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Factors associated with complex regional pain syndrome type I in patients with surgically treated distal radius fracture

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Abstract

Purpose

Wrist fracture is considered a typical initiating trauma for complex regional pain syndrome type I (CRPS I). However, few studies have comprehensively evaluated factors associated with the occurrence of CRPS I after the surgical treatment of a distal radius fracture (DRF). This study evaluates the factors influencing the occurrence of CRPS I after the surgical treatment of a DRF.

Methods

A total of 477 patients with a DRF who had been treated surgically were enrolled in this prospective observational study. Patients were followed for 6 months after surgery, and CRPS I was diagnosed using the Budapest diagnostic criteria for research. The factors assessed for the development of CPRS I were age, gender, the body mass index, the type of fracture, the energy of trauma, the number of trial reductions, the type of surgery, and the duration of immobilization. A multivariate logistic regression analysis was conducted to identify independent predictors of the occurrence of CRPS I.

Results

Among the 477 patients, 42 (8.8 %) satisfied the Budapest criteria for CRPS I within 6 months of surgery. Female patients developed CRPS I more frequently, and the patients who developed CRPS I were older and more likely to sustain a high energy injury or have a comminuted fracture. According to the multivariate analysis, female patients and those with a high energy trauma or severe fracture type were significantly more likely to develop CRPS I (p = 0.02, 0.01, and 0.01, respectively).

Conclusions

High energy injuries, severe fractures, and the female gender contribute to the development of CRPS I after the surgical treatment of DRF. The results have important implications for physicians who wish to identify patients at high risk for CRPS I after operative fixation for DRF and instigate treatment accordingly.

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References

  1. Chung KC, Shauver MJ, Birkmeyer JD (2009) Trends in the United States in the treatment of distal radial fractures in the elderly. J Bone Joint Surg Am 91:1868–1873

    Article  PubMed Central  PubMed  Google Scholar 

  2. Ring D, Jupiter JB (2005) Treatment of osteoporotic distal radius fractures. Osteoporos Int 16(Suppl 2):S80–S84

    Article  PubMed  Google Scholar 

  3. de Mos M, de Bruijn AG, Huygen FJ, Dieleman JP, Stricker BH, Sturkenboom MC (2007) The incidence of complex regional pain syndrome: a population-based study. Pain 129:12–20

    Article  PubMed  Google Scholar 

  4. Beerthuizen A, Stronks DL, Van’t Spijker A, Yaksh A, Hanraets BM, Klein J, Huygen FJ (2012) Demographic and medical parameters in the development of complex regional pain syndrome type 1 (CRPS1): prospective study on 596 patients with a fracture. Pain 153:1187–1192

    Article  PubMed  Google Scholar 

  5. Zollinger PE, Tuinebreijer WE, Kreis RW, Breederveld RS (1999) Effect of vitamin C on frequency of reflex sympathetic dystrophy in wrist fractures: a randomised trial. Lancet 354:2025–2028

    Article  CAS  PubMed  Google Scholar 

  6. Roumen RM, Hesp WL, Bruggink ED (1991) Unstable Colles’ fractures in elderly patients. A randomised trial of external fixation for redisplacement. J Bone Joint Surg Br 73:307–311

    CAS  PubMed  Google Scholar 

  7. Veldman PH, Reynen HM, Arntz IE, Goris RJ (1993) Signs and symptoms of reflex sympathetic dystrophy: prospective study of 829 patients. Lancet 342:1012–1016

    Article  CAS  PubMed  Google Scholar 

  8. Dijkstra PU, Groothoff JW, ten Duis HJ, Geertzen JH (2003) Incidence of complex regional pain syndrome type I after fractures of the distal radius. Eur J Pain 7:457–462

    Article  PubMed  Google Scholar 

  9. Gradl G, Gradl G, Wendt M, Mittlmeier T, Kundt G, Jupiter JB (2013) Non-bridging external fixation employing multiplanar K-wires versus volar locked plating for dorsally displaced fractures of the distal radius. Arch Orthop Trauma Surg 133:595–602

