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01.05.2012 | Original Paper

Interleukin-6, -7, -8 and -10 predict outcome in acute myocardial infarction complicated by cardiogenic shock

verfasst von: Roland Prondzinsky, Susanne Unverzagt, Henning Lemm, Nikolas-Arne Wegener, Axel Schlitt, Konstantin M. Heinroth, Sebastian Dietz, Ute Buerke, Patrick Kellner, Harald Loppnow, Martin G. Fiedler, Joachim Thiery, Karl Werdan, Michael Buerke

Erschienen in: Clinical Research in Cardiology | Ausgabe 5/2012

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Abstract

Background

The IABP-SHOCK-trial was a morbidity-based randomized controlled trial in patients with infarction-related cardiogenic shock (CS), which used the change of the quantified degree of multiorgan failure as determined by APACHE II score over a 4-day period as primary outcome measure. The prospective hypothesis was that adding IABP therapy to “standard care” would improve CS-triggered multi organ dysfunction syndrome (MODS). The primary endpoint showed no difference between conventionally managed cardiogenic shock patients and those with IABP support. In an inflammatory marker substudy, we analysed the prognostic value of interleukin (IL)-1β, -6, -7, -8, and -10 in patients with acute myocardial infarction complicated by cardiogenic shock.

Design

Inflammatory marker substudy of the prospective, randomized, controlled, open label IABP-SHOCK-trial (Clinical-Trials-gov-ID-NCT00469248).

Setting and methods

A single-center study was performed in a 12-bed Intensive-Care-Unit in an university hospital in which 40 consecutive patients were enrolled with an observational period of 96 h.

Results

The pro- and anti-inflammatory markers IL-6, -7, -8 and -10 showed a predictive power for mortality of infarct-related CS patients, while IL-1β did not discriminate. The maximal values during the observational period, in case of IL-7 the minimal value, showed the best power to predict mortality. Both, ROC and multivariate analyses confirmed these suggestions (area under the curve: IL-8, 0.80 ± 0.08; IL-6, 0.79 ± 0.08; IL-10, 0.76 ± 0.08; IL-7, 0.69 ± 0.08). Inflammatory markers were not affected by the presence of IABP support.

Conclusion

The inflammatory response in patients with myocardial infarction complicated by cardiogenic shock, as reflected by the inflammatory markers IL-6, IL-7, IL-8 and IL-10, demonstrates a clinically relevant prognostic contribution to clinical outcome.

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Titel: Interleukin-6, -7, -8 and -10 predict outcome in acute myocardial infarction complicated by cardiogenic shock
verfasst von: Roland Prondzinsky
Susanne Unverzagt
Henning Lemm
Nikolas-Arne Wegener
Axel Schlitt
Konstantin M. Heinroth
Sebastian Dietz
Ute Buerke
Patrick Kellner
Harald Loppnow
Martin G. Fiedler
Joachim Thiery
Karl Werdan
Michael Buerke
Publikationsdatum: 01.05.2012
Verlag: Springer-Verlag
Erschienen in: Clinical Research in Cardiology / Ausgabe 5/2012
Print ISSN: 1861-0684
Elektronische ISSN: 1861-0692
DOI: https://doi.org/10.1007/s00392-011-0403-3

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Interleukin-6, -7, -8 and -10 predict outcome in acute myocardial infarction complicated by cardiogenic shock

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Setting and methods

Results

Conclusion

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