nach oben

Erschienen in:

22.05.2019 | Review

Association of vitamin K with cardiovascular events and all-cause mortality: a systematic review and meta-analysis

verfasst von: Heng-Gui Chen, Li-Ting Sheng, Yan-Bo Zhang, An-Lan Cao, Yu-Wei Lai, Setor K. Kunutsor, Limiao Jiang, An Pan

Erschienen in: European Journal of Nutrition | Ausgabe 6/2019

Einloggen, um Zugang zu erhalten

Abstract

Purpose

We conducted a meta-analysis to systematically assess the prospective association between vitamin K and cardiovascular disease (CVD) events and all-cause mortality.

Methods

We searched PubMed and EMBASE through January 2019 for prospective studies that reported the association of vitamin K (assessed by dietary intake or circulating concentration) with CVD events [including total CVD, CVD mortality, total coronary heart disease (CHD), fatal CHD, nonfatal myocardial infarction (MI), and stroke] and all-cause mortality. Multivariable-adjusted hazard ratios (HRs) comparing top versus bottom tertiles of vitamin K were combined using random-effects meta-analysis.

Results

Twenty-one articles were included with 222,592 participants. A significant association was found between dietary phylloquinone and total CHD (pooled HR 0.92; 95% CI 0.84, 0.99; I² = 0%; four studies), as well as menaquinone and total CHD (0.70; 95% CI 0.53, 0.93; I² = 32.1%; two studies). No significant association was observed between dietary vitamin K and all-cause mortality, CVD mortality, or stroke. Elevated plasma desphospho-uncarboxylated MGP (dp-ucMGP), a marker of vitamin K deficiency, was associated with an increased risk of all-cause mortality (1.84; 95% CI 1.48, 2.28; I² = 16.8%; five studies) and CVD mortality (1.96; 95% CI 1.47, 2.61; I² = 0%; two studies). No significant association was observed between circulating total osteocalcin and all-cause mortality or total CVD.

Conclusions

Our findings showed that higher dietary vitamin K consumption was associated with a moderately lower risk of CHD, and higher plasma dp-ucMGP concentration, but not total circulating osteocalcin, was associated with increased risks of all-cause and CVD mortality. However, causal relations cannot be established because of limited number of available studies, and larger prospective studies and randomized clinical trials are needed to validate the findings.

Nur mit Berechtigung zugänglich

GBD 2016 Disease and Injury Incidence and Prevalence Collaborators (2017) Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet 390(10100):1211–1259. https://doi.org/10.1016/S0140-6736(17)32154-2 CrossRef

Pan A, Lin X, Hemler E, Hu FB (2018) Diet and cardiovascular disease: advances and challenges in population-based studies. Cell Metab 27(3):489–496. https://doi.org/10.1016/j.cmet.2018.02.017 CrossRefPubMedPubMedCentral

Du H, Li L, Bennett D, Guo Y, Key TJ, Bian Z, Sherliker P, Gao H, Chen Y, Yang L, Chen J, Wang S, Du R, Su H, Collins R, Peto R, Chen Z, China Kadoorie Biobank S (2016) Fresh fruit consumption and major cardiovascular disease in China. N Engl J Med 374(14):1332–1343. https://doi.org/10.1056/NEJMoa1501451 CrossRefPubMedPubMedCentral

Wang X, Ouyang Y, Liu J, Zhu M, Zhao G, Bao W, Hu FB (2014) Fruit and vegetable consumption and mortality from all causes, cardiovascular disease, and cancer: systematic review and dose-response meta-analysis of prospective cohort studies. BMJ 349:g4490. https://doi.org/10.1136/bmj.g4490 CrossRefPubMedPubMedCentral

Scarborough P, Morgan R, Webster P, Rayner M (2011) Differences in coronary heart disease, stroke and cancer mortality rates between England, Wales, Scotland and Northern Ireland: the role of diet and nutrition. BMJ Open 1(1):e000263. https://doi.org/10.1136/bmjopen-2011-000263 CrossRefPubMedPubMedCentral

Schurgers LJ, Vermeer C (2000) Determination of phylloquinone and menaquinones in food. Effect of food matrix on circulating vitamin K concentrations. Haemostasis 30(6):298–307. https://doi.org/10.1159/000054147 CrossRefPubMed

Shearer MJ (1995) Vitamin K. Lancet 345(8944):229–234CrossRefPubMed

Furie B, Bouchard BA, Furie BC (1999) Vitamin K-dependent biosynthesis of gamma-carboxyglutamic acid. Blood 93(6):1798–1808PubMed

Dalmeijer GW, van der Schouw YT, Vermeer C, Magdeleyns EJ, Schurgers LJ, Beulens JWJ (2013) Circulating matrix Gla protein is associated with coronary artery calcification and vitamin K status in healthy women. J Nutr Biochem 24(4):624–628. https://doi.org/10.1016/j.jnutbio.2012.02.012 CrossRefPubMed

10.

