Skip to main content
Hauptrubriken
CME Facharzt-Training Webinare Zeitschriften Bücher e.Medpedia Podcast
Service
Jobbörse Info & Hilfe
Fachgebiete
Anästhesiologie Allgemeinmedizin Arbeitsmedizin Augenheilkunde Chirurgie Dermatologie Gynäkologie und Geburtshilfe HNO Innere Medizin Kardiologie Neurologie Onkologie und Hämatologie Orthopädie und Unfallchirurgie Pädiatrie Pathologie Psychiatrie Radiologie Rechtsmedizin Urologie Zahnmedizin
Themen
Klimawandel und Gesundheit Neues aus dem Markt COVID-19 Praxis und Beruf Seltene Erkrankungen GOÄ & EBM Panorama
Sammlungen
Kasuistiken Algorithmen & Infografiken Blickdiagnosen Arthropedia FlapFinder (für Dermatochirurgen) Videos Kongressberichterstattung Medizin für Apothekerinnen und Apotheker Für Ärztinnen und Ärzte in Weiterbildung Für Medizinstudierende
Erweiterte Suche
Anmelden
nach oben
European Journal of Nutrition
Erschienen in: European Journal of Nutrition 7/2013

01.10.2013 | Original Contribution

New perspectives on vitamin D sources in Germany based on a novel mathematical bottom-up model of 25(OH)D serum concentrations

verfasst von: Jonathan Brown, Anita Ignatius, Michael Amling, Florian Barvencik

Erschienen in: European Journal of Nutrition | Ausgabe 7/2013

Einloggen, um Zugang zu erhalten

Abstract

Purpose

Up-to-date knowledge about vitamin D supply and serum concentration in Germany is not sufficient. Our purpose was to compare a novel holistic bottom-up modeling of 25(OH)D concentrations with vitamin D sources such as sunlight, food and supplements for all federal states taking seasonal and geographical variations into account. The second purpose was to update and detail vitamin D supply through food in Germany.

Methods

To confirm the model of 25(OH)D concentrations, we used the population (1,763 men and 2,267 women, 18–79 years) participated in the representative German National Health Interview and Examination Survey 1998 and the integrated German Nutrition Survey.

Results

The maximum model value is 67.5 nmol/L in July and minimum model value is 29.3 nmol/L in January, while the average model value is 45.0 nmol/L. Men have a mean daily intake of 137 IU (3.42 μg) and women of 112 IU (2.79 μg). Correlation between model and actual data is 0.77 (p = 0.003).

