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Erschienen in: Child's Nervous System 10/2015

01.10.2015 | Special Annual Issue

Factors affecting survival of medulloblastoma in children: the changing concept of management

verfasst von: Tai-Tong Wong, Yen-Lin Liu, Donald Ming-Tak Ho, Kai-Ping Chang, Muh-Lii Liang, Hsin-Hung Chen, Yi-Yen Lee, Feng-Chi Chang, Shih-Chieh Lin, Ting-Rong Hsu, Kuo-Wei Chen, Wei-Kang Kwang, Wu-Yu Hou, Chung-Yih Wang, Sang-Hue Yen, Wan-You Guo, Yi-Wei Chen

Erschienen in: Child's Nervous System | Ausgabe 10/2015

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Abstract

Medulloblastoma (MB) is a type of malignant tumor arising only in the cerebellum that was first defined by Cushing and Bailey in 1920s. In this review paper, we trace the evolution of risk stratification and the correlated changing concept of management in the past years. Outcome analysis of the hospital series of the Taipei Veterans General Hospital, Cheng Hsin General Hospital, and Taipei Medical University Hospital was performed to correlate prognostic indicators with reported studies. The purpose is to provide clues for age-specific and risk-adjusted optimal, effective, but beneficial and protective treatment strategies of these tumors in children.
Literatur
1.
Zurück zum Zitat Kunschner LJ (2002) Harvey Cushing and medulloblastoma. Arch Neurol 59(4):6CrossRef Kunschner LJ (2002) Harvey Cushing and medulloblastoma. Arch Neurol 59(4):6CrossRef
2.
Zurück zum Zitat Bailey P, Cushing H (1925) Meullobalstoma cerebella, common type of mid cerebellar glioma of childhood. Arch Neurol Psychiatr 14:192–224CrossRef Bailey P, Cushing H (1925) Meullobalstoma cerebella, common type of mid cerebellar glioma of childhood. Arch Neurol Psychiatr 14:192–224CrossRef
3.
Zurück zum Zitat Bailey P (1930) Further notes on the cerebellar medulloblastoma: the effect of roentgen radiation. Am J Pathol 6:125–136PubMedCentralPubMed Bailey P (1930) Further notes on the cerebellar medulloblastoma: the effect of roentgen radiation. Am J Pathol 6:125–136PubMedCentralPubMed
4.
Zurück zum Zitat Brown RC, Gunderson L, Plenk HP (1977) Medulloblastoma: a review of the LDS hospital experience. Cancer 40:56–60CrossRefPubMed Brown RC, Gunderson L, Plenk HP (1977) Medulloblastoma: a review of the LDS hospital experience. Cancer 40:56–60CrossRefPubMed
5.
Zurück zum Zitat Landberg TG, Lingren ML, Cavaln-Stahl EK, Svahn-Tapper GO, Sundbarg G, Garwicz S, Lagergren JA, Gunnesson VL, Brun AE, Cronqvist SE (1980) Improvements in the radiotherapy of medulloblastoma 1946–1975. Cancer 45:670–678CrossRefPubMed Landberg TG, Lingren ML, Cavaln-Stahl EK, Svahn-Tapper GO, Sundbarg G, Garwicz S, Lagergren JA, Gunnesson VL, Brun AE, Cronqvist SE (1980) Improvements in the radiotherapy of medulloblastoma 1946–1975. Cancer 45:670–678CrossRefPubMed
6.
Zurück zum Zitat Tomita T, McLone DG (1986) Medullolastoma in childhood: results of radical resection and low-dosage neuraxis radiation therapy. J Neurosurg 64:238–242CrossRefPubMed Tomita T, McLone DG (1986) Medullolastoma in childhood: results of radical resection and low-dosage neuraxis radiation therapy. J Neurosurg 64:238–242CrossRefPubMed
7.
Zurück zum Zitat Hughes EN, Shillito J, Sallan SE, Loeffler JS (1988) Medulloblastoma at the Joint Center for Radiation Therapy between 1968 and 1984. The influence of radiation dose on the patterns of failure and survival. Cancer 61:1992–1998CrossRefPubMed Hughes EN, Shillito J, Sallan SE, Loeffler JS (1988) Medulloblastoma at the Joint Center for Radiation Therapy between 1968 and 1984. The influence of radiation dose on the patterns of failure and survival. Cancer 61:1992–1998CrossRefPubMed
8.
