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Erschienen in: World Journal of Urology 6/2006

01.12.2006 | Topic Paper

The male biological clock

verfasst von: Sarah M. Lambert, Puneet Masson, Harry Fisch

Erschienen in: World Journal of Urology | Ausgabe 6/2006

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Abstract

Do men have biological clocks that affect their hormone levels, fertility, and the genetic quality of their sperm? Women can no longer be viewed as solely responsible for age-related fertility and genetic problems. The effects of andropause and advanced paternal age on fertility and offspring are still under investigation. Further research is needed to fully characterize the associated risks and to treat the underlying abnormalities. A better understanding of the cellular and biochemical mechanisms of “gonadal” aging is important in order to determine safe, effective ways to delay this process and “rewind” the male biological clock. The benefits may include decreasing the potential for adverse genetic consequences in offspring, improvement in the sexual and reproductive health of aging males, and increase a woman’s chance of having healthy children by correcting defects in the male reproductive system.
Literatur
1.
Zurück zum Zitat Harman S, Metter E, Tobin J, Pearson J, Blackman M (2001) Longitudinal effects of aging on serum total and free testosterone levels in healthy men. Baltimore longitudinal study of aging. J Clin Endocrinol Metab 86:724–31CrossRefPubMed Harman S, Metter E, Tobin J, Pearson J, Blackman M (2001) Longitudinal effects of aging on serum total and free testosterone levels in healthy men. Baltimore longitudinal study of aging. J Clin Endocrinol Metab 86:724–31CrossRefPubMed
2.
Zurück zum Zitat McLachlan RI (2000) The endocrine control of spermatogenesis. Baillieres Best Pract Clin Endocrinol Metab 14:345–362CrossRef McLachlan RI (2000) The endocrine control of spermatogenesis. Baillieres Best Pract Clin Endocrinol Metab 14:345–362CrossRef
3.
Zurück zum Zitat Feldman H, Longcope C, Derby C, Johannes C, Araujo A, Coviello A, Bremner W, McKinlay J (2002) Age trends in the level of serum testosterone and other hormones in middle-aged men: longitudinal results from the Massachusetts Male Aging Study. J Clin Endocrinol Metab 87:589–598CrossRefPubMed Feldman H, Longcope C, Derby C, Johannes C, Araujo A, Coviello A, Bremner W, McKinlay J (2002) Age trends in the level of serum testosterone and other hormones in middle-aged men: longitudinal results from the Massachusetts Male Aging Study. J Clin Endocrinol Metab 87:589–598CrossRefPubMed
4.
Zurück zum Zitat Sparrow D, Bosse R, Rowe J (1980) The influence of age, alcohol consumption, and body build on gonadal function in men. J Clin Endocrinol Metab 51:508–512PubMed Sparrow D, Bosse R, Rowe J (1980) The influence of age, alcohol consumption, and body build on gonadal function in men. J Clin Endocrinol Metab 51:508–512PubMed
5.
Zurück zum Zitat Vermeulen A, Rubens R, Verdonck L (1972) Testosterone secretion and metabolism in male senescence. J Clin Endocrinol Metab 34:730–735PubMedCrossRef Vermeulen A, Rubens R, Verdonck L (1972) Testosterone secretion and metabolism in male senescence. J Clin Endocrinol Metab 34:730–735PubMedCrossRef
6.
Zurück zum Zitat Gray A, Berlin J, McKinlay J, Longcope C (1991) An examination of research design effects on the association of testosterone and male aging: results of a meta-analysis. J Clin Epidemiol 44:671–684CrossRefPubMed Gray A, Berlin J, McKinlay J, Longcope C (1991) An examination of research design effects on the association of testosterone and male aging: results of a meta-analysis. J Clin Epidemiol 44:671–684CrossRefPubMed
7.
Zurück zum Zitat Rhoden E, Morgentaler A (2004) Risks of testosterone-replacement therapy and recommendations for monitoring. N Engl J Med 350:482–492CrossRefPubMed Rhoden E, Morgentaler A (2004) Risks of testosterone-replacement therapy and recommendations for monitoring. N Engl J Med 350:482–492CrossRefPubMed
8.
Zurück zum Zitat Tanemura K, Kurohmaru M, Kuramoto K, Hayashi Y (1993) Age-related morphological changes in the testis of the BDF1 mouse. J Vet Med Sci 55:703–710PubMed Tanemura K, Kurohmaru M, Kuramoto K, Hayashi Y (1993) Age-related morphological changes in the testis of the BDF1 mouse. J Vet Med Sci 55:703–710PubMed
9.
