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Erschienen in: European Journal of Nutrition 1/2017

29.10.2015 | Original Contribution

Vitamin B2, vitamin B12 and total homocysteine status in children and their associations with dietary intake of B-vitamins from different food groups: the Healthy Growth Study

verfasst von: Yannis Manios, George Moschonis, Renske Dekkers, Christina Mavrogianni, Eva Grammatikaki, Ellen van den Heuvel

Erschienen in: European Journal of Nutrition | Ausgabe 1/2017

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Abstract

Purpose

To examine the associations between the dietary intakes of certain B-vitamins from different food sources with the relevant plasma status indices in children.

Methods

A representative subsample of 600 children aged 9–13 years from the Healthy Growth Study was selected. Dietary intakes of vitamins B2, B12, B6 and folate derived from different food sources were estimated. Plasma levels of vitamin B2 (or riboflavin), methylmalonic acid (MMA) and total homocysteine (tHcy) were also measured.

Results

Plasma concentrations of vitamin B2 below 3 μg/L were found in 22.8 % of the children. Children in the lower quartile of dietary vitamin B2 intake were found to have the lowest plasma vitamin B2 levels compared to children in the upper three quartiles (5.06 ± 7.63 vs. 6.48 ± 7.88, 6.34 ± 7.63 and 6.05 ± 4.94 μg/L respectively; P = 0.003). Regarding vitamin B12 children in the lower quartile of dietary intake had higher mean plasma tHcy levels compared to children in the upper two quartiles, respectively (6.00 ± 1.79 vs. 5.41 ± 1.43 and 5.46 ± 1.64 μmol/L; P = 0.012). Positive linear associations were observed between plasma vitamin B2 levels and dietary vitamin B2 derived from milk and fruits (β = 0.133; P = 0.001 and β = 0.086; P = 0.037). Additionally, nonlinear associations were also observed between plasma vitamin B2 levels and vitamin B2 derived from red meat, as well as between tHcy levels and vitamins B12 and B6 derived from milk; vitamins B12, B6 and folate derived from cereal products and folate derived from fruits.

