nach oben

Basic Research in Cardiology

Erschienen in:

01.09.2013 | Original Contribution

Diazoxide postconditioning induces mitochondrial protein S-Nitrosylation and a redox-sensitive mitochondrial phosphorylation/translocation of RISK elements: no role for SAFE

verfasst von: C. Penna, M.-G. Perrelli, F. Tullio, C. Angotti, A. Camporeale, V. Poli, P. Pagliaro

Erschienen in: Basic Research in Cardiology | Ausgabe 5/2013

Einloggen, um Zugang zu erhalten

Abstract

Postconditioning (PostC) can be obtained either with brief cycles of ischemia/reperfusion (I-PostC) or with a direct targeting of mitochondria with Diazoxide (pharmacological PostC, P-PostC). I-PostC may induce the activation of RISK and SAFE pathways and may favor nitric oxide production with S-Nitrosylation of proteins and redox signaling. It is not clear whether Diazoxide can lead to similar effects. We compared the effects of I-PostC and P-PostC on (a) kinases of RISK- and SAFE pathway, (b) S-Nitrosylation of mitochondrial proteins and (c) reduction of death signals (PKCδ, cleaved caspase-3 and Beclin-1) in cytosolic and mitochondrial fractions. Isolated rat hearts underwent (1) perfusion without ischemia (Sham), (2) ischemia/reperfusion (30-min ischemia plus 2-h reperfusion), (3) I-PostC (5 intermittent cycles of 10-s reperfusion and 10-s ischemia immediately after the 30-min ischemia), (4) P-PostC (Diazoxide 30 μM in the first of 3-min of reperfusion) or (5) I-PostC + MPG or P-PostC + MPG (MPG, 2-mercaptopropionylglycine 300 μM). Using Western blot and biotin switch assay, we found that P-PostC induced a redox sensible phosphorylation/translocation of Akt, ERK1/2 and GSK3β into the mitochondria, but not of phospho-STAT3, which was translocated into the mitochondria by I-PostC only. Either I-PostC or P-PostC increased mitochondrial S-Nitrosylated proteins (e.g., VDAC) and reduced the levels of phospho-PKCδ, cleaved caspase-3 and Beclin-1. Therefore, direct targeting of mitochondria with Diazoxide (a) activates the RISK pathway via a redox signaling, (b) favors discrete mitochondrial protein S-Nitrosylation, including VDAC and (c) decreases signals of death. Intriguingly, phospho-STAT3 translocation is induced by I-PostC, but not by P-PostC, thus suggesting a redox-independent mechanism in the SAFE pathway.

Ahmad N, Wang Y, Haider KH, Wang B, Pasha Z, Uzun O, Ashraf M (2006) Cardiac protection by mitoK_ATP channels is dependent on Akt translocation from cytosol to mitochondria during late preconditioning. Am J Physiol Heart Circ Physiol 290:H2402–H2408. doi:10.1152/ajpheart.00737.2005 PubMedCrossRef

Angelone T, Quintieri AM, Pasqua T, Gentile S, Tota B, Mahata SK, Cerra MC (2012) Phosphodiesterase type-2 and NO-dependent S-nitrosylation mediate the cardioinhibition of the antihypertensive catestatin. Am J Physiol Heart Circ Physiol 302:H431–H442. doi:10.1152/ajpheart.00491.2011 PubMedCrossRef

Argaud L, Gateau-Roesch O, Augeul L, Couture-Lepetit E, Loufouat J, Gomez L, Robert D, Ovize M (2008) Increased mitochondrial calcium coexists with decreased reperfusion injury in postconditioned (but not preconditioned) hearts. Am J Physiol Heart Circ Physiol 294:H386–H391. doi:10.1152/ajpheart.01035.2007 PubMedCrossRef

Arrell DK, Elliott ST, Kane LA, Guo Y, Ko YH, Pedersen PL, Robinson J, Murata M, Murphy AM, Marbán E, Van Eyk JE (2006) Proteomic analysis of pharmacological preconditioning: novel protein targets converge to mitochondrial metabolism pathways. Circ Res 99:706–714. doi:10.1161/01.RES.0000243995.74395.f8 PubMedCrossRef

