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Erschienen in: Clinical Research in Cardiology 7/2016

12.02.2016 | Critical Perspective

Impact of SERVE-HF on management of sleep disordered breathing in heart failure: a call for further studies

verfasst von: Dominik Linz, Henrik Fox, Thomas Bitter, Jens Spießhöfer, Christoph Schöbel, Erik Skobel, Anke Türoff, Michael Böhm, Martin R. Cowie, Michael Arzt, Olaf Oldenburg

Erschienen in: Clinical Research in Cardiology | Ausgabe 7/2016

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Abstract

Sleep disordered breathing (SDB) (obstructive sleep apnea, central sleep apnea/Cheyne–Stokes respiration or the combination of both) is highly prevalent in patients with a wide variety of cardiovascular diseases including hypertension, arrhythmia, coronary artery disease, myocardial infarction and stroke (reviewed previously in the September issue of this journal). Its close association with outcomes in chronic heart failure with reduced ejection fraction (HF-REF) suggests that it may be a potential treatment target. Herein, we provide an update on SDB and its treatment in HF-REF.
Literatur
1.
Zurück zum Zitat Linz D, Woehrle H, Bitter T, Fox H, Cowie MR, Böhm M, Oldenburg O (2015) The importance of sleep-disordered breathing in cardiovascular disease. Clin Res Cardiol 104:705–718CrossRefPubMed Linz D, Woehrle H, Bitter T, Fox H, Cowie MR, Böhm M, Oldenburg O (2015) The importance of sleep-disordered breathing in cardiovascular disease. Clin Res Cardiol 104:705–718CrossRefPubMed
2.
Zurück zum Zitat Cowie MR, Woehrle H, Wegscheider K, Angermann C, d’Ortho MP, Erdmann E, Levy P, Simonds AK, Somers VK, Zannad F, Teschler H (2015) Adaptive servo-ventilation for central sleep apnea in systolic heart failure. N Engl J Med 373:1095–1105CrossRefPubMedPubMedCentral Cowie MR, Woehrle H, Wegscheider K, Angermann C, d’Ortho MP, Erdmann E, Levy P, Simonds AK, Somers VK, Zannad F, Teschler H (2015) Adaptive servo-ventilation for central sleep apnea in systolic heart failure. N Engl J Med 373:1095–1105CrossRefPubMedPubMedCentral
3.
Zurück zum Zitat Khayat R, Jarjoura D, Porter K, Sow A, Wannemacher J, Dohar R, Pleister A, Abraham WT (2015) Sleep disordered breathing and post-discharge mortality in patients with acute heart failure. Eur Heart J 36:1463–1469CrossRefPubMedPubMedCentral Khayat R, Jarjoura D, Porter K, Sow A, Wannemacher J, Dohar R, Pleister A, Abraham WT (2015) Sleep disordered breathing and post-discharge mortality in patients with acute heart failure. Eur Heart J 36:1463–1469CrossRefPubMedPubMedCentral
4.
Zurück zum Zitat Oldenburg O, Wellmann B, Buchholz A, Bitter T, Fox H, Thiem U, Horstkotte D, Wegscheider K (2015) Nocturnal hypoxaemia is associated with increased mortality in stable heart failure patients. Eur Heart J. doi:10.1093/eurheartj/ehv624 PubMed Oldenburg O, Wellmann B, Buchholz A, Bitter T, Fox H, Thiem U, Horstkotte D, Wegscheider K (2015) Nocturnal hypoxaemia is associated with increased mortality in stable heart failure patients. Eur Heart J. doi:10.​1093/​eurheartj/​ehv624 PubMed
5.
Zurück zum Zitat Jilek C, Krenn M, Sebah D, Obermeier R, Braune A, Kehl V, Schroll S, Montalvan S, Riegger GA, Pfeifer M, Arzt M (2011) Prognostic impact of sleep disordered breathing and its treatment in heart failure: an observational study. Eur J Heart Fail 13:68–75CrossRefPubMed Jilek C, Krenn M, Sebah D, Obermeier R, Braune A, Kehl V, Schroll S, Montalvan S, Riegger GA, Pfeifer M, Arzt M (2011) Prognostic impact of sleep disordered breathing and its treatment in heart failure: an observational study. Eur J Heart Fail 13:68–75CrossRefPubMed
6.