Conclusion

A considerably high prevalence of poor plasma vitamin B2 status was observed in children. The intake of milk, fruits and cereals was associated with more favorable tHcy levels, while the intake of milk and fruits with more favorable plasma B2 levels. However, these findings need to be further confirmed from controlled dietary intervention studies examining the modulation of biomarkers of B-vitamins.
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Literatur
1.
Zurück zum Zitat Said HM (2011) Intestinal absorption of water-soluble vitamins in health and disease. Biochem J 437(3):357–372CrossRef Said HM (2011) Intestinal absorption of water-soluble vitamins in health and disease. Biochem J 437(3):357–372CrossRef
2.
Zurück zum Zitat Henriques BJ et al (2010) Emerging roles for riboflavin in functional rescue of mitochondrial beta-oxidation flavoenzymes. Curr Med Chem 17(32):3842–3854CrossRef Henriques BJ et al (2010) Emerging roles for riboflavin in functional rescue of mitochondrial beta-oxidation flavoenzymes. Curr Med Chem 17(32):3842–3854CrossRef
3.
Zurück zum Zitat Powers HJ, Corfe BM, Nakano E (2012) Riboflavin in development and cell fate. Subcell Biochem 56:229–245CrossRef Powers HJ, Corfe BM, Nakano E (2012) Riboflavin in development and cell fate. Subcell Biochem 56:229–245CrossRef
4.
Zurück zum Zitat Ross NS, Hansen TP (1992) Riboflavin deficiency is associated with selective preservation of critical flavoenzyme-dependent metabolic pathways. BioFactors 3(3):185–190 Ross NS, Hansen TP (1992) Riboflavin deficiency is associated with selective preservation of critical flavoenzyme-dependent metabolic pathways. BioFactors 3(3):185–190
5.
Zurück zum Zitat Rivlin RS (1970) Riboflavin metabolism. N Engl J Med 283(9):463–472CrossRef Rivlin RS (1970) Riboflavin metabolism. N Engl J Med 283(9):463–472CrossRef
6.
Zurück zum Zitat Powers HJ (2003) Riboflavin (vitamin B-2) and health. Am J Clin Nutr 77(6):1352–1360 Powers HJ (2003) Riboflavin (vitamin B-2) and health. Am J Clin Nutr 77(6):1352–1360
7.
Zurück zum Zitat FAO (2001) Human vitamin and mineral requirements. In: Report of a joint FAO/WHO expert consultation Bangkok, Thailand. Food and Nutrition Division, FAO, Rome FAO (2001) Human vitamin and mineral requirements. In: Report of a joint FAO/WHO expert consultation Bangkok, Thailand. Food and Nutrition Division, FAO, Rome
8.
Zurück zum Zitat Briani C et al (2013) Cobalamin deficiency: clinical picture and radiological findings. Nutrients 5(11):4521–4539CrossRef Briani C et al (2013) Cobalamin deficiency: clinical picture and radiological findings. Nutrients 5(11):4521–4539CrossRef
9.
Zurück zum Zitat Rosenblatt DS, Whitehead VM (1999) Cobalamin and folate deficiency: acquired and hereditary disorders in children. Semin Hematol 36(1):19–34 Rosenblatt DS, Whitehead VM (1999) Cobalamin and folate deficiency: acquired and hereditary disorders in children. Semin Hematol 36(1):19–34
10.
Zurück zum Zitat Whitehead VM (2006) Acquired and inherited disorders of cobalamin and folate in children. Br J Haematol 134(2):125–136CrossRef Whitehead VM (2006) Acquired and inherited disorders of cobalamin and folate in children. Br J Haematol 134(2):125–136CrossRef
11.
Zurück zum Zitat Fowler B, Leonard JV, Baumgartner MR (2008) Causes of and diagnostic approach to methylmalonic acidurias. J Inherit Metab Dis 31(3):350–360CrossRef Fowler B, Leonard JV, Baumgartner MR (2008) Causes of and diagnostic approach to methylmalonic acidurias. J Inherit Metab Dis 31(3):350–360CrossRef
12.
Zurück zum Zitat Monsen AL et al (2003) Cobalamin status and its biochemical markers methylmalonic acid and homocysteine in different age groups from 4 days to 19 years. Clin Chem 49(12):2067–2075CrossRef Monsen AL et al (2003) Cobalamin status and its biochemical markers methylmalonic acid and homocysteine in different age groups from 4 days to 19 years. Clin Chem 49(12):2067–2075CrossRef
13.
Zurück zum Zitat McNulty H et al (2008) Homocysteine, B-vitamins and CVD. Proc Nutr Soc 67(2):232–237CrossRef McNulty H et al (2008) Homocysteine, B-vitamins and CVD. Proc Nutr Soc 67(2):232–237CrossRef
14.
Zurück zum Zitat Debreceni B, Debreceni L (2014) The role of homocysteine-lowering B-vitamins in the primary prevention of cardiovascular disease. Cardiovasc Ther 32(3):130–138CrossRef Debreceni B, Debreceni L (2014) The role of homocysteine-lowering B-vitamins in the primary prevention of cardiovascular disease. Cardiovasc Ther 32(3):130–138CrossRef
