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European Radiology

Erschienen in:

10.02.2020 | Nuclear Medicine

Value of integrated PET-IVIM MR in assessing metastases in hypermetabolic pelvic lymph nodes in cervical cancer: a multi-parameter study

verfasst von: Chen Xu, Siyao Du, Siyu Zhang, Bo Wang, Chengyan Dong, Hongzan Sun

Erschienen in: European Radiology | Ausgabe 5/2020

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Abstract

Purpose

To evaluate the value of integrated multi-parameter positron emission tomography-intravoxel incoherent motion magnetic resonance (PET-IVIM MR) imaging for pelvic lymph nodes with high FDG uptake in cervical cancer, and to determine the best combination of parameters.

Methods

A total of 38 patients with 59 lymph nodes with high FDG uptake were included. The imaging parameters of the lymph nodes were calculated by PET-IVIM MR, and the differences between lymph nodes diagnosed by postoperative pathology as metastasis versus non-metastasis were compared. We used the receiver operating characteristic (ROC) curve and logistic regression to construct a combination prediction model to filter low value and similar parameters, in order to search the optimal combination of PET/MR parameters for predicting pathologically confirmed metastatic lymph nodes. The correlation between diffusion parameters and metabolic parameters was analyzed by Spearman’s rank correlation.

Results

The maximum standardized uptake value (SUV_max), mean standardized uptake value (SUV_mean), total metabolic tumor volume (MTV), total lesion glycolysis (TLG), apparent diffusion coefficient (ADC), diffusion-related coefficient (D), and perfusion-related parameter (F) showed significant differences between the metastatic and non-metastatic groups (p < 0.05). The combination of MTV, SUV_max, and D had the strongest predictive value (area under the ROC 0.983, p < 0.05). SUV_max, SUV_mean, and TLG weakly correlated with F (R = − 0.306, − 0.290, and − 0.310; p < 0.05).

Conclusions

The combination of MTV, SUV_max, and D may have a better diagnostic performance than PET- or IVIM-derived parameters either in combination or individually. No strong correlation exists between diffusion parameters and metabolic parameters.

Key Points

• Integrated PET-IVIM MR may assist to characterize lymph node status.

• The combination of MTV, SUV _max , and D may have a better diagnostic performance than PET- or IVIM-derived parameters either in combination or individually for the assessment of pelvic lymph nodes with high FDG uptake.

• No strong correlation exists between diffusion parameters and metabolic parameters in pelvic lymph nodes with high FDG uptake.

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Titel: Value of integrated PET-IVIM MR in assessing metastases in hypermetabolic pelvic lymph nodes in cervical cancer: a multi-parameter study
verfasst von: Chen Xu
Siyao Du
Siyu Zhang
Bo Wang
Chengyan Dong
Hongzan Sun
Publikationsdatum: 10.02.2020
Verlag: Springer Berlin Heidelberg
Erschienen in: European Radiology / Ausgabe 5/2020
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-019-06611-z

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Value of integrated PET-IVIM MR in assessing metastases in hypermetabolic pelvic lymph nodes in cervical cancer: a multi-parameter study

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Purpose

Methods

Results

Conclusions

Key Points

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