Introduction
Methods
Database | Search build | Occurrences |
---|---|---|
MEDLINE | ((Negative-pressure[Title/Abstract]) OR (Negative pressure[Title/Abstract]) OR (Negative-pressure therapy[Title/Abstract]) OR (Negative pressure therapy[Title/Abstract]) OR (Negative-pressure wound therapy[Title/Abstract]) OR (Negative pressure wound therapy[Title/Abstract]) OR (Prophylactic closed-incision negative-pressure wound therapy[Title/Abstract]) OR (Prophylactic closed-incision negative pressure wound therapy[Title/Abstract]) OR (NPT[Title/Abstract]) OR (NPWT[Title/Abstract]) OR (pNPT[Title/Abstract]) OR (pNPWT[Title/Abstract])) AND ((perineal[Title/Abstract]) OR (perineum[Title/Abstract]) OR (abdominoperineal resection[Title/Abstract]) OR (abdomino-perineal resection[Title/Abstract]) OR (abdominoperineal excision[Title/Abstract]) OR (abdomino-perineal excision[Title/Abstract]) OR (APE[Title/Abstract]) OR (APR[Title/Abstract])) | 77 |
EMBASE | ('negative-pressure therapy':ti,ab,kw OR 'negative pressure therapy':ti,ab,kw OR 'negative-pressure wound therapy':ti,ab,kw OR 'negative pressure wound therapy':ti,ab,kw OR 'NPWT':ti,ab,kw) AND ('perineal':ti,ab,kw OR 'perineum':ti,ab,kw OR 'abdominoperineal resection':ti,ab,kw OR 'abdomino-perineal resection':ti,ab,kw OR 'abdominoperineal excision':ti,ab,kw OR 'abdomino-perineal excision':ti,ab,kw OR 'APE':ti,ab,kw OR 'APR':ti,ab,kw) | 74 |
WEB OF SCIENCE | TI = (negative-pressure therapy OR negative pressure therapy OR negative-pressure wound therapy OR negative pressure wound therapy OR NPWT) ANDTI = (perineal OR perineum OR abdominoperineal resection OR abdomino-perineal resection OR abdominoperineal excision OR abdomino-perineal excision OR APE OR APR) | 14 |
Results
Inclusion process
Characteristics of included studies
Authors | Year | Country | Type of publication | Type of study | Period |
---|---|---|---|---|---|
Chadi et al. | 2014 | Canada | Original publication | Retrospective cohort | 2010–2012 |
Chung et al. | 2014 | USA | Congress abstract | Retrospective cohort | May 2009–September 2013 |
Rather et al. | 2018 | USA | Congress abstract | Retrospective cohort | - |
Sumrien et al. | 2016 | UK | Original publication | Prospective cohort | November 2012–April 2015 |
Takahashi et al. | 2018 | Japan | Congress abstract | Cohort | - |
Van der Walk et al. | 2017 | The Netherlands | Original publication | Prospective cohort with historical controls | January 2015–December 2015 |
Wiegering et al. | 2017 | Germany | Original publication | Cohort | - |
Authors | n | Indications for surgery | Preoperative treatment | Risk factors for SSI | Antibioprophylaxis | Surgery | Perineal closure | Mesh | Drain | Reconstruction | Follow-up |
---|---|---|---|---|---|---|---|---|---|---|---|
Chadi et al. | 32 | Rectal cancer, IBD, anal cancer | Immunosuppression, 4 (13%) Chemotherapy, 15 (47%) Radiotherapy, 16 (50%) | Smoking, 12 (38%) Diabetes, 4 (13%) | Yes | APR, 28 (88%) APR + proctocolectomy, 4 (13%) | Absorbable stiches for subcutaneous tissue and non-absorbable interrupted stiches for skin | No | No | No | 30 days |
Chung et al. | 24 | - | - | - | - | APR, 24 (100%) | - | - | - | - | - |
Rather et al. | 14 | - | - | - | - | APR, 14 (100%) | - | - | - | - | ≥ 14 (100 |