Bijur GN, Jope RS (2003) Rapid accumulation of Akt in mitochondria following phosphatidylinositol 3-kinase activation. J Neurochem 87:1427–1435. doi:10.1046/j.1471-4159.2003.02113.x PubMedCrossRef

Boengler K, Buechert A, Heinen Y, Roeskes C, Hilfiker-Kleiner D, Heusch G, Schulz R (2008) Cardioprotection by ischemic postconditioning is lost in aged and STAT3-deficient mice. Circ Res 102:131–135. doi:10.1161/CIRCRESAHA.107.164699 PubMedCrossRef

Boengler K, Heusch G, Schulz R (2011) Mitochondria in postconditioning. Antioxid Redox Signal 14:863–880. doi:10.1089/ars.2010.3309 PubMedCrossRef

Boengler K, Heusch G, Schulz R (2011) Nuclear-encoded mitochondrial proteins and their role in cardioprotection. Biochim Biophys Acta 1813:194–1286. doi:10.1016/j.bbamcr.2011.01.009 CrossRef

Boengler K, Hilfiker-Kleiner D, Heusch G, Schulz R (2010) Inhibition of permeability transition pore opening by mitochondrial STAT3 and its role in myocardial ischemia/reperfusion. Basic Res Cardiol 105:771–785. doi:10.1007/s00395-010-0124-1 PubMedCrossRef

10.

Boengler K, Konietzka I, Buechert A, Heinen Y, Garcia-Dorado D, Heusch G, Schulz R (2007) Loss of ischemic preconditioning’s cardioprotection in aged mouse hearts is associated with reduced gap junctional and mitochondrial levels of connexin 43. Am J Physiol Heart Circ Physiol 292:H1764–H1769. doi:10.1152/ajpheart.01071.2006 PubMedCrossRef

11.

Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein—dye binding. Anal Biochem 7:248–254CrossRef

12.

Budas GR, Churchill EN, Disatnik MH, Sun L, Mochly-Rosen D (2010) Mitochondrial import of PKCepsilon is mediated by HSP90: a role in cardioprotection from ischaemia and reperfusion injury. Cardiovasc Res 88:83–92. doi:10.1093/cvr/cvq180 PubMedCrossRef

13.

Carré M, André N, Carles G, Borghi H, Brichese L, Briand C, Braguer D (2002) Tubulin is an inherent component of mitochondrial membranes that interacts with the voltage-dependent anion channel. J Biol Chem 277:33664–33669. doi:10.1074/jbc.M203834200 PubMedCrossRef

14.

Carroll R, Gant VA, Yellon DM (2001) Mitochondrial K_ATP channels protects a human atrial-derived cell line by a mechanism involving free radical generation. Cardiovasc Res 51:691–700. doi:10.1016/S0008-6363(01)00330-3 PubMedCrossRef

15.

Churchill EN, Mochly-Rosen D (2007) The roles of PKCdelta and epsilon isoenzymes in the regulation of myocardial ischaemia/reperfusion injury. Biochem Soc Trans 35:1040–1042. doi:10.1042/BST0351040 PubMedCrossRef

16.

Churchill EN, Szweda LI (2005) Translocation of deltaPKC to mitochondria during cardiac reperfusion enhances superoxide anion production and induces loss in mitochondrial function. Arch Biochem Biophys 439:194–199. doi:10.1016/j.abb.2005.05.007 PubMedCrossRef

17.

Cohen MV, Downey JM (2011) Ischemic postconditioning: from receptor to end-effector. Antioxid Redox Signal 14:821–831. doi:10.1089/ars.2010.3318 PubMedCrossRef

18.

Cohen MV, Yang XM, Downey JM (2007) The pH hypothesis of postconditioning: staccato reperfusion reintroduces oxygen and perpetuates myocardial acidosis. Circulation 115:1895–1903. doi:10.1161/CIRCULATIONAHA.106.675710 PubMedCrossRef

19.

Costa AD, Garlid KD, West IC, Lincoln TM, Downey JM, Cohen MV, Critz SD (2005) Protein kinase G transmits the cardioprotective signal from cytosol to mitochondria. Circ Res 97:329–336. doi:10.1161/01.RES.0000178451.08719.5b PubMedCrossRef

20.