Shea MK, Booth SL (2016) Concepts and controversies in evaluating vitamin K status in population-based studies. Nutrients 8:8. https://doi.org/10.3390/nu8010008 CrossRefPubMedCentral

11.

Cranenburg EC, Koos R, Schurgers LJ, Magdeleyns EJ, Schoonbrood TH, Landewe RB, Brandenburg VM, Bekers O, Vermeer C (2010) Characterisation and potential diagnostic value of circulating matrix Gla protein (MGP) species. Thromb Haemost 104(4):811–822. https://doi.org/10.1160/TH09-11-0786 CrossRefPubMed

12.

Rees K, Guraewal S, Wong YL, Majanbu DL, Mavrodaris A, Stranges S, Kandala NB, Clarke A, Franco OH (2010) Is vitamin K consumption associated with cardio-metabolic disorders? A systematic review. Maturitas 67(2):121–128. https://doi.org/10.1016/j.maturitas.2010.05.006 CrossRefPubMed

13.

Hartley L, Clar C, Ghannam O, Flowers N, Stranges S, Rees K (2015) Vitamin K for the primary prevention of cardiovascular disease. Cochrane Database Syst Rev 9:CD011148. https://doi.org/10.1002/14651858.CD011148.pub2 CrossRef

14.

Harshman SG, Shea MK (2016) The role of vitamin K in chronic aging diseases: inflammation, cardiovascular disease, and osteoarthritis. Curr Nutr Rep 5(2):90–98. https://doi.org/10.1007/s13668-016-0162-x CrossRefPubMedPubMedCentral

15.

Zhang S, Guo L, Bu C (2019) Vitamin K status and cardiovascular events or mortality: a meta-analysis. Eur J Prev Cardiol 26:549–553. https://doi.org/10.1177/2047487318808066 CrossRefPubMed

16.

Moher D, Liberati A, Tetzlaff J, Altman D (2009) Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med 6(7):e1000097CrossRefPubMedPubMedCentral

17.

Wells GA, Shea B, O’Connell D, Peterson J, Welch V, Losos M, Tugwell P (2012) The Newcastle-Ottawa Scale (NOS) for assessing the quality if nonrandomized studies in meta-analyses. http://www.ohri.ca/programs/clinical_epidemiology/oxford.asp (cited 1 June 2018)

18.

Danesh J, Collins R, Appleby P, Peto R (1998) Association of fibrinogen, C-reactive protein, albumin, or leukocyte count with coronary heart disease: meta-analyses of prospective studies. JAMA 279(18):1477–1482. https://doi.org/10.1001/jama.279.18.1477 CrossRefPubMed

19.

Chêne G, Thompson SG (1996) Methods for summarizing the risk associations of quantitative variables in epidemiologic studies in a consistent form. Am J Epidemiol 144(6):610–621. https://doi.org/10.1093/oxfordjournals.aje.a008971 CrossRefPubMed

20.

Combettes E, Mazoit JX, Benhamou D, Beloeil H (2015) Modelling of vitamin K half-life in patients treated with vitamin K antagonists before hip fracture surgery. Anaesth Crit Care Pain Med 34(5):295–299. https://doi.org/10.1016/j.accpm.2015.06.003 CrossRefPubMed

21.

Higgins JP, Thompson SG, Deeks JJ, Altman DG (2003) Measuring inconsistency in meta-analyses. BMJ 327(7414):557–560. https://doi.org/10.1136/bmj.327.7414.557 CrossRefPubMedPubMedCentral

22.

Geleijnse JM, Vermeer C, Grobbee DE, Schurgers LJ, Knapen MH, van der Meer IM, Hofman A, Witteman JC (2004) Dietary intake of menaquinone is associated with a reduced risk of coronary heart disease: the Rotterdam Study. J Nutr 134(11):3100–3105. https://doi.org/10.1093/jn/134.11.3100 CrossRef

23.

