Skip to main content
Erschienen in: European Journal of Nutrition 1/2010

01.02.2010 | Original Contribution

Complementary food with low (8%) or high (12%) meat content as source of dietary iron: a double-blinded randomized controlled trial

verfasst von: Katharina Dube, Jana Schwartz, Manfred J. Mueller, Hermann Kalhoff, Mathilde Kersting

Erschienen in: European Journal of Nutrition | Ausgabe 1/2010

Einloggen, um Zugang zu erhalten

Abstract

Background

To investigate whether a low meat content of complementary food as accepted by EU law increases the risk of well-nourished infants to develop iron deficiency during the complementary feeding period.

Methods

Term born, healthy infants were randomized into a ‘High Meat’ Group (HM, n = 48) receiving commercial baby jars with a meat content of 12% by weight (according to pediatric guidelines), and a ‘Low Meat’ Group (LM, n = 49) receiving meals as marketed (meat 8% by weight, the lowest level of EU law). Intervention was from 4 to 10 months of age. Dietary intake was recorded continuously, repeated blood samples were collected.

Results

Estimated intake of bioavailable iron conformed to reference requirements. In the primary analysis of the total sample, iron status was adequate before (4 months), during (7 months), and after (10 months) the intervention. A secondary analysis in the subgroup of infants fully breast-fed for 4–6 months demonstrated an increased risk of low Hb values with 10 months of age in the LM group.

