Skip to main content
Erschienen in: Archives of Orthopaedic and Trauma Surgery 10/2020

Open Access 23.05.2020 | Arthroscopy and Sports Medicine

Decision making for concomitant high tibial osteotomy (HTO) in cartilage repair patients based on a nationwide cohort study of 4968 patients

verfasst von: Svea Faber, Johannes Zellner, Peter Angele, Gunter Spahn, Ingo Löer, Wolfgang Zinser, Philipp Niemeyer

Erschienen in: Archives of Orthopaedic and Trauma Surgery | Ausgabe 10/2020

Einloggen, um Zugang zu erhalten

Abstract

Background

High tibial osteotomy (HTO) for varus deformities is a common concomitant treatment in cartilage surgery. Aim of the present study was to analyze factors influencing the decision towards accompanying HTO in patients with cartilage defects of the medial femoral condyle, such as the amount of varus deformity.

Methods

Data from 4986 patients treated for cartilage defects of the knee from the German Cartilage Registry (KnorpelRegister DGOU) were used for the current analysis. Seven hundred and thirty-six patients fulfilled the inclusion criteria. Their data were analyzed for factors influencing the decision towards performing a concomitant HTO using t test, univariate and multivariate binary logistic regression models.

Results

The break point at which the majority of patients receive a concomitant HTO is 3° of varus deformity. Several factors apart from the amount of varus deformity (5.61 ± 2.73° vs. 1.72 ± 2.38°, p < 0.00) differed significantly between the group of patients with HTO and those without. These included defect size (441.6 ± 225.3 mm2 vs. 386.5 ± 204.2 mm2, p = 0.001), symptom duration (29.53 ± 44.58 months vs. 21.85 ± 34.17 months, p = 0.021), defect grade (62.5% IVa/IVb vs. 57.3% IVa/IVb, p = 0.014), integrity of corresponding joint surface (10.8% grade III–IV vs. 0.2% grade III–IV, p < 0.001), meniscus status (15.5% > 1/3 resected vs. 4.4% > 1/3 resected, p < 0.001) and number of previous surgeries (1.01 ± 1.06 vs. 0.75 ± 1.00, p = 0.001). In the stepwise multivariate binary logistic regression test, only the amount of varus deformity, symptom duration and quality of the corresponding joint surface remained significant predictors associated with performing a concomitant HTO.

