Skip to main content
Erschienen in: Basic Research in Cardiology 4/2016

01.07.2016 | Review

High field magnetic resonance imaging of rodents in cardiovascular research

verfasst von: Laetitia Vanhoutte, Bernhard L. Gerber, Bernard Gallez, Chrystelle Po, Julie Magat, Balligand Jean-Luc, Olivier Feron, Stéphane Moniotte

Erschienen in: Basic Research in Cardiology | Ausgabe 4/2016

Einloggen, um Zugang zu erhalten

Abstract

Transgenic and gene knockout rodent models are primordial to study pathophysiological processes in cardiovascular research. Over time, cardiac MRI has become a gold standard for in vivo evaluation of such models. Technical advances have led to the development of magnets with increasingly high field strength, allowing specific investigation of cardiac anatomy, global and regional function, viability, perfusion or vascular parameters. The aim of this report is to provide a review of the various sequences and techniques available to image mice on 7–11.7 T magnets and relevant to the clinical setting in humans. Specific technical aspects due to the rise of the magnetic field are also discussed.
Literatur
1.
Zurück zum Zitat Abdurrachim D, Ciapaite J, Wessels B, Nabben M, Luiken JJ, Nicolay K, Prompers JJ (2014) Cardiac diastolic dysfunction in high-fat diet fed mice is associated with lipotoxicity without impairment of cardiac energetics in vivo. Biochim Biophys Acta 1842:1525–1537. doi:10.1016/j.bbalip.2014.07.016 PubMedCrossRef Abdurrachim D, Ciapaite J, Wessels B, Nabben M, Luiken JJ, Nicolay K, Prompers JJ (2014) Cardiac diastolic dysfunction in high-fat diet fed mice is associated with lipotoxicity without impairment of cardiac energetics in vivo. Biochim Biophys Acta 1842:1525–1537. doi:10.​1016/​j.​bbalip.​2014.​07.​016 PubMedCrossRef
6.
Zurück zum Zitat Alsaid H, Sabbah M, Bendahmane Z, Fokapu O, Felblinger J, Desbleds-Mansard C, Corot C, Briguet A, Cremillieux Y, Canet-Soulas E (2007) High-resolution contrast-enhanced MRI of atherosclerosis with digital cardiac and respiratory gating in mice. Magn Reson Med 58:1157–1163. doi:10.1002/mrm.21308 PubMedCrossRef Alsaid H, Sabbah M, Bendahmane Z, Fokapu O, Felblinger J, Desbleds-Mansard C, Corot C, Briguet A, Cremillieux Y, Canet-Soulas E (2007) High-resolution contrast-enhanced MRI of atherosclerosis with digital cardiac and respiratory gating in mice. Magn Reson Med 58:1157–1163. doi:10.​1002/​mrm.​21308 PubMedCrossRef
7.
Zurück zum Zitat Amundsen BH, Ericsson M, Seland JG, Pavlin T, Ellingsen O, Brekken C (2011) A comparison of retrospectively self-gated magnetic resonance imaging and high-frequency echocardiography for characterization of left ventricular function in mice. Lab Anim 45:31–37. doi:10.1258/la.2010.010094 PubMedCrossRef Amundsen BH, Ericsson M, Seland JG, Pavlin T, Ellingsen O, Brekken C (2011) A comparison of retrospectively self-gated magnetic resonance imaging and high-frequency echocardiography for characterization of left ventricular function in mice. Lab Anim 45:31–37. doi:10.​1258/​la.​2010.​010094 PubMedCrossRef
8.
9.
Zurück zum Zitat Antkowiak P, Janiczek R, Gibberman L, Xu C, Kramer C, Meyer C, French B, Epstein F (2010) Quantitative first-pass perfusion MRI of the mouse heart. J Cardiovasc Magn Reson 12:M10CrossRef Antkowiak P, Janiczek R, Gibberman L, Xu C, Kramer C, Meyer C, French B, Epstein F (2010) Quantitative first-pass perfusion MRI of the mouse heart. J Cardiovasc Magn Reson 12:M10CrossRef
13.
Zurück zum Zitat Bakermans AJ, Abdurrachim D, Geraedts TR, Houten SM, Nicolay K, Prompers JJ (2015) In vivo proton T1 relaxation times of mouse myocardial metabolites at 9.4 T. Magn Reson Med 73:2069–2074. doi:10.1002/mrm.25340 PubMedCrossRef Bakermans AJ, Abdurrachim D, Geraedts TR, Houten SM, Nicolay K, Prompers JJ (2015) In vivo proton T1 relaxation times of mouse myocardial metabolites at 9.4 T. Magn Reson Med 73:2069–2074. doi:10.​1002/​mrm.​25340 PubMedCrossRef
15.
Zurück zum Zitat Bakermans AJ, Abdurrachim D, van Nierop BJ, Koeman A, van der Kroon I, Baartscheer A, Schumacher CA, Strijkers GJ, Houten SM, Zuurbier CJ, Nicolay K, Prompers JJ (2015) In vivo mouse myocardial P MRS using three-dimensional image-selected in vivo spectroscopy (3D ISIS): technical considerations and biochemical validations. NMR Biomed. doi:10.1002/nbm.3371 PubMed Bakermans AJ, Abdurrachim D, van Nierop BJ, Koeman A, van der Kroon I, Baartscheer A, Schumacher CA, Strijkers GJ, Houten SM, Zuurbier CJ, Nicolay K, Prompers JJ (2015) In vivo mouse myocardial P MRS using three-dimensional image-selected in vivo spectroscopy (3D ISIS): technical considerations and biochemical validations. NMR Biomed. doi:10.​1002/​nbm.​3371 PubMed
16.
Zurück zum Zitat Bakermans AJ, Dodd MS, Nicolay K, Prompers JJ, Tyler DJ, Houten SM (2013) Myocardial energy shortage and unmet anaplerotic needs in the fasted long-chain acyl-CoA dehydrogenase knockout mouse. Cardiovasc Res 100:441–449. doi:10.1093/cvr/cvt212 PubMedCrossRef Bakermans AJ, Dodd MS, Nicolay K, Prompers JJ, Tyler DJ, Houten SM (2013) Myocardial energy shortage and unmet anaplerotic needs in the fasted long-chain acyl-CoA dehydrogenase knockout mouse. Cardiovasc Res 100:441–449. doi:10.​1093/​cvr/​cvt212 PubMedCrossRef
17.
Zurück zum Zitat Bakermans AJ, Geraedts TR, van Weeghel M, Denis S, Joao Ferraz M, Aerts JM, Aten J, Nicolay K, Houten SM, Prompers JJ (2011) Fasting-induced myocardial lipid accumulation in long-chain acyl-CoA dehydrogenase knockout mice is accompanied by impaired left ventricular function. Circ Cardiovasc Imaging 4:558–565. doi:10.1161/CIRCIMAGING.111.963751 PubMedCrossRef Bakermans AJ, Geraedts TR, van Weeghel M, Denis S, Joao Ferraz M, Aerts JM, Aten J, Nicolay K, Houten SM, Prompers JJ (2011) Fasting-induced myocardial lipid accumulation in long-chain acyl-CoA dehydrogenase knockout mice is accompanied by impaired left ventricular function. Circ Cardiovasc Imaging 4:558–565. doi:10.​1161/​CIRCIMAGING.​111.​963751 PubMedCrossRef
18.
Zurück zum Zitat Bakermans AJ, van Weeghel M, Denis S, Nicolay K, Prompers JJ, Houten SM (2013) Carnitine supplementation attenuates myocardial lipid accumulation in long-chain acyl-CoA dehydrogenase knockout mice. J Inherit Metab Dis 36:973–981. doi:10.1007/s10545-013-9604-4 PubMedCrossRef Bakermans AJ, van Weeghel M, Denis S, Nicolay K, Prompers JJ, Houten SM (2013) Carnitine supplementation attenuates myocardial lipid accumulation in long-chain acyl-CoA dehydrogenase knockout mice. J Inherit Metab Dis 36:973–981. doi:10.​1007/​s10545-013-9604-4 PubMedCrossRef
19.
Zurück zum Zitat Baltes C, Bosshard S, Mueggler T, Ratering D, Rudin M (2011) Increased blood oxygen level-dependent (BOLD) sensitivity in the mouse somatosensory cortex during electrical forepaw stimulation using a cryogenic radiofrequency probe. NMR Biomed 24:439–446. doi:10.1002/nbm.1613 PubMed Baltes C, Bosshard S, Mueggler T, Ratering D, Rudin M (2011) Increased blood oxygen level-dependent (BOLD) sensitivity in the mouse somatosensory cortex during electrical forepaw stimulation using a cryogenic radiofrequency probe. NMR Biomed 24:439–446. doi:10.​1002/​nbm.​1613 PubMed
20.
Zurück zum Zitat Bauer WR, Hiller KH, Galuppo P, Neubauer S, Kopke J, Haase A, Waller C, Ertl G (2001) Fast high-resolution magnetic resonance imaging demonstrates fractality of myocardial perfusion in microscopic dimensions. Circ Res 88:340–346PubMedCrossRef Bauer WR, Hiller KH, Galuppo P, Neubauer S, Kopke J, Haase A, Waller C, Ertl G (2001) Fast high-resolution magnetic resonance imaging demonstrates fractality of myocardial perfusion in microscopic dimensions. Circ Res 88:340–346PubMedCrossRef
21.
Zurück zum Zitat Bauer WR, Roder F, Hiller KH, Han H, Frohlich S, Rommel E, Haase A, Ertl G (1997) The effect of perfusion on T1 after slice-selective spin inversion in the isolated cardioplegic rat heart: measurement of a lower bound of intracapillary-extravascular water proton exchange rate. Magn Reson Med 38:917–923PubMedCrossRef Bauer WR, Roder F, Hiller KH, Han H, Frohlich S, Rommel E, Haase A, Ertl G (1997) The effect of perfusion on T1 after slice-selective spin inversion in the isolated cardioplegic rat heart: measurement of a lower bound of intracapillary-extravascular water proton exchange rate. Magn Reson Med 38:917–923PubMedCrossRef
22.
Zurück zum Zitat Beyers RJ, Smith RS, Xu Y, Piras BA, Salerno M, Berr SS, Meyer CH, Kramer CM, French BA, Epstein FH (2012) T(2)-weighted MRI of post-infarct myocardial edema in mice. Magn Reson Med 67:201–209. doi:10.1002/mrm.22975 PubMedCrossRef Beyers RJ, Smith RS, Xu Y, Piras BA, Salerno M, Berr SS, Meyer CH, Kramer CM, French BA, Epstein FH (2012) T(2)-weighted MRI of post-infarct myocardial edema in mice. Magn Reson Med 67:201–209. doi:10.​1002/​mrm.​22975 PubMedCrossRef
24.