Zurück zum Zitat Bitter T, Westerheide N, Prinz C, Hossain MS, Vogt J, Langer C, Horstkotte D, Oldenburg O (2011) Cheyne–Stokes respiration and obstructive sleep apnea are independent risk factors for malignant ventricular arrhythmias requiring appropriate cardioverter-defibrillator therapies in patients with congestive heart failure. Eur Heart J 32:61–74CrossRefPubMed Bitter T, Westerheide N, Prinz C, Hossain MS, Vogt J, Langer C, Horstkotte D, Oldenburg O (2011) Cheyne–Stokes respiration and obstructive sleep apnea are independent risk factors for malignant ventricular arrhythmias requiring appropriate cardioverter-defibrillator therapies in patients with congestive heart failure. Eur Heart J 32:61–74CrossRefPubMed
7.
Zurück zum Zitat Costanzo MR, Khayat R, Ponikowski P, Augostini R, Stellbrink C, Mianulli M, Abraham WT (2015) Mechanisms and clinical consequences of untreated central sleep apnea in heart failure. J Am Coll Cardiol 65:72–84CrossRefPubMedPubMedCentral Costanzo MR, Khayat R, Ponikowski P, Augostini R, Stellbrink C, Mianulli M, Abraham WT (2015) Mechanisms and clinical consequences of untreated central sleep apnea in heart failure. J Am Coll Cardiol 65:72–84CrossRefPubMedPubMedCentral
8.
Zurück zum Zitat Sin DD, Logan AG, Fitzgerald FS, Liu PP, Bradley TD (2000) Effects of continuous positive airway pressure on cardiovascular outcomes in heart failure patients with and without Cheyne–Stokes respiration. Circulation 102:61–66CrossRefPubMed Sin DD, Logan AG, Fitzgerald FS, Liu PP, Bradley TD (2000) Effects of continuous positive airway pressure on cardiovascular outcomes in heart failure patients with and without Cheyne–Stokes respiration. Circulation 102:61–66CrossRefPubMed
9.
Zurück zum Zitat Khayat R, Jarjoura D, Porter K, Sow A, Wannemacher J, Dohar R, Pleister A, Abraham WT (2015) Sleep disordered breathing and post-discharge mortality in patients with acute heart failure. Eur Heart J 36:1463–1469CrossRefPubMedPubMedCentral Khayat R, Jarjoura D, Porter K, Sow A, Wannemacher J, Dohar R, Pleister A, Abraham WT (2015) Sleep disordered breathing and post-discharge mortality in patients with acute heart failure. Eur Heart J 36:1463–1469CrossRefPubMedPubMedCentral
10.
Zurück zum Zitat Bradley TD, Logan AG, Kimoff RJ, Sériès F, Morrison D, Ferguson K, Belenkie I, Pfeifer M, Fleetham J, Hanly P, Smilovitch M, Tomlinson G, Floras JS, CANPAP Investigators (2005) Continuous positive airway pressure for central sleep apnea and heart failure. N Engl J Med 353:2025–2033CrossRefPubMed Bradley TD, Logan AG, Kimoff RJ, Sériès F, Morrison D, Ferguson K, Belenkie I, Pfeifer M, Fleetham J, Hanly P, Smilovitch M, Tomlinson G, Floras JS, CANPAP Investigators (2005) Continuous positive airway pressure for central sleep apnea and heart failure. N Engl J Med 353:2025–2033CrossRefPubMed
11.