Conclusion

Based upon data from a nationwide cohort, additional HTO in context with cartilage repair procedures of the medial femoral condyle is frequently performed even in mild varus deformities less than 5°. Other factors also seem to influence decision for HTO.
Literatur
1.
Zurück zum Zitat Spahn G, Kirschbaum S, Kahl E (2006) Factors that influence high tibial osteotomy results in patients with medial gonarthritis: a score to predict the results. Osteoarthr Cartil 14(2):190–195CrossRef Spahn G, Kirschbaum S, Kahl E (2006) Factors that influence high tibial osteotomy results in patients with medial gonarthritis: a score to predict the results. Osteoarthr Cartil 14(2):190–195CrossRef
2.
Zurück zum Zitat Spahn G, Fritz J, Albrecht D, Angele P, Fickert S, Aurich M, Hofmann GO, Niemeyer P (2017) Koinzidenz und Therapie von Beinachsdeviationen bei degenerativen Knorpelschäden des Kniegelenks. Ergebnisse aus dem Deutschen KnorpelRegister DGOU. Z Orthop Unfall 155(4):457–467CrossRef Spahn G, Fritz J, Albrecht D, Angele P, Fickert S, Aurich M, Hofmann GO, Niemeyer P (2017) Koinzidenz und Therapie von Beinachsdeviationen bei degenerativen Knorpelschäden des Kniegelenks. Ergebnisse aus dem Deutschen KnorpelRegister DGOU. Z Orthop Unfall 155(4):457–467CrossRef
3.
Zurück zum Zitat Amendola A, Panarella L (2005) High tibial osteotomy for the treatment of unicompartmental arthritis of the knee. Orthop Clin N Am 36:497–504CrossRef Amendola A, Panarella L (2005) High tibial osteotomy for the treatment of unicompartmental arthritis of the knee. Orthop Clin N Am 36:497–504CrossRef
4.
Zurück zum Zitat Cantin O, Magnussen RA, Corbi F, Servien E, Neyret P, Lustig S (2015) The role of high tibial osteotomy in the treatment of knee laxity: a comprehensive review. Knee Surg Sports Traumatol Arthrosc 23:3026–3037CrossRef Cantin O, Magnussen RA, Corbi F, Servien E, Neyret P, Lustig S (2015) The role of high tibial osteotomy in the treatment of knee laxity: a comprehensive review. Knee Surg Sports Traumatol Arthrosc 23:3026–3037CrossRef
5.
Zurück zum Zitat Lee OS, Ahn S, Ahn JH, Teo SH, Lee YS (2018) Effectiveness of concurrent procedures during high tibial osteotomy for medial compartment osteoarthritis: a systematic review and meta-analysis. Arch Orthop Trauma Surg 138(2):227–236CrossRef Lee OS, Ahn S, Ahn JH, Teo SH, Lee YS (2018) Effectiveness of concurrent procedures during high tibial osteotomy for medial compartment osteoarthritis: a systematic review and meta-analysis. Arch Orthop Trauma Surg 138(2):227–236CrossRef
6.
Zurück zum Zitat Savarese E, Bisicchia S, Romeo R, Amendola A (2011) Role of high tibial osteotomy in chronic injuries of posterior cruciate ligament and posterolateral corner. J Orthop Traumatol 12(1):1–17CrossRef Savarese E, Bisicchia S, Romeo R, Amendola A (2011) Role of high tibial osteotomy in chronic injuries of posterior cruciate ligament and posterolateral corner. J Orthop Traumatol 12(1):1–17CrossRef
7.
Zurück zum Zitat Niemeyer P, Kreuz PC, Steinwachs M, Südkamp NP (2007) Chirurgische Therapieverfahren zur Behandlung Umschriebener Knorpelschäden am Kniegelenk. Sportverletz Sportschaden 21(1):41–50CrossRef Niemeyer P, Kreuz PC, Steinwachs M, Südkamp NP (2007) Chirurgische Therapieverfahren zur Behandlung Umschriebener Knorpelschäden am Kniegelenk. Sportverletz Sportschaden 21(1):41–50CrossRef
8.
