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World Journal of Urology

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04.11.2015 | Original Article

Ureaplasma urealyticum and Mycoplasma hominis infections and semen quality in 19,098 infertile men in China

verfasst von: Chuan Huang, Xingyu Long, Shuang Jing, Liqing Fan, Kongrong Xu, Siyang Wang, Wenbing Zhu

Erschienen in: World Journal of Urology | Ausgabe 7/2016

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Abstract

Objective

This study aimed to determine the incidence of Ureaplasma urealyticum and Mycoplasma hominis infections in infertile and fertile men and to investigate their effects on the semen quality. The study also aimed to analyze the drug susceptibility of UU and MH to provide guidance for reasonable antibiotic use.

Methods

A total of 19,098 semen specimens were obtained from infertile men at our hospital from January to December 2014. In addition to these specimens, 3368 semen specimens of sperm were obtained from donors at the sperm bank of our hospital from January 2011 to December 2014. Semen analysis was performed using the methods outlined by the World Health Organization.

Results

The prevalence of UU and MH significantly differed between infertile and fertile men. The mean progressive motility, total motility, and normal forms in the semen samples of infertile males positive for UU significantly differed from the corresponding values of uninfected men. However, the semen parameters did not differ between MH-infected and uninfected men. In the antibiotic sensitivity test, UU, MH, and UU mixed with MH were all found susceptible to doxycycline and josamycin with drug resistance rates below 6 %, but both species were highly resistant to ciprofloxacin.

Conclusions

Clinical assessment revealed a significant relationship between UU and MH infections and male infertility. UU was found to significantly affect sperm quality, but this was not the case with MH. Doxycycline and josamycin should be preferred for clinically treating UU and MH infections.

Practice Committee of the American Society of Reproductive Medicine (2013) Definitions of infertility and recurrent pregnancy loss: a committee opinion. Fertil Steril 99:63CrossRef

Thonneau P, Marchand S, Tallec A, Ferial ML, Ducot B, Lansac J et al (1991) Incidence and main causes of infertility in a resident population (1,850,000) of three French regions (1988–1989). Hum Reprod 6:811–816PubMed

Keck C, Gerber-Schafer C, Clad A, Wilhelm C, Breckwoldt M (1998) Seminal tract infections: impact on male fertility and treatment options. Hum Reprod Update 4:891–903CrossRefPubMed

Leli C, Mencacci A, Bombaci JC, D’Alo F, Farinelli S, Vitali M et al (2012) Prevalence and antimicrobial susceptibility of Ureaplasma urealyticum and Mycoplasma hominis in a population of Italian and immigrant outpatients. Infez Med 20:82–87PubMed

Zhang N, Wang R, Li X, Liu X, Tang Z, Liu Y (2014) Are Ureaplasma spp. a cause of nongonococcal urethritis? A systematic review and meta-analysis. PLoS ONE 9:e113771CrossRefPubMedPubMedCentral

Tibaldi C, Cappello N, Latino MA, Masuelli G, Marini S, Benedetto C (2009) Vaginal and endocervical microorganisms in symptomatic and asymptomatic non-pregnant females: risk factors and rates of occurrence. Clin Microbiol Infect 15:670–679CrossRefPubMed

Lanzafame M, Delama A, Lattuada E, Faggian F, Padovani GC, Concia E et al (2006) Prevalence and clinical significance of Ureaplasma urealyticum and Mycoplasma hominis in the lower genital tract of HIV-1-infected women. Infez Med 14:213–215PubMed

Murtha AP, Edwards JM (2014) The role of Mycoplasma and Ureaplasma in adverse pregnancy outcomes. Obstet Gynecol Clin North Am 41:615–627CrossRefPubMed

Andrade-Rocha FT (2003) Ureaplasma urealyticum and Mycoplasma hominis in men attending for routine semen analysis. Prevalence, incidence by age and clinical settings, influence on sperm characteristics, relationship with the leukocyte count and clinical value. Urol Int 71:377–381CrossRefPubMed

10.

Wang Y, Liang CL, Wu JQ, Xu C, Qin SX, Gao ES (2006) Do Ureaplasma urealyticum infections in the genital tract affect semen quality? Asian J Androl 8:562–568CrossRefPubMed

11.

Liu J, Wang Q, Ji X, Guo S, Dai Y, Zhang Z et al (2014) Prevalence of Ureaplasma urealyticum, Mycoplasma hominis, Chlamydia trachomatis infections, and semen quality in infertile and fertile men in China. Urology 83:795–799CrossRefPubMed

12.

Lee JS, Kim KT, Lee HS, Yang KM, Seo JT, Choe JH (2013) Concordance of Ureaplasma urealyticum and Mycoplasma hominis in infertile couples: impact on semen parameters. Urology 81:1219–1224CrossRefPubMed

13.

