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Heart and Vessels

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07.12.2018 | Original Article

Chemokine (C–X–C motif) receptor 2 blockade by SB265610 inhibited angiotensin II-induced abdominal aortic aneurysm in Apo E^−/− mice

verfasst von: Hao Nie, Hong-Xia Wang, Cui Tian, Hua-Liang Ren, Fang-Da Li, Chao-Yu Wang, Hui-Hua Li, Yue-Hong Zheng

Erschienen in: Heart and Vessels | Ausgabe 5/2019

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Abstract

Inflammation plays a critical role in the development of abdominal aortic aneurysm (AAA). Chemokine receptor CXCR2 mediates inflammatory cell chemotaxis in several diseases. However, the role of CXCR2 in AAA and the underlying mechanisms remain unknown. In this study, we found that the CXCR2 expressions in AAA tissues from human and angiotensin II (Ang II)-infused apolipoprotein E knockout (Apo E^−/−) mice were significantly increased. The pharmacological inhibition of CXCR2 (SB265610) markedly reduced Ang II-induced AAA formation. Furthermore, SB265610 treatment significantly reduced collagen deposition, elastin degradation, the metal matrix metalloprotease expression and accumulation of macrophage cells. In conclusion, these results showed CXCR2 plays a pathogenic role in AAA formation. Inhibition of CXCR2 pathway may represent a novel therapeutic approach to treat AAA.

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Titel: Chemokine (C–X–C motif) receptor 2 blockade by SB265610 inhibited angiotensin II-induced abdominal aortic aneurysm in Apo E−/− mice
verfasst von: Hao Nie
Hong-Xia Wang
Cui Tian
Hua-Liang Ren
Fang-Da Li
Chao-Yu Wang
Hui-Hua Li
Yue-Hong Zheng
Publikationsdatum: 07.12.2018
Verlag: Springer Japan
Erschienen in: Heart and Vessels / Ausgabe 5/2019
Print ISSN: 0910-8327
Elektronische ISSN: 1615-2573
DOI: https://doi.org/10.1007/s00380-018-1301-7

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Chemokine (C–X–C motif) receptor 2 blockade by SB265610 inhibited angiotensin II-induced abdominal aortic aneurysm in Apo E^−/− mice

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