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Erschienen in: Acta Neuropathologica 1/2021

Open Access 19.10.2020 | Correspondence

MOG-expressing teratoma followed by MOG-IgG-positive optic neuritis

verfasst von: Brigitte Wildemann, Sven Jarius, Jonas Franz, Klemens Ruprecht, Markus Reindl, Christine Stadelmann

Erschienen in: Acta Neuropathologica | Ausgabe 1/2021

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A paraneoplastic etiology has been reported in few patients with aquaporin-4 (AQP4)-IgG-seropositive neuromyelitis optica spectrum disorders (NMOSD), with lung and breast cancer being the most frequent associated malignancies [12]. Whether MOG encephalomyelitis (MOG-EM; also termed MOG antibody-associated disease [MOGAD]), a rare autoimmune disease characterized by serum immunoglobulin G antibodies (IgG) against myelin oligodendrocyte glycoprotein (MOG) and overlapping clinical and radiological features with both NMOSD and multiple sclerosis (MS) [47, 11], may occur in a paraneoplastic context is less well known. We report on a patient with oligosymptomatic MOG-EM emerging several months after detection and resection of an ovarian teratoma. Histopathology revealed neural tissue expressing MOG protein and accompanying immune cell infiltration within the teratoma, suggesting a possible paraneoplastic origin of MOG-EM in this case.
A 26-year-old woman with a history of Hashimoto thyroiditis developed right abdominal pain persisting for several weeks. A pelvic MRI showed a mass of 6 cm diameter adjacent to the right ovary displaying sebaceous components and calcifications. The right ovary was resected and histology confirmed a mature cystic teratoma. Eleven months later and within 3 weeks of an upper respiratory infection, the patient developed left-sided optic neuritis. Symptoms included mild eye pain, visual blurring, impaired color vision, along with a drop in visual acuity to 0.6. Cranial magnetic resonance imaging (MRI) revealed a normal optic nerve and a solitary small T2/fluid-attenuated inversion recovery lesion in the right frontal white matter; spinal MRI was unremarkable. CSF analysis disclosed normal cell and protein profiles and no oligoclonal bands. Serology for AQP4-IgG and NMDA-receptor-IgG was negative but positive for MOG-IgG (1:320). CSF was negative for MOG-IgG as typically the case in MOG-EM [7, 8]. Seropositivity was confirmed in three cell-based assays using either fixed or live cells expressing recombinant human full-length MOG protein as test substrate, two of which used Fc(γ)-specific secondary antibodies [3, 7, 10]. The symptoms resolved following high-dose intravenous methylprednisolone (IVMP) (5 × 1000 mg) and oral tapering over 4 weeks (initial 60 mg/d). Five months later, the patient noticed recurrence of pain upon eye movement and left-sided visual blurring compatible with a second episode of left-sided ON. Cranial MRI was unchanged and a repeat lumbar puncture disclosed no abnormalities except few activated lymphocytes. MOG-IgG was detectable at low titers (1:32; cut-off 1:10). Treatment with IVMP (3 × 1000 mg) led to recovery of visual acuity, while slight impairment of color vision persists to date. A further pelvic MRI performed within several months after the second ON did not show evidence of recurrent teratoma. Two and four months after the second attack and 18 and 20 months after removal of the teratoma, MOG-IgG had turned negative according to three assays. To investigate a possible paraneoplastic origin of MOG-EM in this patient, tissue blocks of the teratoma were examined neuropathologically.
Histological studies revealed a predominantly cystic, mature teratoma. In addition to well-differentiated epidermis and dermis with sebaceous glands, eccrine glands and hair follicles, the teratoma-contained neuroectodermal tissue with expression of glial fibrillary acidic protein (GFAP) (Fig. 1a–e). Moreover, mesodermal tissue, namely adipocytes and fibroblasts, was present. Significant entodermal tissue or undifferentiated components were not observed. A detailed examination of the neuroectodermal tissue showed oligodendrocytes and axons with intermittent myelination (Fig. 1f–p) as demonstrated by expression of oligodendroglial markers (CNPase, NogoA, BCAS1, NG2, p25, Olig2), among them markers of mature oligodendrocytes, such as myelin basic protein (MBP) and MOG. Also, scattered infiltration with CD4 + and CD8 + T-cells was observed. CD68 + as well as MHC II-expressing macrophages/activated microglia and CD1c + dendritic cells (DCs) were found in and immediately adjacent to the neuroectodermal tissue (Online Resources 1 and 2). Moreover, different DC populations were abundant in the lymphoid tissue (CD1c + , CD205 +) and epidermis (CD1a + , CD1c + , Langerin +) within the teratoma (Online Resource 2). Mutations/copy number variation in the MOG gene within the tumoral tissue could not be assessed in the available sample but should be evaluated in future studies of similar cases.
This patient developed two rather mild episodes of MOG-IgG-associated ON 11 and 16 months after diagnosis of an ovarian teratoma, which expressed MOG and other myelin proteins. Considering the latency of less than 1 year between removal of the tumor and ON, a humoral immune response directed against ectopic MOG expressed in the teratoma may have triggered remote neurologic autoimmunity in our patient. The infection preceding the first episode of ON might have facilitated the onset of MOG-EM. Infections, possibly by general immune cell activation or altering blood/brain barrier permeability, have been shown to frequently precede attacks in MOG-EM and AQP4-IgG-positive NMOSD [4, 6, 9]. A paraneoplastic etiology of MOG-EM in this case is further supported by the immune cell infiltration of the tumor and the fact that resection of the teratoma was followed by disappearance of MOG-IgG in the long-term course. An association of MOG-EM with ovarian teratoma has been previously observed by us and others in 2/77 patients from two cohorts [1, 4, 6] (Table 1). However, different from our patient, MOG expression within the teratoma was not studied in the previous cases. While no data are available in one case, MOG-IgG also disappeared after tumor removal in the other (testing performed by us after publication of [4] using two independent assays; sample taken 42 months after onset of MOG-EM and 40 months after teratoma resection; initial MOG-IgG titer was 1:10,240). Mature cystic teratomas have been reported to represent at least 10% of all ovarian tumors and to occur mostly in women of reproductive age. They often grow slowly at a mean rate of 1.8 mm/year and are often detected incidentally at routine pelvic ultrasound examination in asymptomatic women. Given the recent observations on a strong association of NMDAR-IgG-positive encephalitis with teratoma as well as reports on paraneoplastic NMOSD, studies systematically evaluating the prevalence of teratoma in MOG-IgG-positive adult women may be warranted. Our findings endorse the suggestion to test for MOG-IgG in patients with demyelinating disorders of the CNS and co-existing teratoma included in the recent international consensus recommendations on MOG-IgG testing [5].
Table 1
Clinical and serological findings in patients with MOG encephalomyelitis and teratoma
Case
Age at onset of MOG-EM/sex/origin
Leading symptom
Teratoma classification
MOG antigen present in tumor tissue
Relation of teratoma diagnosis and MOG-EM onset
Neurological outcome
MOG-IgG at last follow-up
NMDAR-antibodies in serum and CSF
Additional remarks
1 (present case)
27/f/Cauc
Recurrent ON
Benign, mature cystic ovarian teratoma
Yes
11 months prior to onset
Full recovery
Disappearance (initial titer 1:320)
Negative
 