Zurück zum Zitat Chang CH (1969) An operative staging system and a megavoltage radiotherapeutic technique for cerebellar medulloblastomas. Radiology 93(6):1351–1359CrossRefPubMed Chang CH (1969) An operative staging system and a megavoltage radiotherapeutic technique for cerebellar medulloblastomas. Radiology 93(6):1351–1359CrossRefPubMed
9.
Zurück zum Zitat Harisiadis L, Chang CH (1977) Medulloblastoma in children: a correlation between staging and results of treatment. Int J Radiat Oncol Biol Phys 2:833–841CrossRefPubMed Harisiadis L, Chang CH (1977) Medulloblastoma in children: a correlation between staging and results of treatment. Int J Radiat Oncol Biol Phys 2:833–841CrossRefPubMed
10.
Zurück zum Zitat Zeltzer PM, Boyett JM, Finlay JL, Albright AL, Rorke LB, Milstein JM, Allen JC, Stevens KR, Stanley P, Li H, Wisoff JH, Geyer JR, McGuire-Cullen P, Susan SB, Packer RJ (1999) Metastasis stage, adjuvant treatment, and residual tumor are prognostic factors for medulloblastoma in children: conclusions from the Children’s Cancer Group 921 randomized phase III study. J Clin Oncol 17(3):832–845PubMed Zeltzer PM, Boyett JM, Finlay JL, Albright AL, Rorke LB, Milstein JM, Allen JC, Stevens KR, Stanley P, Li H, Wisoff JH, Geyer JR, McGuire-Cullen P, Susan SB, Packer RJ (1999) Metastasis stage, adjuvant treatment, and residual tumor are prognostic factors for medulloblastoma in children: conclusions from the Children’s Cancer Group 921 randomized phase III study. J Clin Oncol 17(3):832–845PubMed
11.
Zurück zum Zitat Pakcer RJ, Rood BR, McDonald TJ (2003) Medulloblastoma: present concepts of stratification into risk groups. Pediatr Neurosurg 39:60–67CrossRef Pakcer RJ, Rood BR, McDonald TJ (2003) Medulloblastoma: present concepts of stratification into risk groups. Pediatr Neurosurg 39:60–67CrossRef
12.
Zurück zum Zitat Dufour C, Beaugrand A, Pizer B, Micheli J, Aubelle MS, Fourcade A, Couanet D, Laplanche A, Kalifa C, Grill J (2012) Metastatic medulloblastoma in childhood: Chang’s classification revisited. Int J Surg Oncol, Article ID 245385 Dufour C, Beaugrand A, Pizer B, Micheli J, Aubelle MS, Fourcade A, Couanet D, Laplanche A, Kalifa C, Grill J (2012) Metastatic medulloblastoma in childhood: Chang’s classification revisited. Int J Surg Oncol, Article ID 245385
13.
Zurück zum Zitat Gajjar A, Sanford RA, Bhargava R, Heideman R, Walter A, Li Y, Langston JW, Jenkins JJ, Muhlbauer M, Boyett J, Kun LE (1996) Medulloblastoma with brain stem involvement: the impact of gross total resection on outcome. Pediatr Neurosurg 25:182–187CrossRefPubMed Gajjar A, Sanford RA, Bhargava R, Heideman R, Walter A, Li Y, Langston JW, Jenkins JJ, Muhlbauer M, Boyett J, Kun LE (1996) Medulloblastoma with brain stem involvement: the impact of gross total resection on outcome. Pediatr Neurosurg 25:182–187CrossRefPubMed
14.
Zurück zum Zitat Louis DN, Ohgaki H, Wiestler OD, Cavenee WK (2007) The 2007 WHO classification of tumors of the central nervous system. Acta Neuropathol 114:97–109PubMedCentralCrossRefPubMed Louis DN, Ohgaki H, Wiestler OD, Cavenee WK (2007) The 2007 WHO classification of tumors of the central nervous system. Acta Neuropathol 114:97–109PubMedCentralCrossRefPubMed
15.
Zurück zum Zitat Brandes AA, Paris MK (2004) Review of the prognostic factors in medulloblastoma of children and adults. Crit Rev Oncol Hematol 50:121–128CrossRefPubMed Brandes AA, Paris MK (2004) Review of the prognostic factors in medulloblastoma of children and adults. Crit Rev Oncol Hematol 50:121–128CrossRefPubMed
16.