Erkkila AT, Booth SL, Hu FB, Jacques PF, Manson JE, Rexrode KM, Stampfer MJ, Lichtenstein AH (2005) Phylloquinone intake as a marker for coronary heart disease risk but not stroke in women. Eur J Clin Nutr 59(2):196–204. https://doi.org/10.1038/sj.ejcn.1602058 CrossRefPubMed

24.

Erkkila AT, Booth SL, Hu FB, Jacques PF, Lichtenstein AH (2007) Phylloquinone intake and risk of cardiovascular diseases in men. Nutr Metab Cardiovasc Dis 17(1):58–62. https://doi.org/10.1016/j.numecd.2006.03.008 CrossRefPubMed

25.

Gast GC, de Roos NM, Sluijs I, Bots ML, Beulens JW, Geleijnse JM, Witteman JC, Grobbee DE, Peeters PH, van der Schouw YT (2009) A high menaquinone intake reduces the incidence of coronary heart disease. Nutr Metab Cardiovasc Dis 19(7):504–510. https://doi.org/10.1016/j.numecd.2008.10.004 CrossRef

26.

Vissers LE, Dalmeijer GW, Boer JM, Monique Verschuren WM, van der Schouw YT, Beulens JW (2013) Intake of dietary phylloquinone and menaquinones and risk of stroke. J Am Heart Assoc 2(6):e000455. https://doi.org/10.1161/jaha.113.000455 CrossRefPubMedPubMedCentral

27.

Juanola-Falgarona M, Salas-Salvado J, Martinez-Gonzalez MA, Corella D, Estruch R, Ros E, Fito M, Aros F, Gomez-Gracia E, Fiol M, Lapetra J, Basora J, Lamuela-Raventos RM, Serra-Majem L, Pinto X, Munoz MA, Ruiz-Gutierrez V, Fernandez-Ballart J, Bullo M (2014) Dietary intake of vitamin K is inversely associated with mortality risk. J Nutr 144(5):743–750. https://doi.org/10.3945/jn.113.187740 CrossRefPubMed

28.

Zwakenberg SR, den Braver NR, Engelen AI, Feskens EJ, Vermeer C, Boer JM, Verschuren WM, van der Schouw YT, Beulens JW (2016) Vitamin K intake and all-cause and cause specific mortality. Clin Nutr 36(5):1294–1300. https://doi.org/10.1016/j.clnu.2016.08.017 CrossRefPubMed

29.

Ueland T, Gullestad L, Dahl CP, Aukrust P, Aakhus S, Solberg OG, Vermeer C, Schurgers LJ (2010) Undercarboxylated matrix Gla protein is associated with indices of heart failure and mortality in symptomatic aortic stenosis. J Intern Med 268(5):483–492. https://doi.org/10.1111/j.1365-2796.2010.02264.x CrossRefPubMed

30.

Schurgers LJ, Barreto DV, Barreto FC, Liabeuf S, Renard C, Magdeleyns EJ, Vermeer C, Choukroun G, Massy ZA (2010) The circulating inactive form of matrix Gla protein is a surrogate marker for vascular calcification in chronic kidney disease: a preliminary report. Clin J Am Soc Nephrol 5:568–575. https://doi.org/10.2215/cjn.07081009 CrossRefPubMedPubMedCentral

31.

Dalmeijer GW, van der Schouw YT, Magdeleyns EJ, Vermeer C, Verschuren WM, Boer JM, Beulens JW (2013) Matrix Gla protein species and risk of cardiovascular events in type 2 diabetic patients. Diabetes Care 36(11):3766–3771. https://doi.org/10.2337/dc13-0065 CrossRefPubMedPubMedCentral

32.

van den Heuvel EG, van Schoor NM, Lips P, Magdeleyns EJ, Deeg DJ, Vermeer C, den Heijer M (2014) Circulating uncarboxylated matrix Gla protein, a marker of vitamin K status, as a risk factor of cardiovascular disease. Maturitas 77(2):137–141. https://doi.org/10.1016/j.maturitas.2013.10.008 CrossRefPubMed

33.

Dalmeijer GW, van der Schouw YT, Magdeleyns EJ, Vermeer C, Verschuren WM, Boer JM, Beulens JW (2014) Circulating desphospho-uncarboxylated matrix gamma-carboxyglutamate protein and the risk of coronary heart disease and stroke. J Thromb Haemost 12(7):1028–1034. https://doi.org/10.1111/jth.12609 CrossRefPubMed

34.