Zurück zum Zitat Wang C, Leung A, Sinha-Hikim A (1993) Reproductive aging in the male brown-Norway rat: a model for the human. Endocrinology 133:2773–2781CrossRefPubMed Wang C, Leung A, Sinha-Hikim A (1993) Reproductive aging in the male brown-Norway rat: a model for the human. Endocrinology 133:2773–2781CrossRefPubMed
10.
Zurück zum Zitat Lowe X, Collins B, Allen J, Titenko-Holland N, Breneman J, Beek M, Bishop J, Wyrobek A (1995) Aneuploidies and micronuclei in the germ cells of male mice of advanced age. Mutat Res 338:59–76PubMed Lowe X, Collins B, Allen J, Titenko-Holland N, Breneman J, Beek M, Bishop J, Wyrobek A (1995) Aneuploidies and micronuclei in the germ cells of male mice of advanced age. Mutat Res 338:59–76PubMed
11.
Zurück zum Zitat Serre V, Robaire B (1998) Paternal age affects fertility and progeny outcome in the Brown Norway rat. Fertil Steril 70:625–631CrossRefPubMed Serre V, Robaire B (1998) Paternal age affects fertility and progeny outcome in the Brown Norway rat. Fertil Steril 70:625–631CrossRefPubMed
12.
Zurück zum Zitat Walter C, Intano G, McCarrey J, McMahan C, Walter R (1998) Mutation frequency declines during spermatogenesis in young mice but increases in old mice. Proc Natl Acad Sci USA 95:10015–10019CrossRefPubMed Walter C, Intano G, McCarrey J, McMahan C, Walter R (1998) Mutation frequency declines during spermatogenesis in young mice but increases in old mice. Proc Natl Acad Sci USA 95:10015–10019CrossRefPubMed
13.
Zurück zum Zitat Kidd S, Eskenazi B, Wyrobek A (2001) Effects of male age on semen quality and fertility: a review of the literature. Fertil Steril 75:237–248CrossRefPubMed Kidd S, Eskenazi B, Wyrobek A (2001) Effects of male age on semen quality and fertility: a review of the literature. Fertil Steril 75:237–248CrossRefPubMed
14.
Zurück zum Zitat Fisch H, Goluboff E, Olson J, Feldshuh J, Broder S, Barad D (1996) Semen analyses in 1,283 men from the United States over a 25-year period: no decline in quality. Fertil Steril 65:1009–1014PubMed Fisch H, Goluboff E, Olson J, Feldshuh J, Broder S, Barad D (1996) Semen analyses in 1,283 men from the United States over a 25-year period: no decline in quality. Fertil Steril 65:1009–1014PubMed
15.
Zurück zum Zitat Andolz P, Bielsa M, Vila J (1999) Evolution of semen quality in North-eastern Spain: a study in 22,759 infertile men over a 36 year period. Hum Reprod 14:731–735CrossRefPubMed Andolz P, Bielsa M, Vila J (1999) Evolution of semen quality in North-eastern Spain: a study in 22,759 infertile men over a 36 year period. Hum Reprod 14:731–735CrossRefPubMed
16.
Zurück zum Zitat Auger J, Kunstmann J, Czyglik F, Jouannet P (1995) Decline in semen quality among fertile men in Paris during the past 20 years. N Engl J Med 332:281–285CrossRefPubMed Auger J, Kunstmann J, Czyglik F, Jouannet P (1995) Decline in semen quality among fertile men in Paris during the past 20 years. N Engl J Med 332:281–285CrossRefPubMed
17.
Zurück zum Zitat Schwartz D, Mayaux M, Spira A, Moscato M, Jouannet P, Czyglik F, David G (1983) Semen characteristics as a function of age in 833 fertile men. Fertil Steril 39:530–535PubMed Schwartz D, Mayaux M, Spira A, Moscato M, Jouannet P, Czyglik F, David G (1983) Semen characteristics as a function of age in 833 fertile men. Fertil Steril 39:530–535PubMed
18.
Zurück zum Zitat Rolf C, Behre H, Nieschlag E (1996) Reproductive parameters of older compared to younger men of infertile couples. Int J Androl 19:135–142PubMed Rolf C, Behre H, Nieschlag E (1996) Reproductive parameters of older compared to younger men of infertile couples. Int J Androl 19:135–142PubMed
19.
Zurück zum Zitat Henkel R, Bittner J, Weber R, Huther F, Miska W (1999) Relevance of zinc in human sperm flagella and its relation to motility. Fertil Steril 71:1138–1143CrossRefPubMed Henkel R, Bittner J, Weber R, Huther F, Miska W (1999) Relevance of zinc in human sperm flagella and its relation to motility. Fertil Steril 71:1138–1143CrossRefPubMed
20.