Interpretation

Present day low meat content of complementary food does not significantly impair iron status in well-nourished infants but may increase the risk of developing marginal iron status in older infants after fully breast-feeding for 4–6 months, i.e., in the subgroup of infants with the lowest habitual iron intake.
Literatur
1.
Zurück zum Zitat Aggett PJ, Agostini C, Goulet O et al (2001) The nutritional and safety assessment of breast milk substitutes and other dietary products for infants: a commentary by the ESPGHAN Committee on Nutrition. J Pediatr Gastroenterol Nutr 32:256–258CrossRef Aggett PJ, Agostini C, Goulet O et al (2001) The nutritional and safety assessment of breast milk substitutes and other dietary products for infants: a commentary by the ESPGHAN Committee on Nutrition. J Pediatr Gastroenterol Nutr 32:256–258CrossRef
2.
Zurück zum Zitat Lozoff B, Beard J, Connor J, Barbara F, Georgieff M, Schallert T (2006) Long-lasting neural and behavioral effects of iron deficiency in infancy. Nutr Rev 64:S34–S43 (discussion S72–S91)CrossRef Lozoff B, Beard J, Connor J, Barbara F, Georgieff M, Schallert T (2006) Long-lasting neural and behavioral effects of iron deficiency in infancy. Nutr Rev 64:S34–S43 (discussion S72–S91)CrossRef
3.
Zurück zum Zitat Agostoni C, Riva E, Giovannini M (2007) Functional ingredients in the complementary feeding period and long-term effects. In: Agostoni C, Brunser O (eds) Issues in complementary feeding. Vevey/S. Karger AG, Basel, pp 123–138CrossRef Agostoni C, Riva E, Giovannini M (2007) Functional ingredients in the complementary feeding period and long-term effects. In: Agostoni C, Brunser O (eds) Issues in complementary feeding. Vevey/S. Karger AG, Basel, pp 123–138CrossRef
4.
Zurück zum Zitat Domellof M, Cohen RJ, Dewey KG, Hernell O, Rivera LL, Lonnerdal B (2001) Iron supplementation of breast-fed Honduran and Swedish infants from 4 to 9 months of age. J Pediatr 138:679–687CrossRef Domellof M, Cohen RJ, Dewey KG, Hernell O, Rivera LL, Lonnerdal B (2001) Iron supplementation of breast-fed Honduran and Swedish infants from 4 to 9 months of age. J Pediatr 138:679–687CrossRef
5.
Zurück zum Zitat German Nutrition Society (2000) Compilation of the D-A-CH reference values for nutrient intake (German). D-A-CH, Frankfurt German Nutrition Society (2000) Compilation of the D-A-CH reference values for nutrient intake (German). D-A-CH, Frankfurt
6.
Zurück zum Zitat Institute of Medicine (2001) Dietary reference intakes. National Academy Press, Washington Institute of Medicine (2001) Dietary reference intakes. National Academy Press, Washington
7.
Zurück zum Zitat Dewey KG (2001) Nutrition, growth, and complementary feeding of the breastfed infant. Pediatr Clin North Am 48:87–104CrossRef Dewey KG (2001) Nutrition, growth, and complementary feeding of the breastfed infant. Pediatr Clin North Am 48:87–104CrossRef
8.
Zurück zum Zitat Hopkins D, Emmett P, Steer C, Rogers I, Noble S, Emond A (2007) Infant feeding in the second 6 months of life related to iron status: an observational study. Arch Dis Child 92:850–854CrossRef Hopkins D, Emmett P, Steer C, Rogers I, Noble S, Emond A (2007) Infant feeding in the second 6 months of life related to iron status: an observational study. Arch Dis Child 92:850–854CrossRef
9.
Zurück zum Zitat Dewey KG, Chaparro CM (2007) Session 4: mineral metabolism and body composition iron status of breast-fed infants. Proc Nutr Soc 66:412–422CrossRef Dewey KG, Chaparro CM (2007) Session 4: mineral metabolism and body composition iron status of breast-fed infants. Proc Nutr Soc 66:412–422CrossRef
10.
Zurück zum Zitat Agostoni C, Decsi T, Fewtrell M et al (2008) Complementary feeding: a commentary by the ESPGHAN Committee on Nutrition. J Pediatr Gastroenterol Nutr 46:99–110CrossRef Agostoni C, Decsi T, Fewtrell M et al (2008) Complementary feeding: a commentary by the ESPGHAN Committee on Nutrition. J Pediatr Gastroenterol Nutr 46:99–110CrossRef
11.
Zurück zum Zitat The Commission of the European Communities (1996) Commission Directive 96/5/EC, Euratom of 16 February 1996 on processed cereal-based foods and baby foods for infants and young children. Official Journal L 049, 28 02 1996, 1996:0017–0028 The Commission of the European Communities (1996) Commission Directive 96/5/EC, Euratom of 16 February 1996 on processed cereal-based foods and baby foods for infants and young children. Official Journal L 049, 28 02 1996, 1996:0017–0028
12.
Zurück zum Zitat Schwartz J, Dube K, Sichert-Hellert W et al (2009) Modification of dietary polyunsaturated fatty acids via complementary food enhances n-3 LC-PUFA synthesis in healthy infants—a double blinded randomized controlled trial. Arch Dis Child Schwartz J, Dube K, Sichert-Hellert W et al (2009) Modification of dietary polyunsaturated fatty acids via complementary food enhances n-3 LC-PUFA synthesis in healthy infants—a double blinded randomized controlled trial. Arch Dis Child