Keyzer CA, Vermeer C, Joosten MM, Knapen MH, Drummen NE, Navis G, Bakker SJ, de Borst MH (2015) Vitamin K status and mortality after kidney transplantation: a cohort study. Am J Kidney Dis 65(3):474–483. https://doi.org/10.1053/j.ajkd.2014.09.014 CrossRefPubMed

35.

Mayer O Jr, Seidlerova J, Vanek J, Karnosova P, Bruthans J, Filipovsky J, Wohlfahrt P, Cifkova R, Windrichova J, Knapen MH, Drummen NE, Vermeer C (2016) The abnormal status of uncarboxylated matrix Gla protein species represents an additional mortality risk in heart failure patients with vascular disease. Int J Cardiol 203:916–922. https://doi.org/10.1016/j.ijcard.2015.10.226 CrossRefPubMed

36.

Zwakenberg SR, van der Schouw YT, Vermeer C, Pasterkamp G, den Ruijter HM, Beulens JWJ (2018) Matrix Gla protein, plaque stability, and cardiovascular events in patients with severe atherosclerotic disease. Cardiology 141:32–36. https://doi.org/10.1159/000493006 CrossRefPubMedPubMedCentral

37.

Yeap BB, Chubb SA, Flicker L, McCaul KA, Ebeling PR, Hankey GJ, Beilby JP, Norman PE (2012) Associations of total osteocalcin with all-cause and cardiovascular mortality in older men. The Health In Men Study. Osteoporos Int 23:599–606. https://doi.org/10.1007/s00198-011-1586-1 CrossRefPubMed

38.

Yamashita T, Okano K, Tsuruta Y, Akiba T, Nitta K (2013) Serum osteocalcin levels are useful as a predictor of cardiovascular events in maintenance hemodialysis patients. Int Urol Nephrol 45:207–214. https://doi.org/10.1007/s11255-012-0156-6 CrossRefPubMed

39.

Holvik K, van Schoor NM, Eekhoff EM, den Heijer M, Deeg DJ, Lips P, de Jongh R (2014) Plasma osteocalcin levels as a predictor of cardiovascular disease in older men and women: a population-based cohort study. Eur J Endocrinol 171:161–170. https://doi.org/10.1530/eje-13-1044 CrossRefPubMed

40.

Hwang YC, Kang M, Cho IJ, Jeong IK, Ahn KJ, Chung HY, Lee MK (2015) Association between the circulating total osteocalcin level and the development of cardiovascular disease in middle-aged men: a mean 8.7-year longitudinal follow-up study. J Atheroscler Thromb 22:136–143. https://doi.org/10.5551/jat.25718 CrossRefPubMed

41.

Miyake H, Kanazawa I, Sugimoto T (2018) Association of bone mineral density, bone turnover markers, and vertebral fractures with all-cause mortality in type 2 diabetes mellitus. Calcif Tissue Int 102:1–13. https://doi.org/10.1007/s00223-017-0324-x CrossRefPubMed

42.

Zwakenberg SR, van der Schouw YT, Schalkwijk CG, Spijkerman AMW, Beulens JWJ (2018) Bone markers and cardiovascular risk in type 2 diabetes patients. Cardiovasc Diabetol 17:45. https://doi.org/10.1186/s12933-018-0691-2 CrossRefPubMedPubMedCentral

43.

Cheung CL, Sahni S, Cheung BM, Sing CW, Wong IC (2015) Vitamin K intake and mortality in people with chronic kidney disease from NHANES III. Clin Nutr 34(2):235–240. https://doi.org/10.1016/j.clnu.2014.03.011 CrossRefPubMed

44.

Liu YP, Gu YM, Thijs L, Knapen MH, Salvi E, Citterio L, Petit T, Carpini SD, Zhang Z, Jacobs L, Jin Y, Barlassina C, Manunta P, Kuznetsova T, Verhamme P, Struijker-Boudier HA, Cusi D, Vermeer C, Staessen JA (2015) Inactive matrix Gla protein is causally related to adverse health outcomes: a Mendelian randomization study in a Flemish population. Hypertension 65(2):463–470. https://doi.org/10.1161/hypertensionaha.114.04494 CrossRefPubMed

45.

Riphagen IJ, Keyzer CA, Drummen NEA, de Borst MH, Beulens JWJ, Gansevoort RT, Geleijnse JM, Muskiet FAJ, Navis G, Visser ST, Vermeer C, Kema IP, Bakker SJL (2017) Prevalence and effects of functional vitamin K insufficiency: the PREVEND Study. Nutrients 9(12):1334. https://doi.org/10.3390/nu9121334 CrossRefPubMedCentral

46.