Zurück zum Zitat Eberhart CG, Kepner JL, Goldthwaite PT, Lun LE, Duffner PK, Friedman HS, Strother DR, Burger PC (2002) Histopathologic grading of medulloblastomas. Cancer 94(2):552–560CrossRefPubMed Eberhart CG, Kepner JL, Goldthwaite PT, Lun LE, Duffner PK, Friedman HS, Strother DR, Burger PC (2002) Histopathologic grading of medulloblastomas. Cancer 94(2):552–560CrossRefPubMed
17.
Zurück zum Zitat Rutkowski S, von Hoff K, Emser A, Zwiener I, Pietsch T, Figarellar-Branger F, Giangasepro F, Ellison DW, Garre ML, Biassoni V, Grundy RG, Finlay JL, Dhall G, Raquin MA, Grill J (2010) Survival and prognostic factors of early childhood medulloblastoma: an international meta-analysis. J Clin Oncol 28(33):4961–4968CrossRefPubMed Rutkowski S, von Hoff K, Emser A, Zwiener I, Pietsch T, Figarellar-Branger F, Giangasepro F, Ellison DW, Garre ML, Biassoni V, Grundy RG, Finlay JL, Dhall G, Raquin MA, Grill J (2010) Survival and prognostic factors of early childhood medulloblastoma: an international meta-analysis. J Clin Oncol 28(33):4961–4968CrossRefPubMed
18.
Zurück zum Zitat Northcott PA, Korshunov A, Witt H, Hielscher T, Eberhart CG, Mack S, Bouffet E, Clifford SC, Hawkins CE, French P, Rutka JT, Pfister S, Taylor MD (2011) Medulloblastoma comprises four distinct molecular variants. J Clin Oncol 29(11):1408–1414CrossRefPubMed Northcott PA, Korshunov A, Witt H, Hielscher T, Eberhart CG, Mack S, Bouffet E, Clifford SC, Hawkins CE, French P, Rutka JT, Pfister S, Taylor MD (2011) Medulloblastoma comprises four distinct molecular variants. J Clin Oncol 29(11):1408–1414CrossRefPubMed
19.
Zurück zum Zitat Packer RJ, Boyett JM, Janss AJ, Stavrou T, Kun L, Wisoff J, Russo C, Geyer R, Phillips P, Kieran M, Greenberg M, Goldman S, Hyder D, Heideman R, Jones-Wallace D, August GPm Smith SH, Moshang T (2001) Growth hormone replacement therapy in children with medulloblastoma: use and effect on tumor control. J Clin Oncol 19:480–487PubMed Packer RJ, Boyett JM, Janss AJ, Stavrou T, Kun L, Wisoff J, Russo C, Geyer R, Phillips P, Kieran M, Greenberg M, Goldman S, Hyder D, Heideman R, Jones-Wallace D, August GPm Smith SH, Moshang T (2001) Growth hormone replacement therapy in children with medulloblastoma: use and effect on tumor control. J Clin Oncol 19:480–487PubMed
20.
Zurück zum Zitat Ellison DW, Kocak M, Dalton J, Megahed H, Lusher ME, Ryan SL, Zhao W (2011) Definition of disease-risk stratification groups in childhood medulloblastoma using combined clinical, pathological, and molecular variables. J Clin Oncol 29(11):1400–1407PubMedCentralCrossRefPubMed Ellison DW, Kocak M, Dalton J, Megahed H, Lusher ME, Ryan SL, Zhao W (2011) Definition of disease-risk stratification groups in childhood medulloblastoma using combined clinical, pathological, and molecular variables. J Clin Oncol 29(11):1400–1407PubMedCentralCrossRefPubMed
21.
Zurück zum Zitat Ellison DW, Dalton J, Kocak M, Nicholson SL, Fraga C, Neale G, Kenney AM, Brat DJ, Perry A, Yong WH, Taylor RE, Bailey S, Clifford SC, Gilbertson RJ (2011) Medullobalstoma: clinicopathological correlates of SHH, WNT, and non-SHH/WNT molecular subgroup. Acta Neuropathol 121:381–396PubMedCentralCrossRefPubMed Ellison DW, Dalton J, Kocak M, Nicholson SL, Fraga C, Neale G, Kenney AM, Brat DJ, Perry A, Yong WH, Taylor RE, Bailey S, Clifford SC, Gilbertson RJ (2011) Medullobalstoma: clinicopathological correlates of SHH, WNT, and non-SHH/WNT molecular subgroup. Acta Neuropathol 121:381–396PubMedCentralCrossRefPubMed
22.