15.
Zurück zum Zitat De Laet C et al (1999) Plasma homocysteine concentration in a Belgian school-age population. Am J Clin Nutr 69(5):968–972 De Laet C et al (1999) Plasma homocysteine concentration in a Belgian school-age population. Am J Clin Nutr 69(5):968–972
16.
Zurück zum Zitat Delvin EE et al (2000) Influence of methylenetetrahydrofolate reductase genotype, age, vitamin B-12, and folate status on plasma homocysteine in children. Am J Clin Nutr 72(6):1469–1473 Delvin EE et al (2000) Influence of methylenetetrahydrofolate reductase genotype, age, vitamin B-12, and folate status on plasma homocysteine in children. Am J Clin Nutr 72(6):1469–1473
17.
Zurück zum Zitat Bjorke-Monsen AL, Ueland PM (2011) Cobalamin status in children. J Inherit Metab Dis 34(1):111–119CrossRef Bjorke-Monsen AL, Ueland PM (2011) Cobalamin status in children. J Inherit Metab Dis 34(1):111–119CrossRef
18.
Zurück zum Zitat United States Department of Agriculture, Human Nutrition Information Service, Dietary Guidelines Advisory Committee, United States Agricultural Research Service (2010) Report of the Dietary Guidelines Advisory Committee on the dietary guidelines for Americans, 2010: to the Secretary of Agriculture and the Secretary of Health and Human Services, vol vi. United States Dept. of Agriculture, United States Dept. of Health and Human Services, Washington United States Department of Agriculture, Human Nutrition Information Service, Dietary Guidelines Advisory Committee, United States Agricultural Research Service (2010) Report of the Dietary Guidelines Advisory Committee on the dietary guidelines for Americans, 2010: to the Secretary of Agriculture and the Secretary of Health and Human Services, vol vi. United States Dept. of Agriculture, United States Dept. of Health and Human Services, Washington
19.
Zurück zum Zitat Moschonis G et al (2010) Social, economic and demographic correlates of overweight and obesity in primary-school children: preliminary data from the Healthy Growth Study. Public Health Nutr 13(10A):1693–1700CrossRef Moschonis G et al (2010) Social, economic and demographic correlates of overweight and obesity in primary-school children: preliminary data from the Healthy Growth Study. Public Health Nutr 13(10A):1693–1700CrossRef
20.
Zurück zum Zitat Tanner JM (1955) Growth at adolescence. Blackwell Scientific, Oxford, p 212 Tanner JM (1955) Growth at adolescence. Blackwell Scientific, Oxford, p 212
21.
Zurück zum Zitat Cole TJ et al (2007) Body mass index cut offs to define thinness in children and adolescents: international survey. BMJ 335(7612):194CrossRef Cole TJ et al (2007) Body mass index cut offs to define thinness in children and adolescents: international survey. BMJ 335(7612):194CrossRef
22.
Zurück zum Zitat Cole TJ et al (2000) Establishing a standard definition for child overweight and obesity worldwide: international survey. BMJ 320(7244):1240–1243CrossRef Cole TJ et al (2000) Establishing a standard definition for child overweight and obesity worldwide: international survey. BMJ 320(7244):1240–1243CrossRef
23.
Zurück zum Zitat Trichopoulou A (2004) Composition tables of foods and Greek dishes. Department of Hygiene and Epidemiology, School of MedicineG, Athens Trichopoulou A (2004) Composition tables of foods and Greek dishes. Department of Hygiene and Epidemiology, School of MedicineG, Athens
24.
Zurück zum Zitat National Research Council Subcommittee on Criteria for Dietary Evaluation (1986) Nutrient adequacy: assessment using food consumption surveys. National Academies Press, Washington National Research Council Subcommittee on Criteria for Dietary Evaluation (1986) Nutrient adequacy: assessment using food consumption surveys. National Academies Press, Washington
25.
Zurück zum Zitat Schofield WN (1985) Predicting basal metabolic rate, new standards and review of previous work. Hum Nutr Clin Nutr 39(Suppl 1):5–41 Schofield WN (1985) Predicting basal metabolic rate, new standards and review of previous work. Hum Nutr Clin Nutr 39(Suppl 1):5–41
26.
Zurück zum Zitat Goldberg GR et al (1991) Critical evaluation of energy intake data using fundamental principles of energy physiology: 1. Derivation of cut-off limits to identify under-recording. Eur J Clin Nutr 45(12):569–581 Goldberg GR et al (1991) Critical evaluation of energy intake data using fundamental principles of energy physiology: 1. Derivation of cut-off limits to identify under-recording. Eur J Clin Nutr 45(12):569–581
