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Erschienen in: Basic Research in Cardiology 5/2012

01.09.2012 | Original Contribution

Release of a humoral circulating cardioprotective factor by remote ischemic preconditioning is dependent on preserved neural pathways in diabetic patients

verfasst von: Rebekka Vibjerg Jensen, Nicolaj Brejnholt Støttrup, Steen Buus Kristiansen, Hans Erik Bøtker

Erschienen in: Basic Research in Cardiology | Ausgabe 5/2012

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Abstract

Efficacy of ischemic preconditioning is decreased in animal models of type 2 diabetes mellitus while the responses in humans with diabetes are contradictory. It is unknown whether attenuation is related to decreased release of a mediating humoral cardioprotective factor or reduced ability to respond in the target tissue. The aim of the present study was to investigate the release and effect of a circulating cardioprotective factor in type 2 diabetes mellitus patients. Blood samples were drawn from nine non-diabetic subjects, eight diabetic patients without peripheral neuropathy, and eight diabetic patients with peripheral neuropathy before (control) and after a remote ischemic preconditioning (rIPC) stimulus. Blood samples were dialyzed against Krebs–Henseleit buffer and the cardioprotective effects of the dialysates were tested in rabbit hearts mounted on a Langendorff model and subjected to 30-min global ischemia and 120-min reperfusion. rIPC dialysate from non-diabetic and diabetic subjects without peripheral neuropathy reduced infarct size and improved hemodynamic recovery compared to control dialysate from non-diabetic and diabetic subjects. However, in the subgroup of diabetic patients with neuropathy the cardioprotective effect was attenuated. These findings indicate that the release mechanism involves neural pathways.
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Metadaten
Titel
Release of a humoral circulating cardioprotective factor by remote ischemic preconditioning is dependent on preserved neural pathways in diabetic patients
verfasst von
Rebekka Vibjerg Jensen
Nicolaj Brejnholt Støttrup
Steen Buus Kristiansen
Hans Erik Bøtker
Publikationsdatum
01.09.2012
Verlag
Springer-Verlag
Erschienen in
Basic Research in Cardiology / Ausgabe 5/2012
Print ISSN: 0300-8428
Elektronische ISSN: 1435-1803
DOI
https://doi.org/10.1007/s00395-012-0285-1

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