Introduction
Methods
Study patients
Ankle-brachial pressure index (ABI)
Testing assay
Definition of risk factors
Evaluation of exercise tolerance capacity
Study protocol
Statistical analysis
Results
Pitavastatin (n = 53) | Control (n = 22) |
p
| |
---|---|---|---|
Age (years) | 70 ± 7 | 71 ± 7 | 0.859 |
Gender (M/F) | 39/14 | 19/3 | 0.366 |
Lower ABI | 0.73 ± 0.15 | 0.74 ± 0.20 | 0.811 |
Body mass index | 23.0 ± 3.1 | 22.7 ± 2.8 | 0.671 |
Hemodialysis (±) | 5/48 | 2/20 | 0.963 |
Hypertension (±) | 36/17 | 11/11 | 0.223 |
Diabetes (±) | 36/17 | 4/18 | 0.0002* |
Ischemic heart disease (±) | 30/23 | 5/17 | 0.0015* |
Smoking status (±) | 14/39 | 4/18 | 0.366 |
Glycohemoglobin A1c (%) | 6.3 ± 1.1 | 5.6 ± 0.5 | 0.0048* |
Total cholesterol (mg/dL) | 207 ± 40 | 193 ± 39 | 0.181 |
Triglycerides (mg/dL) | 154 ± 82 | 115 ± 51 | 0.046* |
HDL-C (mg/dL) | 51 ± 14 | 52 ± 12 | 0.770 |
LDL-C (mg/dL) | 123 ± 32 | 115 ± 38 | 0.325 |
hsCRP (mg/dL) | 0.31 ± 0.60 | 0.22 ± 0.23 | 0.593 |
Log10CD34+/133+ cells (100 μL) | 1.67 ± 0.29 | 1.73 ± 0.29 | 0.259 |
Treadmill exercise test | |||
Asymptomatic walking distance (m) | 233 ± 207 | 211 ± 166 | 0.5853 |
Maximum walking distance (m) | 473 ± 345 | 433 ± 321 | 0.5205 |
Daily exercise (steps/day) | 5757 ± 2524 | 6183 ± 3680 | 0.8146 |
Pitavastatin (n = 53) | Control (n = 22) | |||||||
---|---|---|---|---|---|---|---|---|
Baseline | 3 M | 6 M |
p value | Baseline | 3 M | 6 M |
p value | |
Lipid parameters | ||||||||
T-Chol (mg/dL) | 207 ± 40 | 158 ± 29 | 159 ± 29 | <0.0001 | 193 ± 39 | 197 ± 39 | 196 ± 43 | 0.215 |
TG (mg/dL) | 154 ± 82 | 124 ± 81 | 126 ± 88 | 0.005 | 115 ± 51 | 101 ± 45 | 103 ± 42 | 0.057 |
HDL-C (mg/dL) | 51 ± 14 | 53 ± 13 | 53 ± 12 | 0.220 | 52 ± 12 | 53 ± 14 | 55 ± 15 | 0.065 |
LDL-C (mg/dL) | 123 ± 32 | 79 ± 22 | 82 ± 21 | <0.0001 | 115 ± 38 | 131 ± 37 | 116 ± 42 | 0.274 |
hsCRP (mg/dL) | 0.31 ± 0.60 | 0.38 ± 0.70 | 0.17 ± 0.15 | 0.056 | 0.22 ± 0.23 | 0.23 ± 0.23 | 0.23 ± 0.26 | 0.577 |
Log10CD34+/133+ cells | 1.67 ± 0.29 | 1.73 ± 0.31 | 1.74 ± 0.29 | 0.923 | 1.73 ± 0.29 | 1.65 ± 0.24 | 1.68 ± 0.31 | 0.259 |