Zurück zum Zitat Evans AE, Jenkin ET, Sposto R, Ortega JA, Wilson CB, Wara W, Ertel IJ, Kramer S, Chang CH, Leikin SL, Hammond D (1990) The treatment of medulloblastoma: results of a prospective randomized trial of radiation therapy with and without CCNU, vincristine, and prednisone. J Neurosurg 72:575–582CrossRef Evans AE, Jenkin ET, Sposto R, Ortega JA, Wilson CB, Wara W, Ertel IJ, Kramer S, Chang CH, Leikin SL, Hammond D (1990) The treatment of medulloblastoma: results of a prospective randomized trial of radiation therapy with and without CCNU, vincristine, and prednisone. J Neurosurg 72:575–582CrossRef
23.
Zurück zum Zitat Packer JR, Sutton LN, Goldwein JW, Perilongo G, Bunin G, Ryan J, Cohen BH, D’Angio G, Kramer ED, Zimmerman RA, Rorke LB, Evans AE, Schut L (1991) Improved survival with the sue of adjuvant chemotherapy in the treatment of medulloblastoma. J Neursurg 74:433–440CrossRef Packer JR, Sutton LN, Goldwein JW, Perilongo G, Bunin G, Ryan J, Cohen BH, D’Angio G, Kramer ED, Zimmerman RA, Rorke LB, Evans AE, Schut L (1991) Improved survival with the sue of adjuvant chemotherapy in the treatment of medulloblastoma. J Neursurg 74:433–440CrossRef
24.
Zurück zum Zitat Thomas PR, Deutsch M, Kepner JL JM, Krischer J, Patricia R, Albright L, Je Boyett JM, Krischer J, Aronin P, Albright L, Allen JC, Packer RJ, Linggood R, Mulhern R, Stehbens JA, Langston J, Stanley P, Duffner P, Rorke L, Cherlow J, Friedman HS, Jonathan L, Vietti TJ, Kun LE (2000) Low-stage medulloblastoma: final analysis of trial comparing standard-dose with reduced-dose neuraxis irradiation. J Clin Oncol 18(16):3004–3011PubMed Thomas PR, Deutsch M, Kepner JL JM, Krischer J, Patricia R, Albright L, Je Boyett JM, Krischer J, Aronin P, Albright L, Allen JC, Packer RJ, Linggood R, Mulhern R, Stehbens JA, Langston J, Stanley P, Duffner P, Rorke L, Cherlow J, Friedman HS, Jonathan L, Vietti TJ, Kun LE (2000) Low-stage medulloblastoma: final analysis of trial comparing standard-dose with reduced-dose neuraxis irradiation. J Clin Oncol 18(16):3004–3011PubMed
25.
Zurück zum Zitat Bailey CC, Gnekow A, Wellek S, Jones M, Round C, Brown J, Phillips A, Neidhardt MK (1995) Prospective randomized trial of chemotherapy given before radiotherapy in childhood medulloblastomas. International Society of Paediatric Oncology (SIOP) and the German Society of Paediatric Oncology (GPO): Slop II. Med Pediatr Oncol 25:166–178CrossRefPubMed Bailey CC, Gnekow A, Wellek S, Jones M, Round C, Brown J, Phillips A, Neidhardt MK (1995) Prospective randomized trial of chemotherapy given before radiotherapy in childhood medulloblastomas. International Society of Paediatric Oncology (SIOP) and the German Society of Paediatric Oncology (GPO): Slop II. Med Pediatr Oncol 25:166–178CrossRefPubMed
26.
Zurück zum Zitat Packer RJ, Gajjar A, Vezima G, Rorke-Adams L, Burger PC, Robertson PL, Bayer L, LaFond D, Donahue BR, Marymont MH, Muraszko K, Langston J, Sposto R (2006) Phase III study of craniospinal radiation therapy followed by adjuvant chemotherapy for newly diagnosed average-risk medulloblastoma. J Clin Oncol 24(25):4202–4208CrossRefPubMed Packer RJ, Gajjar A, Vezima G, Rorke-Adams L, Burger PC, Robertson PL, Bayer L, LaFond D, Donahue BR, Marymont MH, Muraszko K, Langston J, Sposto R (2006) Phase III study of craniospinal radiation therapy followed by adjuvant chemotherapy for newly diagnosed average-risk medulloblastoma. J Clin Oncol 24(25):4202–4208CrossRefPubMed
27.
