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International Journal of Colorectal Disease
Erschienen in: International Journal of Colorectal Disease 2/2007

01.02.2007 | Original Article

Microsatellite instability did not predict individual survival of unselected patients with colorectal cancer

verfasst von: C. Lamberti, S. Lundin, M. Bogdanow, C. Pagenstecher, N. Friedrichs, R Büttner, T. Sauerbruch

Erschienen in: International Journal of Colorectal Disease | Ausgabe 2/2007

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Abstract

Introduction

High microsatellite instability (MSI-H) occurs in about 15% of colorectal cancers (CRC) and clinical as well as pathological features differ from tumours exhibiting low microsatellite instability (MSI-L) or microsatellite stability (MSS). Conflicting data exists about the relevance of MSI in predicting the prognosis and benefit of 5-fluorouracil (5-FU) based chemotherapy in patients with CRC. We investigated the usefulness of MSI as a predictor of distinct clinical attributes influencing recurrence rate and disease-free survival (DFS) subject to the use of adjuvant or palliative chemotherapy with 5-FU in stage II- stage IV CRC.

Methods

We collected data and tumours of 416 consecutive stage I to IV CRC patients from 2000 to 2002, and followed them for a median time of 33 months. Microsatellite loci recommended by the National Cancer Institute were analysed. Cox proportional hazard modelling was used to compare clinical data and survival as well as associations for MSI and 5-FU treatment status of patients with MSI-H, MSI-L or MSS CRC.

Results

We identified 52 MSI-H (13%), 21 MSI-L (5%) and 343 MSS (82%) tumours. CRC with MSI-H tended to have a decreased likelihood of metastasising to regional lymph nodes (p=0.055), whilst age of diagnosis and tumour location did not differ. In an analysis that did not take into account the use of chemotherapy, univariate and multivariate analyses failed to show a difference between MSI-H and MSS groups with respect to disease-free and overall survival. Furthermore, survival under application of 5-FU did not correlate with MSI status.

Conclusion

No clear influence of MSI status on overall survival and response to 5-FU chemotherapy was found.
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Metadaten
Titel
Microsatellite instability did not predict individual survival of unselected patients with colorectal cancer
verfasst von
C. Lamberti
S. Lundin
M. Bogdanow
C. Pagenstecher
N. Friedrichs
R Büttner
T. Sauerbruch
Publikationsdatum
01.02.2007
Verlag
Springer-Verlag
Erschienen in
International Journal of Colorectal Disease / Ausgabe 2/2007
Print ISSN: 0179-1958
Elektronische ISSN: 1432-1262
DOI
https://doi.org/10.1007/s00384-006-0131-8

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