Gunyeli I, Abike F, Dunder I, Aslan C, Tapisiz OL, Temizkan O (2011) Chlamydia, Mycoplasma and Ureaplasma infections in infertile couples and effects of these infections on fertility. Arch Gynecol Obstet 283:379–385CrossRefPubMed

14.

Chen XS, Gong XD, Liang GJ, Zhang GC (2000) Epidemiologic trends of sexually transmitted diseases in China. Sex Transm 27:138–142CrossRef

15.

Chen XS, Peeling RW, Yin YP, Mabey DC (2010) The epidemic of sexually transmitted infections in China: implications for control and future perspectives. BMC Med 9:111CrossRef

16.

Zeighami H, Peerayeh SN, Yazdi RS, Sorouri R (2009) Prevalence of Ureaplasma urealyticum and Ureaplasma parvum in semen of infertile and healthy men. Int J STD AIDS 20:387–390CrossRefPubMed

17.

Zhang Q, Xiao Y, Zhuang W, Cheng B, Zheng L, Cai Y et al (2014) Effects of biovar I and biovar II of Ureaplasma urealyticum on sperm parameters, lipid peroxidation, and deoxyribonucleic acid damage in male infertility. Urology 84:87–92CrossRefPubMed

18.

Zhang Z, Zhong J, Chen W (2014) Research of male infertility and urogenital mycoplasma infection. Heilongjiang Med J 38:451–452

19.

Huang C, Peng L, Zheng Z, Jiang Y (2014) Value of detection of Mycoplasma, Chlamydia and anti-sperm antibodies in male infertility. Int J Lab Med 35:1412–1414

20.

Uuskula A, Kohl PK (2002) Genital mycoplasmas, including Mycoplasma genitalium, as sexually transmitted agents. Int J STD AIDS 13:79–85CrossRefPubMed

21.

Potts JM, Sharma R, Pasqualotto F et al (2000) Association of Ureaplasma urealyticum with abnormal reactive oxygen species levels and absence of leukocytospermia. J Urol 163:1775–1778CrossRefPubMed

22.

Zeng L, Zou Q, Jing W, Luo X (2013) Analysis of mycoplasma infection and drug susceptibility result in male infertile patients. J Mod Med Health 29:1460–1461

23.

Gdoura R, Kchaou W, Ammar-Keskes L, Chakroun N, Sellemi A, Znazen A et al (2008) Assessment of Chlamydia trachomatis, Ureaplasma urealyticum, Ureaplasma parvum, Mycoplasma hominis, and Mycoplasma genitalium in semen and first void urine specimens of asymptomatic male partners of infertile couples. J Androl 29:198–206CrossRefPubMed

24.

Gdoura R, Kchaou W, Chaari C, Znazen A, Keskes L, Rebai T et al (2007) Ureaplasma urealyticum, Ureaplasma parvum, Mycoplasma hominis and Mycoplasma genitalium infections and semen quality of infertile men. BMC Infect Dis 7:129CrossRefPubMedPubMedCentral

25.

Sanocka-Maciejewska D, Ciupinska M, Kurpisz M (2005) Bacterial infection and semen quality. J Reprod Immunol 67:51–56CrossRefPubMed

26.

Al-Sweih NA, Al-Fadli AH, Omu AE, Rotimi VO (2012) Prevalence of Chlamydia trachomatis, Mycoplasma hominis, Mycoplasma genitalium, and Ureaplasma urealyticum infections and seminal quality in infertile and fertile men in Kuwait. J Androl 33:1323–1329CrossRefPubMed

27.

Koh E, Kim S, Kim I, Maeng K, Lee S (2009) Antimicrobial susceptibilities of Ureaplasma urealyticum and Mycoplasma hominis in pregnant women. Korean J Clin Microbiol 12:159–162CrossRef

28.

Yang Y, Yuan M, Zhang YH, Wang XX (2014) Mycoplasma causing urogenital tract infections and analysis of drug susceptibility. Chin J Nosocomiol 24:316–317

29.

Chen AH, Tao J, Du ZQ, Deng Q, Zuo MZ, Zheng WF (2015) Clinical mycoplasma infections in infertility patients. Chin J Nosocomiol 25:2379–2381

30.

Yang C, Zhao Q (2015) Analysis of 726 patients with mycoplasma infection and drug sensitivity. Med Sci J Central South China 43:192–194

Titel: Ureaplasma urealyticum and Mycoplasma hominis infections and semen quality in 19,098 infertile men in China
verfasst von: Chuan Huang
Xingyu Long
Shuang Jing
Liqing Fan
Kongrong Xu
Siyang Wang
Wenbing Zhu
Publikationsdatum: 04.11.2015
Verlag: Springer Berlin Heidelberg
Erschienen in: World Journal of Urology / Ausgabe 7/2016
Print ISSN: 0724-4983
Elektronische ISSN: 1433-8726
DOI: https://doi.org/10.1007/s00345-015-1724-z

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