Crow MT, Mani K, Nam YJ, Kitsis RN (2004) The mitochondrial death pathway and cardiac myocyte apoptosis. Circ Res 95:957–970. doi:10.1161/01.RES.0000148632.35500.d9 PubMedCrossRef

21.

Danial NN, Korsmeyer SJ (2004) Cell death: critical control points. Cell 116:205–219. doi:10.1016/S0092-8674(04)00046-7 PubMedCrossRef

22.

Darling CE, Jiang R, Maynard M, Whittaker P, Vinten-Johansen J, Przyklenk K (2005) Postconditioning via stuttering reperfusion limits myocardial infarct size in rabbit hearts: role of ERK1/2. Am J Physiol Heart Circ Physiol 289:H1618–H1626. doi:10.1152/ajpheart PubMedCrossRef

23.

Dayoub H, Achan V, Adimoolam S, Jacobi J, Stuehlinger MC, Wang BY, Tsao PS, Kimoto M, Vallance P, Patterson AJ, Cooke JP (2003) Dimethylarginine dimethylaminohydrolase regulates nitric oxide synthesis: genetic and physiological evidence. Circulation 108:3042–3047. doi:10.1161/01.CIR.0000101924.04515.2E PubMedCrossRef

24.

Di Lisa F, Canton M, Carpi A, Kaludercic N, Menabò R, Menazza S, Semenzato M (2011) Mitochondrial injury and protection in ischemic pre- and postconditioning. Antioxid Redox Signal 14:881–891. doi:10.1089/ars.2010.3375 PubMedCrossRef

25.

Downey JM, Cohen MV (2006) A really radical observation—a comment on Penna et al. in Basic Res Cardiol (2006) 101:180–189. Basic Res Cardiol 101:190–191. doi:10.1007/s00395-006-0586-3 PubMedCrossRef

26.

Filice E, Angelone T, De Francesco EM, Pellegrino D, Maggiolini M, Cerra MC (2011) Crucial role of phospholamban phosphorylation and S-nitrosylation in the negative lusitropism induced by 17β-estradiol in the male rat heart. Cell Physiol Biochem 28:41–52. doi:10.1159/000331712 PubMedCrossRef

27.

Forbes RA, Steenbergen C, Murphy E (2001) Diazoxide-induced cardioprotection requires signaling through a redox-sensitive mechanism. Circ Res 88:802–809. doi:10.1161/hh0801.089342 PubMedCrossRef

28.

Fryer RM, Pratt PF, Hsu AK, Gross GJ (2001) Differential activation of extracellular signal regulated kinase isoforms in preconditioning and opioid-induced cardioprotection. J Pharmacol Exp Ther 296:642–649PubMed

29.

Gucek M, Murphy E (2010) What can we learn about cardioprotection from the cardiac mitochondrial proteome? Cardiovasc Res 88:211–218. doi:10.1093/cvr/cvq277 PubMedCrossRef

30.

Hansson CA, Frykman S, Farmery MR, Tjernberg LO, Nilsberth C, Pursglove SE, Ito A, Winblad B, Cowburn RF, Thyberg J, Ankarcrona M (2004) Nicastrin, presenilin, APH-1, and PEN-2 form active gamma-secretase complexes in mitochondria. J Biol Chem 279:51654–51660. doi:10.1074/jbc.M404500200 PubMedCrossRef

31.

Harada N, Miura T, Dairaku Y, Kametani R, Shibuya M, Wang R, Kawamura S, Matsuzaki M (2004) NO donor-activated PKC-delta plays a pivotal role in ischemic myocardial protection through accelerated opening of mitochondrial K-ATP channels. J Cardiovasc Pharmacol 44:35–41. doi:10.1097/00005344-200407000-00005 PubMedCrossRef

32.

Hausenloy D, Wynne A, Duchen M, Yellon D (2004) Transient mitochondrial permeability transition pore opening mediates preconditioning induced protection. Circulation 109:1714–1717. doi:10.1161/01.CIR.0000126294.81407.7D PubMedCrossRef

33.

