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02.05.2018 | Original Paper

Cardiac autonomic modulation impairments in advanced breast cancer patients

verfasst von: Claudia Arab, Luiz Carlos Marques Vanderlei, Laércio da Silva Paiva, Kyle Levi Fulghum, Carlos Elias Fristachi, Afonso Celso Pinto Nazario, Simone Elias, Luiz Henrique Gebrim, Celso Ferreira Filho, Yori Gidron, Celso Ferreira

Erschienen in: Clinical Research in Cardiology | Ausgabe 10/2018

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Abstract

Aim

To compare cardiac autonomic modulation in early- versus advanced-stage breast cancer patients before any type of cancer treatment and investigate associated factors.

Methods and results

This cross-sectional study included women (30–69 years old) with primary diagnosis of breast cancer and women with benign breast tumors. We evaluated cardiac modulation by heart rate variability and assessed factors of anxiety, depression, physical activity, and other relevant medical variables. Patients were divided into three groups based on TNM staging of cancer severity: early-stage cancer (n = 42), advanced-stage cancer (n = 37), or benign breast tumors to serve as a control (n = 37). We analyzed heart rate variability in time and frequency domains. The advanced-stage cancer group had lower vagal modulation than early-stage and benign groups; also, the advance-stage group had lower overall heart rate variability when compared to benign conditions. Heart rate variability was influenced by age, menopausal status, and BMI.

Conclusions

Heart rate variability seems to be a promising, non-invasive tool for early diagnosis of autonomic dysfunction in breast cancer and detection of cardiovascular impairments at cancer diagnosis. Cardiac autonomic modulation is inversely associated with breast cancer staging.

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Titel: Cardiac autonomic modulation impairments in advanced breast cancer patients
verfasst von: Claudia Arab
Luiz Carlos Marques Vanderlei
Laércio da Silva Paiva
Kyle Levi Fulghum
Carlos Elias Fristachi
Afonso Celso Pinto Nazario
Simone Elias
Luiz Henrique Gebrim
Celso Ferreira Filho
Yori Gidron
Celso Ferreira
Publikationsdatum: 02.05.2018
Verlag: Springer Berlin Heidelberg
Erschienen in: Clinical Research in Cardiology / Ausgabe 10/2018
Print ISSN: 1861-0684
Elektronische ISSN: 1861-0692
DOI: https://doi.org/10.1007/s00392-018-1264-9

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Cardiac autonomic modulation impairments in advanced breast cancer patients

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