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Child's Nervous System
Erschienen in: Child's Nervous System 10/2018

03.07.2018 | Special Annual Issue

Management of brain abscesses: where are we now?

verfasst von: Minwei Chen, David C. Y. Low, Sharon Y. Y. Low, Dattatraya Muzumdar, Wan Tew Seow

Erschienen in: Child's Nervous System | Ausgabe 10/2018

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Abstract

Introduction

Brain abscesses affect all age groups and are not peculiar to a particular country, race, or geographical location. It is a disease that, in the past, carried a high morbidity and mortality. With improvements in medical technology and expertise, outcomes have improved tremendously. The causative organisms vary vastly and have evolved with time. Treatment of brain abscesses is primarily with antimicrobial therapy but surgery plays a vital role in achieving better outcomes.

Content

In this article, we review the literature to find out how the epidemiology of this disease has changed through the years and re-visit the basic pathological process of abscess evolution and highlight the new research in the biochemical pathways that initiate and regulate this process. We also highlight how magnetic resonance imaging and its various modalities have improved diagnostic accuracy. Finally, we discuss the pros and cons of traditional open surgery versus newer minimally invasive methods.
Literatur
1.
Arlotti M, Grossi P, Pea F, Tomei G, Vullo V, De Rosa F, Di Perri G et al (2010) Consensus document on controversial issues for the treatment of infections of the central nervous system: bacterial brain abscesses. Int J Infect Dis 14:S79–S92CrossRefPubMed
2.
Baddley J, Salzman D, Pappas P (2002) Fungal brain abscess in transplant recipients: epidemiologic, microbiologic, and clinical features. Clin Transpl 16(6):419–424CrossRef
3.
Barlas O, Sencer A, Erkan K, Eraksoy H, Sencer S, Bayindir C (1999) Stereotactic surgery in the management of brain abscess. World Neurosurg 52(4):404–411
4.
5.
Blattner R (1965) Infection with Haemophilus aphrophilus: brain abscess. J Pediatr 66(4):813–815CrossRefPubMed
6.
Bojanowski M, Seizeur R, Effendi K, Bourgouin P, Magro E, Letourneau-Guillon L (2015) Spreading of multiple listeria monocytogenes abscesses via central nervous system fiber tracts: case report. J Neurosurg 123(6):1593–1599CrossRefPubMed
7.
Brenner D, Elliston C, Hall E, Berdon W (2001) Estimates of the cancer risks from pediatric CT radiation are not merely theoretical: comment on point/counterpoint: in x-ray computed tomography, technique factors should be selected appropriate to patient size. Against the proposition med. Phys 28: 1543–1545. Med Phys 28(11):2387–2388CrossRefPubMed
8.
Britt R, Enzmann DR, Remington J (1981) Intracranial infection in cardiac transplant recipients. Ann Neurol 9(2):107–119CrossRefPubMed
9.
Britt R, Enzmann DR, Yeager A (1981) Neuropathological and computerized tomographic findings in experimental brain abscess. J Neurosurg 55(4):590–603CrossRefPubMed
10.
Brouwer M, Coutinho J, van de Beek D (2014) Clinical characteristics and outcome of brain abscess systematic review and meta-analysis. Neurology 82(9):806–813CrossRefPubMed
11.
Bullock R, van Dellen J, Ketelbey W, Gustav Reinach S (1988) A double-blind placebo-controlled trial of perioperative prophylactic antibiotics for elective neurosurgery. J Neurosurg 69(5):687–691CrossRefPubMed
12.
Canale D (1996) William Macewen and the treatment of brain abscesses: revisited after one hundred years. J Neurosurg 84(1):133–142CrossRefPubMed