Zurück zum Zitat Bohl S, Lygate CA, Barnes H, Medway D, Stork LA, Schulz-Menger J, Neubauer S, Schneider JE (2009) Advanced methods for quantification of infarct size in mice using three-dimensional high-field late gadolinium enhancement MRI. Am J Physiol Heart Circ Physiol 296:H1200–H1208. doi:10.1152/ajpheart.01294.2008 PubMedPubMedCentralCrossRef Bohl S, Lygate CA, Barnes H, Medway D, Stork LA, Schulz-Menger J, Neubauer S, Schneider JE (2009) Advanced methods for quantification of infarct size in mice using three-dimensional high-field late gadolinium enhancement MRI. Am J Physiol Heart Circ Physiol 296:H1200–H1208. doi:10.​1152/​ajpheart.​01294.​2008 PubMedPubMedCentralCrossRef
28.
Zurück zum Zitat Bun SS, Kober F, Jacquier A, Espinosa L, Kalifa J, Bonzi MF, Kopp F, Lalevee N, Zaffran S, Deharo JC, Cozzone PJ, Bernard M (2012) Value of in vivo T2 measurement for myocardial fibrosis assessment in diabetic mice at 11.75 T. Invest Radiol 47:319–323. doi:10.1097/RLI.0b013e318243e062 PubMedCrossRef Bun SS, Kober F, Jacquier A, Espinosa L, Kalifa J, Bonzi MF, Kopp F, Lalevee N, Zaffran S, Deharo JC, Cozzone PJ, Bernard M (2012) Value of in vivo T2 measurement for myocardial fibrosis assessment in diabetic mice at 11.75 T. Invest Radiol 47:319–323. doi:10.​1097/​RLI.​0b013e318243e062​ PubMedCrossRef
29.
Zurück zum Zitat Bunck AC, Engelen MA, Schnackenburg B, Furkert J, Bremer C, Heindel W, Stypmann J, Maintz D (2009) Feasibility of functional cardiac MR imaging in mice using a clinical 3 Tesla whole body scanner. Invest Radiol 44:749–756. doi:10.1097/RLI.0b013e3181b2c135 PubMedCrossRef Bunck AC, Engelen MA, Schnackenburg B, Furkert J, Bremer C, Heindel W, Stypmann J, Maintz D (2009) Feasibility of functional cardiac MR imaging in mice using a clinical 3 Tesla whole body scanner. Invest Radiol 44:749–756. doi:10.​1097/​RLI.​0b013e3181b2c135​ PubMedCrossRef
30.
Zurück zum Zitat Buonincontri G, Hu C-H, Sawiak S, Krieg T (2014) P516Diastolic dysfunction in diabetic mice revealed by MRI. Cardiovasc Res 103 (Suppl 1):S94–S95CrossRef Buonincontri G, Hu C-H, Sawiak S, Krieg T (2014) P516Diastolic dysfunction in diabetic mice revealed by MRI. Cardiovasc Res 103 (Suppl 1):S94–S95CrossRef
31.
Zurück zum Zitat Buscher K, Judenhofer MS, Kuhlmann MT, Hermann S, Wehrl HF, Schafers KP, Schafers M, Pichler BJ, Stegger L (2010) Isochronous assessment of cardiac metabolism and function in mice using hybrid PET/MRI. J Nucl Med 51:1277–1284. doi:10.2967/jnumed.110.076448 PubMedCrossRef Buscher K, Judenhofer MS, Kuhlmann MT, Hermann S, Wehrl HF, Schafers KP, Schafers M, Pichler BJ, Stegger L (2010) Isochronous assessment of cardiac metabolism and function in mice using hybrid PET/MRI. J Nucl Med 51:1277–1284. doi:10.​2967/​jnumed.​110.​076448 PubMedCrossRef
32.
Zurück zum Zitat Campbell-Washburn AE, Price AN, Wells JA, Thomas DL, Ordidge RJ, Lythgoe MF (2013) Cardiac arterial spin labeling using segmented ECG-gated look-locker FAIR: variability and repeatability in preclinical studies. Magn Reson Med 69:238–247. doi:10.1002/mrm.24243 PubMedCrossRef Campbell-Washburn AE, Price AN, Wells JA, Thomas DL, Ordidge RJ, Lythgoe MF (2013) Cardiac arterial spin labeling using segmented ECG-gated look-locker FAIR: variability and repeatability in preclinical studies. Magn Reson Med 69:238–247. doi:10.​1002/​mrm.​24243 PubMedCrossRef
33.
Zurück zum Zitat Cassidy PJ, Schneider JE, Grieve SM, Lygate C, Neubauer S, Clarke K (2004) Assessment of motion gating strategies for mouse magnetic resonance at high magnetic fields. J Magn Reson Imaging 19:229–237. doi:10.1002/jmri.10454 PubMedCrossRef Cassidy PJ, Schneider JE, Grieve SM, Lygate C, Neubauer S, Clarke K (2004) Assessment of motion gating strategies for mouse magnetic resonance at high magnetic fields. J Magn Reson Imaging 19:229–237. doi:10.​1002/​jmri.​10454 PubMedCrossRef
34.
Zurück zum Zitat Chacko VP, Aresta F, Chacko SM, Weiss RG (2000) MRI/MRS assessment of in vivo murine cardiac metabolism, morphology, and function at physiological heart rates. Am J Physiol Heart Circ Physiol 279:H2218–H2224PubMed Chacko VP, Aresta F, Chacko SM, Weiss RG (2000) MRI/MRS assessment of in vivo murine cardiac metabolism, morphology, and function at physiological heart rates. Am J Physiol Heart Circ Physiol 279:H2218–H2224PubMed
37.
38.
Zurück zum Zitat Cochet H, Montaudon M, Laurent F, Calmettes G, Franconi JM, Miraux S, Thiaudiere E, Parzy E (2010) In vivo MR angiography and velocity measurement in mice coronary arteries at 9.4 T: assessment of coronary flow velocity reserve. Radiology 254:441–448. doi:10.1148/radiol.2542090735 PubMedCrossRef Cochet H, Montaudon M, Laurent F, Calmettes G, Franconi JM, Miraux S, Thiaudiere E, Parzy E (2010) In vivo MR angiography and velocity measurement in mice coronary arteries at 9.4 T: assessment of coronary flow velocity reserve. Radiology 254:441–448. doi:10.​1148/​radiol.​2542090735 PubMedCrossRef
39.
Zurück zum Zitat Coolen BF, Geelen T, Paulis LE, Nauerth A, Nicolay K, Strijkers GJ (2011) Three-dimensional T1 mapping of the mouse heart using variable flip angle steady-state MR imaging. NMR Biomed 24:154–162. doi:10.1002/nbm.1566 PubMedCrossRef Coolen BF, Geelen T, Paulis LE, Nauerth A, Nicolay K, Strijkers GJ (2011) Three-dimensional T1 mapping of the mouse heart using variable flip angle steady-state MR imaging. NMR Biomed 24:154–162. doi:10.​1002/​nbm.​1566 PubMedCrossRef
41.
Zurück zum Zitat Coolen BF, Simonis FF, Geelen T, Moonen RP, Arslan F, Paulis LE, Nicolay K, Strijkers GJ (2014) Quantitative T2 mapping of the mouse heart by segmented MLEV phase-cycled T2 preparation. Magn Reson Med 72:409–417. doi:10.1002/mrm.24952 PubMedCrossRef Coolen BF, Simonis FF, Geelen T, Moonen RP, Arslan F, Paulis LE, Nicolay K, Strijkers GJ (2014) Quantitative T2 mapping of the mouse heart by segmented MLEV phase-cycled T2 preparation. Magn Reson Med 72:409–417. doi:10.​1002/​mrm.​24952 PubMedCrossRef
43.
Zurück zum Zitat Dall’Armellina E, Jung BA, Lygate CA, Neubauer S, Markl M, Schneider JE (2012) Improved method for quantification of regional cardiac function in mice using phase-contrast MRI. Magn Reson Med 67:541–551. doi:10.1002/mrm.23022 PubMedCrossRef Dall’Armellina E, Jung BA, Lygate CA, Neubauer S, Markl M, Schneider JE (2012) Improved method for quantification of regional cardiac function in mice using phase-contrast MRI. Magn Reson Med 67:541–551. doi:10.​1002/​mrm.​23022 PubMedCrossRef
47.
Zurück zum Zitat Drelicharz L, Wozniak M, Skorka T, Tyrankiewicz U, Heinze-Paluchowska S, Jablonska M, Gebska A, Chlopicki S (2009) Application of magnetic resonance imaging in vivo for the assessment of the progression of systolic and diastolic dysfunction in a mouse model of dilated cardiomyopathy. Kardiol Pol 67:386–395PubMed Drelicharz L, Wozniak M, Skorka T, Tyrankiewicz U, Heinze-Paluchowska S, Jablonska M, Gebska A, Chlopicki S (2009) Application of magnetic resonance imaging in vivo for the assessment of the progression of systolic and diastolic dysfunction in a mouse model of dilated cardiomyopathy. Kardiol Pol 67:386–395PubMed
51.
54.
55.
Zurück zum Zitat Gutjahr FT, Kampf T, Winter P, Meyer CB, Williams T, Jakob PM, Bauer WR, Ziener CH, Helluy X (2014) Quantification of perfusion in murine myocardium: a retrospectively triggered T-based ASL method using model-based reconstruction. Magn Reson Med. doi:10.1002/mrm.25526 Gutjahr FT, Kampf T, Winter P, Meyer CB, Williams T, Jakob PM, Bauer WR, Ziener CH, Helluy X (2014) Quantification of perfusion in murine myocardium: a retrospectively triggered T-based ASL method using model-based reconstruction. Magn Reson Med. doi:10.​1002/​mrm.​25526
57.
Zurück zum Zitat Hankiewicz JH, Goldspink PH, Buttrick PM, Lewandowski ED (2008) Principal strain changes precede ventricular wall thinning during transition to heart failure in a mouse model of dilated cardiomyopathy. Am J Physiol Heart Circ Physiol 294:H330–H336. doi:10.1152/ajpheart.01109.2007 PubMedCrossRef Hankiewicz JH, Goldspink PH, Buttrick PM, Lewandowski ED (2008) Principal strain changes precede ventricular wall thinning during transition to heart failure in a mouse model of dilated cardiomyopathy. Am J Physiol Heart Circ Physiol 294:H330–H336. doi:10.​1152/​ajpheart.​01109.​2007 PubMedCrossRef
58.
