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European Journal of Nutrition

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01.02.2013 | Original Contribution

Anti-angiogenic properties of carnosol and carnosic acid, two major dietary compounds from rosemary

verfasst von: Auxiliadora López-Jiménez, Melissa García-Caballero, Miguel Ángel Medina, Ana R. Quesada

Erschienen in: European Journal of Nutrition | Ausgabe 1/2013

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Abstract

Background

The use of rosemary (Rosmarinus officinalis) leaves and their constituents as a source of dietary antioxidants and flavoring agents is continuously growing. Carnosol and carnosic acid, two major components of rosemary extracts, have shown activity for cancer prevention and therapy.

Aim of the study

In this study, we investigate the cytotoxic and anti-angiogenic activities of carnosol and carnosic acid, in order to get further insight into their mechanism of action.

Results

Our results demonstrate that the mentioned diterpenes inhibit certain functions of endothelial cells, namely, differentiation, proliferation, migration and proteolytic capability. Our data indicate that their growth inhibitory effect, exerted on proliferative endothelial and tumor cells, could be due to, at least in part, an induction of apoptosis. Inhibition of the mentioned essential steps of in vitro angiogenesis agrees with the observed inhibition of the in vivo angiogenesis, substantiated by using the chick chorioallantoic membrane assay.

Conclusions

The anti-angiogenic activity of carnosol and carnosic acid could contribute to the chemopreventive, antitumoral and antimetastatic activities of rosemary extracts and suggests their potential in the treatment of other angiogenesis-related malignancies.

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Titel: Anti-angiogenic properties of carnosol and carnosic acid, two major dietary compounds from rosemary
verfasst von: Auxiliadora López-Jiménez
Melissa García-Caballero
Miguel Ángel Medina
Ana R. Quesada
Publikationsdatum: 01.02.2013
Verlag: Springer-Verlag
Erschienen in: European Journal of Nutrition / Ausgabe 1/2013
Print ISSN: 1436-6207
Elektronische ISSN: 1436-6215
DOI: https://doi.org/10.1007/s00394-011-0289-x

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Anti-angiogenic properties of carnosol and carnosic acid, two major dietary compounds from rosemary

Abstract

Background

Aim of the study

Results

Conclusions

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Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

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Abstract

Background

Aim of the study

Results

Conclusions

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