Conclusions

A comparison of the model data with population-based values showed good agreement. None of the vitamin D sources can provide the German population with enough vitamin D.
Anhänge
Nur mit Berechtigung zugänglich
Literatur
1.
Bouillon R, Carmeliet G, Verlinden L, van Etten E, Verstuyf A, Luderer HF, Lieben L, Mathieu C, Demay M (2008) Vitamin D and human health: lessons from vitamin D receptor null mice. Endocr Rev 29:726–776CrossRef
2.
3.
Melamed ML, Michos ED, Post W, Astor B (2008) 25-Hydroxyvitamin D levels and the risk of mortality in the general population. Arch Intern Med 168:1629–1637CrossRef
4.
Chiu KC, Chu A, Go VLW, Saad MF (2004) Hypovitaminosis D is associated with insulin resistance and β cell dysfunction. Am J Clin Nutr 79:820–825
5.
Hypponen E, Läärä E, Reunanen A, Järvelin M-R, Virtanen SM (2001) Intake of vitamin D and risk of type 1 diabetes: a birth-cohort study. Lancet 358:1500–1503CrossRef
6.
Pittas AG, Dawson-Hughes B, Li T, Van Dam RM, Willett WC, Manson JE, Hu FB (2006) Vitamin D and calcium intake in relation to type 2 diabetes in women. Diabetes Care 29:650–656CrossRef
7.
Ahonen MH, Tenkanen L, Teppo L, Hakama M, Tuohimaa P (2000) Prostate cancer risk and prediagnostic serum 25-hydroxyvitamin D levels (Finland). Cancer Causes Control 11:847–852CrossRef
8.
Berwick M, Armstrong BK, Ben-Porat L, Fine J, Kricker A, Eberle C, Barnhill R (2005) Sun exposure and mortality from melanoma. J Natl Cancer Inst 97:195–199CrossRef
9.
Chang ET, Smedby KEM, Hjalgrim H, Porwit-MacDonald A, Roos GR, Glimelius B, Adami H-O (2005) Family history of hematopoietic malignancy and risk of lymphoma. J Natl Cancer Inst 97:1466–1474CrossRef
10.
Feskanich D, Ma J, Fuchs CS, Kirkner GJ, Hankinson SE, Hollis BW, Giovannucci EL (2004) Plasma vitamin D metabolites and risk of colorectal cancer in women. Cancer Epidemiol Biomark Prev 13:1502–1508
11.
Garland CF, Garland FC, Gorham ED, Lipkin M, Newmark H, Mohr SB, Holick MF (2006) The role of vitamin D in cancer prevention. Am J Public Health 96:252–261CrossRef
12.
Giovannucci E (2006) The epidemiology of vitamin D and colorectal cancer: recent findings. Curr Opin Gastroenterol 22:24–29CrossRef
13.
Gorham ED, Garland CF, Garland FC, Grant WB, Mohr SB, Lipkin M, Newmark HL, Giovannucci E, Wei M, Holick MF (2005) Vitamin D and prevention of colorectal cancer. J Steroid Biochem Mol Biol 97:179–194CrossRef
14.
Holick MF (2006) Calcium plus vitamin D and the risk of colorectal cancer. New Engl J Med 354:2287–2288CrossRef
15.
Luscombe CJ, Fryer AA, French ME, Liu S, Saxby MF, Jones PW, Strange RC (2001) Exposure to ultraviolet radiation: association with susceptibility and age at presentation with prostate cancer. Lancet 358:641–642CrossRef
16.
Annweiler C, Schott AM, Rolland Y, Blain H, Herrmann FR, Beauchet O (2010) Dietary intake of vitamin D and cognition in older women. Neurology 75:1810–1816CrossRef
17.
Cannell JJ, Hollis BW, Sorenson MB, Taft TN, Anderson JJB (2009) Athletic performance and vitamin D. Med Sci Sport Exer 41:1102–1110CrossRef
18.
Cantorna MT, Zhu Y, Froicu M, Wittke A (2004) Vitamin D status, 1,25-dihydroxyvitamin D3, and the immune system. Am J Clin Nutr 80:1717S–1720S
19.
Zittermann A (2006) Vitamin D and disease prevention with special reference to cardiovascular disease. Prog Biophys Mol Biol 92:39–48CrossRef
20.
Ponsonby A-L, McMichael A, van der Mei I (2002) Ultraviolet radiation and autoimmune disease: insights from epidemiological research. Toxicology 181–182:71–78CrossRef
21.
Roux C, Bischoff-Ferrari HA, Papapoulos SE, de Papp AE, West JA, Bouillon R (2008) New insights into the role of vitamin D and calcium in osteoporosis management: an expert roundtable discussion. Curr Med Res Opin 24:1363–1370CrossRef
22.
von Domarus C, Brown J, Barvencik F, Amling M, Pogoda P (2011) How much vitamin D do we need for skeletal health? Clin Orthop Relat R:1–7
23.
Priemel M, Domarus C, Klatte TO, Kessler S, Schlie J, Meier S, Proksch N, Pastor F, Netter C, Streichert T, Püschel K, Amling M (2010) Bone mineralization defects and vitamin D deficiency: histomorphometric analysis of iliac crest bone biopsies and circulating 25-hydroxyvitamin D in 675 patients. J Bone Miner Res 25:305–312CrossRef
24.
Bischoff-Ferrari HA, Dietrich T, Orav EJ, Dawson-Hughes B (2004) Positive association between 25-hydroxy vitamin d levels and bone mineral density: a population-based study of younger and older adults. Am J Med 116:634–639CrossRef
25.
Hintzpeter B, Mensink GBM, Thierfelder W, Muller MJ, Scheidt-Nave C (2007) Vitamin D status and health correlates among German adults. Eur J Clin Nutr 62:1079–1089CrossRef
26.
Hintzpeter B, Scheidt-Nave C, Muller MJ, Schenk L, Mensink GBM (2008) Higher prevalence of vitamin D deficiency is associated with immigrant background among children and adolescents in Germany. J Nutr 138:1482–1490
27.
Webb AR, Kline L, Holick MF (1988) Influence of season and latitude on the cutaneous synthesis of vitamin D3: exposure to winter sunlight in Boston and Edmonton will not promote vitamin D3 synthesis in human skin. J Clin Endocrinol Metab 67:373–378CrossRef
28.
29.
Zittermann A, Helden RV, Grant WB, Kipshoven C, Ringe JD (2009) An estimate of the survival benefit of improving vitamin D status in the adult German population. Dermatoendocrinol 1(6):300–306CrossRef
30.
Zittermann A (2010) The estimated benefits of vitamin D for Germany. Mol Nutr Food Res 54:1164–1171
31.
32.
BLE Federal association of the German meat industry. Meat consumption per capita from “Federal agency for agriculture and food” (Bundesamt für Landwirtschaft und Ernährung—BLE). Version current 2006. Internet: http://​www.​bvdf.​de/​in_​zahlen/​tab_​06/​. Accessed 14 August 2011