Hausenloy DJ, Baxter G, Bell R, Bøtker HE, Davidson SM, Downey J, Heusch G, Kitakaze M, Lecour S, Mentzer R, Mocanu MM, Ovize M, Schulz R, Shannon R, Walker M, Walkinshaw G, Yellon DM (2010) Translating novel strategies for cardioprotection: the Hatter Workshop Recommendations. Basic Res Cardiol 105:677–686. doi:10.1007/s00395-010-0121-4 PubMedCrossRef

34.

Hausenloy DJ, Lecour S, Yellon DM (2011) Reperfusion injury salvage kinase and survivor activating factor enhancement prosurvival signaling pathways in ischemic postconditioning: two sides of the same coin. Antioxid Redox Signal 14:893–907. doi:10.1089/ars.2010.3360 PubMedCrossRef

35.

Hausenloy DJ, Ong SB, Yellon DM (2009) The mitochondrial permeability transition pore as a target for preconditioning and postconditioning. Basic Res Cardiol 104:189–202. doi:10.1007/s00395-009-0010-x PubMedCrossRef

36.

Hausenloy DJ, Yellon DM (2006) Survival kinases in ischemic preconditioning and postconditioning. Cardiovasc Res 70:240–253. doi:10.1016/j.cardiores.2006.01.017 PubMedCrossRef

37.

Heinzel FR, Luo Y, Li X, Boengler K, Buechert A, García-Dorado D, Di Lisa F, Schulz R, Heusch G (2005) Impairment of diazoxide-induced formation of reactive oxygen species and loss of cardioprotection in connexin 43 deficient mice. Circ Res 97:583–586. doi:10.1161/01.RES.0000181171.65293.65 PubMedCrossRef

38.

Heusch G, Boengler K, Schulz R (2010) Inhibition of mitochondrial permeability transition pore opening: the Holy Grail of cardioprotection. Basic Res Cardiol 105:151–154. doi:10.1007/s00395-009-0080-9 PubMedCrossRef

39.

Heusch G, Musiolik J, Gedik N, Skyschally A (2011) Mitochondrial STAT3 activation and cardioprotection by ischemic postconditioning in pigs with regional myocardial ischemia/reperfusion. Circ Res 109:1302–1308. doi:10.1161/CIRCRESAHA.111.255604 PubMedCrossRef

40.

Heusch G, Musiolik J, Kottenberg E, Peters J, Jakob H, Thielmann M (2012) STAT5 activation and cardioprotection by remote ischemic preconditioning in humans: short communication. Circ Res 110:111–115. doi:10.1161/CIRCRESAHA.111.259556 PubMedCrossRef

41.

Heusch G (2004) Postconditioning: old wine in a new bottle? J Am Coll Cardiol 44:1111–1112. doi:10.1016/j.jacc.2004.06.013 PubMedCrossRef

42.

Heusch G (2012) Reduction of infarct size by ischaemic post-conditioning in humans: fact or fiction? Eur Heart J 33:13–15. doi:10.1007/s00059-008-3101-9 PubMedCrossRef

43.

Hilfiker-Kleiner D, Hilfiker A, Fuchs M, Kaminski K, Schaefer A, Schieffer B, Hillmer A, Schmiedl A, Ding Z, Podewski E, Podewski E, Poli V, Schneider MD, Schulz R, Park JK, Wollert KC, Drexler H (2004) Signal transducer and activator of transcription 3 is required for myocardial capillary growth, control of interstitial matrix deposition, and heart protection from ischemic injury. Circ Res 95:187–195. doi:10.1161/01.RES.0000134921.50377.61 PubMedCrossRef

44.

Hofstaetter B, Taimor G, Inserte J, Garcia-Dorado D, Piper HM (2002) Inhibition of apoptotic responses after ischemic stress in isolated hearts and cardiomyocytes. Basic Res Cardiol 97:479–488. doi:10.1007/s003950200053 PubMedCrossRef

45.

Ikeno F, Inagaki K, Rezaee M, Mochly-Rosen D (2007) Impaired perfusion after myocardial infarction is due to reperfusion-induced deltaPKC-mediated myocardial damage. Cardiovasc Res 73:699–709. doi:10.1016/j.cardiores.2006.12.011 PubMedCrossRef

46.