Zurück zum Zitat Hankiewicz JH, Lewandowski ED (2007) Improved cardiac tagging resolution at ultra-high magnetic field elucidates transmural differences in principal strain in the mouse heart and reduced stretch in dilated cardiomyopathy. J Cardiovasc Magn Reson 9:883–890. doi:10.1080/10976640701693683 PubMedCrossRef Hankiewicz JH, Lewandowski ED (2007) Improved cardiac tagging resolution at ultra-high magnetic field elucidates transmural differences in principal strain in the mouse heart and reduced stretch in dilated cardiomyopathy. J Cardiovasc Magn Reson 9:883–890. doi:10.​1080/​1097664070169368​3 PubMedCrossRef
59.
Zurück zum Zitat Heijman E, Aben JP, Penners C, Niessen P, Guillaume R, van Eys G, Nicolay K, Strijkers GJ (2008) Evaluation of manual and automatic segmentation of the mouse heart from CINE MR images. J Magn Reson Imaging 27:86–93. doi:10.1002/jmri.21236 PubMedCrossRef Heijman E, Aben JP, Penners C, Niessen P, Guillaume R, van Eys G, Nicolay K, Strijkers GJ (2008) Evaluation of manual and automatic segmentation of the mouse heart from CINE MR images. J Magn Reson Imaging 27:86–93. doi:10.​1002/​jmri.​21236 PubMedCrossRef
60.
Zurück zum Zitat Herold V, Morchel P, Faber C, Rommel E, Haase A, Jakob PM (2006) In vivo quantitative three-dimensional motion mapping of the murine myocardium with PC-MRI at 17.6 T. Magn Reson Med 55:1058–1064. doi:10.1002/mrm.20866 PubMedCrossRef Herold V, Morchel P, Faber C, Rommel E, Haase A, Jakob PM (2006) In vivo quantitative three-dimensional motion mapping of the murine myocardium with PC-MRI at 17.6 T. Magn Reson Med 55:1058–1064. doi:10.​1002/​mrm.​20866 PubMedCrossRef
61.
Zurück zum Zitat Herold V, Parczyk M, Morchel P, Ziener CH, Klug G, Bauer WR, Rommel E, Jakob PM (2009) In vivo measurement of local aortic pulse-wave velocity in mice with MR microscopy at 17.6 Tesla. Magn Reson Med 61:1293–1299. doi:10.1002/mrm.21957 PubMedCrossRef Herold V, Parczyk M, Morchel P, Ziener CH, Klug G, Bauer WR, Rommel E, Jakob PM (2009) In vivo measurement of local aortic pulse-wave velocity in mice with MR microscopy at 17.6 Tesla. Magn Reson Med 61:1293–1299. doi:10.​1002/​mrm.​21957 PubMedCrossRef
62.
Zurück zum Zitat Herrmann KH, Schmidt S, Kretz A, Haenold R, Krumbein I, Metzler M, Gaser C, Witte OW, Reichenbach JR (2012) Possibilities and limitations for high resolution small animal MRI on a clinical whole-body 3 T scanner. MAGMA 25:233–244. doi:10.1007/s10334-011-0284-5 PubMedCrossRef Herrmann KH, Schmidt S, Kretz A, Haenold R, Krumbein I, Metzler M, Gaser C, Witte OW, Reichenbach JR (2012) Possibilities and limitations for high resolution small animal MRI on a clinical whole-body 3 T scanner. MAGMA 25:233–244. doi:10.​1007/​s10334-011-0284-5 PubMedCrossRef
64.
Zurück zum Zitat Hiba B, Richard N, Thibault H, Janier M (2007) Cardiac and respiratory self-gated cine MRI in the mouse: comparison between radial and rectilinear techniques at 7 T. Magn Reson Med 58:745–753. doi:10.1002/mrm.21355 PubMedCrossRef Hiba B, Richard N, Thibault H, Janier M (2007) Cardiac and respiratory self-gated cine MRI in the mouse: comparison between radial and rectilinear techniques at 7 T. Magn Reson Med 58:745–753. doi:10.​1002/​mrm.​21355 PubMedCrossRef
65.
Zurück zum Zitat Hoerr V, Nagelmann N, Nauerth A, Kuhlmann MT, Stypmann J, Faber C (2013) Cardiac-respiratory self-gated cine ultra-short echo time (UTE) cardiovascular magnetic resonance for assessment of functional cardiac parameters at high magnetic fields. J Cardiovasc Magn Reson 15:59. doi:10.1186/1532-429X-15-59 PubMedPubMedCentralCrossRef Hoerr V, Nagelmann N, Nauerth A, Kuhlmann MT, Stypmann J, Faber C (2013) Cardiac-respiratory self-gated cine ultra-short echo time (UTE) cardiovascular magnetic resonance for assessment of functional cardiac parameters at high magnetic fields. J Cardiovasc Magn Reson 15:59. doi:10.​1186/​1532-429X-15-59 PubMedPubMedCentralCrossRef
67.
Zurück zum Zitat Hu TC, Bao W, Lenhard SC, Schaeffer TR, Yue TL, Willette RN, Jucker BM (2004) Simultaneous assessment of left-ventricular infarction size, function and tissue viability in a murine model of myocardial infarction by cardiac manganese-enhanced magnetic resonance imaging (MEMRI). NMR Biomed 17:620–626. doi:10.1002/nbm.933 PubMedCrossRef Hu TC, Bao W, Lenhard SC, Schaeffer TR, Yue TL, Willette RN, Jucker BM (2004) Simultaneous assessment of left-ventricular infarction size, function and tissue viability in a murine model of myocardial infarction by cardiac manganese-enhanced magnetic resonance imaging (MEMRI). NMR Biomed 17:620–626. doi:10.​1002/​nbm.​933 PubMedCrossRef
68.
Zurück zum Zitat Hu TC, Pautler RG, MacGowan GA, Koretsky AP (2001) Manganese-enhanced MRI of mouse heart during changes in inotropy. Magn Reson Med 46:884–890PubMedCrossRef Hu TC, Pautler RG, MacGowan GA, Koretsky AP (2001) Manganese-enhanced MRI of mouse heart during changes in inotropy. Magn Reson Med 46:884–890PubMedCrossRef
69.
Zurück zum Zitat Huby AC, Mendsaikhan U, Takagi K, Martherus R, Wansapura J, Gong N, Osinska H, James JF, Kramer K, Saito K, Robbins J, Khuchua Z, Towbin JA, Purevjav E (2014) Disturbance in Z-disk mechanosensitive proteins induced by a persistent mutant myopalladin causes familial restrictive cardiomyopathy. J Am Coll Cardiol 64:2765–2776. doi:10.1016/j.jacc.2014.09.071 PubMedPubMedCentralCrossRef Huby AC, Mendsaikhan U, Takagi K, Martherus R, Wansapura J, Gong N, Osinska H, James JF, Kramer K, Saito K, Robbins J, Khuchua Z, Towbin JA, Purevjav E (2014) Disturbance in Z-disk mechanosensitive proteins induced by a persistent mutant myopalladin causes familial restrictive cardiomyopathy. J Am Coll Cardiol 64:2765–2776. doi:10.​1016/​j.​jacc.​2014.​09.​071 PubMedPubMedCentralCrossRef
70.
Zurück zum Zitat Jacoby C, Borg N, Heusch P, Sauter M, Bonner F, Kandolf R, Klingel K, Schrader J, Flogel U (2014) Visualization of immune cell infiltration in experimental viral myocarditis by (19)F MRI in vivo. MAGMA 27:101–106. doi:10.1007/s10334-013-0391-6 PubMedCrossRef Jacoby C, Borg N, Heusch P, Sauter M, Bonner F, Kandolf R, Klingel K, Schrader J, Flogel U (2014) Visualization of immune cell infiltration in experimental viral myocarditis by (19)F MRI in vivo. MAGMA 27:101–106. doi:10.​1007/​s10334-013-0391-6 PubMedCrossRef
71.
Zurück zum Zitat Jacoby C, Boring YC, Beck A, Zernecke A, Aurich V, Weber C, Schrader J, Flogel U (2008) Dynamic changes in murine vessel geometry assessed by high-resolution magnetic resonance angiography: a 9.4 T study. J Magn Reson Imaging 28:637–645. doi:10.1002/jmri.21482 PubMedCrossRef Jacoby C, Boring YC, Beck A, Zernecke A, Aurich V, Weber C, Schrader J, Flogel U (2008) Dynamic changes in murine vessel geometry assessed by high-resolution magnetic resonance angiography: a 9.4 T study. J Magn Reson Imaging 28:637–645. doi:10.​1002/​jmri.​21482 PubMedCrossRef
72.
Zurück zum Zitat Jahnke C, Nagel E, Gebker R, Kokocinski T, Kelle S, Manka R, Fleck E, Paetsch I (2007) Prognostic value of cardiac magnetic resonance stress tests: adenosine stress perfusion and dobutamine stress wall motion imaging. Circulation 115:1769–1776. doi:10.1161/CIRCULATIONAHA.106.652016 PubMedCrossRef Jahnke C, Nagel E, Gebker R, Kokocinski T, Kelle S, Manka R, Fleck E, Paetsch I (2007) Prognostic value of cardiac magnetic resonance stress tests: adenosine stress perfusion and dobutamine stress wall motion imaging. Circulation 115:1769–1776. doi:10.​1161/​CIRCULATIONAHA.​106.​652016 PubMedCrossRef
75.
Zurück zum Zitat Janssen PM, Murray JD, Schill KE, Rastogi N, Schultz EJ, Tran T, Raman SV, Rafael-Fortney JA (2014) Prednisolone attenuates improvement of cardiac and skeletal contractile function and histopathology by lisinopril and spironolactone in the mdx mouse model of Duchenne muscular dystrophy. PLoS One 9:e88360. doi:10.1371/journal.pone.0088360 PubMedPubMedCentralCrossRef Janssen PM, Murray JD, Schill KE, Rastogi N, Schultz EJ, Tran T, Raman SV, Rafael-Fortney JA (2014) Prednisolone attenuates improvement of cardiac and skeletal contractile function and histopathology by lisinopril and spironolactone in the mdx mouse model of Duchenne muscular dystrophy. PLoS One 9:e88360. doi:10.​1371/​journal.​pone.​0088360 PubMedPubMedCentralCrossRef
76.
Zurück zum Zitat Jerosch-Herold M, Wilke N, Stillman AE (1998) Magnetic resonance quantification of the myocardial perfusion reserve with a Fermi function model for constrained deconvolution. Med Phys 25:73–84PubMedCrossRef Jerosch-Herold M, Wilke N, Stillman AE (1998) Magnetic resonance quantification of the myocardial perfusion reserve with a Fermi function model for constrained deconvolution. Med Phys 25:73–84PubMedCrossRef
77.