Zurück zum Zitat Schneider E (1978) The aging reproductive system. Raven Press, New York Schneider E (1978) The aging reproductive system. Raven Press, New York
21.
Zurück zum Zitat Johnson L (1986) Spermatogenesis and aging in the human. J Androl 7:331–354PubMed Johnson L (1986) Spermatogenesis and aging in the human. J Androl 7:331–354PubMed
22.
Zurück zum Zitat Mathieu C, Ecochard R, Bied V, Lornage J, Czyba J (1995) Cumulative conception rate following intrauterine artificial insemination with husband’s spermatozoa: influence of husband’s age. Hum Reprod 10:1090–1097PubMed Mathieu C, Ecochard R, Bied V, Lornage J, Czyba J (1995) Cumulative conception rate following intrauterine artificial insemination with husband’s spermatozoa: influence of husband’s age. Hum Reprod 10:1090–1097PubMed
23.
Zurück zum Zitat Ford W, North K, Taylor H, Farrow A, Hull M, Golding J (2000) Increasing paternal age is associated with delayed conception in a large population of fertile couples: evidence for declining fecundity in older men. The ALSPAC Study Team (Avon Longitudinal Study of Pregnancy and Childhood). Hum Reprod 15:1703–1708CrossRefPubMed Ford W, North K, Taylor H, Farrow A, Hull M, Golding J (2000) Increasing paternal age is associated with delayed conception in a large population of fertile couples: evidence for declining fecundity in older men. The ALSPAC Study Team (Avon Longitudinal Study of Pregnancy and Childhood). Hum Reprod 15:1703–1708CrossRefPubMed
24.
Zurück zum Zitat Hamilton B, Martin J, Sutton P (2003) Births; Preliminary data for 2003. National Vital Statistics Report 53 Hamilton B, Martin J, Sutton P (2003) Births; Preliminary data for 2003. National Vital Statistics Report 53
25.
Zurück zum Zitat Yershalmy J (1939) Age of father and survival of offspring. Hum Biol 11:342–356 Yershalmy J (1939) Age of father and survival of offspring. Hum Biol 11:342–356
26.
Zurück zum Zitat Slama R, Bouyer J, Windham G, Fenster L, Werwatz A, Swan S (2005) Influence of paternal age on the risk of spontaneous abortion. Am J Epidemiol 161:816–823CrossRefPubMed Slama R, Bouyer J, Windham G, Fenster L, Werwatz A, Swan S (2005) Influence of paternal age on the risk of spontaneous abortion. Am J Epidemiol 161:816–823CrossRefPubMed
27.
Zurück zum Zitat Nybo Andersen A, Hansen KD, Andersen P, Davey Smith G (2004) Advanced paternal age and risk of fetal death: a cohort study. Am J Epidemiol 160:1214–1222CrossRefPubMed Nybo Andersen A, Hansen KD, Andersen P, Davey Smith G (2004) Advanced paternal age and risk of fetal death: a cohort study. Am J Epidemiol 160:1214–1222CrossRefPubMed
28.
Zurück zum Zitat de La Rochebrochard E, Thonneau P (2002) Paternal age and maternal age are risk factors for miscarriage; results of a multicentre European study. Hum Reprod 17:1649–1656CrossRef de La Rochebrochard E, Thonneau P (2002) Paternal age and maternal age are risk factors for miscarriage; results of a multicentre European study. Hum Reprod 17:1649–1656CrossRef
29.
Zurück zum Zitat Evans H (1996) Mutation and mutagenesis in inherited and acquired human disease. Mutat Res 351:89–103PubMed Evans H (1996) Mutation and mutagenesis in inherited and acquired human disease. Mutat Res 351:89–103PubMed
30.
Zurück zum Zitat Roosen-Runge EC (1973) Germinal-cell loss in normal metazoan spermatogenesis. Reprod Fertil 35:339–348CrossRef Roosen-Runge EC (1973) Germinal-cell loss in normal metazoan spermatogenesis. Reprod Fertil 35:339–348CrossRef
31.
Zurück zum Zitat Sartorelli E, Mazzucatto L, Pina-Neto J (2001) Effect of paternal age on human sperm chromosomes. Fertil Steril 76:1119–1123CrossRefPubMed Sartorelli E, Mazzucatto L, Pina-Neto J (2001) Effect of paternal age on human sperm chromosomes. Fertil Steril 76:1119–1123CrossRefPubMed
32.