Zurück zum Zitat Niemeyer P, Albrecht D, Andereya S, Angele P, Ateschrang A, Aurich M, Baumann M, Bosch U, Erggelet C, Fickert S, Gebhard H, Gelse K, Günther D, Hoburg A, Kasten P, Kolombe T, Madry H, Marlovits S, Meenen NM, Müller PE, Nöth U, Petersen JP, Pietschmann M, Richter W, Rolauffs B, Rhunau K, Schewe B, Steinert A, Steinwachs MR, Welsch GH, Zinser W, Fritz J (2016) Autologous chondrocyte implantation (ACI) for cartilage defects of the knee: a guideline by the working group “Clinical Tissue Regeneration” of the German Society of Orthopaedics and Trauma (DGOU). Knee 23(3):426–435CrossRef Niemeyer P, Albrecht D, Andereya S, Angele P, Ateschrang A, Aurich M, Baumann M, Bosch U, Erggelet C, Fickert S, Gebhard H, Gelse K, Günther D, Hoburg A, Kasten P, Kolombe T, Madry H, Marlovits S, Meenen NM, Müller PE, Nöth U, Petersen JP, Pietschmann M, Richter W, Rolauffs B, Rhunau K, Schewe B, Steinert A, Steinwachs MR, Welsch GH, Zinser W, Fritz J (2016) Autologous chondrocyte implantation (ACI) for cartilage defects of the knee: a guideline by the working group “Clinical Tissue Regeneration” of the German Society of Orthopaedics and Trauma (DGOU). Knee 23(3):426–435CrossRef
9.
Zurück zum Zitat Niemeyer P, Laute V, Zinser W, Becher C, Kolombe T, Fay J, Pietsch S, Kuźma T, Widuchowski W, Fickert S (2019) A prospective, randomized, open-label, multicenter, phase III noninferiority trial to compare the clinical efficacy of matrix-associated autologous chondrocyte implantation with spheroid technology versus arthroscopic microfracture for cartilage defects of the knee. Orthop J Sport Med 7(7):24. https://doi.org/10.1177/2325967119854442CrossRef Niemeyer P, Laute V, Zinser W, Becher C, Kolombe T, Fay J, Pietsch S, Kuźma T, Widuchowski W, Fickert S (2019) A prospective, randomized, open-label, multicenter, phase III noninferiority trial to compare the clinical efficacy of matrix-associated autologous chondrocyte implantation with spheroid technology versus arthroscopic microfracture for cartilage defects of the knee. Orthop J Sport Med 7(7):24. https://​doi.​org/​10.​1177/​2325967119854442​CrossRef
10.
Zurück zum Zitat Saris D, Price A, Widuchowski W, Bertrand-Marchand M, Caron J, Drogset JO, Emans P, Podskubka A, Tsuchida A, Kili S, Levine D, Brittberg M (2014) Matrix-applied characterized autologous cultured chondrocytes versus microfracture: two-year follow-up of a prospective randomized trial. Am J Sports Med 42(6):1384–1394CrossRef Saris D, Price A, Widuchowski W, Bertrand-Marchand M, Caron J, Drogset JO, Emans P, Podskubka A, Tsuchida A, Kili S, Levine D, Brittberg M (2014) Matrix-applied characterized autologous cultured chondrocytes versus microfracture: two-year follow-up of a prospective randomized trial. Am J Sports Med 42(6):1384–1394CrossRef
12.
Zurück zum Zitat Bode G, Schmal H, Pestka JM, Ogon P, Südkamp NP, Niemeyer P (2013) A non-randomized controlled clinical trial on autologous chondrocyte implantation (ACI) in cartilage defects of the medial femoral condyle with or without high tibial osteotomy in patients with varus deformity of less than 5. Arch Orthop Trauma Surg 133(1):43–49CrossRef Bode G, Schmal H, Pestka JM, Ogon P, Südkamp NP, Niemeyer P (2013) A non-randomized controlled clinical trial on autologous chondrocyte implantation (ACI) in cartilage defects of the medial femoral condyle with or without high tibial osteotomy in patients with varus deformity of less than 5. Arch Orthop Trauma Surg 133(1):43–49CrossRef
13.
Zurück zum Zitat Kahlenberg CA, Nwachukwu BU, Hamid KS, Steinhaus ME, Williams RJ (2017) Analysis of outcomes for high tibial osteotomies performed with cartilage restoration techniques. Arthrosc J Arthrosc Relat Surg 33:486–492CrossRef Kahlenberg CA, Nwachukwu BU, Hamid KS, Steinhaus ME, Williams RJ (2017) Analysis of outcomes for high tibial osteotomies performed with cartilage restoration techniques. Arthrosc J Arthrosc Relat Surg 33:486–492CrossRef