Zurück zum Zitat Jiang K, Li W, Li W, Jiao S, Castel L, Van Wagoner DR, Yu X (2014) Rapid multislice T mapping of mouse myocardium: application to quantification of manganese uptake in alpha-Dystrobrevin knockout mice. Magn Reson Med. doi:10.1002/mrm.25533 PubMedCentral Jiang K, Li W, Li W, Jiao S, Castel L, Van Wagoner DR, Yu X (2014) Rapid multislice T mapping of mouse myocardium: application to quantification of manganese uptake in alpha-Dystrobrevin knockout mice. Magn Reson Med. doi:10.​1002/​mrm.​25533 PubMedCentral
78.
Zurück zum Zitat Jilkina O, Xiang B, Kuzio B, Rendell J, Kupriyanov VV (2005) Potassium transport in Langendorff-perfused mouse hearts assessed by 87Rb NMR spectroscopy. Magn Reson Med 53:1172–1176. doi:10.1002/mrm.20450 PubMedCrossRef Jilkina O, Xiang B, Kuzio B, Rendell J, Kupriyanov VV (2005) Potassium transport in Langendorff-perfused mouse hearts assessed by 87Rb NMR spectroscopy. Magn Reson Med 53:1172–1176. doi:10.​1002/​mrm.​20450 PubMedCrossRef
79.
80.
Zurück zum Zitat Kampf T, Helluy X, Gutjahr FT, Winter P, Meyer CB, Jakob PM, Bauer WR, Ziener CH (2014) Myocardial perfusion quantification using the T1 -based FAIR-ASL method: the influence of heart anatomy, cardiopulmonary blood flow and look-locker readout. Magn Reson Med 71:1784–1797. doi:10.1002/mrm.24843 PubMedCrossRef Kampf T, Helluy X, Gutjahr FT, Winter P, Meyer CB, Jakob PM, Bauer WR, Ziener CH (2014) Myocardial perfusion quantification using the T1 -based FAIR-ASL method: the influence of heart anatomy, cardiopulmonary blood flow and look-locker readout. Magn Reson Med 71:1784–1797. doi:10.​1002/​mrm.​24843 PubMedCrossRef
81.
Zurück zum Zitat Kim RJ, Lima JA, Chen EL, Reeder SB, Klocke FJ, Zerhouni EA, Judd RM (1997) Fast 23Na magnetic resonance imaging of acute reperfused myocardial infarction. Potential to assess myocardial viability. Circulation 95:1877–1885PubMedCrossRef Kim RJ, Lima JA, Chen EL, Reeder SB, Klocke FJ, Zerhouni EA, Judd RM (1997) Fast 23Na magnetic resonance imaging of acute reperfused myocardial infarction. Potential to assess myocardial viability. Circulation 95:1877–1885PubMedCrossRef
82.
Zurück zum Zitat Klink A, Heynens J, Herranz B, Lobatto ME, Arias T, Sanders HM, Strijkers GJ, Merkx M, Nicolay K, Fuster V, Tedgui A, Mallat Z, Mulder WJ, Fayad ZA (2011) In vivo characterization of a new abdominal aortic aneurysm mouse model with conventional and molecular magnetic resonance imaging. J Am Coll Cardiol 58:2522–2530. doi:10.1016/j.jacc.2011.09.017 PubMedPubMedCentralCrossRef Klink A, Heynens J, Herranz B, Lobatto ME, Arias T, Sanders HM, Strijkers GJ, Merkx M, Nicolay K, Fuster V, Tedgui A, Mallat Z, Mulder WJ, Fayad ZA (2011) In vivo characterization of a new abdominal aortic aneurysm mouse model with conventional and molecular magnetic resonance imaging. J Am Coll Cardiol 58:2522–2530. doi:10.​1016/​j.​jacc.​2011.​09.​017 PubMedPubMedCentralCrossRef
83.
Zurück zum Zitat Klink A, Hyafil F, Rudd J, Faries P, Fuster V, Mallat Z, Meilhac O, Mulder WJ, Michel JB, Ramirez F, Storm G, Thompson R, Turnbull IC, Egido J, Martin-Ventura JL, Zaragoza C, Letourneur D, Fayad ZA (2011) Diagnostic and therapeutic strategies for small abdominal aortic aneurysms. Nat Rev Cardiol 8:338–347. doi:10.1038/nrcardio.2011.1 PubMedCrossRef Klink A, Hyafil F, Rudd J, Faries P, Fuster V, Mallat Z, Meilhac O, Mulder WJ, Michel JB, Ramirez F, Storm G, Thompson R, Turnbull IC, Egido J, Martin-Ventura JL, Zaragoza C, Letourneur D, Fayad ZA (2011) Diagnostic and therapeutic strategies for small abdominal aortic aneurysms. Nat Rev Cardiol 8:338–347. doi:10.​1038/​nrcardio.​2011.​1 PubMedCrossRef
84.
Zurück zum Zitat Kohler S, Hiller KH, Griswold M, Bauer WR, Haase A, Jakob PM (2003) NMR-microscopy with TrueFISP at 11.75 T. J Magn Reson 161:252–257PubMedCrossRef Kohler S, Hiller KH, Griswold M, Bauer WR, Haase A, Jakob PM (2003) NMR-microscopy with TrueFISP at 11.75 T. J Magn Reson 161:252–257PubMedCrossRef
85.
Zurück zum Zitat Lairez O, Lonjaret L, Ruiz S, Marchal P, Franchitto N, Calise D, Fourcade O, Mialet-Perez J, Parini A, Minville V (2013) Anesthetic regimen for cardiac function evaluation by echocardiography in mice: comparison between ketamine, etomidate and isoflurane versus conscious state. Lab Anim 47:284–290. doi:10.1177/0023677213496236 PubMedCrossRef Lairez O, Lonjaret L, Ruiz S, Marchal P, Franchitto N, Calise D, Fourcade O, Mialet-Perez J, Parini A, Minville V (2013) Anesthetic regimen for cardiac function evaluation by echocardiography in mice: comparison between ketamine, etomidate and isoflurane versus conscious state. Lab Anim 47:284–290. doi:10.​1177/​0023677213496236​ PubMedCrossRef
86.
95.
Zurück zum Zitat Majmudar MD, Yoo J, Keliher EJ, Truelove JJ, Iwamoto Y, Sena B, Dutta P, Borodovsky A, Fitzgerald K, Di Carli MF, Libby P, Anderson DG, Swirski FK, Weissleder R, Nahrendorf M (2013) Polymeric nanoparticle PET/MR imaging allows macrophage detection in atherosclerotic plaques. Circ Res 112:755–761. doi:10.1161/CIRCRESAHA.111.300576 PubMedPubMedCentralCrossRef Majmudar MD, Yoo J, Keliher EJ, Truelove JJ, Iwamoto Y, Sena B, Dutta P, Borodovsky A, Fitzgerald K, Di Carli MF, Libby P, Anderson DG, Swirski FK, Weissleder R, Nahrendorf M (2013) Polymeric nanoparticle PET/MR imaging allows macrophage detection in atherosclerotic plaques. Circ Res 112:755–761. doi:10.​1161/​CIRCRESAHA.​111.​300576 PubMedPubMedCentralCrossRef
96.
Zurück zum Zitat Mani V, Adler E, Briley-Saebo KC, Bystrup A, Fuster V, Keller G, Fayad ZA (2008) Serial in vivo positive contrast MRI of iron oxide-labeled embryonic stem cell-derived cardiac precursor cells in a mouse model of myocardial infarction. Magn Reson Med 60:73–81. doi:10.1002/mrm.21642 PubMedCrossRef Mani V, Adler E, Briley-Saebo KC, Bystrup A, Fuster V, Keller G, Fayad ZA (2008) Serial in vivo positive contrast MRI of iron oxide-labeled embryonic stem cell-derived cardiac precursor cells in a mouse model of myocardial infarction. Magn Reson Med 60:73–81. doi:10.​1002/​mrm.​21642 PubMedCrossRef
97.
Zurück zum Zitat Maramraju SH, Smith SD, Junnarkar SS, Schulz D, Stoll S, Ravindranath B, Purschke ML, Rescia S, Southekal S, Pratte JF, Vaska P, Woody CL, Schlyer DJ (2011) Small animal simultaneous PET/MRI: initial experiences in a 9.4 T microMRI. Phys Med Biol 56:2459–2480. doi:10.1088/0031-9155/56/8/009 PubMedCrossRef Maramraju SH, Smith SD, Junnarkar SS, Schulz D, Stoll S, Ravindranath B, Purschke ML, Rescia S, Southekal S, Pratte JF, Vaska P, Woody CL, Schlyer DJ (2011) Small animal simultaneous PET/MRI: initial experiences in a 9.4 T microMRI. Phys Med Biol 56:2459–2480. doi:10.​1088/​0031-9155/​56/​8/​009 PubMedCrossRef
99.
Zurück zum Zitat Messroghli DR, Radjenovic A, Kozerke S, Higgins DM, Sivananthan MU, Ridgway JP (2004) Modified look-locker inversion recovery (MOLLI) for high-resolution T1 mapping of the heart. Magn Reson Med 52:141–146. doi:10.1002/mrm.20110 PubMedCrossRef Messroghli DR, Radjenovic A, Kozerke S, Higgins DM, Sivananthan MU, Ridgway JP (2004) Modified look-locker inversion recovery (MOLLI) for high-resolution T1 mapping of the heart. Magn Reson Med 52:141–146. doi:10.​1002/​mrm.​20110 PubMedCrossRef
100.
Zurück zum Zitat Moon JC, Messroghli DR, Kellman P, Piechnik SK, Robson MD, Ugander M, Gatehouse PD, Arai AE, Friedrich MG, Neubauer S, Schulz-Menger J, Schelbert EB, Society for Cardiovascular Magnetic Resonance I, Cardiovascular Magnetic Resonance Working Group of the European Society of C (2013) Myocardial T1 mapping and extracellular volume quantification: a Society for Cardiovascular Magnetic Resonance (SCMR) and CMR Working Group of the European Society of Cardiology consensus statement. J Cardiovasc Magn Reson 15:92. doi:10.1186/1532-429X-15-92 PubMedPubMedCentralCrossRef Moon JC, Messroghli DR, Kellman P, Piechnik SK, Robson MD, Ugander M, Gatehouse PD, Arai AE, Friedrich MG, Neubauer S, Schulz-Menger J, Schelbert EB, Society for Cardiovascular Magnetic Resonance I, Cardiovascular Magnetic Resonance Working Group of the European Society of C (2013) Myocardial T1 mapping and extracellular volume quantification: a Society for Cardiovascular Magnetic Resonance (SCMR) and CMR Working Group of the European Society of Cardiology consensus statement. J Cardiovasc Magn Reson 15:92. doi:10.​1186/​1532-429X-15-92 PubMedPubMedCentralCrossRef
102.