33.
34.
35.
Chen TC, Chimeh F, Lu Z, Mathieu J, Person KS, Zhang A, Kohn N, Martinello S, Berkowitz R, Holick MF (2007) Factors that influence the cutaneous synthesis and dietary sources of vitamin D. Arch Biochem Biophys 460:213–217CrossRef
36.
Baraké R, Weiler H, Payette H, Gray-Donald K (2010) Vitamin D supplement consumption is required to achieve a minimal target 25-Hydroxyvitamin D concentration of ≥75 nmol/L in older people. J Nutr 140:551–556CrossRef
37.
Vieth R (1999) Vitamin D supplementation, 25-hydroxyvitamin D concentrations, and safety. Am J Clin Nutr 69:842–856
38.
O’Donnell S, Cranney A, Horsley T, Weiler HA, Atkinson SA, Hanley DA, Ooi DS, Ward L, Barrowman N, Fang M, Sampson M, Tsertsvadze A, Yazdi F (2008) Efficacy of food fortification on serum 25-hydroxyvitamin D concentrations: systematic review. Am J Clin Nutr 88:1528–1534CrossRef
39.
Niramitmahapanya S, Harris SS, Dawson-Hughes B (2011) Type of dietary fat is associated with the 25-Hydroxyvitamin D3 increment in response to vitamin D supplementation. J Clin Endocrinol Metab 96:3170–3174CrossRef
40.
Diffey BL (2010) Modelling the seasonal variation of vitamin D due to sun exposure. Brit J Dermatol 162:1342–1348CrossRef
41.
Knuschke P, Kurpiers M, Koch R, Kuhlisch W, Witte K (2004) Mean individual UV-exposures in the population. BMBF report (Federal Ministry of Education and Research—Bundesministerium für Bildung und Forschung) with the reference number 07UVB54C/3
42.
43.
44.
Rigel DS, Rigel EG, Rigel AC (1999) Effects of altitude and latitude on ambient UVB radiation. J Am Acad Dermatol 40:114–116CrossRef
45.
Rigel EG, Lebwohl MG, Rigel AC, Rigel DS (2003) Ultraviolet radiation in alpine skiing: magnitude of exposure and importance of regular protection. Arch Dermatol 139:60–62CrossRef
46.
Khoo A-L, Koenen HJPM, Chai LYA, Sweep FCGJ, Netea MG, van der Ven AJAM, Joosten I (2012) Seasonal variation in vitamin D3 levels is paralleled by changes in the peripheral blood human T cell compartment. PLoS ONE 7:e29250CrossRef
47.
Reusch J, Ackermann H, Badenhoop K (2009) Cyclic changes of vitamin D and PTH are primarily regulated by solar radiation: 5-year analysis of a German (50Å N) population. Horm Metab Res 41(402):407
48.
Mithal A, Wahl D, Bonjour JP, Burckhardt P, Dawson-Hughes B, Eisman J, El-Hajj Fuleihan G, Josse R, Lips P, Morales-Torres J, Group obotIOFCoSANW (2009) Global vitamin D status and determinants of hypovitaminosis D. Osteoporos Int 20:1807–1820
49.
Heaney RP, Davies KM, Chen TC, Holick MF, Barger-Lux MJ (2003) Human serum 25-hydroxycholecalciferol response to extended oral dosing with cholecalciferol. Am J Clin Nutr 77:204–210
50.
Adams JS, Clemens TL, Parrish JA, Holick MF (1982) Vitamin-D synthesis and metabolism after ultraviolet irradiation of normal and vitamin-D-deficient subjects. New Engl J Med 306:722–725CrossRef
51.
Thompson GR, Lewis B, Booth CC (1966) Absorption of vitamin D3–3H in control subjects and patients with intestinal malabsorption. J Clin Investig 45:94–102CrossRef
52.
Jones G (2008) Pharmacokinetics of vitamin D toxicity. Am J Clin Nutr 88:582S–586S
53.
Vieth R (2005) The role of vitamin D in the prevention of osteoporosis. Ann Med 37:278–285CrossRef
54.
MacLaughlin J, Holick MF (1985) Aging decreases the capacity of human skin to produce vitamin D3. J Clin Invest 76:1536–1538CrossRef
55.
56.
57.
58.
Biancuzzo RM, Young A, Bibuld D, Cai MH, Winter MR, Klein EK, Ameri A, Reitz R, Salameh W, Chen TC, Holick MF (2010) Fortification of orange juice with vitamin D2 or vitamin D3 is as effective as an oral supplement in maintaining vitamin D status in adults. Am J Clin Nutr 91:1621–1626CrossRef
59.
Tangpricha V, Koutkia P, Rieke SM, Chen TC, Perez AA, Holick MF (2003) Fortification of orange juice with vitamin D: a novel approach for enhancing vitamin D nutritional health. Am J Clin Nutr 77:1478–1483
60.
Burgaz A, Akesson A, Oster A, Michaëlsson K, Wolk A (2007) Associations of diet, supplement use, and ultraviolet B radiation exposure with vitamin D status in Swedish women during winter. Am J Clin Nutr 86:1399–1404
61.
Kyriakidou-Himonas M, Aloia JF, Yeh JK (1999) Vitamin D supplementation in postmenopausal black women. J Clin Endocrinol Metab 84:3988–3990CrossRef
62.
Byrne P, Freaney R, McKenna M (1995) Vitamin D supplementation in the elderly: review of safety and effectiveness of different regimes. Calcif Tissue Int 56:518–520CrossRef
63.
Cashman KD, Hill TR, Lucey AJ, Taylor N, Seamans KM, Muldowney S, FitzGerald AP, Flynn A, Barnes MS, Horigan G, Bonham MP, Duffy EM, Strain JJ, Wallace JMW, Kiely M (2008) Estimation of the dietary requirement for vitamin D in healthy adults. Am J Clin Nutr 88:1535–1542CrossRef
64.
Ross AC, Manson JE, Abrams SA, Aloia JF, Brannon PM, Clinton SK, Durazo-Arvizu RA, Gallagher JC, Gallo RL, Jones G, Kovacs CS, Mayne ST, Rosen CJ, Shapses SA (2011) The 2011 report on dietary reference intakes for calcium and vitamin D from the institute of medicine: what clinicians need to know. J Clin Endocr Metab 96:53–58CrossRef
Metadaten
Titel
New perspectives on vitamin D sources in Germany based on a novel mathematical bottom-up model of 25(OH)D serum concentrations
verfasst von
Jonathan Brown
Anita Ignatius
Michael Amling
Florian Barvencik
Publikationsdatum
01.10.2013
Verlag
Springer Berlin Heidelberg
Erschienen in
European Journal of Nutrition / Ausgabe 7/2013
Print ISSN: 1436-6207
Elektronische ISSN: 1436-6215
DOI
https://doi.org/10.1007/s00394-012-0477-3