13.
Zurück zum Zitat Michaelsen KF, Milman N, Samuelson G (1995) A longitudinal study of iron status in healthy Danish infants: effects of early iron status, growth velocity and dietary factors. Acta Paediatr 84:1035–1044CrossRef Michaelsen KF, Milman N, Samuelson G (1995) A longitudinal study of iron status in healthy Danish infants: effects of early iron status, growth velocity and dietary factors. Acta Paediatr 84:1035–1044CrossRef
14.
Zurück zum Zitat Kersting M (2001) Feeding the healthy infant. Food- and meal-based recommendations (German). Monatsschr Kinderheilkd 149:4–10CrossRef Kersting M (2001) Feeding the healthy infant. Food- and meal-based recommendations (German). Monatsschr Kinderheilkd 149:4–10CrossRef
15.
Zurück zum Zitat German Society of Pediatrics and Adolescent Medicine (2006) Healthy nutrition for my baby (German) German Society of Pediatrics and Adolescent Medicine (2006) Healthy nutrition for my baby (German)
16.
Zurück zum Zitat Souci SW, Fachmann W, Kraut H (2000) Food composition and nutrition tables (German), 6 edn edn. Medpharm Scientific Publishers, Stuttgart Souci SW, Fachmann W, Kraut H (2000) Food composition and nutrition tables (German), 6 edn edn. Medpharm Scientific Publishers, Stuttgart
17.
Zurück zum Zitat Schoen S, Sichert-Hellert W, Kersting M (2009) Validation of energy requirement equations for estimation of breast milk consumption in infants. Public Health Nutrition (in press) Schoen S, Sichert-Hellert W, Kersting M (2009) Validation of energy requirement equations for estimation of breast milk consumption in infants. Public Health Nutrition (in press)
18.
Zurück zum Zitat Sichert-Hellert W, Kersting M, Chadha C, Schaefer R, Kroke A (2007) German food composition database for dietary evaluations in children and adolescents. J Food Comp Anal 20:63–70CrossRef Sichert-Hellert W, Kersting M, Chadha C, Schaefer R, Kroke A (2007) German food composition database for dietary evaluations in children and adolescents. J Food Comp Anal 20:63–70CrossRef
19.
Zurück zum Zitat Hertrampf E, Olivares M, Pizarro F, Walter T (1998) High absorption of fortification iron from current infant formulas. J Pediatr Gastroenterol Nutr 27:425–430CrossRef Hertrampf E, Olivares M, Pizarro F, Walter T (1998) High absorption of fortification iron from current infant formulas. J Pediatr Gastroenterol Nutr 27:425–430CrossRef
20.
Zurück zum Zitat Monsen ER (1988) Iron nutrition and absorption: dietary factors which impact iron bioavailability. J Am Diet Assoc 88:786–790 Monsen ER (1988) Iron nutrition and absorption: dietary factors which impact iron bioavailability. J Am Diet Assoc 88:786–790
21.
Zurück zum Zitat Bosscher D, Van Cauwenbergh R, Van der Auwera JC, Robberecht H, Deelstra H (2002) Calcium, iron and zinc availability from weaning meals. Acta Paediatr 91:761–768CrossRef Bosscher D, Van Cauwenbergh R, Van der Auwera JC, Robberecht H, Deelstra H (2002) Calcium, iron and zinc availability from weaning meals. Acta Paediatr 91:761–768CrossRef
22.
Zurück zum Zitat Cook JD, Reddy MB, Burri J, Juillerat MA, Hurrell RF (1997) The influence of different cereal grains on iron absorption from infant cereal foods. Am J Clin Nutr 65:964–969 Cook JD, Reddy MB, Burri J, Juillerat MA, Hurrell RF (1997) The influence of different cereal grains on iron absorption from infant cereal foods. Am J Clin Nutr 65:964–969
23.
Zurück zum Zitat Davidsson L, Kastenmayer P, Szajewska H, Hurrell RF, Barclay D (2000) Iron bioavailability in infants from an infant cereal fortified with ferric pyrophosphate or ferrous fumarate. Am J Clin Nutr 71:1597–1602 Davidsson L, Kastenmayer P, Szajewska H, Hurrell RF, Barclay D (2000) Iron bioavailability in infants from an infant cereal fortified with ferric pyrophosphate or ferrous fumarate. Am J Clin Nutr 71:1597–1602
24.
Zurück zum Zitat Lonnerdal B, Kelleher SL (2007) Iron metabolism in infants and children. Food Nutr Bull 28:S491–S499 Lonnerdal B, Kelleher SL (2007) Iron metabolism in infants and children. Food Nutr Bull 28:S491–S499
25.
Zurück zum Zitat van Rheenen PF, de Moor LT, Eschbach S, Brabin BJ (2008) A cohort study of haemoglobin and zinc protoporphyrin levels in term Zambian infants: effects of iron stores at birth, complementary food and placental malaria. Eur J Clin Nutr 62:1379–1387 van Rheenen PF, de Moor LT, Eschbach S, Brabin BJ (2008) A cohort study of haemoglobin and zinc protoporphyrin levels in term Zambian infants: effects of iron stores at birth, complementary food and placental malaria. Eur J Clin Nutr 62:1379–1387
26.