Zurück zum Zitat Singh N, Muller C, Berger R (2003) Effects of age on DNA double-strand breaks and apoptosis in human sperm. Fertil Steril 80:1420–1430CrossRefPubMed Singh N, Muller C, Berger R (2003) Effects of age on DNA double-strand breaks and apoptosis in human sperm. Fertil Steril 80:1420–1430CrossRefPubMed
33.
Zurück zum Zitat Lian A, Zack M, Eriskson J (1986) Paternal age and the occurrence of birth defects. Am J Hum Genet 39:648PubMed Lian A, Zack M, Eriskson J (1986) Paternal age and the occurrence of birth defects. Am J Hum Genet 39:648PubMed
34.
Zurück zum Zitat Glaser R, Broman K, Schulman R, Eskenazi B, Wyrobek A, Jabs E (2003) The paternal-age effect in Apert syndrome is due, in part, to the increased frequency of mutations in sperm. Am J Hum Genet 73:939–947CrossRefPubMed Glaser R, Broman K, Schulman R, Eskenazi B, Wyrobek A, Jabs E (2003) The paternal-age effect in Apert syndrome is due, in part, to the increased frequency of mutations in sperm. Am J Hum Genet 73:939–947CrossRefPubMed
35.
Zurück zum Zitat Orioli I, Castilla E, Scarano G, Mastroiacovo P (1995) Effect of paternal age on the origin of acondroplasia, thanatophoric dysplasia and osteogenesis imperfecta. Am J Med Genet 59:209–217CrossRefPubMed Orioli I, Castilla E, Scarano G, Mastroiacovo P (1995) Effect of paternal age on the origin of acondroplasia, thanatophoric dysplasia and osteogenesis imperfecta. Am J Med Genet 59:209–217CrossRefPubMed
36.
Zurück zum Zitat Rannan-Eliya S, Taylor I, De Heer M, Van Den Ouweland A, Wall S, Wilkie A (2004) Paternal origin of FGFr-3 mutation in Muenke-type craniosynostosis. Hum Genet 115:200–207CrossRefPubMed Rannan-Eliya S, Taylor I, De Heer M, Van Den Ouweland A, Wall S, Wilkie A (2004) Paternal origin of FGFr-3 mutation in Muenke-type craniosynostosis. Hum Genet 115:200–207CrossRefPubMed
37.
Zurück zum Zitat Cunningham F, MacDonald P, Gant N, Leveno K, Gilstrap C, Hankins G et al (1997) Williams obstetrics, 21st ed. McGraw-Hill, New York Cunningham F, MacDonald P, Gant N, Leveno K, Gilstrap C, Hankins G et al (1997) Williams obstetrics, 21st ed. McGraw-Hill, New York
38.
Zurück zum Zitat Fisch H, Golden R, Libersen G, Hyun G, Madsen P, New MI, Hensle T (2001) Maternal age as a risk factor for hypospadias. J Urol 165:934–936CrossRefPubMed Fisch H, Golden R, Libersen G, Hyun G, Madsen P, New MI, Hensle T (2001) Maternal age as a risk factor for hypospadias. J Urol 165:934–936CrossRefPubMed
39.
Zurück zum Zitat Ferguson-Smith M, Yates J (1984) Maternal age specific rates for chromosome aberrations and factors influencing them: report of a collaborative European study on 52,965 amniocenteses. Prenat Diagn 4:5–44PubMed Ferguson-Smith M, Yates J (1984) Maternal age specific rates for chromosome aberrations and factors influencing them: report of a collaborative European study on 52,965 amniocenteses. Prenat Diagn 4:5–44PubMed
40.
Zurück zum Zitat Antonarakis S (1991) Parental origin of the extra chromosome in trisomy 21 as indicated by analysis of DNA polymorphisms. Down Syndrome Collaborative Group. N Engl J Med 324:872–876PubMedCrossRef Antonarakis S (1991) Parental origin of the extra chromosome in trisomy 21 as indicated by analysis of DNA polymorphisms. Down Syndrome Collaborative Group. N Engl J Med 324:872–876PubMedCrossRef
41.
Zurück zum Zitat Jyothy A, Kumar K, Mallikarjuna G, Babu Rao V, Uma Devi B, Sujatha M, Reddy P (2001) Parental age and the origin of extra chromosome 21 in Down syndrome. J Hum Genet 46:347–350CrossRefPubMed Jyothy A, Kumar K, Mallikarjuna G, Babu Rao V, Uma Devi B, Sujatha M, Reddy P (2001) Parental age and the origin of extra chromosome 21 in Down syndrome. J Hum Genet 46:347–350CrossRefPubMed
42.