Ivanes F, Rioufol G, Piot C, Ovize M (2011) Postconditioning in acute myocardial infarction patients. Antioxid Redox Signal 14:811–820. doi:10.1089/ars.2010.3354 PubMedCrossRef

47.

Jaffrey SR, Snyder SH (2001) The biotin switch method for the detection of S-nitrosylated proteins. Sci STKE 86:PL1. doi:10.1126/stke.2001.86.pl1

48.

Kimura T, Horibe T, Sakamoto C, Shitara Y, Fujiwara F, Komiya T, Yamamoto A, Hayano T, Takahashi N, Kikuchi M (2008) Evidence for mitochondrial localization of P5, a member of the protein disulphide isomerase family. J Biochem 144:187–196. doi:10.1093/jb/mvn057 PubMedCrossRef

49.

Lacerda L, Somers S, Opie LH, Lecour S (2009) Ischaemic postconditioning protects against reperfusion injury via the SAFE pathway. Cardiovasc Res 84:201–208. doi:10.1093/cvr/cvp274 PubMedCrossRef

50.

Lai HC, Liu TJ, Ting CT, Sharma PM, Wang PH (2003) Insulin-like growth factor-1 prevents loss of electrochemical gradient in cardiac muscle mitochondria via activation of PI3kinase/Akt pathway. Mol Cell Endocrinol 205:99–106. doi:10.1016/S0303-7207(03)00200-4 PubMedCrossRef

51.

Li H, Xiao YB, Gao YQ, Yang TD (2006) Comparative proteomics analysis of differentially expressed phosphoproteins in adult rat ventricular myocytes subjected to diazoxide preconditioning. Drug Metabol Drug Interact 21:245–258PubMedCrossRef

52.

Liu H, McPherson BC, Yao Z (2001) Preconditioning attenuates apoptosis and necrosis: role of protein kinase C epsilon and -delta isoforms. Am J Physiol Heart Circ Physiol 281:H404–H410PubMed

53.

Malorni W, Farrace MG, Matarrese P, Tinari A, Ciarlo L, Mousavi-Shafaei P, D’Eletto M, Di Giacomo G, Melino G, Palmieri L, Rodolfo C, Piacentini M (2009) The adenine nucleotide translocator 1 acts as a type 2 transglutaminase substrate: implications for mitochondrial-dependent apoptosis. Cell Death Differ 16:1480–1492. doi:10.1038/cdd.2009.100 PubMedCrossRef

54.

Matsui Y, Takagi H, Qu X, Abdellatif M, Sakoda H, Asano T, Levine B, Sadoshima J (2007) Distinct roles of autophagy in the heart during ischemia and reperfusion: roles of AMP-activated protein kinase and Beclin 1 in mediating autophagy. Circ Res 100:914–922. doi:10.1161/01.RES.0000261924.76669.36 PubMedCrossRef

55.

Miyamoto S, Murphy AN, Brown JH (2009) Akt mediated mitochondrial protection in the heart: metabolic and survival pathways to the rescue. J Bioenerg Biomembr 41:169–180. doi:10.1007/s10863-009-9205-y PubMedCrossRef

56.

Murphy E, Steenbergen C (2007) Preconditioning: the mitochondrial connection. Annu Rev Physiol 69:51–67. doi:10.1146/annurev.physiol.69.031905.163645 PubMedCrossRef

57.

Murray CI, Kane LA, Uhrigshardt H, Wang SB, Van Eyk JE (2011) Site-mapping of in vitro S-nitrosation in cardiac mitochondria: implications for cardioprotection. Mol Cell Proteomics 10:M110.004721. doi:10.1074/mcp.M110.004721 PubMedCrossRef

58.

Murriel CL, Mochly-Rosen D (2003) Opposing roles of delta and epsilon PKC in cardiac ischemia and reperfusion: targeting the apoptotic machinery. Arch Biochem Biophys 420:246–254. doi:10.1016/j.abb.2003.08.038 PubMedCrossRef

59.

Neupert W, Brunner M (2002) The protein import motor of mitochondria. Nat Rev Mol Cell Biol 3:555–565. doi:10.1038/nrm878 PubMedCrossRef

60.