Zurück zum Zitat Arzt M, Floras JS, Logan AG, Kimoff RJ, Series F, Morrison D, Ferguson K, Belenkie I, Pfeifer M, Fleetham J, Hanly P, Smilovitch M, Ryan C, Tomlinson G, Bradley TD, CANPAP Investigators (2007) Suppression of central sleep apnea by continuous positive airway pressure and transplant-free survival in heart failure: a post hoc analysis of the Canadian Continuous Positive Airway Pressure for Patients with Central Sleep Apnea and Heart Failure Trial (CANPAP). Circulation 115:3173–3180CrossRefPubMed Arzt M, Floras JS, Logan AG, Kimoff RJ, Series F, Morrison D, Ferguson K, Belenkie I, Pfeifer M, Fleetham J, Hanly P, Smilovitch M, Ryan C, Tomlinson G, Bradley TD, CANPAP Investigators (2007) Suppression of central sleep apnea by continuous positive airway pressure and transplant-free survival in heart failure: a post hoc analysis of the Canadian Continuous Positive Airway Pressure for Patients with Central Sleep Apnea and Heart Failure Trial (CANPAP). Circulation 115:3173–3180CrossRefPubMed
12.
Zurück zum Zitat Teschler H, Döhring J, Wang YM, Berthon-Jones M (2001) Adaptive pressure support servo-ventilation: a novel treatment for Cheyne–Stokes respiration in heart failure. Am J Respir Crit Care Med 164:614–619CrossRefPubMed Teschler H, Döhring J, Wang YM, Berthon-Jones M (2001) Adaptive pressure support servo-ventilation: a novel treatment for Cheyne–Stokes respiration in heart failure. Am J Respir Crit Care Med 164:614–619CrossRefPubMed
13.
Zurück zum Zitat Oldenburg O, Bitter T, Lehmann R, Korte S, Dimitriadis Z, Faber L, Schmidt A, Westerheide N, Horstkotte D (2011) Adaptive servoventilation improves cardiac function and respiratory stability. Clin Res Cardiol 100:107–115CrossRefPubMed Oldenburg O, Bitter T, Lehmann R, Korte S, Dimitriadis Z, Faber L, Schmidt A, Westerheide N, Horstkotte D (2011) Adaptive servoventilation improves cardiac function and respiratory stability. Clin Res Cardiol 100:107–115CrossRefPubMed
14.
Zurück zum Zitat Spießhöfer J, Fox H, Lehmann R, Efken C, Heinrich J, Bitter T, Körber B, Horstkotte D, Oldenburg O (2015) Heterogenous haemodynamic effects of adaptive servoventilation therapy in sleeping patients with heart failure and Cheyne–Stokes respiration compared to healthy volunteers. Heart Vessels. doi:10.1007/s00380-015-0717-6 Spießhöfer J, Fox H, Lehmann R, Efken C, Heinrich J, Bitter T, Körber B, Horstkotte D, Oldenburg O (2015) Heterogenous haemodynamic effects of adaptive servoventilation therapy in sleeping patients with heart failure and Cheyne–Stokes respiration compared to healthy volunteers. Heart Vessels. doi:10.​1007/​s00380-015-0717-6
15.
Zurück zum Zitat Naughton MT, Rahman MA, Hara K, Floras JS, Bradley TD (1995) Effect of continuous positive airway pressure on intrathoracic and left ventricular transmural pressures in patients with congestive heart failure. Circulation 91:1725–1731CrossRefPubMed Naughton MT, Rahman MA, Hara K, Floras JS, Bradley TD (1995) Effect of continuous positive airway pressure on intrathoracic and left ventricular transmural pressures in patients with congestive heart failure. Circulation 91:1725–1731CrossRefPubMed
16.
Zurück zum Zitat Spießhöfer J, Heinrich J, Lehmann R, Efken C, Fox H, Bitter T, Körber B, Horstkotte D, Oldenburg O (2015) Respiratory effects of adaptive servoventilation therapy in patients with heart failure and Cheyne–Stokes respiration compared to healthy volunteers. Respiration 89:374–382CrossRefPubMed Spießhöfer J, Heinrich J, Lehmann R, Efken C, Fox H, Bitter T, Körber B, Horstkotte D, Oldenburg O (2015) Respiratory effects of adaptive servoventilation therapy in patients with heart failure and Cheyne–Stokes respiration compared to healthy volunteers. Respiration 89:374–382CrossRefPubMed
17.