13.
14.
Carpente J, Stapleton S, Holliman R (2007) Retrospective analysis of 49 cases of brain abscess and review of the literature. Eur J Clin Microbiol Infect Dis 26(1):1–11CrossRef
15.
Çavuşoglu H, Kaya RA, Türkmenoglu ON, Çolak I, Aydin Y (2008) Brain abscess: analysis of results in a series of 51 patients with a combined surgical and medical approach during an 11-year period. Neurosurg Focus 24(6):E9CrossRefPubMed
16.
Chang SC, Lai PH, Chen WL, Weng HH, Ho JT, Wang JS, Chang CY, Pan HB, Yang CF (2002) Diffusion-weighted MRI features of brain abscess and cystic or necrotic brain tumors: comparison with conventional MRI. \Clin Imaging 26(4):227–236CrossRefPubMed
17.
Chun CH, Johnson JD, Hofstetter M, Raff MJ (1986) Brain abscess. A study of 45 consecutive cases. Medicine 65(6):415–431CrossRefPubMed
18.
Corti ME, Villafañe MF, Yampolsky CG, Schtirbu RB (2005) Brain abscess due to Mycobacterium tuberculosis in a patient with AIDS: report of a case and review of the literature. Int J Infect Dis 9(4):225–227CrossRefPubMed
19.
Feldmann H (2000) Oscar Wilde. Medical observations on the 100th anniversary of his death 30 November. Laryngo-Rhino-Otologie 79(11):698–702CrossRefPubMed
20.
Fritsch M, Manwaring KH (1997) Endoscopic treatment of brain abscess in children. Minim Invasive Neurosurg 40:103–106CrossRefPubMed
21.
22.
23.
Garvey G (1983) Current concepts of bacterial infections of the central nervous system: bacterial meningitis and bacterial brain abscess. J Neurosurg 59(5):735–744CrossRefPubMed
24.
Goodkin HP, Harper MB, Pomeroy SL (2004) Intracerebral abscess in children: historical trends at Children's hospital Boston. Pediatrics 113(6):1765–1770CrossRefPubMed
25.
Graham DR, Band DJ (1981) Citrobacter diversus brain abscess and meningitis in neonates. JAMA 245(19):1923–1925CrossRefPubMed
26.
Gruszkiewicz J, Doron Y, Peyser E, Borovich B, Schächter J (1982) Brain abscess and its surgical management. Surg Neurol 18(1):7–17CrossRefPubMed
27.
Hanamsagar R, Hanke ML, Kielian T (2012) Toll-like receptor (TLR) and inflammasome actions in the central nervous system. Trends Immunol 33(7):333–342CrossRefPubMedPubMedCentral
28.
Hanamsagar R, Aldrich A, Tammy Kielian T (2014) Critical role for the AIM2 inflammasome during acute CNS bacterial infection. J Neurochem 129(4):704–711CrossRefPubMedPubMedCentral
29.
Heineman HS, Braude AI, Osterholm JL (1971) Intracranial suppurative disease: early presumptive diagnosis and successful treatment without surgery. JAMA 218(10):1542–1547CrossRefPubMed
30.
Held J, Preuße C, Döser A, Richter L, Heppner FL, Stenzel W (2013) Enhanced acute immune response in IL-12p35−/− mice is followed by accelerated distinct repair mechanisms in Staphylococcus aureus-induced murine brain abscess. J Infect Dis 208(5):749–760CrossRefPubMed
31.
Hellwig D, Benes L, Bertalanffy H, Bauer BL (1997) Endoscopic stereotaxy-an eight year's experience. Stereotact Funct Neurosurg 68:90–97CrossRefPubMed
32.
33.
Huang WY, Muo CH, Lin CY, Jen YM, Yang MH, Lin JC, Sung FC, Kao CH (2014) Paediatric head CT scan and subsequent risk of malignancy and benign brain tumour: a nation-wide population-based cohort study. Br J Cancer 110(9):2354CrossRefPubMedPubMedCentral
34.
Joshi SM, Devkota UP (1998) The management of brain abscess in a developing country: are the results any different? Br J Neurosurg 12:325–328CrossRefPubMed
35.
Kamin M, Biddle D (1981) Conservative management of focal intracerebral infection. Neurology 31:103–106CrossRefPubMed