Nguyen T, Wong R, Wang G, Gucek M, Steenbergen C, Murphy E (2012) Acute inhibition of GSK causes mitochondrial remodeling. Am J Physiol Heart Circ Physiol 302:H2439–H2445. doi:10.1152/ajpheart.00033.2012 PubMedCrossRef

61.

Pagliaro P, Mancardi D, Rastaldo R, Penna C, Gattullo D, Miranda KM, Feelisch M, Wink DA, Kass DA, Paolocci N (2003) Nitroxyl affords thiol-sensitive myocardial protective effects akin to early preconditioning. Free Radic Biol Med 34:33–43. doi:10.1016/S0891-5849(02)01179-6 PubMedCrossRef

62.

Pagliaro P, Moro F, Tullio F, Perrelli MG, Penna C (2011) Cardioprotective pathways during reperfusion: focus on redox signaling and other modalities of cell signaling. Antioxid Redox Signal 14:833–850. doi:10.1089/ars.2010.3245 PubMedCrossRef

63.

Penna C, Cappello S, Mancardi D, Raimondo S, Rastaldo R, Gattullo D, Losano G, Pagliaro P (2006) Post-conditioning reduces infarct size in the isolated rat heart: role of coronary flow and pressure and the nitric oxide/cGMP pathway. Basic Res Cardiol 101:168–179. doi:10.1007/s00395-005-0543-6 PubMedCrossRef

64.

Penna C, Mancardi D, Raimondo S, Geuna S, Pagliaro P (2008) The paradigm of postconditioning to protect the heart. J Cell Mol Med 12:435–458. doi:10.1111/j.1582-4934.2007.00210.x PubMedCrossRef

65.

Penna C, Mancardi D, Rastaldo R, Losano G, Pagliaro P (2007) Intermittent activation of bradykinin B₂ receptors and mitochondrial K_ATP channels trigger cardiac postconditioning through redox signaling. Cardiovasc Res 75:168–177. doi:10.1016/j.cardiores.2007.03.001 PubMedCrossRef

66.

Penna C, Perrelli MG, Pagliaro P (2013) Mitochondrial pathways, permeability transition pore, and redox signaling in cardioprotection: therapeutic implications. Antioxid Redox Signal 18:556–599. doi:10.1089/ars.2011.4459 PubMedCrossRef

67.

Penna C, Perrelli MG, Raimondo S, Tullio F, Merlino A, Moro F, Geuna S, Mancardi D, Pagliaro P (2009) Postconditioning induces an anti-apoptotic effect and preserves mitochondrial integrity in isolated rat hearts. Biochim Biophys Acta 1787:794–801. doi:10.1016/j.bbabio.2009.03.013 PubMedCrossRef

68.

Penna C, Perrelli MG, Tullio F, Moro F, Parisella ML, Merlino A, Pagliaro P (2011) Post-ischemic early acidosis in cardiac postconditioning modifies the activity of antioxidant enzymes, reduces nitration, and favors protein S-nitrosylation. Pflugers Arch 462:219–233. doi:10.4330/wjc.v3.i6.186 PubMedCrossRef

69.

Penna C, Rastaldo R, Mancardi D, Raimondo S, Cappello S, Gattullo D, Losano G, Pagliaro P (2006) Post-conditioning induced cardioprotection requires signaling through a redox-sensitive mechanism, mitochondrial ATP-sensitive K⁺ channel and protein kinase C activation. Basic Res Cardiol 101:180–189. doi:10.1007/s00395-006-0584-5 PubMedCrossRef

70.

Perrelli MG, Pagliaro P, Penna C (2011) Ischemia/reperfusion injury and cardioprotective mechanisms: role of mitochondria and reactive oxygen species. World J Cardiol 3:186–200. doi:10.4330/wjc.v3.i6.186 PubMedCrossRef

71.

Rodriguez-Sinovas A, Boengler K, Cabestrero A, Gres P, Morente M, Ruiz-Meana M, Konietzka I, Miró E, Totzeck A, Heusch G, Schulz R, Garcia-Dorado D (2006) Translocation of connexin 43 to the inner mitochondrial membrane of cardiomyocytes through the heat shock protein 90-dependent TOM pathway and its importance for cardioprotection. Circ Res 99:93–101. doi:10.1161/01.RES.0000230315.56904.de PubMedCrossRef

72.