Zurück zum Zitat Mosher TJ, Smith MB (1990) A DANTE tagging sequence for the evaluation of translational sample motion. Magn Reson Med 15:334–339PubMedCrossRef Mosher TJ, Smith MB (1990) A DANTE tagging sequence for the evaluation of translational sample motion. Magn Reson Med 15:334–339PubMedCrossRef
103.
Zurück zum Zitat Motaal AG, Coolen BF, Abdurrachim D, Castro RM, Prompers JJ, Florack LM, Nicolay K, Strijkers GJ (2013) Accelerated high-frame-rate mouse heart cine-MRI using compressed sensing reconstruction. NMR Biomed 26:451–457. doi:10.1002/nbm.2883 PubMedCrossRef Motaal AG, Coolen BF, Abdurrachim D, Castro RM, Prompers JJ, Florack LM, Nicolay K, Strijkers GJ (2013) Accelerated high-frame-rate mouse heart cine-MRI using compressed sensing reconstruction. NMR Biomed 26:451–457. doi:10.​1002/​nbm.​2883 PubMedCrossRef
104.
Zurück zum Zitat Nahrendorf M, Hiller KH, Hu K, Ertl G, Haase A, Bauer WR (2003) Cardiac magnetic resonance imaging in small animal models of human heart failure. Med Image Anal 7:369–375PubMedCrossRef Nahrendorf M, Hiller KH, Hu K, Ertl G, Haase A, Bauer WR (2003) Cardiac magnetic resonance imaging in small animal models of human heart failure. Med Image Anal 7:369–375PubMedCrossRef
105.
Zurück zum Zitat Nahrendorf M, Streif JU, Hiller KH, Hu K, Nordbeck P, Ritter O, Sosnovik D, Bauer L, Neubauer S, Jakob PM, Ertl G, Spindler M, Bauer WR (2006) Multimodal functional cardiac MRI in creatine kinase-deficient mice reveals subtle abnormalities in myocardial perfusion and mechanics. Am J Physiol Heart Circ Physiol 290:H2516–H2521. doi:10.1152/ajpheart.01038.2005 PubMedCrossRef Nahrendorf M, Streif JU, Hiller KH, Hu K, Nordbeck P, Ritter O, Sosnovik D, Bauer L, Neubauer S, Jakob PM, Ertl G, Spindler M, Bauer WR (2006) Multimodal functional cardiac MRI in creatine kinase-deficient mice reveals subtle abnormalities in myocardial perfusion and mechanics. Am J Physiol Heart Circ Physiol 290:H2516–H2521. doi:10.​1152/​ajpheart.​01038.​2005 PubMedCrossRef
106.
Zurück zum Zitat Naresh NK, Chen X, Roy RJ, Antkowiak PF, Annex BH, Epstein FH (2015) Accelerated dual-contrast first-pass perfusion MRI of the mouse heart: development and application to diet-induced obese mice. Magn Reson Med 73:1237–1245. doi:10.1002/mrm.25238 PubMedCrossRef Naresh NK, Chen X, Roy RJ, Antkowiak PF, Annex BH, Epstein FH (2015) Accelerated dual-contrast first-pass perfusion MRI of the mouse heart: development and application to diet-induced obese mice. Magn Reson Med 73:1237–1245. doi:10.​1002/​mrm.​25238 PubMedCrossRef
107.
110.
Zurück zum Zitat Nick H, Allegrini PR, Fozard L, Junker U, Rojkjaer L, Salie R, Niederkofler V, O’Reilly T (2009) Deferasirox reduces iron overload in a murine model of juvenile hemochromatosis. Exp Biol Med (Maywood) 234:492–503. doi:10.3181/0811-RM-337 CrossRef Nick H, Allegrini PR, Fozard L, Junker U, Rojkjaer L, Salie R, Niederkofler V, O’Reilly T (2009) Deferasirox reduces iron overload in a murine model of juvenile hemochromatosis. Exp Biol Med (Maywood) 234:492–503. doi:10.​3181/​0811-RM-337 CrossRef
111.
Zurück zum Zitat Odintsov B, Chun JL, Mulligan JA, Berry SE (2011) 14.1 T whole body MRI for detection of mesoangioblast stem cells in a murine model of Duchenne muscular dystrophy. Magn Reson Med 66:1704–1714. doi:10.1002/mrm.22942 PubMedCrossRef Odintsov B, Chun JL, Mulligan JA, Berry SE (2011) 14.1 T whole body MRI for detection of mesoangioblast stem cells in a murine model of Duchenne muscular dystrophy. Magn Reson Med 66:1704–1714. doi:10.​1002/​mrm.​22942 PubMedCrossRef
112.
113.
Zurück zum Zitat Okayama S, Nakano T, Uemura S, Fujimoto S, Somekawa S, Watanabe M, Nakajima T, Saito Y (2013) Evaluation of left ventricular diastolic function by fractional area change using cine cardiovascular magnetic resonance: a feasibility study. J Cardiovasc Magn Reson 15:87. doi:10.1186/1532-429X-15-87 PubMedPubMedCentralCrossRef Okayama S, Nakano T, Uemura S, Fujimoto S, Somekawa S, Watanabe M, Nakajima T, Saito Y (2013) Evaluation of left ventricular diastolic function by fractional area change using cine cardiovascular magnetic resonance: a feasibility study. J Cardiovasc Magn Reson 15:87. doi:10.​1186/​1532-429X-15-87 PubMedPubMedCentralCrossRef
114.
Zurück zum Zitat Osman NF, Kerwin WS, McVeigh ER, Prince JL (1999) Cardiac motion tracking using CINE harmonic phase (HARP) magnetic resonance imaging. Magn Reson Med 42:1048–1060PubMedPubMedCentralCrossRef Osman NF, Kerwin WS, McVeigh ER, Prince JL (1999) Cardiac motion tracking using CINE harmonic phase (HARP) magnetic resonance imaging. Magn Reson Med 42:1048–1060PubMedPubMedCentralCrossRef
115.
Zurück zum Zitat Parzy E, Miraux S, Franconi JM, Thiaudiere E (2009) In vivo quantification of blood velocity in mouse carotid and pulmonary arteries by ECG-triggered 3D time-resolved magnetic resonance angiography. NMR Biomed 22:532–537. doi:10.1002/nbm.1365 PubMedCrossRef Parzy E, Miraux S, Franconi JM, Thiaudiere E (2009) In vivo quantification of blood velocity in mouse carotid and pulmonary arteries by ECG-triggered 3D time-resolved magnetic resonance angiography. NMR Biomed 22:532–537. doi:10.​1002/​nbm.​1365 PubMedCrossRef
117.
118.
Zurück zum Zitat Protti A, Sirker A, Shah AM, Botnar R (2010) Late gadolinium enhancement of acute myocardial infarction in mice at 7 T: cine-FLASH versus inversion recovery. J Magn Reson Imaging 32:878–886. doi:10.1002/jmri.22325 PubMedCrossRef Protti A, Sirker A, Shah AM, Botnar R (2010) Late gadolinium enhancement of acute myocardial infarction in mice at 7 T: cine-FLASH versus inversion recovery. J Magn Reson Imaging 32:878–886. doi:10.​1002/​jmri.​22325 PubMedCrossRef
119.
Zurück zum Zitat Rafael-Fortney JA, Chimanji NS, Schill KE, Martin CD, Murray JD, Ganguly R, Stangland JE, Tran T, Xu Y, Canan BD, Mays TA, Delfin DA, Janssen PM, Raman SV (2011) Early treatment with lisinopril and spironolactone preserves cardiac and skeletal muscle in Duchenne muscular dystrophy mice. Circulation 124:582–588. doi:10.1161/CIRCULATIONAHA.111.031716 PubMedPubMedCentralCrossRef Rafael-Fortney JA, Chimanji NS, Schill KE, Martin CD, Murray JD, Ganguly R, Stangland JE, Tran T, Xu Y, Canan BD, Mays TA, Delfin DA, Janssen PM, Raman SV (2011) Early treatment with lisinopril and spironolactone preserves cardiac and skeletal muscle in Duchenne muscular dystrophy mice. Circulation 124:582–588. doi:10.​1161/​CIRCULATIONAHA.​111.​031716 PubMedPubMedCentralCrossRef
120.
Zurück zum Zitat Ruff J, Wiesmann F, Hiller KH, Voll S, von Kienlin M, Bauer WR, Rommel E, Neubauer S, Haase A (1998) Magnetic resonance microimaging for noninvasive quantification of myocardial function and mass in the mouse. Magn Reson Med 40:43–48PubMedCrossRef Ruff J, Wiesmann F, Hiller KH, Voll S, von Kienlin M, Bauer WR, Rommel E, Neubauer S, Haase A (1998) Magnetic resonance microimaging for noninvasive quantification of myocardial function and mass in the mouse. Magn Reson Med 40:43–48PubMedCrossRef
123.
Zurück zum Zitat Schneider JE, Cassidy PJ, Lygate C, Tyler DJ, Wiesmann F, Grieve SM, Hulbert K, Clarke K, Neubauer S (2003) Fast, high-resolution in vivo cine magnetic resonance imaging in normal and failing mouse hearts on a vertical 11.7 T system. J Magn Reson Imaging 18:691–701. doi:10.1002/jmri.10411 PubMedCrossRef Schneider JE, Cassidy PJ, Lygate C, Tyler DJ, Wiesmann F, Grieve SM, Hulbert K, Clarke K, Neubauer S (2003) Fast, high-resolution in vivo cine magnetic resonance imaging in normal and failing mouse hearts on a vertical 11.7 T system. J Magn Reson Imaging 18:691–701. doi:10.​1002/​jmri.​10411 PubMedCrossRef
124.
Zurück zum Zitat Schneider JE, Lanz T, Barnes H, Stork LA, Bohl S, Lygate CA, Ordidge RJ, Neubauer S (2011) Accelerated cardiac magnetic resonance imaging in the mouse using an eight-channel array at 9.4 Tesla. Magn Reson Med 65:60–70. doi:10.1002/mrm.22605 PubMedCrossRef Schneider JE, Lanz T, Barnes H, Stork LA, Bohl S, Lygate CA, Ordidge RJ, Neubauer S (2011) Accelerated cardiac magnetic resonance imaging in the mouse using an eight-channel array at 9.4 Tesla. Magn Reson Med 65:60–70. doi:10.​1002/​mrm.​22605 PubMedCrossRef
125.
