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Basic Research in Cardiology

Erschienen in:

01.05.2011 | Invited Review

Stem cell-based therapies in ischemic heart diseases: a focus on aspects of microcirculation and inflammation

verfasst von: Junxi Wu, Jun Li, Nannan Zhang, Cuihua Zhang

Erschienen in: Basic Research in Cardiology | Ausgabe 3/2011

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Abstract

Stem cells possessing the potential to replace damaged myocardium with functional myocytes have drawn increasing attention in the past decade in treating ischemic heart diseases; these diseases are the leading cause of morbidity and mortality in the world. The adult heart has recently been shown to contain a few cardiac stem cells (CSCs) that, in theory, suggest cardiac repair following acute myocardial infarction is possible if the CSC titer could be increased. Stem cell-based therapies, including hematopoietic stem cells and mesenchymal stem cells, were proven to be marginal and transitional. Multiple factors and mechanisms, rather than direct cardiac regeneration are involved in stem cell-mediated cardiac functional improvement. This review will focus on (1) the interaction between inflammation and stem cells; (2) the fate of stem cells at the microcirculatory level, and their subsequent influences on stem cell-based therapies.

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Titel: Stem cell-based therapies in ischemic heart diseases: a focus on aspects of microcirculation and inflammation
verfasst von: Junxi Wu
Jun Li
Nannan Zhang
Cuihua Zhang
Publikationsdatum: 01.05.2011
Verlag: Springer-Verlag
Erschienen in: Basic Research in Cardiology / Ausgabe 3/2011
Print ISSN: 0300-8428
Elektronische ISSN: 1435-1803
DOI: https://doi.org/10.1007/s00395-011-0168-x

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Stem cell-based therapies in ischemic heart diseases: a focus on aspects of microcirculation and inflammation

Abstract

Neu im Fachgebiet Kardiologie

Wie erfolgreich ist eine Re-Ablation nach Rezidiv?

Europäische Ernährungsgewohnheiten: Das sind die häufigsten Fehler

Parodontalbehandlung verbessert Prognose bei Katheterablation

Antihypertensiva schützen auch alte Menschen noch vor Demenz

Update Kardiologie

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

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