Sanada S, Komuro I, Kitakaze M (2011) Pathophysiology of myocardial reperfusion injury: preconditioning, postconditioning, and translational aspects of protective measures. Am J Physiol Heart Circ Physiol 301:H1723–H1741. doi:10.1152/ajpheart.00553.2011 PubMedCrossRef

73.

Sánchez JA, Rodríguez-Sinovas A, Barba I, Miró-Casas E, Fernández-Sanz C, Ruiz-Meana M, Alburquerque-Béjar JJ, García-Dorado D (2013) Activation of RISK and SAFE pathways is not involved in the effects of Cx43 deficiency on tolerance to ischemia-reperfusion injury and preconditioning protection. Basic Res Cardiol 108:351. doi:10.1007/s00395-013-0351-3 PubMedCrossRef

74.

Sasaki K, Sato M, Umezawa Y (2003) Fluorescent indicators for Akt/protein kinase B and dynamics of Akt activity visualized in living cells. J Biol Chem 278:30945–30951. doi:10.1074/jbc.M212167200 PubMedCrossRef

75.

Sivaraman V, Mudalagiri NR, Di Salvo C, Kolvekar S, Hayward M, Yap J, Keogh B, Hausenloy DJ, Yellon DM (2007) Postconditioning protects human atrial muscle through the activation of the RISK pathway. Basic Res Cardiol 102:453–459. doi:10.1007/s00395-007-0664-1 PubMedCrossRef

76.

Skyschally A, Schulz R, Heusch G (2008) Pathophysiology of myocardial infarction: protection by ischemic pre- and postconditioning. Herz 33:88–100. doi:10.1007/s00059-008-3101-9 PubMedCrossRef

77.

Skyschally A, van Caster P, Boengler K, Gres P, Musiolik J, Schilawa D, Heusch G, Schulz R (2009) Ischemic postconditioning in pigs: no causal role for RISK activation. Circ Res 104:15–18. doi:10.1161/CIRCRESAHA.108.186429 PubMedCrossRef

78.

Skyschally A, van Caster P, Iliodromitis EK, Schulz R, Kremastinos DT, Heusch G (2009) Ischemic postconditioning: experimental models and protocol algorithms. Basic Res Cardiol 104:469–483. doi:10.1007/s00395-009-0040-4 PubMedCrossRef

79.

Somers SJ, Frias M, Lacerda L, Opie LH, Lecour S (2012) Interplay between SAFE and RISK pathways in sphingosine-1-phosphate-induced cardioprotection. Cardiovasc Drugs Ther 26:227–237. doi:10.1007/s10557-012-6376-2 PubMedCrossRef

80.

Steenbergen C, Das S, Su J, Wong R, Murphy E (2009) Cardioprotection and altered mitochondrial adenine nucleotide transport. Basic Res Cardiol 104:149–156. doi:10.1007/s00395-009-0002-x PubMedCrossRef

81.

Sun HY, Wang NP, Halkos M, Kerendi F, Kin H, Guyton RA, Vinten-Johansen J, Zhao ZQ (2006) Postconditioning attenuates cardiomyocyte apoptosis via inhibition of JNK and p38 mitogen-activated protein kinase signaling pathways. Apoptosis 11:1583–1593. doi:10.1007/s10495-006-9037-8 PubMedCrossRef

82.

Sun J, Murphy E (2010) Protein S-nitrosylation and cardioprotection. Circ Res 106:285–296. doi:10.1161/CIRCRESAHA.109.209452 PubMedCrossRef

83.

Sun J, Picht E, Ginsburg KS, Bers DM, Steenbergen C, Murphy E (2006) Hypercontractile female hearts exhibit increased S-nitrosylation of the L-type Ca²⁺ Channel α1 subunit and reduced Ischemia/Reperfusion Injury. Circ Res 98:403–411. doi:10.1161/01.RES.0000202707.79018.0a PubMedCrossRef

84.

Tsutsumi YM, Yokoyama T, Horikawa Y, Roth DM, Patel HH (2007) Reactive oxygen species trigger ischemic and pharmacological postconditioning: in vivo and in vitro characterization. Life Sci 81:1223–1227. doi:10.1016/j.lfs.2007.08.031 PubMedCrossRef

85.