Zurück zum Zitat Vazquez Lopez MA, Carracedo A, Lendinez F, Munoz FJ, Lopez J, Munoz A (2006) The usefulness of serum transferrin receptor for discriminating iron deficiency without anemia in children. Haematologica 91:264–265 Vazquez Lopez MA, Carracedo A, Lendinez F, Munoz FJ, Lopez J, Munoz A (2006) The usefulness of serum transferrin receptor for discriminating iron deficiency without anemia in children. Haematologica 91:264–265
27.
Zurück zum Zitat Punnonen K, Irjala K, Rajamaki A (1997) Serum transferrin receptor and its ratio to serum ferritin in the diagnosis of iron deficiency. Blood 89:1052–1057 Punnonen K, Irjala K, Rajamaki A (1997) Serum transferrin receptor and its ratio to serum ferritin in the diagnosis of iron deficiency. Blood 89:1052–1057
28.
Zurück zum Zitat Fewtrell MS, Morgan JB, Duggan C et al (2007) Optimal duration of exclusive breastfeeding: what is the evidence to support current recommendations? Am J Clin Nutr 85:635S–638S Fewtrell MS, Morgan JB, Duggan C et al (2007) Optimal duration of exclusive breastfeeding: what is the evidence to support current recommendations? Am J Clin Nutr 85:635S–638S
29.
Zurück zum Zitat WHO (2001a) Global strategy for infant and young child feeding—the optimal duration of exclusive breastfeeding. World Health Organization, Geneva WHO (2001a) Global strategy for infant and young child feeding—the optimal duration of exclusive breastfeeding. World Health Organization, Geneva
30.
Zurück zum Zitat Gartner LM, Morton J, Lawrence RA et al (2005) Breastfeeding and the use of human milk. Pediatrics 115:496–506CrossRef Gartner LM, Morton J, Lawrence RA et al (2005) Breastfeeding and the use of human milk. Pediatrics 115:496–506CrossRef
31.
Zurück zum Zitat Hurrell RF, Reddy MB, Juillerat M, Cook JD (2006) Meat protein fractions enhance nonheme iron absorption in humans. J Nutr 136:2808–2812 Hurrell RF, Reddy MB, Juillerat M, Cook JD (2006) Meat protein fractions enhance nonheme iron absorption in humans. J Nutr 136:2808–2812
32.
Zurück zum Zitat Hicks PD, Zavaleta N, Chen Z, Abrams SA, Lonnerdal B (2006) Iron deficiency, but not anemia, upregulates iron absorption in breast-fed Peruvian infants. J Nutr 136:2435–2438 Hicks PD, Zavaleta N, Chen Z, Abrams SA, Lonnerdal B (2006) Iron deficiency, but not anemia, upregulates iron absorption in breast-fed Peruvian infants. J Nutr 136:2435–2438
33.
Zurück zum Zitat Domellof M (2007) Iron requirements, absorption and metabolism in infancy and childhood. Curr Opin Clin Nutr Metab Care 10:329–335CrossRef Domellof M (2007) Iron requirements, absorption and metabolism in infancy and childhood. Curr Opin Clin Nutr Metab Care 10:329–335CrossRef
34.
Zurück zum Zitat Engelmann MD, Sandstrom B, Michaelsen KF (1998) Meat intake and iron status in late infancy: an intervention study. J Pediatr Gastroenterol Nutr 26:26–33CrossRef Engelmann MD, Sandstrom B, Michaelsen KF (1998) Meat intake and iron status in late infancy: an intervention study. J Pediatr Gastroenterol Nutr 26:26–33CrossRef
35.
Zurück zum Zitat Morgan J, Taylor A, Fewtrell M (2004) Meat consumption is positively associated with psychomotor outcome in children up to 24 months of age. J Pediatr Gastroenterol Nutr 39:493–498CrossRef Morgan J, Taylor A, Fewtrell M (2004) Meat consumption is positively associated with psychomotor outcome in children up to 24 months of age. J Pediatr Gastroenterol Nutr 39:493–498CrossRef
36.
Zurück zum Zitat Krebs NF, Westcott JE, Butler N, Robinson C, Bell M, Hambidge KM (2006) Meat as a first complementary food for breastfed infants: feasibility and impact on zinc intake and status. J Pediatr Gastroenterol Nutr 42:207–214 Krebs NF, Westcott JE, Butler N, Robinson C, Bell M, Hambidge KM (2006) Meat as a first complementary food for breastfed infants: feasibility and impact on zinc intake and status. J Pediatr Gastroenterol Nutr 42:207–214
37.
Zurück zum Zitat Schuemann K, Ettle T, Szegner B, Elsenhans B, Solomons NW (2007) On risks and benefits of iron supplementation recommendations for iron intake revisited. J Trace Elem Med Biol 21:147–168CrossRef Schuemann K, Ettle T, Szegner B, Elsenhans B, Solomons NW (2007) On risks and benefits of iron supplementation recommendations for iron intake revisited. J Trace Elem Med Biol 21:147–168CrossRef
Metadaten
Titel
Complementary food with low (8%) or high (12%) meat content as source of dietary iron: a double-blinded randomized controlled trial
verfasst von
Katharina Dube
Jana Schwartz
Manfred J. Mueller
Hermann Kalhoff
Mathilde Kersting
Publikationsdatum
01.02.2010
Verlag
D. Steinkopff-Verlag
Erschienen in
European Journal of Nutrition / Ausgabe 1/2010
Print ISSN: 1436-6207
Elektronische ISSN: 1436-6215
DOI
https://doi.org/10.1007/s00394-009-0043-9

Weitere Artikel der Ausgabe 1/2010

European Journal of Nutrition 1/2010 Zur Ausgabe

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.