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European Journal of Nutrition

Erschienen in:

26.12.2015 | Original Contribution

Postnatal high-fat diet enhances ectopic fat deposition in pigs with intrauterine growth retardation

verfasst von: Honglin Yan, Ping Zheng, Bing Yu, Jie Yu, Xiangbing Mao, Jun He, Zhiqing Huang, Daiwen Chen

Erschienen in: European Journal of Nutrition | Ausgabe 2/2017

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Abstract

Objectives

Intrauterine growth retardation (IUGR) and postnatal nutrition are risk factors for adult metabolic syndrome. However, the influences of long-term high-fat diet (HFD) intake on ectopic fat deposition in non-adipose tissues in IUGR pigs remain unclear. The present study was to determine whether HFD consumption would enhance ectopic fat deposition in IUGR pigs.

Methods

At day 28, IUGR and control pigs were fed ad libitum to either a regular diet or a HFD. Lipid store, enzymatic activities and mRNA expression of lipid metabolism-related factors in liver and semitendinosus muscle (SM) were quantified at postnatal day 178.

Results

Feeding a HFD to IUGR pigs but not to control pigs significantly increased daily weight gain, carcass fat mass, plasma leptin level and lipid content and lipoprotein lipase (LPL) activity and mRNA abundances of LPL and peroxisome proliferator-activated receptor gamma (PPARγ) in liver and SM, but decreased daily feed intake and mRNA expression of hormone-sensitive lipase (LIPE) and carnitine palmitoyl transferase-1 (CPT-1) in liver and SM (P < 0.05). Compared with control pigs, IUGR pigs had a lower body weight but higher plasma levels of total cholesterol (TC) and insulin (P < 0.05). HFD-fed pigs exhibited greater body weight, plasma concentrations of triglyceride (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C), regardless of birth weight (P < 0.05).

Conclusion

Our results suggested that IUGR increased the vulnerability of HFD-fed pigs to ectopic fat deposition via enhanced fatty acid flux toward ectopic sites and reduced lipolysis and fatty acid oxidation.

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Titel: Postnatal high-fat diet enhances ectopic fat deposition in pigs with intrauterine growth retardation
verfasst von: Honglin Yan
Ping Zheng
Bing Yu
Jie Yu
Xiangbing Mao
Jun He
Zhiqing Huang
Daiwen Chen
Publikationsdatum: 26.12.2015
Verlag: Springer Berlin Heidelberg
Erschienen in: European Journal of Nutrition / Ausgabe 2/2017
Print ISSN: 1436-6207
Elektronische ISSN: 1436-6215
DOI: https://doi.org/10.1007/s00394-015-1093-9

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Postnatal high-fat diet enhances ectopic fat deposition in pigs with intrauterine growth retardation

Abstract

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Methods

Results

Conclusion

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