Sumrien et al. | 25 | Rectal cancer, 25 (100%) | Chemo-radiotherapy, 10 (25%) | - | - | APR, 25 (100 | Absorbable stiches for subcutaneous tissue and skin | Biological | Yes | No | 30 months (median) |
Takahashi et al. | 6 | - | Chemo-radiotherapy, 6 (100%) | - | - | APR or pelvic exenteration, 6 (100%) | - | - | - | - | 47.6-66.8 days (average) |
Van der Walk et al. | 10 | Rectal cancer, 10 (100%) | Chemo-radiotherapy, 2 (20%) Radiotherapy, 3 (30%) | Smoking, 1 (10%) Cardiovascular comorbidity, 3 (30%) | Yes | APR, 10 (100%) | Various | Various | Various | Various | - |
Wiegering et al. | 0 |
Authors | n | Indications for surgery | Preoperative treatment | Risk factors for SSI | Antibioprophylaxis | Surgery | Perineal closure | Mesh | Drain | Reconstruction | Follow-up |
---|---|---|---|---|---|---|---|---|---|---|---|
Chadi et al. | 27 | Rectal cancer, IBD | Immunosuppression, 6 (22%) Chemotherapy, 17 (63%) Radiotherapy, 16 (59%) | Smoking, 16 (59%) Diabetes, 3 (11%) | Yes | APR, 20 (74%) APR + proctocolectomy, 4 (15%) Pelvic exenteration, 3 (11%) | Absorbable stiches for subcutaneous tissue and non-absorbable interrupted stiches for skin | No | No | No | 30 days |
Chung et al. | 22 | - | - | - | - | APR, 22 (100%) | - | - | - | - | - |
Rather et al. | 16 | - | - | - | - | APR, 16 (100%) | - | - | - | - | ≥ 16 (100 |
Sumrien et al. | 32 | Rectal cancer, 32 (100%) | Chemo-radiotherapy, 13 (41%) | - | - | ELAPE, 32 (100%) | Absorbable stiches for subcutaneous tissue and skin | Biological | Yes | No | 30 months (median) |
Takahashi et al. | 5 | - | Chemo-radiotherapy, 5 (100%) | - | - | APR or pelvic exenteration, 5 (100%) | - | - | - | - | 47.6-66.8 days (average) |
Van der Walk et al. | 10 | Rectal cancer, 10 (100%) + IBD, 2 (20%) | Chemo-radiotherapy, 4 (40%) | Smoking, 2 (20%) Cardiovascular comorbidity, 5 (50%) | Yes | APR, 10 (100%) | Various | Various | Various | Various | - |
Wiegering et al. | 6 | Rectal cancer, 5 (83%) Rectal NET, 1 (17%) | Chemo-radiotherapy, 6 (100%) | - | - | APR, 5 (83%) Pelvic exenteration, 1 (17%) | Non-absorbable interrupted stiches | - | - | VRAM flap, 1 (17%) | - |
Perineal wound complications
pNPWT | Controls | |||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Authors | Patients, n | SSI, n (%) | Wound dehiscence, n (%) | Intra-abdominal abscess, n (%) | ED visit, n (%) | V.A.C., n (%) | Reoperation, n (%) | Length of stay (days) | Patients, n | SSI, n (%) | Wound dehiscence, n (%) | Intra-abdominal abscess, n (%) | ED visit, n (%) | V.A.C., n (%) | Reoperation, n (%) | Length of stay (days |
Chadi et al. | 27 | 4 (14.8%) | - | 2 (7.4%) | 0 (0%) | - | - | 11** | 32 | 13 (40.6%) | - | 1 (3.1%) | 2 (6.2%) | - | - | 8** |
Chung et al. | 22 | 2 (9.1%) | - | - | - | - | - | 24 | 10 (41.7%) | - | - | - | - | - | ||
Rather et al. | 16 | 8 (50%) | - | - | 0 (0%) | 3 (18.8%) | 0 (0%) | 14 | 9 (64.3%) | - | - | - | 7 (50%) | 1 (7.1%) | ||
Sumrien et al. | 32 | - | 3 (9.4%) | - | - | - | - | 25 | - | 10 (40%) | - | - | - | - | ||
Takahashi et al. | 5 | - | 0 (0%) | - | - | - | - | 47.6*** | 6 | - | 3 (50%) | - | - | - | - | 66.8*** |
Van der Walk et al. | 10 | 7 (70%) | - | - | - | - | 0 (0%) | 10 | 6 (60%)* | - | - | - | - | 1 (10%) | ||
Wiegering et al. | 6 | - | 1 (16.7%) | - | - | 1 (16.7%) | - | - | - | - | - | - | - | - |