14.
Zurück zum Zitat Hancock KJ, Westermann RR, Shamrock AG, Duchman KR, Wolf BR, Amendola A (2019) Trends in knee articular cartilage treatments: an american board of orthopaedic surgery database study. J Knee Surg 32(1):85–90CrossRef Hancock KJ, Westermann RR, Shamrock AG, Duchman KR, Wolf BR, Amendola A (2019) Trends in knee articular cartilage treatments: an american board of orthopaedic surgery database study. J Knee Surg 32(1):85–90CrossRef
15.
Zurück zum Zitat Frank RM, Cotter EJ, Hannon CP, Harrast JJ, Cole BJ (2019) Cartilage restoration surgery: incidence rates, complications, and trends as reported by the American Board of Orthopaedic Surgery Part II candidates. Arthrosc J Arthrosc Relat Surg 35(1):171–178CrossRef Frank RM, Cotter EJ, Hannon CP, Harrast JJ, Cole BJ (2019) Cartilage restoration surgery: incidence rates, complications, and trends as reported by the American Board of Orthopaedic Surgery Part II candidates. Arthrosc J Arthrosc Relat Surg 35(1):171–178CrossRef
16.
Zurück zum Zitat Westermann RW (2019) Editorial commentary: when performing cartilage restoration, please don’t put down the osteotomy saw! Arthrosc J Arthrosc Relat Surg 35:147–148CrossRef Westermann RW (2019) Editorial commentary: when performing cartilage restoration, please don’t put down the osteotomy saw! Arthrosc J Arthrosc Relat Surg 35:147–148CrossRef
17.
Zurück zum Zitat Mina C, Garrett WE, Pietrobon R, Glisson R, Higgins L (2008) High tibial osteotomy for unloading osteochondral defects in the medial compartment of the knee. Am J Sports Med 36(5):949–955CrossRef Mina C, Garrett WE, Pietrobon R, Glisson R, Higgins L (2008) High tibial osteotomy for unloading osteochondral defects in the medial compartment of the knee. Am J Sports Med 36(5):949–955CrossRef
18.
Zurück zum Zitat Agneskirchner JD, Hurschler C, Wrann CD, Lobenhoffer P (2007) The effects of valgus medial opening wedge high tibial osteotomy on articular cartilage pressure of the knee: a biomechanical study. Arthrosc J Arthrosc Relat Surg 23(8):852–861CrossRef Agneskirchner JD, Hurschler C, Wrann CD, Lobenhoffer P (2007) The effects of valgus medial opening wedge high tibial osteotomy on articular cartilage pressure of the knee: a biomechanical study. Arthrosc J Arthrosc Relat Surg 23(8):852–861CrossRef
19.
Zurück zum Zitat Agneskirchner JD, Hurschler C, Stukenborg-Colsman C, Imhoff AB, Lobenhoffer P (2004) Effect of high tibial flexion osteotomy on cartilage pressure and joint kinematics: a biomechanical study in human cadaveric knees. Winner of the AGA-DonJoy Award 2004. Arch Orthop Trauma Surg 124(9):575–584CrossRef Agneskirchner JD, Hurschler C, Stukenborg-Colsman C, Imhoff AB, Lobenhoffer P (2004) Effect of high tibial flexion osteotomy on cartilage pressure and joint kinematics: a biomechanical study in human cadaveric knees. Winner of the AGA-DonJoy Award 2004. Arch Orthop Trauma Surg 124(9):575–584CrossRef
20.
Zurück zum Zitat Floerkemeier S, Staubli AE, Schroeter S, Goldhahn S, Lobenhoffer P (2013) Outcome after high tibial open-wedge osteotomy: a retrospective evaluation of 533 patients. Knee Surg Sport Traumatol Arthrosc 21(1):170–180CrossRef Floerkemeier S, Staubli AE, Schroeter S, Goldhahn S, Lobenhoffer P (2013) Outcome after high tibial open-wedge osteotomy: a retrospective evaluation of 533 patients. Knee Surg Sport Traumatol Arthrosc 21(1):170–180CrossRef
21.
