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Effects of intracoronary injection of autologous bone marrow-derived stem cells on natriuretic peptides and inflammatory markers in patients with acute ST-elevation myocardial infarction

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Abstract

Background

Intracoronary administration of autologous bone marrow stem cells (BMC) has been shown to result in a subtle improvement of global left ventricular ejection fraction after ST-elevation myocardial infarction (STEMI), but the overall benefits of BMC therapy are still unclear. We studied the influence of intracoronary injections of BMC on levels of natriuretic peptides and inflammatory mediators, which are well established prognostic biomarkers, in patients with STEMI.

Methods

In this randomized, double-blind study, consecutive patients with an acute STEMI treated with thrombolysis followed by PCI 2–6 days after STEMI, were randomly assigned to receive either intracoronary BMC or placebo medium into the infarct-related artery. Blood samples were drawn for biochemical determinations.

Results

From baseline to 6 months, there was a significant decrease in the levels of N-terminal probrain natriuretic peptide (NT-proBNP), interleukin-6 (IL-6) and high-sensitivity C-reactive protein (hsCRP) in the whole patient population (P < 0.001 for all). However, no difference was observed between the BMC group (n = 39) and the placebo group (n = 39) in the change of the levels of NT-proANP (median −54 vs. +112 pmol/L), NT-proBNP (−88 vs. −115 pmol/L) or inflammatory markers IL-6 (−3.86 vs. −5.61 pg/mL), hsCRP (−20.29 vs. −22.36 mg/L) and tumor necrosis factor α (−0.12 vs. −0.80 pg/mL) between baseline and 6 months.

Conclusion

Intracoronary BMC therapy does not appear to exert any significant effects on the secretion of natriuretic peptides or inflammatory biomarkers in STEMI patients.

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Acknowledgments

We would like to thank Ms. Kirsi Kvist-Mäkelä, Ms. Pirkko Huikuri, Ms. Päivi Koski, and Ms. Päivi Kastell for their excellent assistance in this study. This study was supported by grants from the Medical Council of the Academy of Finland, Helsinki, Finland and Finnish Foundation for Cardiovascular Research, Helsinki, Finland, and to Ms. Miettinen; grant from Ida Montin Foundation, Helsinki, Finland.

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Authors and Affiliations

  1. Department of Internal Medicine, Institute of Clinical Medicine, University of Oulu, Kajaanintie 50, P.O. Box 5000, FI-90014, Oulu, Finland

    Johanna A. Miettinen, Kari Ylitalo, Kari Kervinen, Matti Niemelä, Marjaana Säily, Pirjo Koistinen, Timo H. Mäkikallio & Heikki V. Huikuri

  2. Department of Clinical Chemistry, Institute of Diagnostics, University of Oulu, Kajaanintie 50, P.O. Box 5000, FI-90014, Oulu, Finland

    Pirjo Hedberg & Eeva-Riitta Savolainen

  3. Department of Internal Medicine, Division of Cardiology and PET-Center, University of Turku, Kiinamyllynkatu 4-8, FI-20520, Turku, Finland

    Heikki Ukkonen, Mikko Pietilä, K. E. Juhani Airaksinen & Juhani Knuuti

  4. Department of Physiology, Institute of Biomedicine, University of Oulu, Kajaanintie 50, P.O. Box 5000, FI-90014, Oulu, Finland

    Olli Vuolteenaho

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  1. Johanna A. Miettinen
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Correspondence to Johanna A. Miettinen.

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Miettinen, J.A., Ylitalo, K., Hedberg, P. et al. Effects of intracoronary injection of autologous bone marrow-derived stem cells on natriuretic peptides and inflammatory markers in patients with acute ST-elevation myocardial infarction. Clin Res Cardiol 100, 317–325 (2011). https://doi.org/10.1007/s00392-010-0246-3

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