36.
Kielian T, Bearden ED, Baldwin AC, Esen N (2004) IL-1 and TNF-α play a pivotal role in the host immune response in a mouse model of Staphylococcus aureus-induced experimental brain abscess. J Neuropathol Exp Neurol 63(4):381–396CrossRefPubMed
37.
Kielian T, Haney A, Mayes PM, Garg S, Esen N (2005) Toll-like receptor 2 modulates the proinflammatory milieu in Staphylococcus aureus-induced brain abscess. Infect Immun 73(11):7428–7435CrossRefPubMedPubMedCentral
38.
Kline MW (1988) Citrobacter meningitis and brain abscess in infancy: epidemiology, pathogenesis, and treatment. J Pediatr 113(3):430–434CrossRefPubMed
39.
Kondziolka D, Duma CM, Lunsford LD (1994) Factors that enhance the likelihood of successful stereotactic treatment of brain abscesses. Acta Neurochir 127(1–2):85–90CrossRefPubMed
40.
Korinek AM, Golmard JL, Elcheick A, Bismuth R, van Effenterre R, Coriat P, Puybasset L (2005) Risk factors for neurosurgical site infections after craniotomy: a critical reappraisal of antibiotic prophylaxis on 4,578 patients. Br J Neurosurg 19(2):155–162CrossRefPubMed
41.
Kothari M, Goel A, Muzumdar D (2015) Brain abscess: heuristics, principles,pathobiology, practice. Neurol India 63(3):329–337CrossRefPubMed
42.
Lai PH, Hsu SS, Ding SW, Ko CW, Fu JH, Weng MJ, Yeh LR, Wu MT, Liang HL, Chen CK, Pan HB (2007) Proton magnetic resonance spectroscopy and diffusion-weighted imaging in intracranial cystic mass lesions. Surg Neurol 68:S25–S36CrossRefPubMed
43.
Lakshmi V, Umabala P, Anuradha K, Padmaja K, Padmasree C, Rajesh A, Purohit AK (2011, 2011) Microbiological spectrum of brain abscess at a tertiary care hospital in South India: 24-year data and review. Patholog Res Int. https://​doi.​org/​10.​4061/​2011/​583139
44.
Leys D, Christiaens JL, Derambure PH, Hladky JP, Lesoin F, Rousseaux M, Jomin M, Petit H (1990) Management of focal intracranial infections: is medical treatment better than surgery? J Neurol Neurosurg Psychiatry 53(6):472–475CrossRefPubMedPubMedCentral
45.
Liu L, Xu K, Wang H, Tan PKJ, Fan W, Venkatraman SS, Li L, Yang YY (2009) Self-assembled cationic peptide nanoparticles as an efficient antimicrobial agent. Nat Nanotechnol 4(7):457–463CrossRefPubMed
46.
Lu CH, Chang WN, Lin YC, Tsai NW, Liliang PC, Su TM, Rau CS, Tsai YD, Liang CL, Chang CJ, Lee PY, Chang HW, Wu JJ (2002) Bacterial brain abscess: microbiological features, epidemiological trends and therapeutic outcomes. QJM 95(8):501–509CrossRefPubMed
47.
Lunardi P, Acqui M, Ferrante L, Mastronardi L, Fortuna A (1993) Non-traumatic brain abscess. Neurosurg Rev 16(3):189–196CrossRefPubMed
48.
Macewen W (1893) Pyogenic infective diseases of the brain and spinal cord: meningitis, abscess of brain, infective sinus thrombosis. Maclehose, Glasgow
49.
Mamelak AN, Obana WG, Flaherty JF, Rosenblum ML (1994) Nocardial brain abscess: treatment strategies and factors influencing outcome. Neurosurgery 35(4):622–631CrossRefPubMed
50.
Mamelak AN, Mampalam TJ, Obana WG, Rosenblum ML (1995) Improved management of multiple brain abscesses: a combined surgical and medical approach. Neurosurgery 36:76e86
51.
Menon S, Bharadwaj R, Chowdhary A, Kaundinya DV, Palande DA (2008) Current epidemiology of intracranial abscesses: a prospective 5 year study. J Med Microbiol 57(10):1259–1268CrossRefPubMed
52.
Miglioretti DL, Johnson E, Williams A, Greenlee RT, Weinmann S, Solberg LI, Feigelson HS, Flynn RD, Vanneman MJN, Smith-Bindman R (2013) The use of computed tomography in pediatrics and the associated radiation exposure and estimated cancer risk. JAMA Pediatr 167(8):700–707CrossRefPubMedPubMedCentral