Zurück zum Zitat Kanamori M, Kumabe T, Saito R, Yamashita Y, Sonoda Y, Tominaga T (2010) The safety of combination chemotherapy with ifosfamide, cisplatin, and etoposide (ICE): single-institution retrospective review of 108 cases. No Shinkei Geka 38:997–1005PubMed Kanamori M, Kumabe T, Saito R, Yamashita Y, Sonoda Y, Tominaga T (2010) The safety of combination chemotherapy with ifosfamide, cisplatin, and etoposide (ICE): single-institution retrospective review of 108 cases. No Shinkei Geka 38:997–1005PubMed
28.
Zurück zum Zitat Sawamura Y, Ikeda J, Ishii N, Kato T, Tada M, Abe H, Shirato H (1996) Combined irradiation and chemotherapy using ifosfamide, cisplatin, and etoposide for children with medulloblastoma/posterior fossa primitive neuroectodermal tumor—results of a pilot study. Neurol Med Chir (Tokyo) 36:632–638CrossRef Sawamura Y, Ikeda J, Ishii N, Kato T, Tada M, Abe H, Shirato H (1996) Combined irradiation and chemotherapy using ifosfamide, cisplatin, and etoposide for children with medulloblastoma/posterior fossa primitive neuroectodermal tumor—results of a pilot study. Neurol Med Chir (Tokyo) 36:632–638CrossRef
29.
Zurück zum Zitat Yasuda K, Taguchi H, Sawamura Y, Ikeda J, Aoyama H, Fujieda K, Ishii N, Kashiwamura M, Iwasaki Y, Shirato H (2008) Low-dose craniospinal irradiation and ifosfamide, cisplatin and etoposide for non-metastatic embryonal tumors in the central nervous system. Jpn J Clin Oncol 38:486–492CrossRefPubMed Yasuda K, Taguchi H, Sawamura Y, Ikeda J, Aoyama H, Fujieda K, Ishii N, Kashiwamura M, Iwasaki Y, Shirato H (2008) Low-dose craniospinal irradiation and ifosfamide, cisplatin and etoposide for non-metastatic embryonal tumors in the central nervous system. Jpn J Clin Oncol 38:486–492CrossRefPubMed
30.
Zurück zum Zitat Saito R, Kumabe T, Sonoda Y, Kanamori M, Yamashita Y, Watanabe M, Tominaga T (2011) Combination chemotherapy with ifosfamide, cisplatin, and etoposide for medulloblastoma: single-institute experience and differences in efficacy for subgroups of medulloblastoma. Childs Nerv Syst 27:1399–1406CrossRefPubMed Saito R, Kumabe T, Sonoda Y, Kanamori M, Yamashita Y, Watanabe M, Tominaga T (2011) Combination chemotherapy with ifosfamide, cisplatin, and etoposide for medulloblastoma: single-institute experience and differences in efficacy for subgroups of medulloblastoma. Childs Nerv Syst 27:1399–1406CrossRefPubMed
31.
Zurück zum Zitat Gajjar A, Chintagumpala M, Ashley D, Kellie S, Kun LE, Merchant TE, Woo S, Wheeler G, Ahern V, Krasin MJ, Fouladi M, Broniscer A, Krance R, Hale GA, Stewart CF, Dauser R, Sanford RA, Fuller C, Lau C, Boyett JM, Wallace D, Gilbertson RJ (2006) Risk-adapted craniospinal radiotherapy followed by high-dose chemotherapy and stem-cell rescue in children with newly diagnosed medulloblastoma (St Jude Medulloblastoma-96): long-term results from a prospective, multicentre trial. Lancet Oncol 7:813–820CrossRefPubMed Gajjar A, Chintagumpala M, Ashley D, Kellie S, Kun LE, Merchant TE, Woo S, Wheeler G, Ahern V, Krasin MJ, Fouladi M, Broniscer A, Krance R, Hale GA, Stewart CF, Dauser R, Sanford RA, Fuller C, Lau C, Boyett JM, Wallace D, Gilbertson RJ (2006) Risk-adapted craniospinal radiotherapy followed by high-dose chemotherapy and stem-cell rescue in children with newly diagnosed medulloblastoma (St Jude Medulloblastoma-96): long-term results from a prospective, multicentre trial. Lancet Oncol 7:813–820CrossRefPubMed
32.
