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Erschienen in: Acta Neuropathologica 3/2006

01.09.2006 | Review

α-Synuclein structure, posttranslational modification and alternative splicing as aggregation enhancers

verfasst von: Katrin Beyer

Erschienen in: Acta Neuropathologica | Ausgabe 3/2006

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Abstract

α-Synuclein aggregation is thought to be a key event in the pathogenesis of synucleinopathies. Although different α-synuclein alterations and modifications have been proposed to be responsible for early aggregation steps, the mechanisms underlying these events remain unclarified. α-Synuclein is a small protein localized to synaptic terminals and its intrinsic structure has been claimed to be an important factor for self-oligomerization and self-aggregation. α-Synuclein expression studies in cell cultures have demonstrated that posttranslational modifications, such as phosphorylation, oxidation, and sumoylation, are primarily involved in α-synuclein aggregation. Furthermore, in the last few years accumulating evidence has pointed to alternative splicing as a crucial mechanism in the development of neurodegenerative disorders. At least three different α-synuclein isoforms have been described as products of alternative splicing. Two of these isoforms (α-synuclein 112 and α-synuclein 126) are shorter proteins with probably altered functions and aggregation propensity. The present review attempts to summarize the data so far available on α-synuclein structure, posttranslational modifications, and alternative splicing as possible enhancers of aggregation.
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Metadaten
Titel
α-Synuclein structure, posttranslational modification and alternative splicing as aggregation enhancers
verfasst von
Katrin Beyer
Publikationsdatum
01.09.2006
Verlag
Springer-Verlag
Erschienen in
Acta Neuropathologica / Ausgabe 3/2006
Print ISSN: 0001-6322
Elektronische ISSN: 1432-0533
DOI
https://doi.org/10.1007/s00401-006-0104-6

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