Zurück zum Zitat Erickson J (1978) Down syndrome, paternal age, maternal age and birth order. Ann Hum Genet 41:289–298CrossRefPubMed Erickson J (1978) Down syndrome, paternal age, maternal age and birth order. Ann Hum Genet 41:289–298CrossRefPubMed
43.
Zurück zum Zitat Hook E (1987) Issues in analysis of data on paternal age and 47:+21: implication for genetic counseling for Down syndrome. Hum Genet 77:303–306CrossRefPubMed Hook E (1987) Issues in analysis of data on paternal age and 47:+21: implication for genetic counseling for Down syndrome. Hum Genet 77:303–306CrossRefPubMed
44.
Zurück zum Zitat Erickson J, Bjerkedal T (1981) Down syndrome associated with father’s age in Norway. J Med Genet 18:22–28PubMedCrossRef Erickson J, Bjerkedal T (1981) Down syndrome associated with father’s age in Norway. J Med Genet 18:22–28PubMedCrossRef
45.
Zurück zum Zitat Fisch H, Hyun G, Golden R, Hensle T, Olsson C, Liberson G (2003) The influence of paternal age on Down syndrome. J Urol 169:2275–2278CrossRefPubMed Fisch H, Hyun G, Golden R, Hensle T, Olsson C, Liberson G (2003) The influence of paternal age on Down syndrome. J Urol 169:2275–2278CrossRefPubMed
46.
Zurück zum Zitat Kendler K, Diehl S (1993) The genetics of schizophrenia: a current genetic-epidemiologica perspective. Schizophr Bull 19:261–285PubMed Kendler K, Diehl S (1993) The genetics of schizophrenia: a current genetic-epidemiologica perspective. Schizophr Bull 19:261–285PubMed
47.
Zurück zum Zitat Fananas L, Bertranpetit J (1991) Reproductive rates in families of schizophrenic patients in a case-control study. Acta Psychiatr Scand 99:441–446 Fananas L, Bertranpetit J (1991) Reproductive rates in families of schizophrenic patients in a case-control study. Acta Psychiatr Scand 99:441–446
48.
Zurück zum Zitat Gregory I (1959) An analysis of family data on 1000 patients admitted to a Canadian mental hospital. Acta Genet Stat Med 9:54–56PubMed Gregory I (1959) An analysis of family data on 1000 patients admitted to a Canadian mental hospital. Acta Genet Stat Med 9:54–56PubMed
49.
Zurück zum Zitat Hare E, Moran P (1979) Raised paternal age in psychiatric patients: evidence for the constitutional hypothesis. Br J Psychiatry 134:169–177PubMedCrossRef Hare E, Moran P (1979) Raised paternal age in psychiatric patients: evidence for the constitutional hypothesis. Br J Psychiatry 134:169–177PubMedCrossRef
50.
Zurück zum Zitat Zammit S, Allebeck P, Dalman C, Lundberg I, Hemmingson T, Owen M, Lewis G (2003) Paternal age and risk for schizophrenia. Br J Psych 183:405–408CrossRef Zammit S, Allebeck P, Dalman C, Lundberg I, Hemmingson T, Owen M, Lewis G (2003) Paternal age and risk for schizophrenia. Br J Psych 183:405–408CrossRef
51.
Zurück zum Zitat Malaspina D, Harlap S, Fennig S, Heiman D, Nahon D, Feldman D, Susser E (2001) Advancing paternal age and the risk of schizophrenia. Arch Gen Psych 58:361–367CrossRef Malaspina D, Harlap S, Fennig S, Heiman D, Nahon D, Feldman D, Susser E (2001) Advancing paternal age and the risk of schizophrenia. Arch Gen Psych 58:361–367CrossRef
52.
Zurück zum Zitat Sipos A, Fasmussen F, Harrison G, Tynelius P, Lewis G, Leon D, Gunnell D (2004) Paternal age and schizophrenia: a population based cohort study. BMJ 329:1070CrossRefPubMed Sipos A, Fasmussen F, Harrison G, Tynelius P, Lewis G, Leon D, Gunnell D (2004) Paternal age and schizophrenia: a population based cohort study. BMJ 329:1070CrossRefPubMed
53.
Zurück zum Zitat Fisch H (2005) The male biological clock. Free Press, New York Fisch H (2005) The male biological clock. Free Press, New York
Metadaten
Titel
The male biological clock
verfasst von
Sarah M. Lambert
Puneet Masson
Harry Fisch
Publikationsdatum
01.12.2006
Verlag
Springer-Verlag
Erschienen in
World Journal of Urology / Ausgabe 6/2006
Print ISSN: 0724-4983
Elektronische ISSN: 1433-8726
DOI
https://doi.org/10.1007/s00345-006-0130-y

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