Zurück zum Zitat Ji W, Luo C, Zhan Y, Xie X, He Q, Zhang B (2019) A residual intra-articular varus after medial opening wedge high tibial osteotomy (HTO) for varus osteoarthritis of the knee. Arch Orthop Trauma Surg 139(6):743–750CrossRef Ji W, Luo C, Zhan Y, Xie X, He Q, Zhang B (2019) A residual intra-articular varus after medial opening wedge high tibial osteotomy (HTO) for varus osteoarthritis of the knee. Arch Orthop Trauma Surg 139(6):743–750CrossRef
22.
Zurück zum Zitat Hinman RS, May RL, Crossley KM (2006) Is there an alternative to the full-leg radiograph for determining knee joint alignment in osteoarthritis? Arthritis Care Res 55(2):306–313CrossRef Hinman RS, May RL, Crossley KM (2006) Is there an alternative to the full-leg radiograph for determining knee joint alignment in osteoarthritis? Arthritis Care Res 55(2):306–313CrossRef
24.
Zurück zum Zitat Niemeyer P, Stöhr A, Köhne M, Hochrein A (2017) Medial opening wedge high tibial osteotomy. Oper Orthop Traumatol 29:294–305CrossRef Niemeyer P, Stöhr A, Köhne M, Hochrein A (2017) Medial opening wedge high tibial osteotomy. Oper Orthop Traumatol 29:294–305CrossRef
25.
Zurück zum Zitat Pestka JM, Luu NH, Südkamp NP, Angele P, Spahn G, Zinser W, Niemeyer P (2018) Revision surgery after cartilage repair: data from the german cartilage registry (KnorpelRegister DGOU). Orthop J Sport Med 6(2):1–8CrossRef Pestka JM, Luu NH, Südkamp NP, Angele P, Spahn G, Zinser W, Niemeyer P (2018) Revision surgery after cartilage repair: data from the german cartilage registry (KnorpelRegister DGOU). Orthop J Sport Med 6(2):1–8CrossRef
26.
Zurück zum Zitat Bode G, Ogon P, Pestka J, Zwingmann J, Feucht M, Südkamp N, Niemeyer P (2015) Clinical outcome and return to work following single-stage combined autologous chondrocyte implantation and high tibial osteotomy. Int Orthop 39(4):689–696CrossRef Bode G, Ogon P, Pestka J, Zwingmann J, Feucht M, Südkamp N, Niemeyer P (2015) Clinical outcome and return to work following single-stage combined autologous chondrocyte implantation and high tibial osteotomy. Int Orthop 39(4):689–696CrossRef
27.
Zurück zum Zitat Attinger MC, Behrend H, Jost B (2014) Complete rupture of the popliteal artery complicating high tibial osteotomy. J Orthop 11:192–196CrossRef Attinger MC, Behrend H, Jost B (2014) Complete rupture of the popliteal artery complicating high tibial osteotomy. J Orthop 11:192–196CrossRef
29.
Zurück zum Zitat Jakma TSC, Verhaar JAN, Brouwer KH, Brouwer RW (2007) Pitfalls in determining knee alignment. J Knee Surg 20(3):210–215 Jakma TSC, Verhaar JAN, Brouwer KH, Brouwer RW (2007) Pitfalls in determining knee alignment. J Knee Surg 20(3):210–215
30.
Zurück zum Zitat Khare R, Jaramaz B (2017) Accuracy of leg alignment measurements from antero-posterior radiographs. Biomed Tech 62(3):315–320CrossRef Khare R, Jaramaz B (2017) Accuracy of leg alignment measurements from antero-posterior radiographs. Biomed Tech 62(3):315–320CrossRef
Metadaten
Titel
Decision making for concomitant high tibial osteotomy (HTO) in cartilage repair patients based on a nationwide cohort study of 4968 patients
verfasst von
Svea Faber
Johannes Zellner
Peter Angele
Gunter Spahn
Ingo Löer
Wolfgang Zinser
Philipp Niemeyer
Publikationsdatum
23.05.2020
Verlag
Springer Berlin Heidelberg
Erschienen in
Archives of Orthopaedic and Trauma Surgery / Ausgabe 10/2020
Print ISSN: 0936-8051
Elektronische ISSN: 1434-3916
DOI
https://doi.org/10.1007/s00402-020-03476-6

Weitere Artikel der Ausgabe 10/2020

Archives of Orthopaedic and Trauma Surgery 10/2020 Zur Ausgabe

Arthropedia

Grundlagenwissen der Arthroskopie und Gelenkchirurgie. Erweitert durch Fallbeispiele, Videos und Abbildungen. 
» Jetzt entdecken

Update Orthopädie und Unfallchirurgie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.