Erschienen in:
19.03.2020 | Correspondence
Histone H3 wild-type DIPG/DMG overexpressing EZHIP extend the spectrum diffuse midline gliomas with PRC2 inhibition beyond H3-K27M mutation
verfasst von:
David Castel, Thomas Kergrohen, Arnault Tauziède-Espariat, Alan Mackay, Samia Ghermaoui, Emmanuèle Lechapt, Stefan M. Pfister, Christof M. Kramm, Nathalie Boddaert, Thomas Blauwblomme, Stéphanie Puget, Kévin Beccaria, Chris Jones, David T. W. Jones, Pascale Varlet, Jacques Grill, Marie-Anne Debily
Erschienen in:
Acta Neuropathologica
|
Ausgabe 6/2020
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Excerpt
Diffuse midline gliomas (DMG) H3 K27M-
mutant was introduced in the 2016 WHO Classification of Tumors of the Central Nervous System, unifying diffuse intrinsic pontine gliomas (DIPG) and gliomas from the thalamus and spinal cord harboring a histone H3-K27M mutation leading to Polycomb Repressor Complex 2 (PRC2) inhibition [
7]. These gliomas are relatively much more common in the pediatric than the adult population, and patients show a dismal prognosis with a median overall survival below 1 year [
11]. …