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Clinicopathologic features and prognostic analysis of MSI-high colon cancer

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International Journal of Colorectal Disease Aims and scope Submit manuscript

Abstract

Purpose

The objectives of the study were to estimate the incidence and clarify the clinicopathologic feature of sporadic microsatellite instability (MSI)-high (MSI-H) colon cancer. Furthermore, the role of MSI in colon cancer prognosis was also investigated.

Methods

Microsatellite status was identified by genotyping. The clinicopathologic differences between two groups (MSI-H vs. MSI-L/S) and the prognostic value of MSI were analyzed.

Results

From 1993 to 2006, 709 sporadic colon cancer patients were enrolled. MSI-H colon cancers showed significant association with poorly differentiated (28.3% vs. 7.2%, p = 0.001), proximally located (76.7% vs. 34.5%, p = 0.001), more high mucin-containing tumor (10.0% vs. 5.1%, p = 0.001) and female predominance (56.7% vs. 30.2%, p = 0.001). In multivariate analysis, MSI-H is an independent factor for better overall survival (HR, 0.459; 95% CI, 0.241–0.872, p = 0.017).

Conclusions

Based on the hospital-based study, MSI-H colon cancers demonstrated distinguished clinicopathologic features from MSI-L/S colon cancers. MSI-H is an independent favorable prognostic factor for overall survival in colon cancer.

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Acknowledgments

We thank the Cancer Registry of Cancer Center, Taipei Veterans General Hospital for providing part of patient follow-up information. The research was supported by Taipei Veterans General Hospital: V100E2-008 and National Science Council 97-2314-B-075-051-MY3

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Authors and Affiliations

  1. Division of Colon and Rectal Surgery, Department of Surgery, Taipei Veterans General Hospital, No. 201, Sec. 2, Shih-Pai Road, 11217, Taipei, Taiwan, Republic of China

    Chun-Chi Lin, Yi-Ling Lai, Tzu-Chen Lin, Wei-Shone Chen, Jeng-Kai Jiang, Shung-Haur Yang, Huann-Sheng Wang, Yuan-Tzu Lan, Jen-Kou Lin & Shih-Ching Chang

  2. National Yang-Ming University, Taipei, Taiwan, Republic of China

    Chun-Chi Lin, Wei-Shone Chen, Jeng-Kai Jiang, Shung-Haur Yang, Huann-Sheng Wang, Yuan-Tzu Lan, Jen-Kou Lin & Shih-Ching Chang

  3. Department of Medical Research and Education, Taipei Veterans General Hospital, Taipei, Taiwan, Republic of China

    Chun-Chi Lin

  4. Department of Pathology, Taipei Veterans General Hospital, Taipei, Taiwan, Republic of China

    Wen-Yih Liang

  5. Oncology Case Manager, Department of Nursing, Taipei Veterans General Hospital, Taipei, Taiwan, Republic of China

    Hui-Mei Hsu

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  1. Chun-Chi Lin
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Corresponding author

Correspondence to Shih-Ching Chang.

Additional information

Chun-Chi Lin and Yi-Ling Lai equally contributed to this study.

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Lin, CC., Lai, YL., Lin, TC. et al. Clinicopathologic features and prognostic analysis of MSI-high colon cancer. Int J Colorectal Dis 27, 277–286 (2012). https://doi.org/10.1007/s00384-011-1341-2

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  • DOI: https://doi.org/10.1007/s00384-011-1341-2

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