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Erschienen in: Heart and Vessels 9/2017

05.05.2017 | Original Article

Predictors of thrombus formation after percutaneous left atrial appendage closure using the WATCHMAN device

verfasst von: Hidehiro Kaneko, Michael Neuss, Jens Weissenborn, Christian Butter

Erschienen in: Heart and Vessels | Ausgabe 9/2017

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Abstract

Percutaneous left atrial appendage (LAA) closure using the WATCHMAN device is a novel option for prevention of stroke associated with atrial fibrillation. However, device-related thrombus (DRT) formation is a concern after WATCHMAN implantation and the predictors of DRT still remain unclear. We aimed to clarify the predictors of DRT after WATCHMAN implantation by analyzing 78 patients (50 males, 72 ± 8 years, average CHA2DS2-VASc score of 4.3 + 1.8) who had undergone WATCHMAN implantation. WATCHMAN was successfully implanted in all patients and four (5%) developed DRT. Patients with DRT were more often female (75 vs. 34%, p = 0.094). CHA2DS2-VASc score was higher for patients with DRT (6.3 ± 2.5 vs. 4.2 ± 1.7, p = 0.022). Chronic kidney disease (100% vs. 43%, p = 0.024) and deep implantation of the device, which was defined as implant position below the LAA ostial plane (75 vs. 24%, p = 0.026), were more common in patients with DRT. HAS-BLED score (4.5 ± 1.0 vs. 3.5 ± 1.1, p = 0.074) was higher and oral anticoagulants (50 vs. 84%, p = 0.086) were less commonly prescribed for patients with DRT. Multivariable logistic regression analysis showed that higher CHA2DS2-VASc score (p = 0.022, OR 2.8) and deep implantation (p = 0.032, OR 24.7) were associated with DRT. These results suggest the possible role of CHA2S2-VASc scores and implantation depth in the development of DRT after percutaneous LAA closure using the WATCHMAN device.
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Metadaten
Titel
Predictors of thrombus formation after percutaneous left atrial appendage closure using the WATCHMAN device
verfasst von
Hidehiro Kaneko
Michael Neuss
Jens Weissenborn
Christian Butter
Publikationsdatum
05.05.2017
Verlag
Springer Japan
Erschienen in
Heart and Vessels / Ausgabe 9/2017
Print ISSN: 0910-8327
Elektronische ISSN: 1615-2573
DOI
https://doi.org/10.1007/s00380-017-0971-x

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