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Erschienen in: Heart and Vessels 9/2017

10.04.2017 | Original Article

Pravastatin improves postprandial endothelial dysfunction and hemorheological deterioration in patients with effort angina pectoris

verfasst von: Tomio Umemoto, Takanori Yasu, Kenshiro Arao, Nahoko Ikeda, Yasuto Horie, Hiroyuki Sugimura, Masanobu Kawakami, Hideo Fujita, Shin-ichi Momomura

Erschienen in: Heart and Vessels | Ausgabe 9/2017

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Abstract

Postprandial hypertriglyceridemia and hyperglycemia may promote endothelial and hemorheological dysfunction. The present study investigated the effects of pravastatin on endothelial function and hemorheology in patients with stable angina pectoris (AP) before and after eating a test meal. We recruited 26 patients with stable AP who had impaired glucose tolerance and mild dyslipidemia and six healthy men as controls to assess endothelial function and hemorheological behavior. In each group, we measured forearm blood flow (FBF) during post-ischemic reactive hyperemia and obtained blood samples before and 2 h after the test meal. Pravastatin 20 mg/day was then commenced in the 26 AP patients. The above tests were repeated after 2 days and 6 months. Maximum FBF during hyperemia in the baseline fasting phase was significantly lower in the AP patients than in the controls (p < 0.05). Fasting and postprandial FBF during reactive hyperemia time-dependently improved after pravastatin treatment (p < 0.05 vs. baseline data for each phase). Pravastatin treatment for 6 months, but not for 2 days, inhibited leukocyte activation and improved hemorheological parameters. In conclusion, pravastatin treatment for 6 months improved fasting and postprandial endothelial and hemorheological dysfunction in AP patients.
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Metadaten
Titel
Pravastatin improves postprandial endothelial dysfunction and hemorheological deterioration in patients with effort angina pectoris
verfasst von
Tomio Umemoto
Takanori Yasu
Kenshiro Arao
Nahoko Ikeda
Yasuto Horie
Hiroyuki Sugimura
Masanobu Kawakami
Hideo Fujita
Shin-ichi Momomura
Publikationsdatum
10.04.2017
Verlag
Springer Japan
Erschienen in
Heart and Vessels / Ausgabe 9/2017
Print ISSN: 0910-8327
Elektronische ISSN: 1615-2573
DOI
https://doi.org/10.1007/s00380-017-0974-7

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