53.
Morand SF (1768) Surgery Opuscules. Paris, Despres 1768:161
54.
Muccio CF, Caranci F, D’Arco F, Cerase A, De Lipsis L, Esposito G, Tedeschi E, Andreula C (2014) Magnetic resonance features of pyogenic brain abscesses and differential diagnosis using morphological and functional imaging studies: a pictorial essay. J Neuroradiol 41(3):153–167CrossRefPubMed
55.
Mut M, Dinc G, Naderi S (2007) On the report of the first successful surgical treatment of brain abscess in the ottoman empire by Dr. Cemil Topuzlu in 1891. Neurosurgery 61(4):869–872CrossRefPubMed
56.
57.
Nadvi SS, Parboosing R, Van Dellen JR (1988) Cerebellar abscess: the significance of cerebrospinal fluid diversion. Br J Neurosurg 2:439–446CrossRef
58.
Nathoo N, Nadvi SS, Narotam PK, James R, van Dellen Brain abscess: management and outcome analysis of a computed tomography era experience with 973 patients. World Neurosurg 75(5):716–726
59.
Newton EJ (1956) Haematogenous brain abscess in cyanotic congenital heart disease1. Q J Med 25(2):201–220PubMed
60.
Ng PY, Seow WT, Ong PL (1995) Brain abscesses: review of 30 cases treated with surgery. ANZ J Surg 65(9):664–666CrossRef
61.
Ojemann G, Ojemann J, Lettich E, Berger M (1989) Cortical language localization in left, dominant hemisphere: an electrical stimulation mapping investigation in 117 patients. J Neurosurg 71(3):316–326CrossRefPubMed
62.
Özsürekci Y, Kara A, Cengiz AB, Çelik M, Özkaya-Parlakay A, Karadag-Öncel E, Ceyhan M (2012) Brain abscess in childhood: a 28-year experience. Turk J Pediatr 54(2):144PubMed
63.
Pandey P, Srikantha U, Bhat D, Srinivas D, Abraham R, Pillai S, Balasubramaniam A, Devi I, Sampath S, Chandramouli BA (2008) Cerebellar abscesses in children: excision or aspiration? J Neurosurg Pediatr 1(1):31–34CrossRefPubMed
64.
Pearce MS, Salotti JA, Little MP, McHugh K, Lee C, Kim KP, Howe NL, Ronckers CM, Rajaraman P, Craft AW, Parker L, Berrington de González A (2012) Radiation exposure from CT scans in childhood and subsequent risk of leukaemia and brain tumours: a retrospective cohort study. Lancet 380(9840):499–505CrossRefPubMedPubMedCentral
65.
Raimondi AJ, Matsumoto S, Miller RA (1965) Brain abscess in children with congenital heart disease: J. Neurosurg 23(6):588–595CrossRef
66.
Rosenblum ML Hoff JT, Norman D, Edwards MS, Berg BO (1980) Nonoperative treatment of brain abscesses in selected high-risk patients. J Neurosurg 52(2):217–225CrossRefPubMed
67.
Rosenblum ML, Hoff JT, Norman D, Weinstein PR, Pitts L (1978) Decreased mortality from brain abscesses since advent of computerized tomography. J Neurosurg 49(5):658–668CrossRefPubMed
68.
Sáez-Llorens X, McCracken GH Jr (2003) Bacterial meningitis in children. Lancet 361(9375):2139–2148CrossRefPubMed
69.
Schliamser SE, Bäckman K, Ragnar Norrby SR (1988) Intracranial abscesses in adults: an analysis of 54 consecutive cases. Scand J Infect Dis 20(1):1–9CrossRefPubMed
70.
Schrenzel J (2007) Clinical relevance of new diagnostic methods for bloodstream infections. Int J Antimicrob Agents 30:2–6CrossRef
71.
Seydoux CH, Francioli P (1992) Bacterial brain abscesses: factors influencing mortality and sequelae. Clin Infect Dis 15(3):394–401CrossRefPubMed
72.
Shachor-Meyouhas Y, Bar-Joseph G, Guilburd JN, Lorber A, Hadash A, Kassis I (2010) Brain abscess in children–epidemiology, predisposing factors and management in the modern medicine era. Acta Paediatr 99(8):1163–1167CrossRefPubMed
73.
