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Basic Research in Cardiology

Erschienen in:

01.03.2018 | Invited Review

The SAFE pathway for cardioprotection: is this a promising target?

verfasst von: Nkanyiso Hadebe, Martin Cour, Sandrine Lecour

Erschienen in: Basic Research in Cardiology | Ausgabe 2/2018

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Abstract

The survivor activating factor enhancement (SAFE) pathway was discovered as an alternative intrinsic pro-survival signaling pathway to the reperfusion injury salvage kinase pathway for cardioprotection against ischemia–reperfusion injury. The delineation of this pathway, made of key components such as cytokines of the immune system and transcription factors, has brought major advancements in our understanding on how the heart is able to protect itself against ischemia–reperfusion injury. In this viewpoint, we describe the major steps leading to the discovery of the SAFE pathway in small animal models to date and we discuss its translation to large animals and humans.

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Titel: The SAFE pathway for cardioprotection: is this a promising target?
verfasst von: Nkanyiso Hadebe
Martin Cour
Sandrine Lecour
Publikationsdatum: 01.03.2018
Verlag: Springer Berlin Heidelberg
Erschienen in: Basic Research in Cardiology / Ausgabe 2/2018
Print ISSN: 0300-8428
Elektronische ISSN: 1435-1803
DOI: https://doi.org/10.1007/s00395-018-0670-5

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The SAFE pathway for cardioprotection: is this a promising target?

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