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European Journal of Nutrition

Erschienen in:

01.05.2008

Selenium and cancer: biomarkers of selenium status and molecular action of selenium supplements

verfasst von: Jolanta Gromadzińska, Edyta Reszka, Katharina Bruzelius, Wojciech Wąsowicz, Björn Åkesson

Erschienen in: European Journal of Nutrition | Sonderheft 2/2008

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Abstract

Background

The relationship between selenium and cancer involves many different aspects. These include the forms of selenium present in the diet and in the body, their functions and mechanisms of action, and methods employed in assessing an individual’s selenium nutritional status—both in general, and in epidemiological studies of the risk of cancer in relation to diet, as well as in connection with long-term trials for investigating the disease-preventive potential of selenium supplementation.

Aim of the review

To review different aspects on selenium metabolism, the occurrence of different selenoproteins and their use as biomarkers of selenium status, the results of intervention trials of the cancer-preventive effects of selenium supplementation, the mechanisms of action involved, together with epidemiological findings on relations between the selenium status in the body and risk of cancer.

Results and conclusions

The rapid advance in the knowledge of different selenoproteins and their biological functions has opened up new possibilities for the understanding of the biological effects of selenium supplementation. A wide variety of effects of different forms and doses of selenium has been observed in a number of experimental systems, and it is at present difficult to pinpoint the mechanism that may explain the positive preventive effects of selenium supplementation observed in some human long-term trials. Moreover, additional such trials are needed to define the benefits and risks of different types and doses of selenium supplements which in the future may be implemented for public health reasons. Another necessary focus for future research is a better understanding of the mechanisms by which selenium interferes with the carcinogenesis process.

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Titel: Selenium and cancer: biomarkers of selenium status and molecular action of selenium supplements
verfasst von: Jolanta Gromadzińska
Edyta Reszka
Katharina Bruzelius
Wojciech Wąsowicz
Björn Åkesson
Publikationsdatum: 01.05.2008
Verlag: D. Steinkopff-Verlag
Erschienen in: European Journal of Nutrition / Ausgabe Sonderheft 2/2008
Print ISSN: 1436-6207
Elektronische ISSN: 1436-6215
DOI: https://doi.org/10.1007/s00394-008-2005-z

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Selenium and cancer: biomarkers of selenium status and molecular action of selenium supplements

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Aim of the review

Results and conclusions

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Abstract

Background

Aim of the review

Results and conclusions

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