Sharma RK, Cooke RPD (2009) Intracranial abscesses: changes in epidemiology and management over five decades in Merseyside. Infection 37(1):39–43CrossRefPubMed
74.
Sharma BS, Gupta SKVK (2000) Current concepts in the management of pyogenic brain abscess. Neurol India 48(2):105PubMed
75.
Shu-yuan Y (1989) Brain abscess associated with congenital heart disease. World Neurosurg 31(2):129–132
76.
Stapleton SR, Bell BA, Uttley D (1993) Stereotactic aspiration of brain abscesses: is this the treatment of choice? Acta Neurochir 121(1–2):15–19CrossRefPubMed
77.
Stenzel W, Soltek S, Miletic H, Hermann MM, Körner H, Sedgwick JD, Schlüter D, Deckert M (2005) An essential role for tumor necrosis factor in the formation of experimental murine Staphylococcus aureus-induced brain abscess and clearance. J Neuropathol Exp Neurol 64(1):27–36CrossRefPubMed
78.
79.
Takeshita M, Kagawa M, Yato S, Izawa M, Onda H, Takakura K, Momma K (1997) Current treatment of brain abscess in patients with congenital cyanotic heart disease. Neurosurgery 41(6):1270–1278CrossRefPubMed
80.
Tonon E, Scotton PG, Maurizio Gallucci M, Vaglia A (2006) Brain abscess: clinical aspects of 100 patients. Int J Infect Dis 10(2):103–109CrossRefPubMed
81.
Unnikrishnan M, Chandy MJ, Abraham J (1989) Posterior fossa abscesses. A review of 33 cases. J Assoc Physicians India 37(6):376–378PubMed
82.
Verboon-Maciolek M, Vandertop WP, Peters ACB, Roord JJ, Geelen SPM (1995) Neonatal brain abscess caused by Morganella morgagni. Clin Infect Dis 20(2):471–471CrossRefPubMed
83.
Viale GL, Deseri S, Gennaro S, Sehrbundt E (2002) A craniocerebral infectious disease: case report on the traces of Hippocrates. Neurosurgery 50(6):1376–1379PubMed
84.
Vidlak D, Mariani MM, Aldrich A, Liu S, Kielian T (2011) Roles of toll-like receptor 2 (TLR2) and superantigens on adaptive immune responses during CNS staphylococcal infection. Brain Behav Immun 25(5):905–914CrossRefPubMed
85.
Wang KK, Chen YC Teng LJ, Hung CC, Chen ML, Du SH, Pan HJ, Hsueh PR, Chang SC (2007) Brain abscess associated with multidrug-resistant Capnocytophaga ochracea infection. J Clin Microbiol 45(2):645–647CrossRefPubMed
86.
Werner R, Volker Schuchardt V, Hagen T, Il’yasov KA, Billmann P, Weber J (2010) Differential diagnosis of intracranial ring enhancing cystic mass lesions—role of diffusion-weighted imaging (DWI) and diffusion-tensor imaging (DTI). Clin Neurol Neurosurg 112(3):218–225CrossRef
87.
Winn RH, Mendes M, Moore P, Wheeler C, Rodeheaver G (1979) Production of experimental brain abscess in the rat. J Neurosurg 51(5):685–690CrossRefPubMed
88.
Wood JH, Doppman JL, Lightfoote WEII et al (1978) Role of vascular proliferation on angiographic appearance and encapsulation of experimental traumatic and metastatic brain abscesses. J Neurosurg 48:264–273CrossRefPubMed
89.
90.
Yogev R, Bar-Meir M (2004) Management of brain abscesses in children. Pediatr Infect Dis J 23(2):157–159CrossRefPubMed
91.
Yu X Liu R, Wang Y, Zhao H, Chen J, Zhang J, Hu C (2017) CONSORT: may stereotactic intracavity administration of antibiotics shorten the course of systemic antibiotic therapy for brain abscesses? Medicine 96(21)
Metadaten
Titel
Management of brain abscesses: where are we now?
verfasst von
Minwei Chen
David C. Y. Low
Sharon Y. Y. Low
Dattatraya Muzumdar
Wan Tew Seow
Publikationsdatum
03.07.2018
Verlag
Springer Berlin Heidelberg
Erschienen in
Child's Nervous System / Ausgabe 10/2018
Print ISSN: 0256-7040
Elektronische ISSN: 1433-0350
DOI
https://doi.org/10.1007/s00381-018-3886-7

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