Weitere Artikel der Ausgabe 7/2013

European Journal of Nutrition 7/2013 Zur Ausgabe

Original Contribution

Increased gain in bone mineral content of preterm infants fed an isocaloric, protein-, and mineral-enriched postdischarge formula

Original Contribution

Supplementation with tocotrienol-rich fraction alters the plasma levels of Apolipoprotein A-I precursor, Apolipoprotein E precursor, and C-reactive protein precursor from young and old individuals

Original Contribution

Diverse effects of oats on cholesterol metabolism in C57BL/6 mice correlate with expression of hepatic bile acid-producing enzymes

Original Contribution

Iodine status in preschool children and evaluation of major dietary iodine sources: a German experience

Review

Markers for nutrition studies: review of criteria for the evaluation of markers

Original Contribution

Low-volume exercise can prevent sucrose-induced weight gain but has limited impact on metabolic measures in rats

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Kostenlos registrieren

Neu im Fachgebiet Innere Medizin

24.04.2024 | DGIM 2024 | Kongressbericht | Nachrichten

Metformin rückt in den Hintergrund

24.04.2024 | DGIM 2024 | Kongressbericht | Nachrichten

Myokarditis nach Infekt – richtig schwierig wird es bei Profisportlern

24.04.2024 | DGIM 2024 | Kongressbericht | Nachrichten

Thrombophiliescreening – Wenn, dann richtig und nur bei therapeutischer Konsequenz

24.04.2024 | DGIM 2024 | Nachrichten

Bei Senioren mit Prostatakarzinom auf Anämie achten!
weitere anzeigen

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen
Bildnachweise