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18.02.2016 | Original Contribution

Dietary antioxidant capacity and all-cause and cause-specific mortality in the E3N/EPIC cohort study

verfasst von: Nadia Bastide, Laureen Dartois, Valérie Dyevre, Laure Dossus, Guy Fagherazzi, Mauro Serafini, Marie-Christine Boutron-Ruault

Erschienen in: European Journal of Nutrition | Ausgabe 3/2017

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Abstract

Purpose

The cellular oxidative stress (balance between pro-oxidant and antioxidant) may be a major risk factor for chronic diseases. Antioxidant capacity of human diet can be globally assessed through the dietary non-enzymatic antioxidant capacity (NEAC). Our aim was to investigate the relationship between the NEAC and all-cause and cause-specific mortality, and to test potential interactions with smoking status, a well-known pro-oxidant factor.

Methods

Among the French women of the E3N prospective cohort study initiated in 1990, including 4619 deaths among 1,199,011 persons-years of follow-up. A validated dietary history questionnaire assessed usual food intake; NEAC intake was estimated using a food composition table from two different methods: ferric ion reducing antioxidant power (FRAP) and total radical-trapping antioxidant parameter (TRAP). Hazard ratio (HR) estimates and 95 % confidence intervals (CI) were derived from Cox proportional hazards regression models.

Results

In multivariate analyses, FRAP dietary equivalent intake was inversely associated with mortality from all-causes (HR for the fourth vs. the first quartile: HR₄ = 0.75, 95 % CI 0.67, 0.83, p _trend < 0.0001), cancer, and cardiovascular diseases. Similar results were obtained with TRAP. There was an interaction between NEAC dietary equivalent intake and smoking status for all-cause and cardiovascular disease mortality, but not cancer mortality (respectively, for FRAP, p _inter = 0.002; 0.013; 0.113, results were similar with TRAP), and the association was the strongest among current smokers.

Conclusion

This prospective cohort study highlights the importance of antioxidant consumption for mortality prevention, especially among current smokers.

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Titel: Dietary antioxidant capacity and all-cause and cause-specific mortality in the E3N/EPIC cohort study
verfasst von: Nadia Bastide
Laureen Dartois
Valérie Dyevre
Laure Dossus
Guy Fagherazzi
Mauro Serafini
Marie-Christine Boutron-Ruault
Publikationsdatum: 18.02.2016
Verlag: Springer Berlin Heidelberg
Erschienen in: European Journal of Nutrition / Ausgabe 3/2017
Print ISSN: 1436-6207
Elektronische ISSN: 1436-6215
DOI: https://doi.org/10.1007/s00394-016-1172-6

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Dietary antioxidant capacity and all-cause and cause-specific mortality in the E3N/EPIC cohort study

Abstract

Purpose

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Results

Conclusion

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