Zurück zum Zitat Laughton SJ, Merchant TE, Sklar CA, Kun LE, Fouladi M, Broniscer A, Morris EB, Sanders RP, Krasin MJ, Shelso J, Xiong Z, Wallace D, Gajjar A (2008) Endocrine outcomes for children with embryonal brain tumors after risk-adapted craniospinal and conformal primary-site irradiation and high-dose chemotherapy with stem-cell rescue on the SJMB-96 trial. J Clin Oncol 26:1112–1118CrossRefPubMed Laughton SJ, Merchant TE, Sklar CA, Kun LE, Fouladi M, Broniscer A, Morris EB, Sanders RP, Krasin MJ, Shelso J, Xiong Z, Wallace D, Gajjar A (2008) Endocrine outcomes for children with embryonal brain tumors after risk-adapted craniospinal and conformal primary-site irradiation and high-dose chemotherapy with stem-cell rescue on the SJMB-96 trial. J Clin Oncol 26:1112–1118CrossRefPubMed
33.
Zurück zum Zitat DeWire M, Green DM, Sklar CA, Merchant TE, Wallace D, Lin T, Vern-Gross T, Kun LE, Krasin MJ, Boyett JM, Wright KD, Wetmore C, Broniscer A, Gajjar A (2014) Pubertal development and primary ovarian insufficiency in female survivors of embryonal brain tumors following risk-adapted craniospinal irradiation and adjuvant chemotherapy. Pediatr Blood Cancer DeWire M, Green DM, Sklar CA, Merchant TE, Wallace D, Lin T, Vern-Gross T, Kun LE, Krasin MJ, Boyett JM, Wright KD, Wetmore C, Broniscer A, Gajjar A (2014) Pubertal development and primary ovarian insufficiency in female survivors of embryonal brain tumors following risk-adapted craniospinal irradiation and adjuvant chemotherapy. Pediatr Blood Cancer
34.
Zurück zum Zitat Gurney JG, Bass JK, Onar-Thomas A, Huang J, Chintagumpala M, Bouffet E, Hassall T, Gururangan S, Heath JA, Kellie S, Cohn R, Fisher MJ, Panandiker AP, Merchant TE, Srinivasan A, Wetmore C, Qaddoumi I, Stewart CF, Armstrong GT, Broniscer A, Gajjar A (2014) Evaluation of amifostine for protection against cisplatin-induced serious hearing loss in children treated for average-risk or high-risk medulloblastoma. Neuro-Oncology 16:848–855PubMedCentralCrossRefPubMed Gurney JG, Bass JK, Onar-Thomas A, Huang J, Chintagumpala M, Bouffet E, Hassall T, Gururangan S, Heath JA, Kellie S, Cohn R, Fisher MJ, Panandiker AP, Merchant TE, Srinivasan A, Wetmore C, Qaddoumi I, Stewart CF, Armstrong GT, Broniscer A, Gajjar A (2014) Evaluation of amifostine for protection against cisplatin-induced serious hearing loss in children treated for average-risk or high-risk medulloblastoma. Neuro-Oncology 16:848–855PubMedCentralCrossRefPubMed
35.
Zurück zum Zitat Palmer SL, Armstrong C, Onar-Thomas A, Wu S, Wallace D, Bonner MJ, Schreiber J, Swain M, Chapieski L, Mabbott D, Knight S, Boyle R, Gajjar A (2013) Processing speed, attention, and working memory after treatment for medulloblastoma: an international, prospective, and longitudinal study. J Clin Oncol 31:3494–3500PubMedCentralCrossRefPubMed Palmer SL, Armstrong C, Onar-Thomas A, Wu S, Wallace D, Bonner MJ, Schreiber J, Swain M, Chapieski L, Mabbott D, Knight S, Boyle R, Gajjar A (2013) Processing speed, attention, and working memory after treatment for medulloblastoma: an international, prospective, and longitudinal study. J Clin Oncol 31:3494–3500PubMedCentralCrossRefPubMed
36.