    Article  PubMed  Google Scholar 

  10. Kang JE, Kim YC, Lee SC, Kim JH (2012) Relationship between complex regional pain syndrome and working life: a Korean study. J Korean Med Sci 27:929–933

    Article  PubMed Central  PubMed  Google Scholar 

  11. Galer BS, Henderson J, Perander J, Jensen MP (2000) Course of symptoms and quality of life measurement in complex regional pain syndrome: a pilot survey. J Pain Symptom Manage 20:286–292

    Article  CAS  PubMed  Google Scholar 

  12. de Mos M, Sturkenboom MC, Huygen FJ (2009) Current understandings on complex regional pain syndrome. Pain Pract 9:86–99

    Article  PubMed  Google Scholar 

  13. Bruehl S (2010) An update on the pathophysiology of complex regional pain syndrome. Anesthesiology 113:713–725

    PubMed  Google Scholar 

  14. Raja SN, Grabow TS (2002) Complex regional pain syndrome I (reflex sympathetic dystrophy). Anesthesiology 96:1254–1260

    Article  PubMed  Google Scholar 

  15. Li Z, Smith BP, Smith TL, Koman LA (2005) Diagnosis and management of complex regional pain syndrome complicating upper extremity recovery. J Hand Ther 18:270–276

    Article  PubMed  Google Scholar 

  16. Zyluk A (2004) Complex regional pain syndrome type I. Risk factors, prevention and risk of recurrence. J Hand Surg Br 29:334–337

    Article  PubMed  Google Scholar 

  17. Puchalski P, Zyluk A (2005) Complex regional pain syndrome type 1 after fractures of the distal radius: a prospective study of the role of psychological factors. J Hand Surg Br 30:574–580

    Article  CAS  PubMed  Google Scholar 

  18. Bruehl S, Harden RN, Galer BS, Saltz S, Bertram M, Backonja M, Gayles R, Rudin N, Bhugra MK, Stanton-Hicks M (1999) External validation of IASP diagnostic criteria for complex regional pain syndrome and proposed research diagnostic criteria. International Association for the Study of Pain. Pain 81:147–154

    Article  CAS  PubMed  Google Scholar 

  19. Harden RN, Bruehl S, Stanton-Hicks M, Wilson PR (2007) Proposed new diagnostic criteria for complex regional pain syndrome. Pain Med 8:326–331

    Article  PubMed  Google Scholar 

  20. Bickerstaff DR, Kanis JA (1994) Algodystrophy: an under-recognized complication of minor trauma. Br J Rheumatol 33:240–248

    Article  CAS  PubMed  Google Scholar 

  21. Zollinger PE, Tuinebreijer WE, Breederveld RS, Kreis RW (2007) Can vitamin C prevent complex regional pain syndrome in patients with wrist fractures? A randomized, controlled, multicenter dose-response study. J Bone Joint Surg Am 89:1424–1431

    Article  CAS  PubMed  Google Scholar 

  22. Demir SE, Ozaras N, Karamehmetoglu SS, Karacan I, Aytekin E (2010) Risk factors for complex regional pain syndrome in patients with traumatic extremity injury. Ulus Travma Acil Cerrahi Derg 16:144–148

    PubMed  Google Scholar 

  23. Peduzzi P, Concato J, Kemper E, Holford TR, Feinstein AR (1996) A simulation study of the number of events per variable in logistic regression analysis. J Clin Epidemiol 49:1373–1379

    Article  CAS  PubMed  Google Scholar 

  24. Dilek B, Yemez B, Kizil R, Kartal E, Gulbahar S, Sari O, Akalin E (2012) Anxious personality is a risk factor for developing complex regional pain syndrome type I. Rheumatol Int 32:915–920

    Article  PubMed  Google Scholar 

  25. Zyluk A, Mosiejczuk H (2013) A comparison of the accuracy of two sets of diagnostic criteria in the early detection of complex regional pain syndrome following surgical treatment of distal radial fractures. J Hand Surg Eur 38:609–615

