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Acta Neuropathologica

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01.06.2009 | Case Report

Hippocampal sclerosis with four-repeat tau-positive round inclusions in the dentate gyrus: a new type of four-repeat tauopathy

verfasst von: Yasuo Miki, Fumiaki Mori, Emiko Hori, Mitsuomi Kaimori, Koichi Wakabayashi

Erschienen in: Acta Neuropathologica | Ausgabe 6/2009

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Abstract

Hippocampal sclerosis is defined as selective neuronal loss and gliosis of the hippocampus with heterogeneous etiologies, including neurodegenerative tauopathies. We report a 78-year-old woman who presented with depression, in whom postmortem examination revealed almost complete loss of neurons with gliosis in the subiculum and CA1-3 regions of the hippocampus and abundant neuronal cytoplasmic inclusions in the dentate gyrus. The inclusions were round, slightly basophilic and argyrophilic, resembling Pick bodies. However, they were Gallyas- and 4-repeat tau-positive, and 3-repeat tau- and ubiquitin-negative. To our knowledge, the histopathological features in this case were different from those in hippocampal sclerosis or 4-repeat tauopathies reported previously. It is likely that this case is a new variant of 4-repeat tauopathy presenting with hippocampal sclerosis.

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Titel: Hippocampal sclerosis with four-repeat tau-positive round inclusions in the dentate gyrus: a new type of four-repeat tauopathy
verfasst von: Yasuo Miki
Fumiaki Mori
Emiko Hori
Mitsuomi Kaimori
Koichi Wakabayashi
Publikationsdatum: 01.06.2009
Verlag: Springer-Verlag
Erschienen in: Acta Neuropathologica / Ausgabe 6/2009
Print ISSN: 0001-6322
Elektronische ISSN: 1432-0533
DOI: https://doi.org/10.1007/s00401-009-0531-2

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Hippocampal sclerosis with four-repeat tau-positive round inclusions in the dentate gyrus: a new type of four-repeat tauopathy

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