Zurück zum Zitat McManamy CS, Pears J, Weston CL, Hanzely Z, Ironside JW, Taylor RE, Grundy RG, Clifford SC (2007) Nodule formation and desmoplasia in medulloblastomas—defining the nodular/desmoplastic variant and its biological behavior. Brain Pathol 17:151–164CrossRefPubMed McManamy CS, Pears J, Weston CL, Hanzely Z, Ironside JW, Taylor RE, Grundy RG, Clifford SC (2007) Nodule formation and desmoplasia in medulloblastomas—defining the nodular/desmoplastic variant and its biological behavior. Brain Pathol 17:151–164CrossRefPubMed
37.
Zurück zum Zitat Giangaspero F, Ferilongo G, Fondelli MP, Brisigotti M, Carollo C, Bumelli R, Burger P, Garre ML (1999) Medulloblastoma with extensive nodularity: a variant with favorable prognosis. J Neursurg 91(6):971–977CrossRef Giangaspero F, Ferilongo G, Fondelli MP, Brisigotti M, Carollo C, Bumelli R, Burger P, Garre ML (1999) Medulloblastoma with extensive nodularity: a variant with favorable prognosis. J Neursurg 91(6):971–977CrossRef
38.
Zurück zum Zitat Grill J, Sainte-Rose C, Jouvet A et al (2005) Treatment of medulloblastoma with postoperative chemotherapy alone: an SFOP prospective trial in young children. Lancet Oncol 6:573–580CrossRefPubMed Grill J, Sainte-Rose C, Jouvet A et al (2005) Treatment of medulloblastoma with postoperative chemotherapy alone: an SFOP prospective trial in young children. Lancet Oncol 6:573–580CrossRefPubMed
39.
Zurück zum Zitat Rutkowski S, Bode U, Deinlein F, Ottensmeier H, Warmuth-Metz M, Soerensen N, Graf N, Emser A, Pietsch T, Wolff JE, Kortmann RD, Kuehl J (2005) Treatment of early childhood medulloblastoma by postoperative chemotherapy alone. N Engl J Med 352(10):978–986CrossRefPubMed Rutkowski S, Bode U, Deinlein F, Ottensmeier H, Warmuth-Metz M, Soerensen N, Graf N, Emser A, Pietsch T, Wolff JE, Kortmann RD, Kuehl J (2005) Treatment of early childhood medulloblastoma by postoperative chemotherapy alone. N Engl J Med 352(10):978–986CrossRefPubMed
40.
Zurück zum Zitat Rutkowski S, Gerber NU, von Hoff K, Gnekow A, Bode U, Graf N, Berthold F, Henze G, Wolff JEA, Warmuth-Metz M, Soerensen N, Emser A, Ottensmeier H, Deinlein F, Schlegel PG, Kortmann RD, Pietsch T, Kuehl J (2009) Treatment of early childhood medulloblastoma by postoperative chemotherapy and deferred radiotherapy. Neuro-Oncology 11(2):201–210PubMedCentralCrossRefPubMed Rutkowski S, Gerber NU, von Hoff K, Gnekow A, Bode U, Graf N, Berthold F, Henze G, Wolff JEA, Warmuth-Metz M, Soerensen N, Emser A, Ottensmeier H, Deinlein F, Schlegel PG, Kortmann RD, Pietsch T, Kuehl J (2009) Treatment of early childhood medulloblastoma by postoperative chemotherapy and deferred radiotherapy. Neuro-Oncology 11(2):201–210PubMedCentralCrossRefPubMed
41.
Zurück zum Zitat Garre ML, Massimino M, Cefalo G et al (2003) High risk malignant CNS tumor in infants: standard vs myeloablative chemotherapy: the experience of the Italian cooperative study for children <3 years of age. Neuro-Oncology 1:40 Garre ML, Massimino M, Cefalo G et al (2003) High risk malignant CNS tumor in infants: standard vs myeloablative chemotherapy: the experience of the Italian cooperative study for children <3 years of age. Neuro-Oncology 1:40
42.
Zurück zum Zitat Chi SN, Gardner SL, Levy AS et al (2004) Feasibility and response to induction chemotherapy intensified with high-dose methotrexate for young children with newly diagnosed high-risk disseminated medulloblastoma. J Clin Oncol 22:4881–4887CrossRefPubMed Chi SN, Gardner SL, Levy AS et al (2004) Feasibility and response to induction chemotherapy intensified with high-dose methotrexate for young children with newly diagnosed high-risk disseminated medulloblastoma. J Clin Oncol 22:4881–4887CrossRefPubMed
43.