Zurück zum Zitat Schneider JE, Tyler DJ, ten Hove M, Sang AE, Cassidy PJ, Fischer A, Wallis J, Sebag-Montefiore LM, Watkins H, Isbrandt D, Clarke K, Neubauer S (2004) In vivo cardiac 1H-MRS in the mouse. Magn Reson Med 52:1029–1035. doi:10.1002/mrm.20257 PubMedCrossRef Schneider JE, Tyler DJ, ten Hove M, Sang AE, Cassidy PJ, Fischer A, Wallis J, Sebag-Montefiore LM, Watkins H, Isbrandt D, Clarke K, Neubauer S (2004) In vivo cardiac 1H-MRS in the mouse. Magn Reson Med 52:1029–1035. doi:10.​1002/​mrm.​20257 PubMedCrossRef
127.
Zurück zum Zitat Shao Y, Cherry SR, Farahani K, Meadors K, Siegel S, Silverman RW, Marsden PK (1997) Simultaneous PET and MR imaging. Phys Med Biol 42:1965–1970PubMedCrossRef Shao Y, Cherry SR, Farahani K, Meadors K, Siegel S, Silverman RW, Marsden PK (1997) Simultaneous PET and MR imaging. Phys Med Biol 42:1965–1970PubMedCrossRef
128.
Zurück zum Zitat Shea SM, Fieno DS, Schirf BE, Bi X, Huang J, Omary RA, Li D (2005) T2-prepared steady-state free precession blood oxygen level-dependent MR imaging of myocardial perfusion in a dog stenosis model. Radiology 236:503–509. doi:10.1148/radiol.2362040149 PubMedCrossRef Shea SM, Fieno DS, Schirf BE, Bi X, Huang J, Omary RA, Li D (2005) T2-prepared steady-state free precession blood oxygen level-dependent MR imaging of myocardial perfusion in a dog stenosis model. Radiology 236:503–509. doi:10.​1148/​radiol.​2362040149 PubMedCrossRef
129.
Zurück zum Zitat Skardal K, Rolim NP, Haraldseth O, Goa PE, Thuen M (2013) Late gadolinium enhancement in the assessment of the infarcted mouse heart: a longitudinal comparison with manganese-enhanced MRI. J Magn Reson Imaging 38:1388–1394. doi:10.1002/jmri.24127 PubMedCrossRef Skardal K, Rolim NP, Haraldseth O, Goa PE, Thuen M (2013) Late gadolinium enhancement in the assessment of the infarcted mouse heart: a longitudinal comparison with manganese-enhanced MRI. J Magn Reson Imaging 38:1388–1394. doi:10.​1002/​jmri.​24127 PubMedCrossRef
130.
Zurück zum Zitat Song R, Lin W, Chen Q, Asakura T, Wehrli FW, Song HK (2008) Relationships between MR transverse relaxation parameters R*(2), R(2) and R’(2) and hepatic iron content in thalassemic mice at 1.5 T and 3 T. NMR Biomed 21:574–580. doi:10.1002/nbm.1227 PubMedCrossRef Song R, Lin W, Chen Q, Asakura T, Wehrli FW, Song HK (2008) Relationships between MR transverse relaxation parameters R*(2), R(2) and R’(2) and hepatic iron content in thalassemic mice at 1.5 T and 3 T. NMR Biomed 21:574–580. doi:10.​1002/​nbm.​1227 PubMedCrossRef
131.
Zurück zum Zitat Song W, Dyer E, Stuckey D, Leung MC, Memo M, Mansfield C, Ferenczi M, Liu K, Redwood C, Nowak K, Harding S, Clarke K, Wells D, Marston S (2010) Investigation of a transgenic mouse model of familial dilated cardiomyopathy. J Mol Cell Cardiol 49:380–389. doi:10.1016/j.yjmcc.2010.05.009 PubMedCrossRef Song W, Dyer E, Stuckey D, Leung MC, Memo M, Mansfield C, Ferenczi M, Liu K, Redwood C, Nowak K, Harding S, Clarke K, Wells D, Marston S (2010) Investigation of a transgenic mouse model of familial dilated cardiomyopathy. J Mol Cell Cardiol 49:380–389. doi:10.​1016/​j.​yjmcc.​2010.​05.​009 PubMedCrossRef
132.
Zurück zum Zitat Sosnovik DE, Dai G, Nahrendorf M, Rosen BR, Seethamraju R (2007) Cardiac MRI in mice at 9.4 Tesla with a transmit-receive surface coil and a cardiac-tailored intensity-correction algorithm. J Magn Reson Imaging 26:279–287. doi:10.1002/jmri.20966 PubMedCrossRef Sosnovik DE, Dai G, Nahrendorf M, Rosen BR, Seethamraju R (2007) Cardiac MRI in mice at 9.4 Tesla with a transmit-receive surface coil and a cardiac-tailored intensity-correction algorithm. J Magn Reson Imaging 26:279–287. doi:10.​1002/​jmri.​20966 PubMedCrossRef
133.
Zurück zum Zitat Sosnovik DE, Nahrendorf M, Deliolanis N, Novikov M, Aikawa E, Josephson L, Rosenzweig A, Weissleder R, Ntziachristos V (2007) Fluorescence tomography and magnetic resonance imaging of myocardial macrophage infiltration in infarcted myocardium in vivo. Circulation 115:1384–1391. doi:10.1161/CIRCULATIONAHA.106.663351 PubMedCrossRef Sosnovik DE, Nahrendorf M, Deliolanis N, Novikov M, Aikawa E, Josephson L, Rosenzweig A, Weissleder R, Ntziachristos V (2007) Fluorescence tomography and magnetic resonance imaging of myocardial macrophage infiltration in infarcted myocardium in vivo. Circulation 115:1384–1391. doi:10.​1161/​CIRCULATIONAHA.​106.​663351 PubMedCrossRef
134.
Zurück zum Zitat Streif JU, Herold V, Szimtenings M, Lanz TE, Nahrendorf M, Wiesmann F, Rommel E, Haase A (2003) In vivo time-resolved quantitative motion mapping of the murine myocardium with phase contrast MRI. Magn Reson Med 49:315–321. doi:10.1002/mrm.10342 PubMedCrossRef Streif JU, Herold V, Szimtenings M, Lanz TE, Nahrendorf M, Wiesmann F, Rommel E, Haase A (2003) In vivo time-resolved quantitative motion mapping of the murine myocardium with phase contrast MRI. Magn Reson Med 49:315–321. doi:10.​1002/​mrm.​10342 PubMedCrossRef
135.
Zurück zum Zitat Streif JU, Nahrendorf M, Hiller KH, Waller C, Wiesmann F, Rommel E, Haase A, Bauer WR (2005) In vivo assessment of absolute perfusion and intracapillary blood volume in the murine myocardium by spin labeling magnetic resonance imaging. Magn Reson Med 53:584–592. doi:10.1002/mrm.20327 PubMedCrossRef Streif JU, Nahrendorf M, Hiller KH, Waller C, Wiesmann F, Rommel E, Haase A, Bauer WR (2005) In vivo assessment of absolute perfusion and intracapillary blood volume in the murine myocardium by spin labeling magnetic resonance imaging. Magn Reson Med 53:584–592. doi:10.​1002/​mrm.​20327 PubMedCrossRef
137.
Zurück zum Zitat Stuckey DJ, Carr CA, Tyler DJ, Clarke K (2008) Cine-MRI versus two-dimensional echocardiography to measure in vivo left ventricular function in rat heart. NMR Biomed 21:765–772. doi:10.1002/nbm.1268 PubMedCrossRef Stuckey DJ, Carr CA, Tyler DJ, Clarke K (2008) Cine-MRI versus two-dimensional echocardiography to measure in vivo left ventricular function in rat heart. NMR Biomed 21:765–772. doi:10.​1002/​nbm.​1268 PubMedCrossRef
138.
Zurück zum Zitat Stuckey DJ, McSweeney SJ, Thin MZ, Habib J, Price AN, Fiedler LR, Gsell W, Prasad SK, Schneider MD (2014) T(1) mapping detects pharmacological retardation of diffuse cardiac fibrosis in mouse pressure-overload hypertrophy. Circ Cardiovasc Imaging 7:240–249. doi:10.1161/CIRCIMAGING.113.000993 PubMedCrossRef Stuckey DJ, McSweeney SJ, Thin MZ, Habib J, Price AN, Fiedler LR, Gsell W, Prasad SK, Schneider MD (2014) T(1) mapping detects pharmacological retardation of diffuse cardiac fibrosis in mouse pressure-overload hypertrophy. Circ Cardiovasc Imaging 7:240–249. doi:10.​1161/​CIRCIMAGING.​113.​000993 PubMedCrossRef
140.
Zurück zum Zitat Suever JD, Wehner GJ, Haggerty CM, Jing L, Hamlet SM, Binkley CM, Kramer SP, Mattingly AC, Powell DK, Bilchick KC, Epstein FH, Fornwalt BK (2014) Simplified post processing of cine DENSE cardiovascular magnetic resonance for quantification of cardiac mechanics. J Cardiovasc Magn Reson 16:94. doi:10.1186/s12968-014-0094-9 PubMedPubMedCentralCrossRef Suever JD, Wehner GJ, Haggerty CM, Jing L, Hamlet SM, Binkley CM, Kramer SP, Mattingly AC, Powell DK, Bilchick KC, Epstein FH, Fornwalt BK (2014) Simplified post processing of cine DENSE cardiovascular magnetic resonance for quantification of cardiac mechanics. J Cardiovasc Magn Reson 16:94. doi:10.​1186/​s12968-014-0094-9 PubMedPubMedCentralCrossRef
141.
142.
Zurück zum Zitat Temme S, Grapentin C, Quast C, Jacoby C, Grandoch M, Ding Z, Owenier C, Mayenfels F, Fischer JW, Schubert R, Schrader J, Flogel U (2015) Noninvasive imaging of early venous thrombosis by 19F magnetic resonance imaging with targeted perfluorocarbon nanoemulsions. Circulation 131:1405–1414. doi:10.1161/CIRCULATIONAHA.114.010962 PubMedCrossRef Temme S, Grapentin C, Quast C, Jacoby C, Grandoch M, Ding Z, Owenier C, Mayenfels F, Fischer JW, Schubert R, Schrader J, Flogel U (2015) Noninvasive imaging of early venous thrombosis by 19F magnetic resonance imaging with targeted perfluorocarbon nanoemulsions. Circulation 131:1405–1414. doi:10.​1161/​CIRCULATIONAHA.​114.​010962 PubMedCrossRef
143.