27.
Zurück zum Zitat Fauci AS et al (2008) Harrison’s principles of internal medicine, 17th edn. McGraw-Hill Medical, New York Fauci AS et al (2008) Harrison’s principles of internal medicine, 17th edn. McGraw-Hill Medical, New York
28.
Zurück zum Zitat Erdogan E et al (2010) Evaluation of reference intervals for methylmalonic acid in plasma/serum and urine. Clin Chim Acta 411(21–22):1827–1829CrossRef Erdogan E et al (2010) Evaluation of reference intervals for methylmalonic acid in plasma/serum and urine. Clin Chim Acta 411(21–22):1827–1829CrossRef
29.
Zurück zum Zitat Papandreou D et al (2006) Reference range of total serum homocysteine level and dietary indexes in healthy Greek schoolchildren aged 6–15 years. Br J Nutr 96(4):719–724 Papandreou D et al (2006) Reference range of total serum homocysteine level and dietary indexes in healthy Greek schoolchildren aged 6–15 years. Br J Nutr 96(4):719–724
30.
Zurück zum Zitat Rush EC et al (2009) Dietary patterns and vitamin B(12) status of migrant Indian preadolescent girls. Eur J Clin Nutr 63(4):585–587CrossRef Rush EC et al (2009) Dietary patterns and vitamin B(12) status of migrant Indian preadolescent girls. Eur J Clin Nutr 63(4):585–587CrossRef
31.
Zurück zum Zitat MacFarlane AJ, Shi Y, Greene-Finestone LS (2014) High-dose compared with low-dose vitamin B-12 supplement use is not associated with higher vitamin B-12 status in children, adolescents, and older adults. J Nutr 144(6):915–920CrossRef MacFarlane AJ, Shi Y, Greene-Finestone LS (2014) High-dose compared with low-dose vitamin B-12 supplement use is not associated with higher vitamin B-12 status in children, adolescents, and older adults. J Nutr 144(6):915–920CrossRef
32.
Zurück zum Zitat Hay G et al (2011) Folate and cobalamin status in relation to diet in healthy 2-y-old children. Am J Clin Nutr 93(4):727–735CrossRef Hay G et al (2011) Folate and cobalamin status in relation to diet in healthy 2-y-old children. Am J Clin Nutr 93(4):727–735CrossRef
33.
Zurück zum Zitat Enquobahrie DA et al (2012) Serum homocysteine and folate concentrations among a US cohort of adolescents before and after folic acid fortification. Public Health Nutr 15(10):1818–1826CrossRef Enquobahrie DA et al (2012) Serum homocysteine and folate concentrations among a US cohort of adolescents before and after folic acid fortification. Public Health Nutr 15(10):1818–1826CrossRef
35.
Zurück zum Zitat Oldham H, Roberts LJ, Young M (1945) Results of providing a liberally adequate diet to children in an institution; blood and urinary excretion studies before and after dietary improvement. J Pediatr 27:418–427CrossRef Oldham H, Roberts LJ, Young M (1945) Results of providing a liberally adequate diet to children in an institution; blood and urinary excretion studies before and after dietary improvement. J Pediatr 27:418–427CrossRef
36.
Zurück zum Zitat Drewnowski A (2011) The contribution of milk and milk products to micronutrient density and affordability of the US diet. J Am Coll Nutr 30(5 Suppl 1):422S–428SCrossRef Drewnowski A (2011) The contribution of milk and milk products to micronutrient density and affordability of the US diet. J Am Coll Nutr 30(5 Suppl 1):422S–428SCrossRef
37.
Zurück zum Zitat Coudray B (2011) The contribution of dairy products to micronutrient intakes in France. J Am Coll Nutr 30(5 Suppl 1):410S–414SCrossRef Coudray B (2011) The contribution of dairy products to micronutrient intakes in France. J Am Coll Nutr 30(5 Suppl 1):410S–414SCrossRef
38.
Zurück zum Zitat Dainty JR et al (2007) Quantification of the bioavailability of riboflavin from foods by use of stable-isotope labels and kinetic modeling. Am J Clin Nutr 85(6):1557–1564 Dainty JR et al (2007) Quantification of the bioavailability of riboflavin from foods by use of stable-isotope labels and kinetic modeling. Am J Clin Nutr 85(6):1557–1564
39.
Zurück zum Zitat USDA (2014) United States Department of Agriculture and National Agricultural Library. Standard Reference Database USDA (2014) United States Department of Agriculture and National Agricultural Library. Standard Reference Database
40.