Zurück zum Zitat Grundy RG, Wilne SH, Robinson KJ et al (2010) Primary postoperative chemotherapy without radiotherapy for treatment of brain tumours other than ependymoma in children under 3 years: results of the first UKCCSG/SIOP CNS 9204 trial. Eur J Cancer 46:120–133CrossRefPubMed Grundy RG, Wilne SH, Robinson KJ et al (2010) Primary postoperative chemotherapy without radiotherapy for treatment of brain tumours other than ependymoma in children under 3 years: results of the first UKCCSG/SIOP CNS 9204 trial. Eur J Cancer 46:120–133CrossRefPubMed
44.
Zurück zum Zitat Ostrom QT, de Blank PM, Kruchko C, Petersen CM, Liao P, Finlay JL, Stearns DS, Wolff JE, Wolinsky Y, Letterio JJ, Barnholtz-Sloan JS (2015) Alex’s Lemonade Stand Foundation Infant and Childhood Primary Brain and Central Nervous System Tumors Diagnosed in the United States in 2007–2011. Neuro-Oncology 16(Suppl 10):x1–x36CrossRefPubMed Ostrom QT, de Blank PM, Kruchko C, Petersen CM, Liao P, Finlay JL, Stearns DS, Wolff JE, Wolinsky Y, Letterio JJ, Barnholtz-Sloan JS (2015) Alex’s Lemonade Stand Foundation Infant and Childhood Primary Brain and Central Nervous System Tumors Diagnosed in the United States in 2007–2011. Neuro-Oncology 16(Suppl 10):x1–x36CrossRefPubMed
45.
Zurück zum Zitat Peris-Bonet R, Martinez-Garcia C, Lacour B, Petrovich S, Giner-Ripoll B, Navajas A, Steliarova-Foucher E (2006) Childhood central nervous system tumours—incidence and survival in Europe (1978–1997): report from Automated Childhood Cancer Information System project. Eur J Cancer 42:2064–2080CrossRefPubMed Peris-Bonet R, Martinez-Garcia C, Lacour B, Petrovich S, Giner-Ripoll B, Navajas A, Steliarova-Foucher E (2006) Childhood central nervous system tumours—incidence and survival in Europe (1978–1997): report from Automated Childhood Cancer Information System project. Eur J Cancer 42:2064–2080CrossRefPubMed
46.
Zurück zum Zitat Makino K, Nakamura H, Yano S, Kuratsu J, Kumamoto Brain Tumor G (2010) Population-based epidemiological study of primary intracranial tumors in childhood. Childs Nerv Syst 26:1029–1034CrossRefPubMed Makino K, Nakamura H, Yano S, Kuratsu J, Kumamoto Brain Tumor G (2010) Population-based epidemiological study of primary intracranial tumors in childhood. Childs Nerv Syst 26:1029–1034CrossRefPubMed
47.
Zurück zum Zitat Liu YL, Lo WC, Chiang CJ, Yang YW, Lu MY, Hsu WM, Ho WL, Li MJ, Miser JS, Lin DT, Lai MS (2015) Incidence of cancer in children aged 0–14 years in Taiwan, 1996–2010. Cancer Epidemiol 39:21–28CrossRefPubMed Liu YL, Lo WC, Chiang CJ, Yang YW, Lu MY, Hsu WM, Ho WL, Li MJ, Miser JS, Lin DT, Lai MS (2015) Incidence of cancer in children aged 0–14 years in Taiwan, 1996–2010. Cancer Epidemiol 39:21–28CrossRefPubMed
Metadaten
Titel
Factors affecting survival of medulloblastoma in children: the changing concept of management
verfasst von
Tai-Tong Wong
Yen-Lin Liu
Donald Ming-Tak Ho
Kai-Ping Chang
Muh-Lii Liang
Hsin-Hung Chen
Yi-Yen Lee
Feng-Chi Chang
Shih-Chieh Lin
Ting-Rong Hsu
Kuo-Wei Chen
Wei-Kang Kwang
Wu-Yu Hou
Chung-Yih Wang
Sang-Hue Yen
Wan-You Guo
Yi-Wei Chen
Publikationsdatum
01.10.2015
Verlag
Springer Berlin Heidelberg
Erschienen in
Child's Nervous System / Ausgabe 10/2015
Print ISSN: 0256-7040
Elektronische ISSN: 1433-0350
DOI
https://doi.org/10.1007/s00381-015-2884-2

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