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Erschienen in: Acta Neuropathologica 2/2009

01.08.2009 | Review

Pathology and new players in the pathogenesis of brain edema

verfasst von: Sukriti Nag, Janet L. Manias, Duncan J. Stewart

Erschienen in: Acta Neuropathologica | Ausgabe 2/2009

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Abstract

Brain edema continues to be a major cause of mortality after diverse types of brain pathologies such as major cerebral infarcts, hemorrhages, trauma, infections and tumors. The classification of edema into vasogenic, cytotoxic, hydrocephalic and osmotic has stood the test of time although it is recognized that in most clinical situations there is a combination of different types of edema during the course of the disease. Basic information about the types of edema is provided for better understanding of the expression pattern of some of the newer molecules implicated in the pathogenesis of brain edema. These molecules include the aquaporins, matrix metalloproteinases and growth factors such as vascular endothelial growth factors A and B and the angiopoietins. The potential of these agents in the treatment of edema is discussed. Since many molecules are involved in the pathogenesis of brain edema, effective treatment cannot be achieved by a single agent but will require the administration of a “magic bullet” containing a variety of agents released at different times during the course of edema in order to be successful.
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Metadaten
Titel
Pathology and new players in the pathogenesis of brain edema
verfasst von
Sukriti Nag
Janet L. Manias
Duncan J. Stewart
Publikationsdatum
01.08.2009
Verlag
Springer-Verlag
Erschienen in
Acta Neuropathologica / Ausgabe 2/2009
Print ISSN: 0001-6322
Elektronische ISSN: 1432-0533
DOI
https://doi.org/10.1007/s00401-009-0541-0

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