Zurück zum Zitat Oldenburg O, Spießhöfer J, Fox H, Prib N, Horstkotte D (2015) Performance of conventional and enhanced adaptive servoventilation (ASV) in heart failure patients with central sleep apnea who have adapted to conventional ASV. Sleep Breath 19:795–800CrossRefPubMed Oldenburg O, Spießhöfer J, Fox H, Prib N, Horstkotte D (2015) Performance of conventional and enhanced adaptive servoventilation (ASV) in heart failure patients with central sleep apnea who have adapted to conventional ASV. Sleep Breath 19:795–800CrossRefPubMed
18.
Zurück zum Zitat Bitter T, Gutleben KJ, Nölker G, Westerheide N, Prinz C, Dimitriadis Z, Horstkotte D, Vogt J, Oldenburg O (2013) Treatment of Cheyne–Stokes respiration reduces arrhythmic events in chronic heart failure. J Cardiovasc Electrophysiol 24:1132–1140PubMed Bitter T, Gutleben KJ, Nölker G, Westerheide N, Prinz C, Dimitriadis Z, Horstkotte D, Vogt J, Oldenburg O (2013) Treatment of Cheyne–Stokes respiration reduces arrhythmic events in chronic heart failure. J Cardiovasc Electrophysiol 24:1132–1140PubMed
19.
20.
Zurück zum Zitat Oldenburg O, Spießhöfer J, Fox H, Bitter T, Horstkotte D (2015) Cheyne–Stokes respiration in heart failure: friend or foe? Hemodynamic effects of hyperventilation in heart failure patients and healthy volunteers. Clin Res Cardiol 104:328–333CrossRefPubMed Oldenburg O, Spießhöfer J, Fox H, Bitter T, Horstkotte D (2015) Cheyne–Stokes respiration in heart failure: friend or foe? Hemodynamic effects of hyperventilation in heart failure patients and healthy volunteers. Clin Res Cardiol 104:328–333CrossRefPubMed
21.
Zurück zum Zitat Lenique E, Habis M, Lofaso F et al (1997) Ventilatory and hemodynamic effects of continuous positive airway pressure (CPAP) in congestive heart failure. Am J Respir Crit Care Med 155:500e5CrossRef Lenique E, Habis M, Lofaso F et al (1997) Ventilatory and hemodynamic effects of continuous positive airway pressure (CPAP) in congestive heart failure. Am J Respir Crit Care Med 155:500e5CrossRef
22.
Zurück zum Zitat Grace MP, Greenbaum DM (1982) Cardiac performance in response to PEEP in patients with cardiac dysfunction. Crit Care Med 10:358e60CrossRef Grace MP, Greenbaum DM (1982) Cardiac performance in response to PEEP in patients with cardiac dysfunction. Crit Care Med 10:358e60CrossRef
23.
Zurück zum Zitat Maze SS, Kotler MN, Parry WR (1989) Doppler evaluation of changing cardiac dynamics during Cheynee–Stokes respiration. Chest 95:525e9CrossRef Maze SS, Kotler MN, Parry WR (1989) Doppler evaluation of changing cardiac dynamics during Cheynee–Stokes respiration. Chest 95:525e9CrossRef
24.
Zurück zum Zitat Levine M, Cleave JP, Dodds C (1995) Can periodic breathing have advantages for oxygenation? J Theor Biol 172:355e68CrossRef Levine M, Cleave JP, Dodds C (1995) Can periodic breathing have advantages for oxygenation? J Theor Biol 172:355e68CrossRef
25.
Zurück zum Zitat van de Borne P, Oren R, Abouassaly C, Anderson E, Somers VK (1998) Effect of Cheynee–Stokes respiration on muscle sympathetic nerve activity in severe congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy. Am J Cardiol. 81:432e6 van de Borne P, Oren R, Abouassaly C, Anderson E, Somers VK (1998) Effect of Cheynee–Stokes respiration on muscle sympathetic nerve activity in severe congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy. Am J Cardiol. 81:432e6
26.