Zurück zum Zitat Institute of Medicine (US) Standing Committee on the Scientific Evaluation of Dietary Reference Intakes and its Panel on Folate Other B Vitamins and Choline (1998) Dietary reference intakes for thiamin, riboflavin, niacin, vitamin B6, folate, vitamin B12, pantothenic acid, biotin, and choline. National Academies Press, Washington Institute of Medicine (US) Standing Committee on the Scientific Evaluation of Dietary Reference Intakes and its Panel on Folate Other B Vitamins and Choline (1998) Dietary reference intakes for thiamin, riboflavin, niacin, vitamin B6, folate, vitamin B12, pantothenic acid, biotin, and choline. National Academies Press, Washington
41.
Zurück zum Zitat Manios Y et al (2015) Food group and micronutrient intake adequacy among children, adults and elderly women in Greece. Nutrients 7(3):1841–1858CrossRef Manios Y et al (2015) Food group and micronutrient intake adequacy among children, adults and elderly women in Greece. Nutrients 7(3):1841–1858CrossRef
42.
Zurück zum Zitat Lutsey PL et al (2006) Serum homocysteine is related to food intake in adolescents: the Child and Adolescent Trial for Cardiovascular Health. Am J Clin Nutr 83(6):1380–1386 Lutsey PL et al (2006) Serum homocysteine is related to food intake in adolescents: the Child and Adolescent Trial for Cardiovascular Health. Am J Clin Nutr 83(6):1380–1386
43.
Zurück zum Zitat Berstad P et al (2007) Dietary fat and plasma total homocysteine concentrations in 2 adult age groups: the Hordaland Homocysteine Study. Am J Clin Nutr 85(6):1598–1605 Berstad P et al (2007) Dietary fat and plasma total homocysteine concentrations in 2 adult age groups: the Hordaland Homocysteine Study. Am J Clin Nutr 85(6):1598–1605
44.
Zurück zum Zitat Makarewicz-Wujec M, Kozlowska-Wojciechowska M (2011) Nutrient intake and serum level of gamma-glutamyltransferase, MCP-1 and homocysteine in early stages of heart failure. Clin Nutr 30(1):73–78CrossRef Makarewicz-Wujec M, Kozlowska-Wojciechowska M (2011) Nutrient intake and serum level of gamma-glutamyltransferase, MCP-1 and homocysteine in early stages of heart failure. Clin Nutr 30(1):73–78CrossRef
45.
Zurück zum Zitat Tucker KL et al (2000) Plasma vitamin B-12 concentrations relate to intake source in the Framingham Offspring study. Am J Clin Nutr 71(2):514–522 Tucker KL et al (2000) Plasma vitamin B-12 concentrations relate to intake source in the Framingham Offspring study. Am J Clin Nutr 71(2):514–522
46.
Zurück zum Zitat Vogiatzoglou A et al (2009) Dietary sources of vitamin B-12 and their association with plasma vitamin B-12 concentrations in the general population: the Hordaland Homocysteine Study. Am J Clin Nutr 89(4):1078–1087CrossRef Vogiatzoglou A et al (2009) Dietary sources of vitamin B-12 and their association with plasma vitamin B-12 concentrations in the general population: the Hordaland Homocysteine Study. Am J Clin Nutr 89(4):1078–1087CrossRef
47.
Zurück zum Zitat Jacques PF et al (2002) The relationship between riboflavin and plasma total homocysteine in the Framingham Offspring cohort is influenced by folate status and the C677T transition in the methylenetetrahydrofolate reductase gene. J Nutr 132(2):283–288 Jacques PF et al (2002) The relationship between riboflavin and plasma total homocysteine in the Framingham Offspring cohort is influenced by folate status and the C677T transition in the methylenetetrahydrofolate reductase gene. J Nutr 132(2):283–288
48.
Zurück zum Zitat Green R (2011) Indicators for assessing folate and vitamin B-12 status and for monitoring the efficacy of intervention strategies. Am J Clin Nutr 94(2):666S–672SCrossRef Green R (2011) Indicators for assessing folate and vitamin B-12 status and for monitoring the efficacy of intervention strategies. Am J Clin Nutr 94(2):666S–672SCrossRef
49.
Zurück zum Zitat Klee GG (2000) Cobalamin and folate evaluation: measurement of methylmalonic acid and homocysteine vs vitamin B(12) and folate. Clin Chem 46(8 Pt 2):1277–1283 Klee GG (2000) Cobalamin and folate evaluation: measurement of methylmalonic acid and homocysteine vs vitamin B(12) and folate. Clin Chem 46(8 Pt 2):1277–1283
Metadaten
Titel
Vitamin B2, vitamin B12 and total homocysteine status in children and their associations with dietary intake of B-vitamins from different food groups: the Healthy Growth Study
verfasst von
Yannis Manios
George Moschonis
Renske Dekkers
Christina Mavrogianni
Eva Grammatikaki
Ellen van den Heuvel
Publikationsdatum
29.10.2015
Verlag
Springer Berlin Heidelberg
Erschienen in
European Journal of Nutrition / Ausgabe 1/2017
Print ISSN: 1436-6207
Elektronische ISSN: 1436-6215
DOI
https://doi.org/10.1007/s00394-015-1082-z

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