2 (Ref. 4, 6)
18/f/Cauc
LETM, BSTE
Benign, mature cystic ovarian teratoma
Not reported
2 months after onset
Almost full recovery
Disappearance (initial titer 1:10,240)
Negative
Diagnosis of retroperitoneal ganglioneuroma shortly after onset of MOG-EM
3 (Ref. 1)
16/f/Cauc
LETM, encephalopathy
Ovarian teratoma
Not reported
At onset?
Full recovery
Not reported (initial titer 1:640)
Negative
 
BSTE brain stem encephalitis, Cauc caucasian, CSF cerebrospinal fluid, EM encephalomyelitis,  f female, LETM longitudinally extensive transverse myelitis, MOG myelin oligodendrocyte glycoprotein, ON optic neuritis

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Conflicts of interest

Brigitte Wildemann received grants from German Ministry of Education and Research, Deutsche Forschungsgemeinschaft, Dietmar Hopp Foundation, and Klaus Tschira Foundation, grants and personal fees from Merck Serono, Sanofi Genzyme, and Novartis pharmaceuticals, and personal fees from Bayer Healthcare, Biogen, Teva Pharma. Sven Jarius reports no conflicts of interest. Jonas Franz reports no conflicts of interest. Klemens Ruprecht received research support from Novartis, Merck Serono, German Ministry of Education and Research, European Union (821283-2), Stiftung Charité (BIH Clinical Fellow Program) and Arthur Arnstein Foundation; received speaker honoraria and travel grants from Bayer, Biogen Idec, Merck Serono, sanofi-aventis/Genzyme, Teva, Roche, Novartis, and Guthy Jackson Charitable Foundation. Markus Reindl reports the following conflicts of interest: The University Hospital and Medical University of Innsbruck (Austria; employer of MR) receives payments for antibody assays (MOG, AQP4 and other autoantibodies) and for MOG and AQP4 antibody validation experiments organized by Euroimmun (Lübeck, Germany). Markus Reindl is supported by a research grant from the Austrian Science Fund (FWF, project P32699). Christine Stadelmann has received research support from Novartis and Medday, speaker’s honoraria from Novartis and Roche and served on advisory boards of Merck Serono and Roche. No conflicts of interests with regard to the present work.
The patient has given written consent to the publication of this case report.
Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://​creativecommons.​org/​licenses/​by/​4.​0/​.

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Metadaten
Titel
MOG-expressing teratoma followed by MOG-IgG-positive optic neuritis
verfasst von
Brigitte Wildemann
Sven Jarius
Jonas Franz
Klemens Ruprecht
Markus Reindl
Christine Stadelmann
Publikationsdatum
19.10.2020
Verlag
Springer Berlin Heidelberg
Erschienen in
Acta Neuropathologica / Ausgabe 1/2021
Print ISSN: 0001-6322
Elektronische ISSN: 1432-0533
DOI
https://doi.org/10.1007/s00401-020-02236-5

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