Zurück zum Zitat Seals DR, Suwarno NO, Dempsey JA (1990) Influence of lung volume on sympathetic nerve discharge in normal humans. Circ Res 67:130e41CrossRef Seals DR, Suwarno NO, Dempsey JA (1990) Influence of lung volume on sympathetic nerve discharge in normal humans. Circ Res 67:130e41CrossRef
27.
Zurück zum Zitat Naughton MT, Floras JS, Rahman MA, Jamal M, Bradley TD (1998) Respiratory correlates of muscle sympathetic nerve activity in heart failure. Clin Sci (Lond) 95:277e85CrossRef Naughton MT, Floras JS, Rahman MA, Jamal M, Bradley TD (1998) Respiratory correlates of muscle sympathetic nerve activity in heart failure. Clin Sci (Lond) 95:277e85CrossRef
28.
Zurück zum Zitat Bing OH, Brooks WW, Messer JV (1973) Heart muscle viability following hypoxia: protective effect of acidosis. Science 180:1297e8CrossRef Bing OH, Brooks WW, Messer JV (1973) Heart muscle viability following hypoxia: protective effect of acidosis. Science 180:1297e8CrossRef
29.
Zurück zum Zitat Wexels JC, Mjøs OD (1987) Effects of carbon dioxide and pH on myocardial function in dogs with acute left ventricular failure. Crit Care Med. 15:1116e20CrossRef Wexels JC, Mjøs OD (1987) Effects of carbon dioxide and pH on myocardial function in dogs with acute left ventricular failure. Crit Care Med. 15:1116e20CrossRef
30.
Zurück zum Zitat Porter JM, Markos F, Snow HM, Shorten GD (2000) Effects of respiratory and metabolic pH changes and hypoxia on ropivacaine-induced cardiotoxicity in dogs. Br J Anaesth 84:92e4CrossRef Porter JM, Markos F, Snow HM, Shorten GD (2000) Effects of respiratory and metabolic pH changes and hypoxia on ropivacaine-induced cardiotoxicity in dogs. Br J Anaesth 84:92e4CrossRef
31.
Zurück zum Zitat Linz D, Denner A, Illing S, Hohl M, Ukena C, Mahfoud F, Ewen S, Reil JC, Wirth K, Böhm M (2016) Impact of obstructive and central apneas on ventricular repolarisation: lessons learned from studies in man and pigs. Clin Res Cardiol. doi:10.1007/s00392-016-0961-5 Linz D, Denner A, Illing S, Hohl M, Ukena C, Mahfoud F, Ewen S, Reil JC, Wirth K, Böhm M (2016) Impact of obstructive and central apneas on ventricular repolarisation: lessons learned from studies in man and pigs. Clin Res Cardiol. doi:10.​1007/​s00392-016-0961-5
32.
Zurück zum Zitat Eltzschig HK, Eckle T (2011) Ischemia and reperfusion—from mechanism to translation. Nat Med 17:1391–1401CrossRefPubMed Eltzschig HK, Eckle T (2011) Ischemia and reperfusion—from mechanism to translation. Nat Med 17:1391–1401CrossRefPubMed
33.
Zurück zum Zitat Solin P, Bergin P, Richardson M, Kaye DM, Walters EH, Naughton MT (1999) Influence of pulmonary capillary wedge pressure on central apnea in heart failure. Circulation 99:1574–1579CrossRefPubMed Solin P, Bergin P, Richardson M, Kaye DM, Walters EH, Naughton MT (1999) Influence of pulmonary capillary wedge pressure on central apnea in heart failure. Circulation 99:1574–1579CrossRefPubMed
34.
