Skip to main content
Erschienen in: World Journal of Urology 10/2018

03.05.2018 | Original Article

Oncological safety and quality of life in men undergoing simultaneous transurethral resection of bladder tumor and prostate: results from a randomized controlled trial

verfasst von: Marco Dellabella, Alessandro Branchi, Luca Gasparri, Redi Claudini, Daniele Castellani

Erschienen in: World Journal of Urology | Ausgabe 10/2018

Einloggen, um Zugang zu erhalten

Abstract

Purpose

To assess oncological safety and quality of life (QL) of men undergoing simultaneous transurethral resection of bladder tumor (TURBT) and transurethral resection of the prostate (TURP) for symptomatic benign prostatic hyperplasia (BPH).

Methods

Ninety-five men with a new diagnosis of bladder cancer (BC) and symptomatic BPH were randomized to receive TURBT + tamsulosin (Group 1) or TURBT + TURP (Group 2). Inclusion criteria were age ≤ 75 years, first diagnosis of BC up to 4 cm, and prostate volume ≤ 80 ml. All patients were evaluated preoperatively with digital rectal examination, PSA, maximal urine flow rate (Qmax), and International Prostate Symptom Score (IPSS). IPSS and Qmax were repeated at 1-year follow-up. QL was evaluated at 1 year using a modified version of the self-report bladder cancer subscale of the Functional Assessment of Cancer Therapy.

Results

Eighty-five men completed the study (43 in Group 1 and 42 in Group 2). Adjuvant instillation therapy was given to 26 patients in Group 1 and to 27 in Group 2. Average time to the first recurrence was 16.64 months in Group 1 and 17.7 in Group 2. Total recurrences were 27 in Group 1 and 22 in Group 2. Bladder neck/prostatic urethra recurrences were 9 in Group 1 vs. 8 in Group 2. QL, IPSS, and Qmax 12 months after surgery were better in Group 2.

Conclusion

Concomitant TURBT and TURP appear to be oncologically safe procedures in terms of total and prostatic urethra recurrence, and improve QL in men with BC who require surgery for symptomatic BPH.
Literatur
1.
Zurück zum Zitat Malats NRF (2015) Epidemiology of bladder cancer. Hematol Oncol Clin North Am 29:177–189CrossRef Malats NRF (2015) Epidemiology of bladder cancer. Hematol Oncol Clin North Am 29:177–189CrossRef
14.
Zurück zum Zitat Eble JN, Sauter G, Epstein JISIA (eds) (2004) World Health Organization classification of tumours. pathology and genetics of tumours of the urinary system and male genital organs. IARC Press, Lyon Eble JN, Sauter G, Epstein JISIA (eds) (2004) World Health Organization classification of tumours. pathology and genetics of tumours of the urinary system and male genital organs. IARC Press, Lyon
16.
Zurück zum Zitat Dindo D, Demartines N, Clavien P-A (2004) Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg 240:205–213CrossRef Dindo D, Demartines N, Clavien P-A (2004) Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg 240:205–213CrossRef
19.
Zurück zum Zitat Albarran J, Imbert L (1903) Les Tumeurs du rein. Mason, Paris Albarran J, Imbert L (1903) Les Tumeurs du rein. Mason, Paris
20.
Zurück zum Zitat Hinman F (1956) Recurrence of bladder tumors by surgical implantation. J Urol 75:695–696CrossRef Hinman F (1956) Recurrence of bladder tumors by surgical implantation. J Urol 75:695–696CrossRef
21.
Zurück zum Zitat Kiefer J (1953) Bladder tumor recurrence in the urethra: a warning. J Urol 69:652–656CrossRef Kiefer J (1953) Bladder tumor recurrence in the urethra: a warning. J Urol 69:652–656CrossRef
22.
Zurück zum Zitat Pode D, Alon Y, Horowitz AT et al (1986) The mechanism of human bladder tumor implantation in an in vitro model. J Urol 136:482–486CrossRef Pode D, Alon Y, Horowitz AT et al (1986) The mechanism of human bladder tumor implantation in an in vitro model. J Urol 136:482–486CrossRef
28.
Zurück zum Zitat Kadlubar FF, Dooley KL, Teitel CH et al (1991) Frequency of urination and its effects on metabolism, pharmacokinetics, blood hemoglobin adduct formation, and liver and urinary bladder DNA adduct levels in beagle dogs given the carcinogen 4-aminobiphenyl. Cancer Res 51:4371–4377PubMed Kadlubar FF, Dooley KL, Teitel CH et al (1991) Frequency of urination and its effects on metabolism, pharmacokinetics, blood hemoglobin adduct formation, and liver and urinary bladder DNA adduct levels in beagle dogs given the carcinogen 4-aminobiphenyl. Cancer Res 51:4371–4377PubMed
Metadaten
Titel
Oncological safety and quality of life in men undergoing simultaneous transurethral resection of bladder tumor and prostate: results from a randomized controlled trial
verfasst von
Marco Dellabella
Alessandro Branchi
Luca Gasparri
Redi Claudini
Daniele Castellani
Publikationsdatum
03.05.2018
Verlag
Springer Berlin Heidelberg
Erschienen in
World Journal of Urology / Ausgabe 10/2018
Print ISSN: 0724-4983
Elektronische ISSN: 1433-8726
DOI
https://doi.org/10.1007/s00345-018-2317-4

Weitere Artikel der Ausgabe 10/2018

World Journal of Urology 10/2018 Zur Ausgabe

Update Urologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.