Zurück zum Zitat ten Hove M, Lygate CA, Fischer A, Schneider JE, Sang AE, Hulbert K, Sebag-Montefiore L, Watkins H, Clarke K, Isbrandt D, Wallis J, Neubauer S (2005) Reduced inotropic reserve and increased susceptibility to cardiac ischemia/reperfusion injury in phosphocreatine-deficient guanidinoacetate-N-methyltransferase-knockout mice. Circulation 111:2477–2485. doi:10.1161/01.CIR.0000165147.99592.01 PubMedCrossRef ten Hove M, Lygate CA, Fischer A, Schneider JE, Sang AE, Hulbert K, Sebag-Montefiore L, Watkins H, Clarke K, Isbrandt D, Wallis J, Neubauer S (2005) Reduced inotropic reserve and increased susceptibility to cardiac ischemia/reperfusion injury in phosphocreatine-deficient guanidinoacetate-N-methyltransferase-knockout mice. Circulation 111:2477–2485. doi:10.​1161/​01.​CIR.​0000165147.​99592.​01 PubMedCrossRef
144.
Zurück zum Zitat Troalen T, Capron T, Cozzone PJ, Bernard M, Kober F (2013) Cine-ASL: a steady-pulsed arterial spin labeling method for myocardial perfusion mapping in mice. Part I. Experimental study. Magn Reson Med 70:1389–1398. doi:10.1002/mrm.24565 PubMedCrossRef Troalen T, Capron T, Cozzone PJ, Bernard M, Kober F (2013) Cine-ASL: a steady-pulsed arterial spin labeling method for myocardial perfusion mapping in mice. Part I. Experimental study. Magn Reson Med 70:1389–1398. doi:10.​1002/​mrm.​24565 PubMedCrossRef
145.
Zurück zum Zitat Trotier AJ, Lefrancois W, Ribot EJ, Thiaudiere E, Franconi JM, Miraux S (2015) Time-resolved TOF MR angiography in mice using a prospective 3D radial double golden angle approach. Magn Reson Med 73:984–994. doi:10.1002/mrm.25201 PubMedCrossRef Trotier AJ, Lefrancois W, Ribot EJ, Thiaudiere E, Franconi JM, Miraux S (2015) Time-resolved TOF MR angiography in mice using a prospective 3D radial double golden angle approach. Magn Reson Med 73:984–994. doi:10.​1002/​mrm.​25201 PubMedCrossRef
146.
Zurück zum Zitat Tucci S, Flogel U, Hermann S, Sturm M, Schafers M, Spiekerkoetter U (2014) Development and pathomechanisms of cardiomyopathy in very long-chain acyl-CoA dehydrogenase deficient (VLCAD(−/−)) mice. Biochim Biophys Acta 1842:677–685. doi:10.1016/j.bbadis.2014.02.001 PubMedCrossRef Tucci S, Flogel U, Hermann S, Sturm M, Schafers M, Spiekerkoetter U (2014) Development and pathomechanisms of cardiomyopathy in very long-chain acyl-CoA dehydrogenase deficient (VLCAD(−/−)) mice. Biochim Biophys Acta 1842:677–685. doi:10.​1016/​j.​bbadis.​2014.​02.​001 PubMedCrossRef
147.
Zurück zum Zitat Tyrankiewicz U, Skorka T, Jablonska M, Petkow-Dimitrow P, Chlopicki S (2013) Characterization of the cardiac response to a low and high dose of dobutamine in the mouse model of dilated cardiomyopathy by MRI in vivo. J Magn Reson Imaging 37:669–677. doi:10.1002/jmri.23854 PubMedCrossRef Tyrankiewicz U, Skorka T, Jablonska M, Petkow-Dimitrow P, Chlopicki S (2013) Characterization of the cardiac response to a low and high dose of dobutamine in the mouse model of dilated cardiomyopathy by MRI in vivo. J Magn Reson Imaging 37:669–677. doi:10.​1002/​jmri.​23854 PubMedCrossRef
149.
Zurück zum Zitat van Bochove GS, Straathof R, Krams R, Nicolay K, Strijkers GJ (2010) MRI-determined carotid artery flow velocities and wall shear stress in a mouse model of vulnerable and stable atherosclerotic plaque. MAGMA 23:77–84. doi:10.1007/s10334-010-0200-4 PubMedCrossRef van Bochove GS, Straathof R, Krams R, Nicolay K, Strijkers GJ (2010) MRI-determined carotid artery flow velocities and wall shear stress in a mouse model of vulnerable and stable atherosclerotic plaque. MAGMA 23:77–84. doi:10.​1007/​s10334-010-0200-4 PubMedCrossRef
150.
Zurück zum Zitat van de Weijer T, van Ewijk PA, Zandbergen HR, Slenter JM, Kessels AG, Wildberger JE, Hesselink MK, Schrauwen P, Schrauwen-Hinderling VB, Kooi ME (2012) Geometrical models for cardiac MRI in rodents: comparison of quantification of left ventricular volumes and function by various geometrical models with a full-volume MRI data set in rodents. Am J Physiol Heart Circ Physiol 302:H709–H715. doi:10.1152/ajpheart.00710.2011 PubMedCrossRef van de Weijer T, van Ewijk PA, Zandbergen HR, Slenter JM, Kessels AG, Wildberger JE, Hesselink MK, Schrauwen P, Schrauwen-Hinderling VB, Kooi ME (2012) Geometrical models for cardiac MRI in rodents: comparison of quantification of left ventricular volumes and function by various geometrical models with a full-volume MRI data set in rodents. Am J Physiol Heart Circ Physiol 302:H709–H715. doi:10.​1152/​ajpheart.​00710.​2011 PubMedCrossRef
151.
Zurück zum Zitat van Geuns RJ, Wielopolski PA, de Bruin HG, Rensing BJ, van Ooijen PM, Hulshoff M, Oudkerk M, de Feyter PJ (1999) Basic principles of magnetic resonance imaging. Prog Cardiovasc Dis 42:149–156PubMedCrossRef van Geuns RJ, Wielopolski PA, de Bruin HG, Rensing BJ, van Ooijen PM, Hulshoff M, Oudkerk M, de Feyter PJ (1999) Basic principles of magnetic resonance imaging. Prog Cardiovasc Dis 42:149–156PubMedCrossRef
152.
Zurück zum Zitat van Heeswijk RB, De Blois J, Kania G, Gonzales C, Blyszczuk P, Stuber M, Eriksson U, Schwitter J (2013) Selective in vivo visualization of immune-cell infiltration in a mouse model of autoimmune myocarditis by fluorine-19 cardiac magnetic resonance. Circ Cardiovasc Imaging 6:277–284. doi:10.1161/CIRCIMAGING.112.000125 PubMedCrossRef van Heeswijk RB, De Blois J, Kania G, Gonzales C, Blyszczuk P, Stuber M, Eriksson U, Schwitter J (2013) Selective in vivo visualization of immune-cell infiltration in a mouse model of autoimmune myocarditis by fluorine-19 cardiac magnetic resonance. Circ Cardiovasc Imaging 6:277–284. doi:10.​1161/​CIRCIMAGING.​112.​000125 PubMedCrossRef
153.
Zurück zum Zitat van Heeswijk RB, Pellegrin M, Flogel U, Gonzales C, Aubert JF, Mazzolai L, Schwitter J, Stuber M (2015) Fluorine MR imaging of inflammation in atherosclerotic plaque in vivo. Radiology 275:421–429. doi:10.1148/radiol.14141371 PubMedCrossRef van Heeswijk RB, Pellegrin M, Flogel U, Gonzales C, Aubert JF, Mazzolai L, Schwitter J, Stuber M (2015) Fluorine MR imaging of inflammation in atherosclerotic plaque in vivo. Radiology 275:421–429. doi:10.​1148/​radiol.​14141371 PubMedCrossRef
154.
Zurück zum Zitat van Nierop BJ, Coolen BF, Bax NA, Dijk WJ, van Deel ED, Duncker DJ, Nicolay K, Strijkers GJ (2014) Myocardial perfusion MRI shows impaired perfusion of the mouse hypertrophic left ventricle. Int J Cardiovasc Imaging 30:619–628. doi:10.1007/s10554-014-0369-0 PubMedCrossRef van Nierop BJ, Coolen BF, Bax NA, Dijk WJ, van Deel ED, Duncker DJ, Nicolay K, Strijkers GJ (2014) Myocardial perfusion MRI shows impaired perfusion of the mouse hypertrophic left ventricle. Int J Cardiovasc Imaging 30:619–628. doi:10.​1007/​s10554-014-0369-0 PubMedCrossRef
155.
Zurück zum Zitat van Nierop BJ, Coolen BF, Dijk WJ, Hendriks AD, de Graaf L, Nicolay K, Strijkers GJ (2013) Quantitative first-pass perfusion MRI of the mouse myocardium. Magn Reson Med 69:1735–1744. doi:10.1002/mrm.24424 PubMedCrossRef van Nierop BJ, Coolen BF, Dijk WJ, Hendriks AD, de Graaf L, Nicolay K, Strijkers GJ (2013) Quantitative first-pass perfusion MRI of the mouse myocardium. Magn Reson Med 69:1735–1744. doi:10.​1002/​mrm.​24424 PubMedCrossRef
156.
Zurück zum Zitat van Oorschot JW, Gho JM, van Hout GP, Froeling M, Jansen Of Lorkeers SJ, Hoefer IE, Doevendans PA, Luijten PR, Chamuleau SA, Zwanenburg JJ (2015) Endogenous contrast MRI of cardiac fibrosis: beyond late gadolinium enhancement. J Magn Reson Imaging 41:1181–1189. doi:10.1002/jmri.24715 PubMedCrossRef van Oorschot JW, Gho JM, van Hout GP, Froeling M, Jansen Of Lorkeers SJ, Hoefer IE, Doevendans PA, Luijten PR, Chamuleau SA, Zwanenburg JJ (2015) Endogenous contrast MRI of cardiac fibrosis: beyond late gadolinium enhancement. J Magn Reson Imaging 41:1181–1189. doi:10.​1002/​jmri.​24715 PubMedCrossRef
158.
Zurück zum Zitat Vandsburger M, Vandoorne K, Oren R, Leftin A, Mpofu S, Delli Castelli D, Aime S, Neeman M (2015) Cardio-chemical exchange saturation transfer magnetic resonance imaging reveals molecular signatures of endogenous fibrosis and exogenous contrast media. Circ Cardiovasc Imaging. doi:10.1161/CIRCIMAGING.114.002180 PubMed Vandsburger M, Vandoorne K, Oren R, Leftin A, Mpofu S, Delli Castelli D, Aime S, Neeman M (2015) Cardio-chemical exchange saturation transfer magnetic resonance imaging reveals molecular signatures of endogenous fibrosis and exogenous contrast media. Circ Cardiovasc Imaging. doi:10.​1161/​CIRCIMAGING.​114.​002180 PubMed
160.