Shea MK, Booth SL, Weiner DE, Brinkley TE, Kanaya AM, Murphy RA, Simonsick EM, Wassel CL, Vermeer C, Kritchevsky SB (2017) Circulating vitamin K is inversely associated with incident cardiovascular disease risk among those treated for hypertension in the Health, Aging, and Body Composition Study (Health ABC). J Nutr 147(5):888–895. https://doi.org/10.1161/strokeaha.117.01720610.3945/jn.117.249375 CrossRefPubMedPubMedCentral

47.

Guo J, Astrup A, Lovegrove JA, Gijsbers L, Givens DI, Soedamah-Muthu SS (2017) Milk and dairy consumption and risk of cardiovascular diseases and all-cause mortality: dose-response meta-analysis of prospective cohort studies. Eur J Epidemiol 32:269–287. https://doi.org/10.1007/s10654-017-0243-1 CrossRefPubMedPubMedCentral

48.

Rong Y, Chen L, Zhu T, Song Y, Yu M, Shan Z, Sands A, Hu FB, Liu L (2013) Egg consumption and risk of coronary heart disease and stroke: dose-response meta-analysis of prospective cohort studies. BMJ 346:e8539. https://doi.org/10.1136/bmj.e8539 CrossRefPubMedPubMedCentral

49.

Bechthold A, Boeing H, Schwedhelm C, Hoffmann G, Knuppel S, Iqbal K, De Henauw S, Michels N, Devleesschauwer B, Schlesinger S, Schwingshackl L (2019) Food groups and risk of coronary heart disease, stroke and heart failure: a systematic review and dose-response meta-analysis of prospective studies. Crit Rev Food Sci Nutr 59:1071–1090. https://doi.org/10.1080/10408398.2017.1392288 CrossRefPubMed

50.

Holick CN, Michaud DS, Stolzenberg-Solomon R, Mayne ST, Pietinen P, Taylor PR, Virtamo J, Albanes D (2002) Dietary carotenoids, serum beta-carotene, and retinol and risk of lung cancer in the alpha-tocopherol, beta-carotene cohort study. Am J Epidemiol 156(6):536–547. https://doi.org/10.1093/aje/kwf072 CrossRefPubMed

51.

Dietary Assessment Primer (2016) Food frequency questionnaire at a Glance. National Cancer Institute, National Institutes of Health. https://dietassessmentprimer.cancer.gov/profiles/questionnaire/ (cited 1 June 2018)

52.

Lawlor DA, Smith GD, Bruckdorfer KR, Kundu D, Ebrahim S (2004) Those confounded vitamins: what can we learn from the differences between observational versus randomised trial evidence? Lancet 363(9422):1724–1727. https://doi.org/10.1016/s0140-6736(04)16260-0 CrossRefPubMed

53.

Pan A, Chen M, Chowdhury R, Wu JH, Sun Q, Campos H, Mozaffarian D, Hu FB (2012) alpha-Linolenic acid and risk of cardiovascular disease: a systematic review and meta-analysis. Am J Clin Nutr 96(6):1262–1273. https://doi.org/10.3945/ajcn.112.044040 CrossRefPubMedPubMedCentral

54.

Jones KS, Bluck LJ, Wang LY, Coward WA (2008) A stable isotope method for the simultaneous measurement of vitamin K₁ (phylloquinone) kinetics and absorption. Eur J Clin Nutr 62(11):1273–1281. https://doi.org/10.1038/sj.ejcn.1602859 CrossRefPubMed

55.

van Ballegooijen AJ, Beulens JW (2017) The role of vitamin K status in cardiovascular health: evidence from observational and clinical studies. Curr Nutr Rep 6:197–205. https://doi.org/10.1007/s13668-017-0208-8 CrossRefPubMedPubMedCentral

56.

EFSA NDA Panel (EFSA Panel on Dietetic Products, Nutrition and Allergies), Turck D, Bresson JL, Burlingame B, Dean T, Fairweather-Tait S, Heinonen M, Hirsch-Ernst KI, Mangelsdorf I, McArdle HJ, Naska A, Nowicka G, Pentieva K, Sanz Y, Siani A, Sjodin A, Stern M, Tome D, Van Loveren H, Vinceti M, Willatts P, Lamberg-Allardt C, Przyrembel H, Tetens I, Dumas C, Fabiani L, Ioannidou S, Neuhauser-Berthold M, Nutr EPDP (2017) Scientific Opinion on the dietary reference values for vitamin K. EFSA J 15(5):4780. https://doi.org/10.2903/j.efsa.2017.4780 CrossRef

57.