Wegrzyn J, Potla R, Chwae YJ, Sepuri NB, Zhang Q, Koeck T, Derecka M, Szczepanek K, Szelag M, Gornicka A, Moh A, Moghaddas S, Chen Q, Bobbili S, Cichy J, Dulak J, Baker DP, Wolfman A, Stuehr D, Hassan MO, Fu XY, Avadhani N, Drake JI, Fawcett P, Lesnefsky EJ, Larner AC (2009) Function of mitochondrial Stat3 in cellular respiration. Science 323:793–797. doi:10.1126/science.1164551 PubMedCrossRef

86.

Yang BK, Vivas EX, Reiter CD, Gladwin MT (2003) Methodologies for the sensitive and specific measurement of S-nitrosothiols, iron-nitrosyls, and nitrite in biological samples. Free Radic Res 37:1–10. doi:10.1080/1071576021000033112 PubMedCrossRef

87.

Yang XM, Philipp S, Downey JM, Cohen MV (2005) Postconditioning’s protection is not dependent on circulating blood factors or cells but involves adenosine receptors and requires PI3-kinase and guanylyl cyclase activation. Basic Res Cardiol 100:57–63. doi:10.1007/s00395-004-0498-4 PubMedCrossRef

88.

Yellon DM, Hausenloy DJ (2007) Myocardial reperfusion injury. N Engl J Med 357:1121–1135. doi:10.1056/NEJMra071667 PubMedCrossRef

89.

Zhao ZQ, Corvera JS, Halkos ME, Kerendi F, Wang NP, Guyton RA, Vinten-Johansen J (2003) Inhibition of myocardial injury by ischemic postconditioning during reperfusion: comparison with ischemic preconditioning. Am J Physiol Heart Circ Physiol 285:H579–H588. doi:10.1152/ajpheart.01064.2002 PubMed

Titel: Diazoxide postconditioning induces mitochondrial protein S-Nitrosylation and a redox-sensitive mitochondrial phosphorylation/translocation of RISK elements: no role for SAFE
verfasst von: C. Penna
M.-G. Perrelli
F. Tullio
C. Angotti
A. Camporeale
V. Poli
P. Pagliaro
Publikationsdatum: 01.09.2013
Verlag: Springer Berlin Heidelberg
Erschienen in: Basic Research in Cardiology / Ausgabe 5/2013
Print ISSN: 0300-8428
Elektronische ISSN: 1435-1803
DOI: https://doi.org/10.1007/s00395-013-0371-z

Neu im Fachgebiet Kardiologie

23.04.2024 | Ablationstherapie | Nachrichten

Update Kardiologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Diazoxide postconditioning induces mitochondrial protein S-Nitrosylation and a redox-sensitive mitochondrial phosphorylation/translocation of RISK elements: no role for SAFE

Abstract

Neu im Fachgebiet Kardiologie

Wie erfolgreich ist eine Re-Ablation nach Rezidiv?

Europäische Ernährungsgewohnheiten: Das sind die häufigsten Fehler

Parodontalbehandlung verbessert Prognose bei Katheterablation

Antihypertensiva schützen auch alte Menschen noch vor Demenz

Update Kardiologie

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 5/2013

A distinct subgroup of cardiomyopathy patients characterized by transcriptionally active cardiotropic erythrovirus and altered cardiac gene expression

Remote ischaemic preconditioning involves signalling through the SDF-1α/CXCR4 signalling axis

Notch1 cardioprotection in myocardial ischemia/reperfusion involves reduction of oxidative/nitrative stress

Contribution of electromechanical coupling between KV and CaV1.2 channels to coronary dysfunction in obesity

Cyclosporine A at reperfusion fails to reduce infarct size in the in vivo rat heart

Fibronectin contributes to pathological cardiac hypertrophy but not physiological growth

Neu im Fachgebiet Kardiologie

Wie erfolgreich ist eine Re-Ablation nach Rezidiv?

Europäische Ernährungsgewohnheiten: Das sind die häufigsten Fehler

Parodontalbehandlung verbessert Prognose bei Katheterablation

Antihypertensiva schützen auch alte Menschen noch vor Demenz

Update Kardiologie