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Zeitschrift für Rheumatologie

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13.07.2016 | Neues aus der Forschung

Bone and adipose tissue formation

verfasst von: J. Luther, Ph.D., J.-P. David

Erschienen in: Zeitschrift für Rheumatologie | Sonderheft 1/2017

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Abstract

Leptin has been described to have a crucial role in bone homeostasis by systemic as well as local action. Systemically, leptin seems to inhibit bone formation controlled by a feedback loop including osteocalcin and insulin. Even though the action seems to be bone site specific, as well as gender- and time-dependent, the results showing the interaction of these three factors are in part still inconsistent. In this article the complex effects of leptin, insulin, and osteocalcin on bone and fat metabolism are summarized.

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Titel: Bone and adipose tissue formation
verfasst von: J. Luther, Ph.D.
J.-P. David
Publikationsdatum: 13.07.2016
Verlag: Springer Medizin
Erschienen in: Zeitschrift für Rheumatologie / Ausgabe Sonderheft 1/2017
Print ISSN: 0340-1855
Elektronische ISSN: 1435-1250
DOI: https://doi.org/10.1007/s00393-016-0143-x

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