Zurück zum Zitat Kara T, Novak M, Nykodym J, Bybee KA, Meluzin J, Orban M, Novakova Z, Lipoldova J, Hayes DL, Soucek M, Vitovec J, Somers VK (2008) Short-term effects of cardiac resynchronization therapy on sleep-disordered breathing in patients with systolic heart failure. Chest 134:87–93CrossRefPubMed Kara T, Novak M, Nykodym J, Bybee KA, Meluzin J, Orban M, Novakova Z, Lipoldova J, Hayes DL, Soucek M, Vitovec J, Somers VK (2008) Short-term effects of cardiac resynchronization therapy on sleep-disordered breathing in patients with systolic heart failure. Chest 134:87–93CrossRefPubMed
35.
Zurück zum Zitat Kasai T, Narui K, Dohi T, Yanagisawa N, Ishiwata S, Ohno M, Yamaguchi T, Momomura S (2008) Prognosis of patients with heart failure and obstructive sleep apnea treated with continuous positive airway pressure. Chest 133:690–696CrossRefPubMed Kasai T, Narui K, Dohi T, Yanagisawa N, Ishiwata S, Ohno M, Yamaguchi T, Momomura S (2008) Prognosis of patients with heart failure and obstructive sleep apnea treated with continuous positive airway pressure. Chest 133:690–696CrossRefPubMed
36.
Zurück zum Zitat Iftikhar IH, Valentine CW, Bittencourt LR, Cohen DL, Fedson AC, Gíslason T, Penzel T, Phillips CL, Yu-sheng L, Pack AI, Magalang UJ (2014) Effects of continuous positive airway pressure on blood pressure in patients with resistant hypertension and obstructive sleep apnea: a meta-analysis. J Hypertens 32:2341–2350CrossRefPubMedPubMedCentral Iftikhar IH, Valentine CW, Bittencourt LR, Cohen DL, Fedson AC, Gíslason T, Penzel T, Phillips CL, Yu-sheng L, Pack AI, Magalang UJ (2014) Effects of continuous positive airway pressure on blood pressure in patients with resistant hypertension and obstructive sleep apnea: a meta-analysis. J Hypertens 32:2341–2350CrossRefPubMedPubMedCentral
37.
Zurück zum Zitat Li L, Wang ZW, Li J, Ge X, Guo LZ, Wang Y, Guo WH, Jiang CX, Ma CS (2014) Efficacy of catheter ablation of atrial fibrillation in patients with obstructive sleep apnea with and without continuous positive airway pressure treatment: a meta-analysis of observational studies. Europace 16:1309–1314CrossRefPubMed Li L, Wang ZW, Li J, Ge X, Guo LZ, Wang Y, Guo WH, Jiang CX, Ma CS (2014) Efficacy of catheter ablation of atrial fibrillation in patients with obstructive sleep apnea with and without continuous positive airway pressure treatment: a meta-analysis of observational studies. Europace 16:1309–1314CrossRefPubMed
38.
Zurück zum Zitat Echt DS, Liebson PR, Mitchell LB, Peters RW, Obias-Manno D, Barker AH, Arensberg D, Baker A, Friedman L, Greene HL, Huther ML, Richardson DW (1991) Mortality and morbidity in patients receiving encainide, flecainide, or placebo. N Engl J Med 324:781–788CrossRefPubMed Echt DS, Liebson PR, Mitchell LB, Peters RW, Obias-Manno D, Barker AH, Arensberg D, Baker A, Friedman L, Greene HL, Huther ML, Richardson DW (1991) Mortality and morbidity in patients receiving encainide, flecainide, or placebo. N Engl J Med 324:781–788CrossRefPubMed
Metadaten
Titel
Impact of SERVE-HF on management of sleep disordered breathing in heart failure: a call for further studies
verfasst von
Dominik Linz
Henrik Fox
Thomas Bitter
Jens Spießhöfer
Christoph Schöbel
Erik Skobel
Anke Türoff
Michael Böhm
Martin R. Cowie
Michael Arzt
Olaf Oldenburg
Publikationsdatum
12.02.2016
Verlag
Springer Berlin Heidelberg
Erschienen in
Clinical Research in Cardiology / Ausgabe 7/2016
Print ISSN: 1861-0684
Elektronische ISSN: 1861-0692
DOI
https://doi.org/10.1007/s00392-016-0970-4

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