Shea MK, O’Donnell CJ, Hoffmann U, Dallal GE, Dawson-Hughes B, Ordovas JM, Price PA, Williamson MK, Booth SL (2009) Vitamin K supplementation and progression of coronary artery calcium in older men and women. Am J Clin Nutr 89(6):1799–1807. https://doi.org/10.3945/ajcn.2008.27338 CrossRefPubMedPubMedCentral

58.

Knapen MH, Braam LA, Drummen NE, Bekers O, Hoeks AP, Vermeer C (2015) Menaquinone-7 supplementation improves arterial stiffness in healthy postmenopausal women. A double-blind randomised clinical trial. Thromb Haemost 113(5):1135–1144. https://doi.org/10.1160/TH14-08-0675 CrossRefPubMed

59.

Schurgers LJ, Uitto J, Reutelingsperger CP (2013) Vitamin K-dependent carboxylation of matrix Gla-protein: a crucial switch to control ectopic mineralization. Trends Mol Med 19(4):217–226. https://doi.org/10.1016/j.molmed.2012.12.008 CrossRefPubMed

60.

Cranenburg EC, Schurgers LJ, Vermeer C (2007) Vitamin K: the coagulation vitamin that became omnipotent. Thromb Haemost 98(1):120–125. https://doi.org/10.1160/TH07-04-0266 CrossRefPubMed

61.

Spronk HM, Soute BA, Schurgers LJ, Thijssen HH, De Mey JG, Vermeer C (2003) Tissue-specific utilization of menaquinone-4 results in the prevention of arterial calcification in warfarin-treated rats. J Vasc Res 40(6):531–537. https://doi.org/10.1159/000075344 CrossRefPubMed

62.

Tsugawa N (2015) Cardiovascular diseases and fat soluble vitamins: vitamin D and vitamin K. J Nutr Sci Vitaminol (Tokyo) 61(Suppl):S170–S172. https://doi.org/10.3177/jnsv.61.S170 CrossRef

Titel: Association of vitamin K with cardiovascular events and all-cause mortality: a systematic review and meta-analysis
verfasst von: Heng-Gui Chen
Li-Ting Sheng
Yan-Bo Zhang
An-Lan Cao
Yu-Wei Lai
Setor K. Kunutsor
Limiao Jiang
An Pan
Publikationsdatum: 22.05.2019
Verlag: Springer Berlin Heidelberg
Erschienen in: European Journal of Nutrition / Ausgabe 6/2019
Print ISSN: 1436-6207
Elektronische ISSN: 1436-6215
DOI: https://doi.org/10.1007/s00394-019-01998-3

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Neu im Fachgebiet Innere Medizin

19.04.2024 | Vorhofflimmern | Nachrichten

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Association of vitamin K with cardiovascular events and all-cause mortality: a systematic review and meta-analysis

Abstract

Purpose

Methods

Results

Conclusions

Leitlinien kompakt für die Innere Medizin

Neu im Fachgebiet Innere Medizin

Parodontalbehandlung verbessert Prognose bei Katheterablation

Antihypertensiva schützen auch alte Menschen noch vor Demenz

Stereotaktische Radiatio schlägt konventionelle Bestrahlung

Denken Sie bei starker Blutung auch an die Hemmkörper-Hämophilie

Update Innere Medizin

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusions

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 6/2019

Gallic acid, a common dietary phenolic protects against high fat diet induced DNA damage

Determinants of successful lifestyle change during a 6-month preconception lifestyle intervention in women with obesity and infertility

Iodine status in Norwegian preschool children and associations with dietary iodine sources: the FINS-KIDS study

Healthier diet quality and dietary patterns are associated with lower risk of mobility limitation in older men

Acute and residual effects of aerobic exercise on fructose-induced postprandial lipemia on lean male subjects

High intake of dietary fibre from fruit and vegetables reduces the risk of hospitalisation for diverticular disease

Leitlinien kompakt für die Innere Medizin

Neu im Fachgebiet Innere Medizin

Parodontalbehandlung verbessert Prognose bei Katheterablation

Antihypertensiva schützen auch alte Menschen noch vor Demenz

Stereotaktische Radiatio schlägt konventionelle Bestrahlung

Denken Sie bei starker Blutung auch an die Hemmkörper-Hämophilie

Update Innere Medizin