glass nodules.

• The diagnostic performance of volumetric measurements was lower on contrast-enhanced CT scans.

• The correlation between the volumetric measurements and the invasive component size was moderate on non-enhanced CT scans and weak on contrast-enhanced CT scans.

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Travis WD, Asamura H, Bankier AA et al (2016) The IASLC Lung Cancer Staging Project: proposals for coding T categories for subsolid nodules and assessment of tumor size in part-solid tumors in the forthcoming eighth edition of the TNM classification of lung cancer. J Thorac Oncol 11:1204–1223CrossRef

Lee KH, Goo JM, Park SJ et al (2014) Correlation between the size of the solid component on thin-section CT and the invasive component on pathology in small lung adenocarcinomas manifesting as ground-glass nodules. J Thorac Oncol 9:74–82CrossRef

Ko JP, Suh J, Ibidapo O et al (2016) Lung adenocarcinoma: correlation of quantitative CT findings with pathologic findings. Radiology 280:931–939CrossRef

Yanagawa M, Johkoh T, Noguchi M et al (2017) Radiological prediction of tumor invasiveness of lung adenocarcinoma on thin-section CT. Medicine (Baltimore) 96:e6331CrossRef

Lee SM, Park CM, Goo JM, Lee HJ, Wi JY, Kang CH (2013) Invasive pulmonary adenocarcinomas versus preinvasive lesions appearing as ground-glass nodules: differentiation by using CT features. Radiology 268:265–273CrossRef

Moon Y, Sung SW, Lee KY, Sim SB, Park JK (2016) Pure ground-glass opacity on chest computed tomography: predictive factors for invasive adenocarcinoma. J Thorac Dis 8:1561–1570CrossRef

Lim HJ, Ahn S, Lee KS et al (2013) Persistent pure ground-glass opacity lung nodules ≥10 mm in diameter at CT scan: histopathologic comparisons and prognostic implications. Chest 144:1291–1299CrossRef

Heidinger BH, Anderson KR, Nemec U et al (2017) Lung adenocarcinoma manifesting as pure ground-glass nodules: correlating CT size, volume, density, and roundness with histopathologic invasion and size. J Thorac Oncol 12:1288–1298CrossRef

Ding H, Shi J, Zhou X et al (2017) Value of CT characteristics in predicting invasiveness of adenocarcinoma presented as pulmonary ground-glass nodules. Thorac Cardiovasc Surg 65:136–141PubMed

10.

Hwang IP, Park CM, Park SJ et al (2015) Persistent pure ground-glass nodules larger than 5 mm: differentiation of invasive pulmonary adenocarcinomas from preinvasive lesions or minimally invasive adenocarcinomas using texture analysis. Invest Radiol 50:798–804CrossRef

11.

Li Q, Fan L, Cao ET, Li QC, Gu YF, Liu SY (2017) Quantitative CT analysis of pulmonary pure ground-glass nodule predicts histological invasiveness. Eur J Radiol 89:67–71CrossRef

12.

de Hoop B, Gietema H, van de Vorst S, Murphy K, van Klaveren RJ, Prokop M (2010) Pulmonary ground-glass nodules: increase in mass as an early indicator of growth. Radiology 255:199–206CrossRef

13.

Cohen JG, Goo JM, Yoo RE et al (2016) Software performance in segmenting ground-glass and solid components of subsolid nodules in pulmonary adenocarcinomas. Eur Radiol 26:4465–4474CrossRef

14.

Cohen JG, Goo JM, Yoo RE et al (2016) The effect of late-phase contrast enhancement on semi-automatic software measurements of CT attenuation and volume of part-solid nodules in lung adenocarcinomas. Eur J Radiol 85:1174–1180CrossRef

15.

Cohen JG, Kim H, Park SB et al (2017) Comparison of the effects of model-based iterative reconstruction and filtered back projection algorithms on software measurements in pulmonary subsolid nodules. Eur Radiol 27:3266–3274CrossRef

16.

Kim H, Park CM, Hwang EJ, Ahn SY, Goo JM (2017) Pulmonary subsolid nodules: value of semi-automatic measurement in diagnostic accuracy, diagnostic reproducibility and nodule classification agreement. Eur Radiol. https://doi.org/10.1007/s00330-017-5171-7 CrossRef

17.

