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01.01.2011 | Review

Heart rate reduction in cardiovascular disease and therapy

verfasst von: Jan-Christian Reil, Florian Custodis, Karl Swedberg, Michel Komajda, Jeffrey S. Borer, Ian Ford, Luigi Tavazzi, Ulrich Laufs, Michael Böhm

Erschienen in: Clinical Research in Cardiology | Ausgabe 1/2011

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Abstract

Heart rate influences myocardial oxygen demand, coronary blood flow, and myocardial function. Clinical and experimental studies support an association between elevated resting heart rate and a broad range of maladaptive effects on the function and structure of the cardiovascular system. Heart rate has been shown to be an important predictor of mortality in cardiovascular disorders such as coronary artery disease, myocardial infarction, and chronic heart failure. This review summarizes the specific influence of heart rate on vascular morphology and function as well as on myocardial lesions leading from early impact on vascular homeostasis to myocardial hemodynamics in chronic heart failure. Heart rate can be easily determined during physical examination of the patient and therefore allows a simple hint on prognosis and efficiency of therapy.

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Titel: Heart rate reduction in cardiovascular disease and therapy
verfasst von: Jan-Christian Reil
Florian Custodis
Karl Swedberg
Michel Komajda
Jeffrey S. Borer
Ian Ford
Luigi Tavazzi
Ulrich Laufs
Michael Böhm
Publikationsdatum: 01.01.2011
Verlag: Springer-Verlag
Erschienen in: Clinical Research in Cardiology / Ausgabe 1/2011
Print ISSN: 1861-0684
Elektronische ISSN: 1861-0692
DOI: https://doi.org/10.1007/s00392-010-0207-x

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