    Article  CAS  Google Scholar 

  26. Harden RN, Bruehl S, Perez RS, Birklein F, Marinus J, Maihofner C, Lubenow T, Buvanendran A, Mackey S, Graciosa J, Mogilevski M, Ramsden C, Chont M, Vatine JJ (2010) Validation of proposed diagnostic criteria (the “Budapest Criteria”) for Complex Regional Pain Syndrome. Pain 150:268–274

    Article  PubMed Central  PubMed  Google Scholar 

  27. Atkins RM, Duckworth T, Kanis JA (1989) Algodystrophy following Colles’ fracture. J Hand Surg Br 14:161–164

    Article  CAS  PubMed  Google Scholar 

  28. Field J, Atkins RM (1997) Algodystrophy is an early complication of Colles’ fracture. What are the implications? J Hand Surg Br 22:178–182

    Article  CAS  PubMed  Google Scholar 

  29. Esenwein P, Sonderegger J, Gruenert J, Ellenrieder B, Tawfik J, Jakubietz M (2013) Complications following palmar plate fixation of distal radius fractures: a review of 665 cases. Arch Orthop Trauma Surg 133:1155–1162

    Article  CAS  PubMed  Google Scholar 

  30. Leversedge FJ, Srinivasan RC (2012) Management of soft-tissue injuries in distal radius fractures. Hand Clin 28:225–233

    Article  PubMed  Google Scholar 

  31. Suso S, Combalia A, Segur JM, Garcia-Ramiro S, Ramon R (1993) Comminuted intra-articular fractures of the distal end of the radius treated with the Hoffmann external fixator. J Trauma 35:61–66

    Article  CAS  PubMed  Google Scholar 

  32. Hegeman JH, Oskam J, Vierhout PA, Ten Duis HJ (2005) External fixation for unstable intra-articular distal radial fractures in women older than 55 years. Acceptable functional end results in the majority of the patients despite significant secondary displacement. Injury 36:339–344

    Article  CAS  PubMed  Google Scholar 

  33. Zollinger PE, Kreis RW, van der Meulen HG, van der Elst M, Breederveld RS, Tuinebreijer WE (2010) No higher risk of CRPS after external fixation of distal radial fractures—subgroup analysis under randomised vitamin C prophylaxis. Open Orthop J 4:71–75

    PubMed Central  PubMed  Google Scholar 

  34. Marx C, Wiedersheim P, Michel BA, Stucki G (2001) Preventing recurrence of reflex sympathetic dystrophy in patients requiring an operative intervention at the site of dystrophy after surgery. Clin Rheumatol 20:114–118

    Article  CAS  PubMed  Google Scholar 

  35. Cappello ZJ, Kasdan ML, Louis DS (2012) Meta-analysis of imaging techniques for the diagnosis of complex regional pain syndrome type I. J Hand Surg Am 37:288–296

    Article  PubMed  Google Scholar 

  36. Goris RJ, Leixnering M, Huber W, Figl M, Jaindl M, Redl H (2007) Delayed recovery and late development of complex regional pain syndrome in patients with an isolated fracture of the distal radius: prediction of a regional inflammatory response by early signs. J Bone Joint Surg Br 89:1069–1076

    Article  CAS  PubMed  Google Scholar 

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Acknowledgments

We thank S.Y. Lee MD, C.H. Hwang MD and S.H Lee MD, for their role in data management and statistical support. This study was supported by the Korean Human Technology Research Foundation (KOHTERF-2014-01).

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Corresponding author

Correspondence to Jung Ho Noh.

Additional information

This work was performed at Gil Medical Center, Gachon University School of Medicine, Incheon, Korea.

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Roh, Y.H., Lee, B.K., Noh, J.H. et al. Factors associated with complex regional pain syndrome type I in patients with surgically treated distal radius fracture. Arch Orthop Trauma Surg 134, 1775–1781 (2014). https://doi.org/10.1007/s00402-014-2094-5

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  • DOI: https://doi.org/10.1007/s00402-014-2094-5

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