Zurück zum Zitat Vandsburger MH, French BA, Helm PA, Roy RJ, Kramer CM, Young AA, Epstein FH (2007) Multi-parameter in vivo cardiac magnetic resonance imaging demonstrates normal perfusion reserve despite severely attenuated beta-adrenergic functional response in neuronal nitric oxide synthase knockout mice. Eur Heart J 28:2792–2798. doi:10.1093/eurheartj/ehm241 PubMedCrossRef Vandsburger MH, French BA, Helm PA, Roy RJ, Kramer CM, Young AA, Epstein FH (2007) Multi-parameter in vivo cardiac magnetic resonance imaging demonstrates normal perfusion reserve despite severely attenuated beta-adrenergic functional response in neuronal nitric oxide synthase knockout mice. Eur Heart J 28:2792–2798. doi:10.​1093/​eurheartj/​ehm241 PubMedCrossRef
161.
Zurück zum Zitat Vandsburger MH, French BA, Kramer CM, Zhong X, Epstein FH (2012) Displacement-encoded and manganese-enhanced cardiac MRI reveal that nNOS, not eNOS, plays a dominant role in modulating contraction and calcium influx in the mammalian heart. Am J Physiol Heart Circ Physiol 302:H412–H419. doi:10.1152/ajpheart.00705.2011 PubMedCrossRef Vandsburger MH, French BA, Kramer CM, Zhong X, Epstein FH (2012) Displacement-encoded and manganese-enhanced cardiac MRI reveal that nNOS, not eNOS, plays a dominant role in modulating contraction and calcium influx in the mammalian heart. Am J Physiol Heart Circ Physiol 302:H412–H419. doi:10.​1152/​ajpheart.​00705.​2011 PubMedCrossRef
162.
Zurück zum Zitat Vandsburger MH, Janiczek RL, Xu Y, French BA, Meyer CH, Kramer CM, Epstein FH (2010) Improved arterial spin labeling after myocardial infarction in mice using cardiac and respiratory gated look-locker imaging with fuzzy C-means clustering. Magn Reson Med 63:648–657. doi:10.1002/mrm.22280 PubMedPubMedCentralCrossRef Vandsburger MH, Janiczek RL, Xu Y, French BA, Meyer CH, Kramer CM, Epstein FH (2010) Improved arterial spin labeling after myocardial infarction in mice using cardiac and respiratory gated look-locker imaging with fuzzy C-means clustering. Magn Reson Med 63:648–657. doi:10.​1002/​mrm.​22280 PubMedPubMedCentralCrossRef
163.
Zurück zum Zitat Vanhoutte L, Gallez B, Feron O, Balligand JL, Esfahani H, d’Hoore W, Moniotte S (2015) Variability of mouse left ventricular function assessment by 11.7 Tesla MRI. J Cardiovasc Transl Res. doi:10.1007/s12265-015-9638-0 PubMed Vanhoutte L, Gallez B, Feron O, Balligand JL, Esfahani H, d’Hoore W, Moniotte S (2015) Variability of mouse left ventricular function assessment by 11.7 Tesla MRI. J Cardiovasc Transl Res. doi:10.​1007/​s12265-015-9638-0 PubMed
165.
Zurück zum Zitat von Elverfeldt D, Maier A, Duerschmied D, Braig M, Witsch T, Wang X, Mauler M, Neudorfer I, Menza M, Idzko M, Zirlik A, Heidt T, Bronsert P, Bode C, Peter K, von Zur Muhlen C (2014) Dual-contrast molecular imaging allows noninvasive characterization of myocardial ischemia/reperfusion injury after coronary vessel occlusion in mice by magnetic resonance imaging. Circulation 130:676–687. doi:10.1161/CIRCULATIONAHA.113.008157 CrossRef von Elverfeldt D, Maier A, Duerschmied D, Braig M, Witsch T, Wang X, Mauler M, Neudorfer I, Menza M, Idzko M, Zirlik A, Heidt T, Bronsert P, Bode C, Peter K, von Zur Muhlen C (2014) Dual-contrast molecular imaging allows noninvasive characterization of myocardial ischemia/reperfusion injury after coronary vessel occlusion in mice by magnetic resonance imaging. Circulation 130:676–687. doi:10.​1161/​CIRCULATIONAHA.​113.​008157 CrossRef
166.
Zurück zum Zitat von Morze C, Xu D, Purcell DD, Hess CP, Mukherjee P, Saloner D, Kelley DA, Vigneron DB (2007) Intracranial time-of-flight MR angiography at 7 T with comparison to 3 T. J Magn Reson Imaging 26:900–904. doi:10.1002/jmri.21097 CrossRef von Morze C, Xu D, Purcell DD, Hess CP, Mukherjee P, Saloner D, Kelley DA, Vigneron DB (2007) Intracranial time-of-flight MR angiography at 7 T with comparison to 3 T. J Magn Reson Imaging 26:900–904. doi:10.​1002/​jmri.​21097 CrossRef
168.
Zurück zum Zitat Waghorn B, Edwards T, Yang Y, Chuang KH, Yanasak N, Hu TC (2008) Monitoring dynamic alterations in calcium homeostasis by T (1)-weighted and T (1)-mapping cardiac manganese-enhanced MRI in a murine myocardial infarction model. NMR Biomed 21:1102–1111. doi:10.1002/nbm.1287 PubMedCrossRef Waghorn B, Edwards T, Yang Y, Chuang KH, Yanasak N, Hu TC (2008) Monitoring dynamic alterations in calcium homeostasis by T (1)-weighted and T (1)-mapping cardiac manganese-enhanced MRI in a murine myocardial infarction model. NMR Biomed 21:1102–1111. doi:10.​1002/​nbm.​1287 PubMedCrossRef
169.
Zurück zum Zitat Waghorn B, Yang Y, Baba A, Matsuda T, Schumacher A, Yanasak N, Hu TC (2009) Assessing manganese efflux using SEA0400 and cardiac T1-mapping manganese-enhanced MRI in a murine model. NMR Biomed 22:874–881. doi:10.1002/nbm.1414 PubMedCrossRef Waghorn B, Yang Y, Baba A, Matsuda T, Schumacher A, Yanasak N, Hu TC (2009) Assessing manganese efflux using SEA0400 and cardiac T1-mapping manganese-enhanced MRI in a murine model. NMR Biomed 22:874–881. doi:10.​1002/​nbm.​1414 PubMedCrossRef
170.
Zurück zum Zitat Waller C, Kahler E, Hiller KH, Hu K, Nahrendorf M, Voll S, Haase A, Ertl G, Bauer WR (2000) Myocardial perfusion and intracapillary blood volume in rats at rest and with coronary dilatation: MR imaging in vivo with use of a spin-labeling technique. Radiology 215:189–197. doi:10.1148/radiology.215.1.r00ap07189 PubMedCrossRef Waller C, Kahler E, Hiller KH, Hu K, Nahrendorf M, Voll S, Haase A, Ertl G, Bauer WR (2000) Myocardial perfusion and intracapillary blood volume in rats at rest and with coronary dilatation: MR imaging in vivo with use of a spin-labeling technique. Radiology 215:189–197. doi:10.​1148/​radiology.​215.​1.​r00ap07189 PubMedCrossRef
171.
172.
Zurück zum Zitat Weissler B, Gebhardt P, Duppenbecker P, Wehner J, Schug D, Lerche C, Goldschmidt B, Salomon A, Verel I, Heijman E, Perkuhn M, Heberling D, Botnar R, Kiessling F, Schulz V (2015) A digital preclinical PET/MRI insert and initial results. IEEE Trans Med Imaging. doi:10.1109/TMI.2015.2427993 PubMed Weissler B, Gebhardt P, Duppenbecker P, Wehner J, Schug D, Lerche C, Goldschmidt B, Salomon A, Verel I, Heijman E, Perkuhn M, Heberling D, Botnar R, Kiessling F, Schulz V (2015) A digital preclinical PET/MRI insert and initial results. IEEE Trans Med Imaging. doi:10.​1109/​TMI.​2015.​2427993 PubMed
173.
Zurück zum Zitat Wiesmann F, Neubauer S, Haase A, Hein L (2001) Can we use vertical bore magnetic resonance scanners for murine cardiovascular phenotype characterization? Influence of upright body position on left ventricular hemodynamics in mice. J Cardiovasc Magn Reson 3:311–315PubMedCrossRef Wiesmann F, Neubauer S, Haase A, Hein L (2001) Can we use vertical bore magnetic resonance scanners for murine cardiovascular phenotype characterization? Influence of upright body position on left ventricular hemodynamics in mice. J Cardiovasc Magn Reson 3:311–315PubMedCrossRef
174.
Zurück zum Zitat Wiesmann F, Ruff J, Engelhardt S, Hein L, Dienesch C, Leupold A, Illinger R, Frydrychowicz A, Hiller KH, Rommel E, Haase A, Lohse MJ, Neubauer S (2001) Dobutamine-stress magnetic resonance microimaging in mice: acute changes of cardiac geometry and function in normal and failing murine hearts. Circ Res 88:563–569PubMedCrossRef Wiesmann F, Ruff J, Engelhardt S, Hein L, Dienesch C, Leupold A, Illinger R, Frydrychowicz A, Hiller KH, Rommel E, Haase A, Lohse MJ, Neubauer S (2001) Dobutamine-stress magnetic resonance microimaging in mice: acute changes of cardiac geometry and function in normal and failing murine hearts. Circ Res 88:563–569PubMedCrossRef
175.
Zurück zum Zitat Wiesmann F, Ruff J, Hiller KH, Rommel E, Haase A, Neubauer S (2000) Developmental changes of cardiac function and mass assessed with MRI in neonatal, juvenile, and adult mice. Am J Physiol Heart Circ Physiol 278:H652–H657PubMed Wiesmann F, Ruff J, Hiller KH, Rommel E, Haase A, Neubauer S (2000) Developmental changes of cardiac function and mass assessed with MRI in neonatal, juvenile, and adult mice. Am J Physiol Heart Circ Physiol 278:H652–H657PubMed
178.
Metadaten
Titel
High field magnetic resonance imaging of rodents in cardiovascular research
verfasst von
Laetitia Vanhoutte
Bernhard L. Gerber
Bernard Gallez
Chrystelle Po
Julie Magat
Balligand Jean-Luc
Olivier Feron
Stéphane Moniotte
Publikationsdatum
01.07.2016
Verlag
Springer Berlin Heidelberg
Erschienen in
Basic Research in Cardiology / Ausgabe 4/2016
Print ISSN: 0300-8428
Elektronische ISSN: 1435-1803
DOI
https://doi.org/10.1007/s00395-016-0565-2

Weitere Artikel der Ausgabe 4/2016

Basic Research in Cardiology 4/2016 Zur Ausgabe

Update Kardiologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.