Yoo RE, Goo JM, Hwang EJ et al (2017) Retrospective assessment of interobserver agreement and accuracy in classifications and measurements in subsolid nodules with solid components less than 8mm: which window setting is better? Eur Radiol 27:1369–1376CrossRef

18.

de Hoop B, Gietema H, van Ginneken B, Zanen P, Groenewegen G, Prokop M (2009) A comparison of six software packages for evaluation of solid lung nodules using semi-automated volumetry: what is the minimum increase in size to detect growth in repeated CT examinations. Eur Radiol 19:800–808CrossRef

19.

Travis WD, Brambilla E, Noguchi M et al (2011) International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society international multidisciplinary classification of lung adenocarcinoma. J Thorac Oncol 6:244–285CrossRef

20.

DeLong ER, DeLong DM, Clarke-Pearson DL (1988) Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach. Biometrics 44:837–845CrossRef

21.

Karlik SJ (2003) Exploring and summarizing radiologic data. AJR Am J Roentgenol 180:47–54CrossRef

22.

Das M, Ley-Zaporozhan J, Gietema HA et al (2007) Accuracy of automated volumetry of pulmonary nodules across different multislice CT scanners. Eur Radiol 17:1979–1984CrossRef

23.

Das M, Muhlenbruch G, Katoh M et al (2007) Automated volumetry of solid pulmonary nodules in a phantom: accuracy across different CT scanner technologies. Invest Radiol 42:297–302CrossRef

24.

Doo KW, Kang EY, Yong HS, Woo OH, Lee KY, Oh YW (2014) Accuracy of lung nodule volumetry in low-dose CT with iterative reconstruction: an anthropomorphic thoracic phantom study. Br J Radiol 87:20130644CrossRef

25.

Gietema HA, Wang Y, Xu D et al (2006) Pulmonary nodules detected at lung cancer screening: interobserver variability of semiautomated volume measurements. Radiology 241:251–257CrossRef

26.

Goodman LR, Gulsun M, Washington L, Nagy PG, Piacsek KL (2006) Inherent variability of CT lung nodule measurements in vivo using semiautomated volumetric measurements. AJR Am J Roentgenol 186:989–994CrossRef

27.

Revel MP, Lefort C, Bissery A et al (2004) Pulmonary nodules: preliminary experience with three-dimensional evaluation. Radiology 231:459–466CrossRef

28.

Kim H, Park CM, Woo S et al (2013) Pure and part-solid pulmonary ground-glass nodules: measurement variability of volume and mass in nodules with a solid portion less than or equal to 5 mm. Radiology 269:585–593CrossRef

29.

Scholten ET, de Hoop B, Jacobs C et al (2013) Semi-automatic quantification of subsolid pulmonary nodules: comparison with manual measurements. PLoS One 8:e80249CrossRef

30.

Scholten ET, de Jong PA, Jacobs C et al (2015) Interscan variation of semi-automated volumetry of subsolid pulmonary nodules. Eur Radiol 25:1040–1047CrossRef

31.

Bankier AA, MacMahon H, Goo JM, Rubin GD, Schaefer-Prokop CM, Naidich DP (2017) Recommendations for measuring pulmonary nodules at CT: a statement from the Fleischner Society. Radiology 285:584–600CrossRef

32.

MacMahon H, Naidich DP, Goo JM et al (2017) Guidelines for management of incidental pulmonary nodules detected on CT images: from the Fleischner society 2017. Radiology 284:228–243CrossRef

33.

Bae KT (2010) Intravenous contrast medium administration and scan timing at CT: considerations and approaches. Radiology 256:32–61CrossRef

34.

McDonald JH (2014) Handbook of biological statistics, 3rd edn. Sparky House Publishing, Baltimore

35.

Garzelli L, Goo JM, Ahn SY et al (2018) Improving the prediction of lung adenocarcinoma invasive component on CT: value of a vessel removal algorithm during software segmentation of subsolid nodules. Eur J Radiol 100:58–65CrossRef

Titel: Evaluation of T categories for pure ground-glass nodules with semi-automatic volumetry: is mass a better predictor of invasive part size than other volumetric parameters?
verfasst von: Hyungjin Kim
Jin Mo Goo
Chang Min Park
Publikationsdatum: 30.04.2018
Verlag: Springer Berlin Heidelberg
Erschienen in: European Radiology / Ausgabe 10/2018
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-018-5440-0

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Evaluation of T categories for pure ground-glass nodules with semi-automatic volumetry: is mass a better predictor of invasive part size than other volumetric parameters?

Abstract

Objectives

Methods

Results

Conclusions

Key Points

Neu im Fachgebiet Radiologie

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Update Radiologie

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

Objectives

Methods

Results

Conclusions

Key Points

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