Erschienen in:
19.07.2018 | Original Article
The effect of hexanic extract of Serenoa repens on prostatic inflammation: results from a randomized biopsy study
verfasst von:
Stavros Gravas, Michael Samarinas, Konstantina Zacharouli, Anastasios Karatzas, Vasileios Tzortzis, Georgios Koukoulis, Michael Melekos
Erschienen in:
World Journal of Urology
|
Ausgabe 3/2019
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Abstract
Purpose
To evaluate the effect of hexanic extract of Serenoa repens (HESr) on prostatic inflammation in patients with diagnosed prostatic inflammation.
Methods
Patients with prostatic inflammation histologically confirmed by TRUS prostatic biopsy were randomized either to receive HESr (320 mg/day) or no treatment. A second biopsy was performed 6 months later according to standard clinical practice. Inflammation was assessed by the Irani’s score and immunohistochemical staining using the CD3, CD4 and CD8 (for T-leucocytes), CD20 (for B-leucocytes) and CD163 (for macrophages) antibodies.
Results
Overall 97 patients were eligible for analysis. In the HESr group the mean inflammation grading and aggressiveness grading score significantly decreased from 1.55 and 1.55 at baseline to 0.79 (p = 0.001) and 0.87 (p = 0.001) at the second biopsy, respectively. In the control group the mean inflammation grading score was 1.44 at first biopsy and 1.23 at the second biopsy. The mean aggressiveness gradings core was 1.09 and 0.89, respectively. No statistical significance was found (p = 0.09 and p = 0.74).The mean decrease in all inflammation scores was statistically higher in the HESr patients compared to controls. The immunohistochemical staining showed a significant change in the expression of the analyzed antibodies for the HESr patients compared to the first biopsy. In the nontreatment group, no significant difference was found at the second biopsy. The change in expression of each antibody in the HESr group was statistical significant compared to control.
Conclusions
HESr seems to reduce prostatic inflammation in terms of histological and immunohistochemical parameters in this specific patients population.